{"id":59908,"date":"2024-02-28T06:23:19","date_gmt":"2024-02-28T06:23:19","guid":{"rendered":"https:\/\/medsname.com\/ondem-injection\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"ondem-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/ondem-injection\/","title":{"rendered":"Ondem Injeksjon"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Ondem Injection?<\/h3>\n<p style=\"margin:0;\"><strong>Ondem Injeksjon<\/strong> inneholder <strong>ondansetron 2 mg\/ml<\/strong> in 2 ml ampoules (4 mg total) &mdash; a selective serotonin <strong>5-HT3 receptor antagonist<\/strong> used in hospitals to prevent and treat <strong>kjemoterapi-indusert<\/strong>, <strong>str\u00e5lebehandlingsindusert<\/strong>, og <strong>post-operative nausea and vomiting (PONV)<\/strong>. Administered by a healthcare professional intravenously (slow push or short infusion) or intramuscularly. Onset within 5&ndash;10 minutes IV. Manufactured by Alkem Laboratories &mdash; the generic equivalent of Zofran injection. <strong>FDA single-dose cap 16 mg IV<\/strong> due to QT signal at higher doses.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Hvorfor bestille fra MedsBase:<\/strong> \u2714 <strong>WHO-GMP-sertifisert produsent<\/strong> \u2714 Diskret emballasje \u2714 Verdensomspennende frakt \u2714 <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">Verifiserte kundeanmeldelser (1,400+ kunder)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>V\u00e5re generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, n\u00f8ytral emballasje \u2014 ingen legemiddelnavn p\u00e5 utsiden av pakken. Kortbetalinger h\u00e5ndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor \u2014 aldri \u201cMedsBase\u201d eller noe legemiddelnavn). Krypto og SEPA bankoverf\u00f8rsel godtas ogs\u00e5. Hver ordre er dekket av v\u00e5r Reshipment Assurance Policy.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Hospital-only injection &mdash; not for self-administration.<\/strong> Parenteral ondansetron is administered by a healthcare professional in a clinical setting (chemotherapy unit, hospital theatre, emergency department) where ECG and resuscitation equipment are available. Self-administration is not appropriate. Single doses &gt; 16 mg IV have been associated with QT prolongation and torsades-de-pointes &mdash; the FDA dose cap is 16 mg per dose. Avoid in <strong>congenital long-QT syndrome<\/strong>, hypokalaemia, hypomagnesaemia, and with concurrent QT-prolonging drugs (azithromycin, citalopram, methadone, amiodarone, fluoroquinolones, antipsychotics, hydroxychloroquine). Apomorphine is an absolute contraindication.<\/div>\n<h3 class=\"wp-block-heading\">Hvorfor bestille fra MedsBase<\/h3>\n<p>Ondem Injection is supplied from a <strong>WHO-GMP-sertifisert produsent<\/strong>. Hver ordre sendes diskret over hele verden og er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Ondem Injection is the global standard parenteral 5-HT3 antagonist for inpatient antiemesis. Alkem is one of India&rsquo;s largest WHO-GMP injectable manufacturers and the formulation is bioequivalent to the reference brand.<\/p>\n<h2 class=\"wp-block-heading\">Mekanisme for virkning<\/h2>\n<p>Chemotherapy, radiation, and surgical stress damage gut enterochromaffin cells, releasing massive amounts of <strong>serotonin (5-HT)<\/strong>. The serotonin binds 5-HT3 receptors on vagal afferents and on the chemoreceptor trigger zone (area postrema), generating the strongest known oral\/intestinal emetic stimulus. Ondansetron is a highly selective antagonist at the 5-HT3 receptor &mdash; it interrupts this signal at both peripheral and central sites without affecting D2, H1, muscarinic, or alpha-adrenergic receptors. The clean receptor profile explains the absence of sedation, extrapyramidal reactions, and anticholinergic side effects that limit older antiemetics like prochlorperazine and metoclopramide.<\/p>\n<h2 class=\"wp-block-heading\">Indikasjoner<\/h2>\n<ul>\n<li><strong>CINV:<\/strong> moderately or highly emetogenic chemotherapy &mdash; usually with dexamethasone &plusmn; aprepitant for highly emetogenic regimens.<\/li>\n<li><strong>Str\u00e5lingsindusert kvalme:<\/strong> total body irradiation, high-dose abdominal\/pelvic radiation.<\/li>\n<li><strong>Postoperativ kvalme og oppkast (PONV):<\/strong> single 4 mg dose at induction or end of surgery; prophylaxis for high-risk patients (Apfel score &ge; 2).<\/li>\n<li><strong>Severe gastroenteritis<\/strong> in patients unable to retain oral fluids.<\/li>\n<li><strong>Refractory hyperemesis gravidarum<\/strong> &mdash; second\/third-line after doxylamine+B6 and metoclopramide.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dose<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indikasjon<\/th>\n<th style=\"padding:8px;text-align:left;\">Dose<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (highly emetogenic)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">8 mg slow IV (over &gt; 15 min) 30 min before chemo, then 8 mg every 4 h &times; 2 doses, then transition to oral 8 mg every 12 h<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">CINV (moderately emetogenic)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">8 mg slow IV 30 min before chemo, then transition to oral<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">PONV (adult)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">4 mg slow IV at induction or end of surgery (single dose); some protocols 8 mg for high-risk<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Pediatrisk (CINV)<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">5 mg\/m&sup2; IV before chemo (max 8 mg per dose); weight-based for gastroenteritis<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Single-dose maximum<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">16 mg IV (FDA cap due to QT signal); slow IV push over 30 sec or short infusion 15 min<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Alvorlig leversvikt<\/td>\n<td style=\"padding:8px;\">Maximum 8 mg\/day (Child-Pugh C)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Compatible with 0.9% sodium chloride and 5% dextrose; do not mix in the same syringe with other drugs. Administer slow IV (over 30 seconds for push or 15 min for infusion) &mdash; rapid bolus increases the QT signal.<\/p>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<ul>\n<li><strong>Vanlig:<\/strong> headache (often within minutes of injection), constipation, mild flushing, transient AST\/ALT rise, fatigue<\/li>\n<li><strong>Mindre vanlige:<\/strong> dizziness, hot flushes, hiccups, mild bradycardia, hypotension after rapid IV<\/li>\n<li><strong>Sjeldne, men alvorlige:<\/strong> QT prolongation\/torsades (especially with single doses &gt; 16 mg), serotonin syndrome (with SSRIs\/SNRIs\/triptans), severe hypersensitivity, transient blindness (very rare), arrhythmia<\/li>\n<li><strong>Mindre vanlig:<\/strong> extrapyramidal reactions (rare with ondansetron unlike older antiemetics)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Legemiddelinteraksjoner<\/h2>\n<ul>\n<li><strong>Apomorphine:<\/strong> ABSOLUTE contraindication &mdash; severe hypotension and loss of consciousness reported.<\/li>\n<li><strong>Andre QT-forlengende legemidler<\/strong> (azithromycin, clarithromycin, citalopram, escitalopram, methadone, amiodarone, sotalol, fluoroquinolones, hydroxychloroquine, antipsychotics): avoid combination or monitor ECG.<\/li>\n<li><strong>Serotonerge legemidler<\/strong> (SSRIs, SNRIs, MAOIs, triptans, tramadol, fentanyl, linezolid, methylene blue): rare serotonin syndrome reported.<\/li>\n<li><strong>Sterke CYP3A4-indusere<\/strong> (rifampicin, phenytoin, carbamazepine): may lower ondansetron levels and reduce efficacy.<\/li>\n<li><strong>Tramadol:<\/strong> ondansetron may reduce tramadol analgesic effect (5-HT3 blockade interferes with descending pain inhibition).<\/li>\n<\/ul>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does Ondem Injection work?<\/h3>\n<p>Onset is within 5&ndash;10 minutes after slow IV push and 15&ndash;30 minutes after IM injection. Antiemetic effect lasts 8&ndash;12 hours. The IV form is preferred for active vomiting where oral routes are unreliable.<\/p>\n<h3 class=\"wp-block-heading\">Why is the IV ondansetron dose capped at 16 mg?<\/h3>\n<p>FDA review of cardiac safety data found that single IV doses &gt; 16 mg significantly increase the risk of QT prolongation and torsades-de-pointes. The 16 mg cap applies to single doses; total daily dose can still be 24 mg given as 8 mg every 8 hours.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem Injection be given IM?<\/h3>\n<p>Yes &mdash; IM is a reasonable route when IV access is difficult, with onset 15&ndash;30 minutes (slower than IV but faster than oral). The standard IM dose is 4 mg; do not exceed 16 mg per single dose.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem Injection be used in pregnancy?<\/h3>\n<p>Reserved for refractory hyperemesis gravidarum after doxylamine+B6 and metoclopramide have failed. Some observational studies suggest a small first-trimester cardiac and cleft-palate signal &mdash; weigh against the maternal risk of severe untreated hyperemesis. Specialist supervision recommended.<\/p>\n<h3 class=\"wp-block-heading\">Is Ondem Injection safe in children?<\/h3>\n<p>Yes &mdash; weight or BSA-based dosing is well established for paediatric chemotherapy and severe gastroenteritis. The dose is typically 5 mg\/m&sup2; IV before chemo (max 8 mg) or weight-based (0.15 mg\/kg) for gastroenteritis.<\/p>\n<h3 class=\"wp-block-heading\">Why does Ondem Injection cause constipation?<\/h3>\n<p>5-HT3 receptors in the gut wall regulate gut motility &mdash; blocking them reduces peristalsis and slows colonic transit. Constipation is the most clinically meaningful side effect; pre-empt with hydration, fibre, and prophylactic laxatives during multi-day chemo courses.<\/p>\n<h3 class=\"wp-block-heading\">Does Ondem Injection cause sedation?<\/h3>\n<p>No. Unlike promethazine, prochlorperazine, and metoclopramide, ondansetron does not cause sedation, extrapyramidal reactions, or anticholinergic side effects.<\/p>\n<h3 class=\"wp-block-heading\">Can Ondem Injection be mixed with chemotherapy in the same line?<\/h3>\n<p>Ondansetron is incompatible with several chemotherapy agents in the same syringe; flush the line with normal saline between drugs. Compatibility is product-specific and should be checked against pharmacy guidelines for each chemotherapy combination.<\/p>\n<h3 class=\"wp-block-heading\">What if a single dose &gt; 16 mg is needed?<\/h3>\n<p>For highly emetogenic chemotherapy, give 8 mg slow IV every 4 hours rather than a single high dose. Switching to a different 5-HT3 (granisetron, palonosetron) or adding an NK1 antagonist (aprepitant) is usually a better strategy than exceeding the 16 mg single-dose cap.<\/p>\n<h3 class=\"wp-block-heading\">How is Ondem Injection stored?<\/h3>\n<p>Store ampoules at room temperature (15&ndash;25&deg;C), protect from light. Do not freeze. Inspect the solution before use &mdash; it should be clear and colourless.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Andre kvalmebehandlinger<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/ondem\/\">Ondem (ondansetron oral tablet &mdash; oral switch after IV)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/emeset-4-odt\/\">Emeset 4 ODT (oral disintegrating &mdash; transition from IV)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/granicip\/\">Granicip (granisetron &mdash; once-daily 5-HT3)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/dompewal-tablet\/\">Dompewal (domperidone &mdash; alternative class)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/stemetil-md\/\">Stemetil MD (prochlorperazine ODT &mdash; rescue antiemetic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/nausea-treatment\/\"><strong>Se alle kvalmebehandlinger<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medisinsk ansvarsfraskrivelse.<\/strong> Denne siden er kun til informasjonsform\u00e5l og erstatter ikke medisinsk r\u00e5dgivning fra en kvalifisert helsepersonell. Vedvarende oppkast, blod i oppkastet, alvorlig magesmerter, tegn p\u00e5 dehydrering, mistenkte svangerskapskomplikasjoner eller kjemoterapirelaterte symptomer b\u00f8r vurderes av en lege.<\/div>","protected":false},"excerpt":{"rendered":"<p>Ondem Injection (Ondansetron 2 mg\/ml, 4 mg per 2 ml ampoule) \u2014 hospital-administered IV\/IM 5-HT3 antagonist for chemotherapy, radiation, and post-operative nausea. Alkem generic of Zofran injection.<\/p>","protected":false},"featured_media":59909,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[3613,4766],"class_list":{"0":"post-59908","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-ondansetron","10":"product_tag-ondem-injection","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/59908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=59908"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/59909"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=59908"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=59908"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=59908"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=59908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}