{"id":60802,"date":"2024-02-28T07:09:25","date_gmt":"2024-02-28T07:09:25","guid":{"rendered":"https:\/\/medsname.com\/unicontin-e\/"},"modified":"2026-04-30T10:23:42","modified_gmt":"2026-04-30T10:23:42","slug":"unicontin-e","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/unicontin-e\/","title":{"rendered":"Unicontin-E"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Unicontin-E?<\/h3>\n<p><strong>Unicontin-E<\/strong> inneholder <strong>theophylline<\/strong>, en <strong>metylxantin bronkodilatator<\/strong> med antiinflammatorisk effekt, brukt som tilleggsterapi ved kronisk astma og KOLS. Teofyllin virker p\u00e5 flere m\u00e5l \u2014 fosfodiesterasehemming (\u00f8ker cAMP), adenosinreseptorantagonisme og HDAC2-aktivering (antiinflammatorisk). Det har et <strong>smalt terapeutisk vindu<\/strong> (target serum 10\u201320 mg\/L; toxicity at 20+) and many drug interactions, requiring careful dosing and (in some patients) blood-level monitoring. Each controlled-release tablet contains <strong>400 mg<\/strong>, produsert av <strong>Modi-Mundipharma<\/strong> ved WHO-GMP-sertifiserte anlegg.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hva du f\u00e5r med MedsBase:<\/strong> WHO-GMP-sertifisert produsent \u00b7 Diskret emballasje \u00b7 Verdensomspennende levering \u00b7 1 400+ verifiserte <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>V\u00e5re generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, n\u00f8ytral emballasje \u2014 ingen legemiddelnavn p\u00e5 utsiden av pakken. Kortbetalinger h\u00e5ndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor \u2014 aldri \u201cMedsBase\u201d eller noe legemiddelnavn). Krypto og SEPA bankoverf\u00f8rsel godtas ogs\u00e5. Hver ordre er dekket av v\u00e5r Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Kryptert kasse<\/strong> \u00b7 <strong>\ud83d\udcb3 Verifisert betalingsbehandler<\/strong> \u00b7 <strong>\ud83d\ude9a Verdensomspennende frakt<\/strong> \u00b7 <strong>\u2b50 4,9\/5 fra 1 400+ kunder<\/strong>\n<\/div>\n<h2>What Is Unicontin-E?<\/h2>\n<p>Unicontin-E is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled \u03b22-agonists and corticosteroids became first-line \u2014 but they retain a role as third-line add-on therapy in difficult asthma and COPD.<\/p>\n<h2>How Does Unicontin-E Work?<\/h2>\n<ul>\n<li><strong>Hemming av fosfodiesterase (PDE3, PDE4)<\/strong> \u2014 \u00f8ker syklisk AMP i glatt muskulatur i luftveiene og inflammatoriske celler; nettoresultatet er bronkodilatasjon og redusert frigj\u00f8ring av mediatorer.<\/li>\n<li><strong>Antagonisme av adenosinreseptorer<\/strong> \u2014 blokkerer adenosinmediert bronkokonstriksjon og frigj\u00f8ring av mediatorer fra mastceller.<\/li>\n<li><strong>Aktivering av HDAC2<\/strong> (teofyllin ved lave serumkonsentrasjoner 5\u201310 mg\/L) \u2014 gjenoppretter kortikosteroidrespons ved KOLS og alvorlig astma der steroidresistens delvis skyldes redusert HDAC2.<\/li>\n<li><strong>Kontraktilitet i diafragma<\/strong> \u2014 metylksantiner reduserer diafragma-trethet, nyttig ved KOLS med alvorlig luftstr\u00f8msbegrensning.<\/li>\n<\/ul>\n<h2>Bruk og indikasjoner<\/h2>\n<ul>\n<li><strong>Alvorlig kronisk astma<\/strong> \u2014 tillegg til h\u00f8y dose ICS-LABA der ytterligere bronkodilatasjon er n\u00f8dvendig<\/li>\n<li><strong>KOLS-vedlikehold<\/strong> \u2014 tillegg til LAMA-LABA eller trippelterapi<\/li>\n<li><strong>Nattlig astma<\/strong> \u2014 langtidsvirkende formulering gir bronkodilatasjon over natten<\/li>\n<li><strong>Prematur apn\u00e9<\/strong> (teofyllin) \u2014 bruk hos nyf\u00f8dte<\/li>\n<li><strong>Cor pulmonale og pulmonal hypertensjon<\/strong> \u2014 tilskudd<\/li>\n<\/ul>\n<h2>Unicontin-E Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pasient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Dose<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frekvens<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Voksne \u2014 initial<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily; titrate to serum level 10\u201320 mg\/L<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Voksne \u2014 vedlikehold<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily (or 600 mg once daily ER)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Elderly \/ heart failure \/ liver disease<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Halvere dose<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor serum level<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Unicontin-E<\/h2>\n<ul>\n<li>Kvalme, oppkast, ford\u00f8yelsesbesv\u00e6r<\/li>\n<li>Hodepine<\/li>\n<li>Tremor<\/li>\n<li>S\u00f8vnl\u00f8shet, uro<\/li>\n<li>Takykardi, hjertebank<\/li>\n<li>Mild hypokalemi ved h\u00f8ye doser<\/li>\n<\/ul>\n<p><strong>Toksiske niv\u00e5er (&gt;20 mg\/L) \u2014 akutt tilstand:<\/strong><\/p>\n<ul>\n<li>Kraftig kvalme, vedvarende oppkast<\/li>\n<li>Hjerterytmeforstyrrelser (atrieflimmer, supraventrikul\u00e6r takykardi)<\/li>\n<li>Kramper (ofte uten forvarsel)<\/li>\n<li>Hypotensjon, hyperglykemi, hypokalemi, hyperkalcemi<\/li>\n<\/ul>\n<h2>Advarsler og forholdsregler<\/h2>\n<ul>\n<li><strong>Smalt terapeutisk vindu.<\/strong> M\u00e5lsyre 10\u201320 mg\/L. Kontroller blodniv\u00e5 5 dager etter start, etter doseendring, ved bruk av nytt interagerende legemiddel, ved r\u00f8ykeslutt og under sykdom\/feber (klaringen reduseres).<\/li>\n<li><strong>Mange legemiddelinteraksjoner<\/strong> \u2014 se interaksjonstabell. Mesteparten metaboliseres av CYP1A2; mange hemmere og indus\u00f8rer endrer niv\u00e5ene betydelig.<\/li>\n<li><strong>R\u00f8yking<\/strong> induserer CYP1A2 og reduserer teofyllinniv\u00e5ene med ~50% \u2014 juster dosering ved r\u00f8ykeslutt.<\/li>\n<li><strong>Hjertesykdom:<\/strong> bruk med forsiktighet ved arytmier, hjertesvikt, alvorlig hypertensjon.<\/li>\n<li><strong>Hypertyreose:<\/strong> \u00f8kt klaring pluss forsterkede adrenerge effekter.<\/li>\n<li><strong>Graviditet og amming:<\/strong> vanligvis unng\u00e5s; bruk kun hvis fordelen er tydelig.<\/li>\n<li><strong>Leversykdom:<\/strong> reduser dose \u2014 metylksantiner metaboliseres i leveren.<\/li>\n<\/ul>\n<h2>Kontraindikasjoner<\/h2>\n<ul>\n<li>Overf\u00f8lsomhet for teofyllin eller andre xantiner (koffein, teobromin)<\/li>\n<li>Aktiv mages\u00e5rlidelse<\/li>\n<li>Ukontrollerte takyarytmier<\/li>\n<li>Alvorlig hjertesvikt (NYHA IV)<\/li>\n<\/ul>\n<h2>Legemiddelinteraksjoner<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interagerende legemiddel<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Effekt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Hva du b\u00f8r gj\u00f8re<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin, erytromycin, klaritromycin, fluvoksamin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hemmer CYP1A2 \u2192 \u00f8ker teofyllinniv\u00e5er \u2192 toksisitet (kvalme, arytmi, anfall)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Unng\u00e5 eller reduser teofyllindose med 50%; kontroller serumverdier<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidin, allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u00d8ker teofyllinniv\u00e5er<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduser dose; overv\u00e5k niv\u00e5er<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fenytoin, karbamazepin, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induserer CYP \u2014 lavere niv\u00e5er<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">H\u00f8yere dose kan v\u00e6re n\u00f8dvendig<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">R\u00f8yking<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induserer CYP1A2 \u2014 lavere niv\u00e5er<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Juster dose p\u00e5 nytt ved r\u00f8ykeslutt<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agonister, diuretika<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additiv hypokalemi<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Overv\u00e5k kaliumniv\u00e5et<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Oppbevaring<\/h2>\n<ul>\n<li>Oppbevar under <strong>25\u00b0C<\/strong> p\u00e5 et kj\u00f8lig, t\u00f8rt sted unna direkte sollys.<\/li>\n<li>Oppbevar i originalemballasje til bruk for \u00e5 beskytte mot fuktighet og lys.<\/li>\n<li>Ikke bruk etter utl\u00f8psdatoen som st\u00e5r p\u00e5 strimlen.<\/li>\n<li>Oppbevar utilgjengelig for barn.<\/li>\n<\/ul>\n<h2>Relaterte alternativer p\u00e5 MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol lindringsmiddel<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS forebyggende<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA for KOLS<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/montair\/\"><strong>Montair \u2014 montelukast LTRA tablett<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3>Is theophylline still used in modern asthma management?<\/h3>\n<p>Yes, but as third-line add-on. Inhaled \u03b22 agonists, ICS, ICS-LABA, LTRA, and LAMA are first-line; theophylline is added for refractory disease, particularly nocturnal asthma. The narrow therapeutic index and many drug interactions limit its use.<\/p>\n<h3>How is the dose decided?<\/h3>\n<p>Adjusted to serum theophylline level 10\u201320 mg\/L. Check 5 days after starting, after dose change, with new interacting drug, with smoking cessation, and during illness\/fever.<\/p>\n<h3>Why so many interactions?<\/h3>\n<p>Theophylline is metabolised by CYP1A2 \u2014 many drugs raise levels (ciprofloxacin, erythromycin, fluvoxamine, cimetidine) or lower levels (rifampicin, phenytoin, smoking).<\/p>\n<h3>How long does Unicontin-E last?<\/h3>\n<p>The controlled-release tablet provides 12-hour cover. Twice-daily dosing maintains stable serum levels.<\/p>\n<h3>What are the toxic symptoms?<\/h3>\n<p>Severe nausea, persistent vomiting, tachycardia, palpitations, tremor, hyperactivity, seizures (often without warning), arrhythmias, hypotension. Toxicity above 20 mg\/L is an emergency \u2014 withhold dose, check level, supportive care.<\/p>\n<h3>Can I take it with caffeine?<\/h3>\n<p>Caffeine and theophylline are both methylxanthines with overlapping effects. Heavy caffeine can amplify tremor, tachycardia, and insomnia. Reduce caffeine if symptomatic.<\/p>\n<h3>Why does smoking affect dose?<\/h3>\n<p>Smoking induces CYP1A2 (the enzyme that metabolises theophylline). Smokers need higher doses; on stopping, levels rise \u2014 re-titrate.<\/p>\n<h3>Is Unicontin-E safe in pregnancy?<\/h3>\n<p>Generally avoided unless benefit clear. Inhaled therapy is preferred.<\/p>\n<h3>Can I crush or split Unicontin-E tablets?<\/h3>\n<p>No \u2014 controlled-release tablets must be swallowed whole. Crushing destroys the release matrix and risks acute toxicity.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Medisinsk ansvarsfraskrivelse:<\/strong> Denne siden er opplysningsmessig og erstatter ikke profesjonell medisinsk r\u00e5dgivning. Alltid konsulter en kvalifisert helsepersonell f\u00f8r du starter, stopper eller endrer enhver inhalator eller respirasjonsmedisin, spesielt hvis du har andre medisinske tilstander, tar andre reseptbelagte legemidler, er gravid eller ammer, eller er over 65 \u00e5r.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterte alternativer<\/h3>\n<p>Andre produkter innen <strong>Kroniske tilstander<\/strong> som kunder ogs\u00e5 ser p\u00e5:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/amifru\/\">Amifru<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/unibrom-eye-drops\/\">Unibrom \u00f8yedr\u00e5per<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/nise-gel\/\">Nise Gel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/dynapar\/\">Dynapar<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Lindrer bronkospasme<br \/>\n\u2705 Enhances lung function<br \/>\n\u2705 Reduces shortness of breath<br \/>\n\u2705 Improves airway flow<br \/>\n\u2705 Manages asthma symptoms<\/p>\n<p>Unicontin-E contains Theophylline.<\/p>","protected":false},"featured_media":60803,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3731,4926],"class_list":{"0":"post-60802","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-theophylline","10":"product_tag-unicontin-e","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/60802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=60802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/60803"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=60802"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=60802"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=60802"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=60802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}