{"id":60809,"date":"2024-02-28T07:09:30","date_gmt":"2024-02-28T07:09:30","guid":{"rendered":"https:\/\/medsname.com\/metabolis\/"},"modified":"2026-04-30T10:23:42","modified_gmt":"2026-04-30T10:23:42","slug":"metabolis","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nb\/product\/metabolis\/","title":{"rendered":"Metabolis"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Kort svar<\/h3>\n<p><strong>Metabolis (methylation-support multivitamin tablet)<\/strong> is a methylation-support multivitamin combining methylated B vitamins (methylfolate, methylcobalamin, P-5-P pyridoxal) with key cofactor minerals for patients with elevated homocysteine or MTHFR polymorphisms.<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>Methylated B-complex (methylfolate, methylcobalamin, P-5-P), choline, betaine, magnesium, zinc, selenium<\/li>\n<li>Indications: elevated homocysteine, MTHFR polymorphism, methylation-related conditions<\/li>\n<li>Daily oral tablet with food<\/li>\n<li>WHO-GMP-sertifisert produsent<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e0e4e7;padding:12px 16px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\n<strong>WHO-GMP-sertifisert produsent<\/strong> \u00b7 Diskret emballasje \u00b7 Verdensomspennende levering \u00b7 <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\" style=\"color:#2c7cb0;\">1,400+ verifiserte kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.<\/p>\n<p style=\"font-size:13px;color:#666;margin:4px 0 18px;\">Hver bestilling er dekket av v\u00e5r <a href=\"https:\/\/medsbase.com\/nb\/medsbase-re-shipment-assurance-policy\/\" style=\"color:#2c7cb0;\">Reshipment Assurance Policy<\/a>.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Metabolis is sourced from a WHO-GMP certified manufacturer. Every order ships in discreet, unbranded packaging worldwide and is covered by our Reshipment Assurance Policy. Pay securely with credit card, SEPA bank transfer, or cryptocurrency. See our <a href=\"https:\/\/medsbase.com\/nb\/reviews\/\">1,400+ verifiserte kundeanmeldelser<\/a>.<\/p>\n<h2>What is Metabolis?<\/h2>\n<p>Metabolis is a methylation-support multivitamin built around bioactive forms of folate (5-methyltetrahydrofolate \/ 5-MTHF), vitamin B12 (methylcobalamin), and vitamin B6 (pyridoxal-5-phosphate, P-5-P), plus methyl-donor cofactors (choline, betaine, methionine) and key minerals (magnesium, zinc, selenium). It is designed for patients with elevated homocysteine, with MTHFR (C677T or A1298C) polymorphisms, or for whom standard B-complex preparations may not provide optimal methylation support.<\/p>\n<h2>Indikasjoner<\/h2>\n<ul>\n<li><strong>Elevated homocysteine<\/strong> &mdash; cardiovascular and dementia risk factor; methylation cofactor support reduces levels<\/li>\n<li><strong>MTHFR polymorphism<\/strong> (C677T homozygous reduces enzyme activity ~70%; A1298C reduces ~40%) &mdash; methylated folate bypasses the MTHFR step<\/li>\n<li><strong>Adjunct in depression \/ mood disorders<\/strong> with low folate or B12 status &mdash; modest evidence for SSRI augmentation<\/li>\n<li><strong>Pregnancy planning in MTHFR carriers<\/strong> &mdash; methylated folate may be preferred over folic acid<\/li>\n<li><strong>Recurrent miscarriage with hyperhomocysteinaemia<\/strong><\/li>\n<li><strong>Adjunct in chronic fatigue with documented B-vitamin deficiency<\/strong><\/li>\n<li><strong>Long-term metformin or PPI users<\/strong> with documented B12 deficiency<\/li>\n<\/ul>\n<h3>Hvordan ta<\/h3>\n<p>One tablet daily with food. Effects on homocysteine are visible at 4&ndash;8 weeks &mdash; recheck levels at 12 weeks to assess response.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Methylated forms versus folic acid &mdash; the practical reality<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Folic acid (synthetic) requires reduction by DHFR and methylation by MTHFR to become bioactive 5-MTHF. In patients with MTHFR polymorphisms (~30% of the population is heterozygous; ~10% homozygous), this conversion is inefficient. Methylated folate (5-MTHF in Metabolis) bypasses this step. For most healthy adults, regular folic acid works fine. For patients with confirmed MTHFR polymorphism plus elevated homocysteine, the methylated form is more rationally chosen. Routine MTHFR testing in healthy adults is not recommended &mdash; the clinical impact is small and not all guidelines support testing.<\/p>\n<\/div>\n<h2>Bivirkninger<\/h2>\n<ul>\n<li><strong>Mild mageubehag<\/strong> \u2014 kvalme, ford\u00f8yelsesbesv\u00e6r; ta sammen med mat<\/li>\n<li><strong>Lysegul urin<\/strong> fra riboflavin \u2014 harml\u00f8st<\/li>\n<li><strong>Initial sensitivity<\/strong> to high-dose methylated B vitamins &mdash; some patients report transient anxiety, irritability, headache &mdash; ease in with half a tablet for the first week<\/li>\n<li><strong>Niacin-flushing<\/strong> \u2014 midlertidig<\/li>\n<li><strong>Pyridoksin-sensorisk nevropati<\/strong> &mdash; only at sustained extreme doses; standard product doses are well below threshold<\/li>\n<\/ul>\n<h2>Legemiddelinteraksjoner<\/h2>\n<ul>\n<li><strong>Metotrexat<\/strong> &mdash; folate (any form) may reduce efficacy in oncology dosing; in low-dose RA \/ psoriasis dosing folate is co-prescribed to reduce side effects<\/li>\n<li><strong>Antiepileptics (phenytoin, carbamazepine, phenobarbital, valproate)<\/strong> &mdash; deplete folate; supplementation appropriate but discuss with neurologist<\/li>\n<li><strong>Trimethoprim, pyrimethamin<\/strong> &mdash; antifolates; high-dose folate may theoretically reduce efficacy<\/li>\n<li><strong>Levodopa (uten dekarboksylasehemmer)<\/strong> &mdash; B6 effect (rare)<\/li>\n<li><strong>Langtids bruk av metformin eller PPI<\/strong> &mdash; reduce B12 absorption; combination with Metabolis appropriate<\/li>\n<\/ul>\n<h2>Kontraindikasjoner<\/h2>\n<ul>\n<li>Overf\u00f8lsomhet mot noe av innholdsstoffene<\/li>\n<li>Untreated B12 deficiency (folate alone &mdash; even methylated &mdash; can mask megaloblastic anaemia and let neurological B12 damage progress; Metabolis contains B12 so this risk is reduced but baseline B12 should still be checked)<\/li>\n<li>Active malignancy on antifolate chemotherapy without oncology approval<\/li>\n<\/ul>\n<h2>Oppbevaring<\/h2>\n<p>Oppbevares under 25\u00b0C i originalemballasje, beskytt mot fuktighet og lys.<\/p>\n<h2 id=\"faqs\">Vanlige sp\u00f8rsm\u00e5l<\/h2>\n<h3>What is methylation and why does it matter?<\/h3>\n<p>Methylation is the body&#8217;s reaction of adding a methyl group (-CH<sub>3<\/sub>) to molecules &mdash; central to DNA repair, neurotransmitter synthesis, hormone metabolism, and homocysteine clearance. The methyl donor is S-adenosyl-methionine (SAM), regenerated from homocysteine using B12, methylfolate, and B6 as cofactors. Inefficient methylation raises homocysteine and may contribute to cardiovascular and cognitive risk.<\/p>\n<h3>B\u00f8r jeg teste meg for MTHFR?<\/h3>\n<p>For most healthy adults &mdash; no. The clinical impact of MTHFR polymorphism is modest, and not all guidelines recommend testing. Indications: unexplained recurrent miscarriage, premature thrombosis, hyperhomocysteinaemia, family history. Routine pre-conception MTHFR testing is not recommended.<\/p>\n<h3>Will it lower my homocysteine?<\/h3>\n<p>Yes &mdash; in patients with elevated homocysteine, B12 + methylfolate + B6 supplementation reliably reduces it (often by 25&ndash;30%). Whether this reduces cardiovascular events is less clear &mdash; large RCTs (HOPE-2, VISP, NORVIT, SEARCH) showed homocysteine lowering but no consistent reduction in MACE. Treatment is most justified when homocysteine is markedly elevated (&gt;15 &mu;mol\/l) or where there is also a clear deficiency.<\/p>\n<h3>Methylated folate or regular folic acid in pregnancy?<\/h3>\n<p>For most women, regular folic acid 400&ndash;800 mcg\/day from 3 months pre-conception works perfectly to prevent neural tube defects. In MTHFR homozygous carriers, methylated folate (5-MTHF) is more rationally chosen but evidence that it is superior to folic acid for NTD prevention is limited. Discuss with your obstetrician.<\/p>\n<h3>Will it help my mood?<\/h3>\n<p>Methylated folate at 7.5&ndash;15 mg\/day has modest evidence as SSRI augmentation in MDD (the L-methylfolate \/ Deplin protocol). At standard multivitamin doses (in Metabolis) the effect is smaller. Worth supplementing if folate or B12 is deficient; not a replacement for antidepressant therapy.<\/p>\n<h3>Can methylation supplements feel &#8220;too strong&#8221;?<\/h3>\n<p>Some patients (often labelled &#8220;slow methylators&#8221; in functional medicine circles) report transient anxiety, headache, or irritability at high methylated B doses. Start with half a tablet for the first week, then full dose; symptoms usually settle.<\/p>\n<h3>B\u00f8r jeg ta det p\u00e5 lang sikt?<\/h3>\n<p>Yes if the indication persists (chronic hyperhomocysteinaemia, MTHFR with documented benefit, ongoing depression with deficiency). Reassess every 6&ndash;12 months &mdash; recheck homocysteine and B12 levels.<\/p>\n<h3>Will it interfere with my antidepressant?<\/h3>\n<p>Generally compatible. Methylated folate is studied as SSRI augmentation. Discuss with your prescriber if you start or stop &mdash; baseline B12 and folate should be checked.<\/p>\n<h3>Is it different from Beplex Forte?<\/h3>\n<p>Beplex Forte uses standard cyanocobalamin and folic acid &mdash; cheap and effective for most. Metabolis uses methylated forms (methylcobalamin, 5-MTHF, P-5-P) and adds methyl-donor cofactors (choline, betaine). For patients with MTHFR polymorphism or elevated homocysteine, Metabolis is more rationally targeted. For everyone else, Beplex Forte does the job.<\/p>\n<h3>Should I avoid folic acid if I take methylated folate?<\/h3>\n<p>No need. The body handles both. Stacking is fine but pointless. Pick one. If you take a prenatal multivitamin with folic acid, that is sufficient unless you have a specific MTHFR-related indication for switching.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Andre vitaminer og mineraler<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nb\/multivite-gold\/\">Multivite Gold<\/a> \u2014 omfattende multivitamin softgel<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/cheri\/\">Cheri<\/a> \u2014 jern + protein + kalsium + vitaminer kapsel<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/becozinc\/\">Becozinc<\/a> \u2014 B-kompleks med sink<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/c-vitan-z\/\">C Vitan Z<\/a> \u2014 vitamin C + sink + mineraler<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/metabolis\/\">Metabolis<\/a> \u2014 metyleringst\u00f8ttende multivitamin<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nb\/celin\/\">Celin<\/a> \u2014 vitamin C 500 mg<\/li>\n<\/ul>\n<h2>Medisinsk ansvarsfraskrivelse<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\nDenne siden er kun til informasjonsform\u00e5l og er ikke erstatning for profesjonell medisinsk r\u00e5dgivning. Vitamin- og mineraltilskudd b\u00f8r ideelt sett veiledes av laboratorietester n\u00e5r mangel mistenkes. Megadosetilskudd er ikke ufarlige \u2014 vitamin A er teratogent, vitamin E \u00f8ker bl\u00f8dningsrisiko, beta-karoten \u00f8ker risiko for lungekreft hos r\u00f8ykere, og h\u00f8ydose kalsium har en kardiovaskul\u00e6r signalering. Gravide eller ammende pasienter b\u00f8r f\u00f8lge f\u00f8dselsveiledning for prenatalt tilskudd. Pasienter p\u00e5 warfarin m\u00e5 opprettholde stabilt vitamin K-inntak. Pasienter p\u00e5 levotyroksin, fluorkinoloner eller tetracycliner m\u00e5 skille jern og kalsium med 4 timer. Oppgi alltid alle kosttilskudd til din lege og apoteker.\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Boosts overall health<br \/>\n\u2705 Provides essential nutrients<br \/>\n\u2705 St\u00f8tter metabolisme<br \/>\n\u2705 \u00d8ker energiniv\u00e5et<br \/>\n\u2705 Strengthens immune system<\/p>\n<p>Metabolis contains multivitamins and multiminerals.<\/p>","protected":false},"featured_media":60810,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[4927,4928,4021],"class_list":{"0":"post-60809","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-metabolis","10":"product_tag-multimineral","11":"product_tag-multivitamin","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product\/60809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/comments?post=60809"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media\/60810"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/media?parent=60809"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_brand?post=60809"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_cat?post=60809"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nb\/wp-json\/wp\/v2\/product_tag?post=60809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}