Endoxan (cyclofosfamide 50 mg)<\/a><\/li>\n<\/ul>\nVeelgestelde vragen<\/h2>\nWhy is Siromus listed under Anti-Cancer?<\/h3>\n
Sirolimus is primarily a transplant immunosuppressant. The mTOR pathway is implicated in multiple cancers and the structurally related everolimus has FDA approval for several oncology indications, but sirolimus itself is not a standard cancer drug. The current category placement appears to be a historical taxonomy issue.<\/p>\n
Siromus versus tacrolimus — which is better?<\/h3>\n
They have different mechanisms (mTOR vs calcineurin), different side-effect profiles, and different roles. Tacrolimus is the standard backbone for early post-transplant induction and maintenance. Sirolimus is typically introduced from 2–4 months post-transplant, often replacing or reducing tacrolimus, particularly in patients with calcineurin-inhibitor nephrotoxicity. They are not interchangeable.<\/p>\n
Siromus versus everolimus?<\/h3>\n
Everolimus is a sirolimus analogue with a hydroxyethyl modification that gives a shorter half-life (28 vs 60 hours) allowing twice-daily dosing and faster dose adjustment. Everolimus has more on-label indications (HR+ HER2- breast cancer with exemestane, advanced renal cell carcinoma, neuroendocrine tumours, SEGA, TSC-AML, drug-eluting stents). Sirolimus is the parent compound and remains widely used in transplant maintenance and LAM.<\/p>\n
Will Siromus increase my cancer risk?<\/h3>\n
Long-term immunosuppression with any agent (sirolimus, tacrolimus, ciclosporin, mycophenolate) increases lifetime risk of skin cancer, post-transplant lymphoproliferative disorder, and several other malignancies. The mTOR inhibitor class may have a een lager<\/em> skin cancer risk than calcineurin inhibitors based on transplant cohort data — some centres switch patients with multiple skin cancers to sirolimus. Annual full-body skin examination + SPF 50+ daily is standard regardless of regimen.<\/p>\nWhy do I need a sirolimus blood test?<\/h3>\n
Sirolimus has a narrow therapeutic window. Below the target trough you risk transplant rejection; above the target you risk pneumonitis, severe hyperlipidaemia, infection, and other toxicity. The 24-hour pre-dose trough on whole blood is the standard monitoring sample. Targets vary by indication and regimen — your transplant team will set yours.<\/p>\n
Can I have an operation while on Siromus?<\/h3>\n
Sirolimus impairs wound healing through mTOR inhibition of fibroblast and endothelial proliferation. For elective surgery, sirolimus is typically held for 2–4 weeks pre-op and resumed after the wound is well-healed (typically 2–4 weeks post-op). For emergency surgery, sirolimus is held immediately and a calcineurin-inhibitor-based regimen substituted under transplant team guidance.<\/p>\n
Why do I need to take Siromus consistently with or without food?<\/h3>\n
A high-fat meal increases sirolimus AUC by ~35% and peak by ~65%. If you switch between fed and fasted dosing, your trough levels become unpredictable. Pick a routine (most people prefer consistently fasting because it’s easier to be reproducible) and stick with it.<\/p>\n
Are Rapacan and Siromus the same as Rapamune?<\/h3>\n
Yes — Rapacan, Siromus, and Rapamune are all sirolimus 1 mg. Rapamune is the original Wyeth\/Pfizer brand. Rapacan and Siromus are bioequivalent generic versions from different manufacturers.<\/p>\n
What is LAM?<\/h3>\n
Lymphangioleiomyomatosis is a rare progressive cystic lung disease that almost exclusively affects women, often associated with tuberous sclerosis. mTOR inhibition with sirolimus stabilises lung function (FEV1) in LAM — the MILES trial led to FDA approval in 2015. LAM is diagnosed and managed at specialist centres.<\/p>\n
Can I drink alcohol on Siromus?<\/h3>\n
No specific alcohol interaction. Moderate intake is generally acceptable but alcohol worsens hyperlipidaemia (a common sirolimus side effect) and may interact with hepatic metabolism. If you have a transplanted liver or other hepatic disease, alcohol is contraindicated.<\/p>\n
Medische disclaimer:<\/strong> Deze productpagina is voor educatieve doeleinden en is geen vervanging voor medisch advies. Immunosuppressiva kunnen levensbedreigende infecties, maligniteiten en geboorteafwijkingen veroorzaken. Gebruik alleen onder specialistisch toezicht met passende monitoring.<\/p>","protected":false},"excerpt":{"rendered":"\u2705 Immunosuppressive drug
\n\u2705 Voorkomt orgaanafstoting
\n\u2705 Treats Lymphangioleiomyomatosis
\n\u2705 Reduces kidney damage
\n\u2705 Controls rheumatoid arthritis<\/p>","protected":false},"featured_media":53495,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53494","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/53494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=53494"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/53495"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=53494"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=53494"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=53494"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=53494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}