{"id":54331,"date":"2023-09-20T09:57:38","date_gmt":"2023-09-20T09:57:38","guid":{"rendered":"https:\/\/medsname.com\/doxolin\/"},"modified":"2026-04-30T10:24:59","modified_gmt":"2026-04-30T10:24:59","slug":"doxolin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/doxolin\/","title":{"rendered":"Doxolin"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Doxolin?<\/h3>\n<p><strong>Doxolin<\/strong> bevat <strong>doxofylline<\/strong>, een <strong>methylxanthine bronchodilator<\/strong> with anti-inflammatory effects, used as add-on therapy for chronic asthma and COPD. Doxofylline is a newer methylxanthine with similar efficacy to theophylline but a wider safety margin \u2014 fewer cardiac, GI, and CNS side effects. No routine drug-level monitoring required. Dose is 400 mg once or twice daily. Each tablet contains <strong>400 mg<\/strong>, geproduceerd door <strong>Zydus Cadila<\/strong> in WHO-GMP gecertificeerde faciliteiten.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Versleutelde afrekenprocedure<\/strong> \u00b7 <strong>\ud83d\udcb3 Geverifieerde betalingsverwerker<\/strong> \u00b7 <strong>\ud83d\ude9a Wereldwijde verzending<\/strong> \u00b7 <strong>\u2b50 4,9\/5 van 1.400+ klanten<\/strong>\n<\/div>\n<h2>What Is Doxolin?<\/h2>\n<p>Doxolin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled \u03b22-agonists and corticosteroids became first-line \u2014 but they retain a role as third-line add-on therapy in difficult asthma and COPD.<\/p>\n<h2>How Does Doxolin Work?<\/h2>\n<ul>\n<li><strong>Phosphodiesterase inhibition (PDE3, PDE4)<\/strong> \u2014 raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.<\/li>\n<li><strong>Adenosine receptor antagonism<\/strong> \u2014 blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.<\/li>\n<li><strong>HDAC2 activation<\/strong> (theophylline at low serum levels 5\u201310 mg\/L) \u2014 restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.<\/li>\n<li><strong>Diaphragm contractility<\/strong> \u2014 methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.<\/li>\n<\/ul>\n<h2>Toepassingen en Indicaties<\/h2>\n<ul>\n<li><strong>Severe chronic asthma<\/strong> \u2014 add-on to high-dose ICS-LABA where additional bronchodilation is needed<\/li>\n<li><strong>COPD maintenance<\/strong> \u2014 add-on to LAMA-LABA or triple therapy<\/li>\n<li><strong>Nocturnal asthma<\/strong> \u2014 sustained-release formulation provides overnight bronchodilation<\/li>\n<li><strong>Apnoea of prematurity<\/strong> (theophylline) \u2014 neonatal use<\/li>\n<li><strong>Theophylline-intolerant patients<\/strong> \u2014 better-tolerated alternative<\/li>\n<\/ul>\n<h2>Doxolin Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pati\u00ebnt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Dosering<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frequentie<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 initial<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Three times daily \u2014 first 7 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 maintenance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Een of twee keer per dag<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Elderly \/ liver disease<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Halve dose<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Een of twee keer per dag<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Doxolin<\/h2>\n<ul>\n<li>Nausea, vomiting, dyspepsia<\/li>\n<li>Hoofdpijn<\/li>\n<li>Tremor<\/li>\n<li>Insomnia, restlessness<\/li>\n<li>Mild palpitations (less than theophylline)<\/li>\n<li>Mild hypokalaemia at high doses<\/li>\n<\/ul>\n<p><strong>Ernstig \u2014 stop en zoek hulp:<\/strong><\/p>\n<ul>\n<li>Severe palpitations or arrhythmia<\/li>\n<li>Persistent vomiting<\/li>\n<li>Ernstige allergische reactie<\/li>\n<\/ul>\n<h2>Waarschuwingen en voorzorgsmaatregelen<\/h2>\n<ul>\n<li><strong>No routine blood-level monitoring<\/strong> \u2014 wider safety margin than theophylline.<\/li>\n<li><strong>Many drug interactions<\/strong> \u2014 see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.<\/li>\n<li><strong>Smoking<\/strong> induces CYP1A2 and lowers theophylline levels by ~50% \u2014 re-titrate at smoking cessation.<\/li>\n<li><strong>Cardiac disease:<\/strong> use cautiously in arrhythmias, heart failure, severe hypertension.<\/li>\n<li><strong>Hyperthyroidism:<\/strong> increased clearance plus exaggerated adrenergic effects.<\/li>\n<li><strong>Zwangerschap en borstvoeding:<\/strong> generally avoided; use only if benefit clear.<\/li>\n<li><strong>Leveraandoening:<\/strong> reduce dose \u2014 methylxanthines are hepatically metabolised.<\/li>\n<\/ul>\n<h2>Contra-indicaties<\/h2>\n<ul>\n<li>Hypersensitivity to doxofylline or other xanthines (caffeine, theobromine)<\/li>\n<li>Actieve maagzweer<\/li>\n<li>Uncontrolled tachyarrhythmias<\/li>\n<li>Severe heart failure (NYHA IV)<\/li>\n<\/ul>\n<h2>Geneesmiddelinteracties<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interagerend geneesmiddel<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Effect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Wat te doen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin, erythromycin, clarithromycin, fluvoxamine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibit CYP1A2 \u2192 raise theophylline levels \u2192 toxicity (nausea, arrhythmia, seizures)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid or reduce theophylline dose 50%; check serum levels<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidine, allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Raise theophylline levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce dose; monitor levels<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Phenytoin, carbamazepine, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induce CYP \u2014 lower levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Higher dose may be needed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Smoking<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induces CYP1A2 \u2014 lower levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Re-titrate dose at smoking cessation<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agonists, diuretics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additieve hypokali\u00ebmie<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor potassium<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Opslag<\/h2>\n<ul>\n<li>Bewaren beneden <strong>25\u00b0C<\/strong> in a cool, dry place away from direct sunlight.<\/li>\n<li>Keep in original packaging until use to protect from moisture and light.<\/li>\n<li>Do not use after the expiry date printed on the strip.<\/li>\n<li>Buiten bereik van kinderen houden.<\/li>\n<\/ul>\n<h2>Gerelateerde alternatieven op MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol verlichter<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS-preventer<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA voor COPD<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/montair\/\"><strong>Montair \u2014 montelukast LTRA-tablet<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>How is doxofylline different from theophylline?<\/h3>\n<p>Doxofylline is a newer methylxanthine (introduced in the 1990s) with similar bronchodilator efficacy and a wider safety margin. Cardiac, GI, and CNS side effects are less common; routine blood-level monitoring is not required; and it has fewer drug interactions.<\/p>\n<h3>Why prefer doxofylline over theophylline?<\/h3>\n<p>Better tolerability, simpler dosing (no level monitoring), fewer interactions. Particularly useful in elderly patients and those who could not tolerate theophylline.<\/p>\n<h3>How fast does Doxolin work?<\/h3>\n<p>Bronchodilation begins within 1 hour; full effect over days.<\/p>\n<h3>Is Doxolin a reliever?<\/h3>\n<p>No \u2014 it is a controller. Keep a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Can I take Doxolin with my ICS?<\/h3>\n<p>Yes \u2014 doxofylline is typically added on top of ICS or ICS-LABA when additional bronchodilation is needed.<\/p>\n<h3>Wat zijn de veelvoorkomende bijwerkingen?<\/h3>\n<p>Nausea, mild headache, tremor, insomnia. Generally milder than theophylline at equivalent bronchodilation.<\/p>\n<h3>Is Doxolin safe in pregnancy?<\/h3>\n<p>Limited data; inhaled therapy is preferred.<\/p>\n<h3>Can children take Doxolin?<\/h3>\n<p>Use with caution; specialist supervision recommended in paediatric use.<\/p>\n<h3>How does Doxolin compare to roflumilast (Rofaday)?<\/h3>\n<p>Both are oral non-bronchodilator-class agents with anti-inflammatory effects. Roflumilast is specifically for severe COPD with chronic bronchitis. Doxofylline has broader use across asthma and COPD as an add-on bronchodilator.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Medische disclaimer:<\/strong> Deze pagina is educatief en vervangt geen professioneel medisch advies. Raadpleeg altijd een gekwalificeerde zorgverlener voordat u een inhaler of respiratoir medicijn start, stopt of wijzigt, vooral als u andere medische aandoeningen heeft, andere voorgeschreven medicijnen gebruikt, zwanger bent of borstvoeding geeft, of ouder bent dan 65.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde alternatieven<\/h3>\n<p>Andere producten in <strong>Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/asthalin-syrup\/\">Asthalin Syrup<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/bencid\/\">Bencid<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/dynapar\/\">Dynapar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/decdan\/\">Decdan<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Beheersing van astmasymptomen<br \/>\n\u2705 Convenient tablet format<br \/>\n\u2705 Easy administration<br \/>\n\u2705 Verbeterde respiratoire comfort<\/h5>\n<p><span style=\"color: #999999;\">Contains Doxofylline<\/span><\/p>","protected":false},"featured_media":54332,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3713],"class_list":{"0":"post-54331","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-doxofylline","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/54331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=54331"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/54332"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=54331"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=54331"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=54331"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=54331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}