{"id":54375,"date":"2023-09-20T09:58:09","date_gmt":"2023-09-20T09:58:09","guid":{"rendered":"https:\/\/medsname.com\/triohale-rotacaps\/"},"modified":"2026-04-30T10:24:58","modified_gmt":"2026-04-30T10:24:58","slug":"triohale-rotacaps","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/triohale-rotacaps\/","title":{"rendered":"Triohale Rotacaps"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Triohale Rotacaps?<\/h3>\n<p><strong>Triohale Rotacaps<\/strong> is een <strong>triple-therapy inhaler<\/strong> for severe COPD and difficult asthma, combining three molecules in one device: <strong>tiotropium<\/strong> (LAMA), <strong>formoterol<\/strong> (LABA), and <strong>ciclesonide<\/strong> (ICS). Triple therapy targets all three modifiable mechanisms of obstructive airways disease: parasympathetic tone, smooth-muscle \u03b22 deficiency, and airway inflammation. Used as <strong>twice-daily maintenance<\/strong> in COPD with frequent exacerbations. Each rotacaps delivers <strong>tiotropium 18 mcg + formoterol 12 mcg + ciclesonide 200 mcg per rotacap<\/strong>, geproduceerd door <strong>Cipla<\/strong> in WHO-GMP gecertificeerde faciliteiten.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Versleutelde afrekenprocedure<\/strong> \u00b7 <strong>\ud83d\udcb3 Geverifieerde betalingsverwerker<\/strong> \u00b7 <strong>\ud83d\ude9a Wereldwijde verzending<\/strong> \u00b7 <strong>\u2b50 4,9\/5 van 1.400+ klanten<\/strong>\n<\/div>\n<h2>What Is Triohale Rotacaps?<\/h2>\n<p>Triohale Rotacaps is one of the few <strong>three-in-one fixed-dose triple-therapy inhalers<\/strong> available in India. Major international triple combinations include Trelegy Ellipta (fluticasone furoate + umeclidinium + vilanterol; GSK), Trimbow (beclomethasone + formoterol + glycopyrronium; Chiesi), and Breztri Aerosphere (budesonide + glycopyrrolate + formoterol; AstraZeneca). Triohale Rotacaps is conceptually similar \u2014 a single twice-daily inhaler delivering all three mechanism classes.<\/p>\n<h2>How Does Triohale Rotacaps Work?<\/h2>\n<ul>\n<li><strong>Tiotropium (LAMA)<\/strong> \u2014 blocks M3 muscarinic receptors, relaxing parasympathetic airway tone for 24 hours.<\/li>\n<li><strong>Formoterol (LABA)<\/strong> \u2014 activates \u03b22 receptors for rapid (1\u20133 min) and sustained (12 h) bronchodilation.<\/li>\n<li><strong>Ciclesonide (ICS)<\/strong> \u2014 a prodrug activated by lung esterases; suppresses airway inflammation. The prodrug design minimises oropharyngeal candidiasis seen with older ICS.<\/li>\n<li><strong>Combined:<\/strong> reduces exacerbations more than dual therapy in COPD with frequent exacerbations and elevated blood eosinophils (\u2265100\u2013300\/\u00b5L), per IMPACT, ETHOS, KRONOS, TRIBUTE landmark trials.<\/li>\n<\/ul>\n<h2>Toepassingen en Indicaties<\/h2>\n<ul>\n<li><strong>Severe COPD with frequent exacerbations<\/strong> on LAMA-LABA dual therapy (GOLD group E)<\/li>\n<li><strong>COPD with elevated blood eosinophils<\/strong> (\u2265100\/\u00b5L) \u2014 eosinophilic COPD<\/li>\n<li><strong>Severe asthma (Step 5 GINA)<\/strong> not controlled by ICS-LABA at high dose<\/li>\n<li><strong>Asthma-COPD overlap (ACOS)<\/strong> with frequent exacerbations<\/li>\n<\/ul>\n<h2>Triohale Rotacaps Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pati\u00ebnt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Dosering<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frequentie<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 severe COPD<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>1 rotacap<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 severe asthma (Step 5 GINA)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>1 rotacap<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>How to Use Triohale Rotacaps Properly<\/h3>\n<ul>\n<li>Insert one rotacap into the Rotahaler with the coloured end down.<\/li>\n<li>Twist sharply \u2014 listen for the click.<\/li>\n<li>Breathe out fully away from device.<\/li>\n<li>Seal lips around mouthpiece.<\/li>\n<li><strong>Adem krachtig en diep in<\/strong>; you should hear the rotacap whir.<\/li>\n<li>Houd je adem 10 seconden in, adem dan langzaam uit.<\/li>\n<li>Check rotacap is empty; repeat if powder remains.<\/li>\n<li>Voor ICS-bevattende combinaties: <strong>spoel de mond, gorgel en spuug uit<\/strong>.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Rinse mouth after every dose.<\/strong> The ciclesonide ICS component still warrants oral rinsing despite its prodrug design. Rinse, gargle, and spit.<\/div>\n<h2>Side Effects of Triohale Rotacaps<\/h2>\n<p><strong>Vaak voorkomend:<\/strong><\/p>\n<ul>\n<li>Dry mouth (anticholinergic)<\/li>\n<li>Mild tremor or palpitations (\u03b22)<\/li>\n<li>Mild oral thrush, hoarseness (ICS \u2014 minimised by ciclesonide prodrug design and oral rinsing)<\/li>\n<li>Throat irritation, mild cough on inhalation<\/li>\n<li>Headache, sinusitis<\/li>\n<\/ul>\n<p><strong>Minder vaak:<\/strong><\/p>\n<ul>\n<li>Constipation, urinary hesitancy<\/li>\n<li>Acute angle-closure glaucoma (rare; care with mist near eyes)<\/li>\n<li>Hypokalaemia at high doses (with diuretics, theophylline, oral steroids)<\/li>\n<li>Pneumonia (slight ICS-related increase in COPD)<\/li>\n<li>Atrial fibrillation in susceptible older patients<\/li>\n<\/ul>\n<p><strong>Ernstig \u2014 stop en zoek hulp:<\/strong><\/p>\n<ul>\n<li>Severe allergic reaction \/ anaphylaxis<\/li>\n<li>Paradoxale bronchospasmen<\/li>\n<li>Acute eye pain, red eye, halos (glaucoma \u2014 emergency)<\/li>\n<li>Acute urineretentie<\/li>\n<li>Pneumonia signs in COPD users (fever, productive cough, breathlessness change)<\/li>\n<\/ul>\n<h2>Waarschuwingen en voorzorgsmaatregelen<\/h2>\n<ul>\n<li><strong>{$brand} is a controller, not a reliever.<\/strong> Keep a SABA (Asthalin, Levolin) for acute attacks.<\/li>\n<li><strong>Triple therapy is for selected COPD patients<\/strong> \u2014 those with frequent exacerbations on LAMA-LABA, especially with elevated blood eosinophils. Not first-line for newly diagnosed COPD.<\/li>\n<li><strong>Pneumonia risk:<\/strong> ICS in COPD slightly raises pneumonia risk \u2014 ensure ICS adds value (eosinophilic phenotype, frequent exacerbations).<\/li>\n<li><strong>Glaucoma &#038; prostatism:<\/strong> caution with anticholinergic component.<\/li>\n<li><strong>Cardiovasculaire aandoeningen:<\/strong> use cautiously with arrhythmias, severe coronary disease.<\/li>\n<li><strong>Rinse mouth after every dose<\/strong> to minimise oral thrush and hoarseness.<\/li>\n<li><strong>Zwangerschap:<\/strong> limited data on triple therapy \u2014 discuss benefit\/risk with prescriber.<\/li>\n<\/ul>\n<h2>Contra-indicaties<\/h2>\n<ul>\n<li>Hypersensitivity to tiotropium, formoterol, ciclesonide, atropine derivatives, or excipients<\/li>\n<li>Severe lactose \/ milk-protein hypersensitivity (DPI)<\/li>\n<li>Untreated active fungal, bacterial, mycobacterial, or viral respiratory infection<\/li>\n<li>Acute glaucoma \u2014 relative<\/li>\n<li>Severe prostatic obstruction \u2014 relative<\/li>\n<\/ul>\n<h2>Geneesmiddelinteracties<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interagerend geneesmiddel<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Effect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Wat te doen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Strong CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, clarithromycin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increase systemic ICS exposure \u2192 adrenal suppression \/ Cushing risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid prolonged co-use; monitor cortisol if essential<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Other inhaled or systemic corticosteroids<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive HPA-axis suppression<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use lowest effective dose; monitor for systemic steroid effects<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Levende vaccins<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduced immune response if high-dose ICS<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inactivated vaccines preferred during high-dose use<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Opslag<\/h2>\n<ul>\n<li>Bewaren beneden <strong>25\u00b0C<\/strong> in a dry place. Keep desiccant in the bottle.<\/li>\n<li>Do not store in the bathroom \u2014 humidity makes the powder clump and reduces dose delivery.<\/li>\n<li>Once the strip\/blister is opened, use within the period stated on the leaflet (typically 2\u20133 months).<\/li>\n<li>Buiten bereik van kinderen houden.<\/li>\n<\/ul>\n<h2>Gerelateerde alternatieven op MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/seretide-accuhaler\/\"><strong>Seretide Accuhaler \u2014 fluticason + salmeterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonide ICS-preventer<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/duova-inhaler\/\"><strong>Duova Inhaler \u2014 tiotropium + formoterol LAMA-LABA combinatie<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/triohale-inhaler\/\"><strong>Triohale Inhaler \u2014 tiotropium + formoterol + ciclesonide triple<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>When is triple therapy indicated?<\/h3>\n<p>For COPD with frequent exacerbations on LAMA-LABA (especially with elevated blood eosinophils), or for severe asthma uncontrolled on high-dose ICS-LABA. Not first-line in newly diagnosed COPD or mild asthma.<\/p>\n<h3>How is Triohale different from Foracort plus Tiova?<\/h3>\n<p>Triohale combines all three molecules in one device \u2014 single inhaler, twice daily. Taking Foracort + Tiova achieves a similar pharmacological effect but requires two inhalers (and more compliance burden). Single-device triple has been shown in trials to improve adherence.<\/p>\n<h3>How fast does Triohale work?<\/h3>\n<p>Formoterol = 1\u20133 min onset (rapid). Tiotropium and ciclesonide build over hours-to-days. Full benefit at 2\u20134 weeks.<\/p>\n<h3>Is Triohale a reliever?<\/h3>\n<p>No \u2014 controller only. Keep a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Why must I rinse my mouth?<\/h3>\n<p>Ciclesonide ICS component still warrants oral rinsing to prevent thrush, although ciclesonide produces less oropharyngeal candidiasis than older ICS due to its prodrug design.<\/p>\n<h3>Is Triohale safe long-term?<\/h3>\n<p>Yes, with regular review. Annual checks for glaucoma, cataracts, urinary symptoms, oral thrush, pneumonia in COPD users.<\/p>\n<h3>Pneumonia risk?<\/h3>\n<p>ICS in COPD slightly raises pneumonia risk (~1\u20132% absolute increase in trials). Ensure ICS is needed (eosinophilic phenotype, frequent exacerbations).<\/p>\n<h3>Can I take Triohale during pregnancy?<\/h3>\n<p>Limited data on triple therapy in pregnancy. Discuss with prescriber; budesonide-based ICS-LABA is preferred where the LAMA can be omitted.<\/p>\n<h3>How does Triohale compare to Trimbow or Trelegy?<\/h3>\n<p>Trimbow (beclomethasone + formoterol + glycopyrronium, Chiesi) and Trelegy Ellipta (fluticasone furoate + umeclidinium + vilanterol, GSK) are international triple inhalers. Triohale (tiotropium + formoterol + ciclesonide) is the Indian-market triple. Pharmacological class equivalent; molecule choice varies.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Medische disclaimer:<\/strong> Deze pagina is educatief en vervangt geen professioneel medisch advies. Raadpleeg altijd een gekwalificeerde zorgverlener voordat u een inhaler of respiratoir medicijn start, stopt of wijzigt, vooral als u andere medische aandoeningen heeft, andere voorgeschreven medicijnen gebruikt, zwanger bent of borstvoeding geeft, of ouder bent dan 65.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde alternatieven<\/h3>\n<p>Andere producten in <strong>Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/bonair-inhaler\/\">Bonair Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/reactin\/\">Reactin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/clodict\/\">Clodict<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/leptomate\/\">Leptomate<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/simlo-5\/\">Simlo 5<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Comprehensive symptom control<br \/>\n\u2705 Enhanced lung function<br \/>\n\u2705 Reduced exacerbation risk<br \/>\n\u2705 Verbeterde levenskwaliteit<\/h5>\n<p><span style=\"color: #999999;\">Contains Tiotropium Bromide, Formoterol Fumarate, and Ciclesonide<\/span><\/p>","protected":false},"featured_media":54376,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3722,3723,3724,3725],"class_list":{"0":"post-54375","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-ciclesonide","10":"product_tag-formoterol-fumarate","11":"product_tag-tiotropium-bromide","12":"product_tag-triohale-rotacaps","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/54375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=54375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/54376"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=54375"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=54375"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=54375"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=54375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}