{"id":54739,"date":"2023-09-20T10:02:53","date_gmt":"2023-09-20T10:02:53","guid":{"rendered":"https:\/\/medsname.com\/donecept\/"},"modified":"2026-04-30T16:30:23","modified_gmt":"2026-04-30T16:30:23","slug":"donecept","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/donecept\/","title":{"rendered":"Donecept"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Snelle antwoord<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Donecept<\/strong> \u2014 donepezil 5\/10 mg (Cipla Inc). Reversible centrally-acting acetylcholinesterase inhibitor for mild, moderate, and severe Alzheimer&#8217;s disease and dementia in Parkinson&#8217;s. Modest symptomatic improvement in cognition and ADLs; does not slow disease progression.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Wat u krijgt bij MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>WHO-GMP gecertificeerde fabrikant<\/li>\n<li>Discrete verpakking in een gewone envelop<\/li>\n<li>Wereldwijde verzending<\/li>\n<li>Beoordeeld door 1.400+ klanten (<a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">lees beoordelingen<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Reshipment Assurance:<\/strong> als uw bestelling niet is aangekomen binnen 20 werkdagen na verzending, sturen wij het opnieuw zonder extra kosten. <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Lees het beleid<\/a>.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Donecept ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor \u2014 never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Set realistic expectations<\/strong><br \/>Donepezil produces a modest, short-lived improvement in cognition (typically 2-4 points on the ADAS-cog) and may delay nursing-home placement. It does NOT slow underlying neurodegeneration. Effect plateaus and benefits may wear off over 6-24 months. Discuss realistic goals with the family before starting.<\/div>\n<h2>Dosering<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;\">Indicatie<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;\">Dosering<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Mild-moderate Alzheimer&#8217;s<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5 mg at bedtime \u00d7 4 weeks \u2192 10 mg at bedtime<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Severe Alzheimer&#8217;s<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">10 mg\/day; some clinicians titrate to 23 mg\/day (where available)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Parkinson&#8217;s dementia \/ DLB<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">5-10 mg\/day at bedtime<\/td>\n<\/tr>\n<\/table>\n<p>Take in the evening with or without food. The 23 mg formulation must be swallowed whole; the 5\/10 mg tablets can be crushed if needed.<\/p>\n<h2>Bijwerkingen<\/h2>\n<ul>\n<li><strong>Cholinergic GI (most common, dose-related):<\/strong> nausea, vomiting, diarrhoea, anorexia, weight loss<\/li>\n<li><strong>CNS:<\/strong> insomnia (try morning dosing if persistent), vivid dreams, dizziness, fatigue<\/li>\n<li><strong>Cardiac:<\/strong> bradycardia, syncope, AV block \u2014 caution with sick-sinus syndrome or pre-existing conduction defects; avoid combining with non-DHP CCBs or beta blockers without monitoring<\/li>\n<li><strong>Overig:<\/strong> urinary incontinence (rare), seizure threshold lowering, NSAID-augmented GI bleed<\/li>\n<\/ul>\n<h2>Geneesmiddelinteracties<\/h2>\n<ul>\n<li><strong>Strong anticholinergics:<\/strong> oxybutynin, hyoscine, TCAs, first-gen antihistamines \u2014 directly antagonise donepezil; avoid combining if possible<\/li>\n<li><strong>Bradycardic drugs:<\/strong> beta blockers, non-DHP CCBs (verapamil\/diltiazem), digoxin \u2014 increased bradycardia\/AV block risk; monitor<\/li>\n<li><strong>NSAID's:<\/strong> increased GI bleed risk<\/li>\n<li><strong>CYP2D6 + CYP3A4 inhibitors:<\/strong> ketoconazole, paroxetine, fluoxetine \u2014 modest rise in donepezil levels; usually clinically insignificant<\/li>\n<li><strong>Succinylcholine (anaesthesia):<\/strong> prolonged neuromuscular block \u2014 tell the anaesthetist about donepezil use before any surgery<\/li>\n<\/ul>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>How quickly will I see improvement?<\/h3>\n<p>Cognitive and behavioural benefits, when they appear, are typically modest and emerge over 6-12 weeks. Some patients show no measurable benefit; this is expected and not a treatment failure.<\/p>\n<h3>Wanneer moet het worden gestopt?<\/h3>\n<p>Stop if there is no perceived benefit after 3-6 months at the maximum tolerated dose, or if side effects (especially weight loss) outweigh benefit. Some clinicians continue into late-stage disease \u2014 the evidence is mixed.<\/p>\n<h3>Can it be combined with memantine?<\/h3>\n<p>Yes \u2014 combination therapy (donepezil + memantine) is approved and commonly used in moderate-to-severe disease. Memantine targets glutamate (NMDA) receptors, donepezil targets acetylcholine \u2014 different mechanisms, additive benefit, no major drug interactions.<\/p>\n<h3>Insomnia?<\/h3>\n<p>Donepezil can cause vivid dreams and insomnia. If persistent, switch to morning dosing.<\/p>\n<h3>Will it slow Alzheimer&#8217;s?<\/h3>\n<p>No. It is a symptomatic treatment. Underlying neurodegeneration continues. Newer disease-modifying agents (lecanemab, donanemab) do reduce amyloid plaques but are separate, expensive, infusion-based therapies with their own risks.<\/p>\n<h3>What about bradycardia?<\/h3>\n<p>Get a baseline ECG before starting if you have known heart conduction issues, are on beta blockers, or have unexplained syncope. Donepezil enhances vagal tone and rarely causes AV block.<\/p>\n<h3>Can my partner stop using anticholinergic OAB drugs?<\/h3>\n<p>If your loved one is on donepezil for Alzheimer&#8217;s, anticholinergic OAB drugs (oxybutynin, tolterodine) directly oppose the donepezil effect AND independently worsen cognition. Mirabegron (beta-3 agonist) is preferred for OAB in dementia patients.<\/p>\n<h3>Wat als een dosis wordt vergeten?<\/h3>\n<p>Skip the missed dose and resume the normal schedule. Do not double up. If multiple doses (more than a few days) are missed, restart at the lower 5 mg dose to avoid GI side effects.<\/p>\n<h3>Mag ik alcohol drinken?<\/h3>\n<p>Modest alcohol is acceptable. Heavy alcohol worsens cognitive decline independently of donepezil and should be discouraged.<\/p>\n<h3>Surgery and anaesthesia?<\/h3>\n<p>Tell the anaesthetist about donepezil \u2014 it prolongs the action of succinylcholine and other neuromuscular blockers. Some surgeons prefer to pause donepezil 24-48 hours before elective surgery; do this only on specialist advice.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Alzheimer&#8217;s &#038; Dementia Medications<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/nemdaa\/\">Nemdaa<\/a> \u2014 memantine 5\/10 mg \u2014 NMDA antagonist for moderate-severe disease<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/donamem\/\">Donamem<\/a> \u2014 donepezil + memantine fixed combo<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/alzil\/\">Alzil<\/a> \u2014 donepezil 5\/10 mg \u2014 alternative brand<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/donecept\/\">Donecept<\/a> \u2014 donepezil 5\/10 mg \u2014 Cipla brand<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/donep\/\">Donep<\/a> \u2014 donepezil 5\/10 mg \u2014 Alkem brand<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Medische disclaimer:<\/strong> Deze pagina is alleen voor informatieve doeleinden en is geen vervanging voor medisch advies van een gekwalificeerde clinicus. Overleg altijd met uw arts of apotheker over nieuwe medicatie.<\/div>","protected":false},"excerpt":{"rendered":"<p>Donecept (Donepezil 5\/10 mg) \u2014 Cipla brand cholinesterase inhibitor for Alzheimer&#8217;s disease. Slow titration from 5 mg to 10 mg after 4 weeks. Once daily evening dosing.<\/p>","protected":false},"featured_media":54740,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3772,3141,3223],"product_tag":[3776],"class_list":{"0":"post-54739","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alzheimers-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-donecept","11":"first","12":"outofstock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/54739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=54739"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/54740"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=54739"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=54739"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=54739"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=54739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}