<\/p>\n
Roko tablet contains loperamide hydrochloride 2 mg \u2014 an opioid-receptor agonist restricted to the gut wall that slows intestinal motility and relieves acute and chronic diarrhoea. Manufactured by Cipla, the standard dose is 4 mg initially followed by 2 mg after each loose stool, up to 16 mg in 24 hours. It reduces stool frequency and urgency without the central nervous system effects of other opioids.<\/p>\n<\/div>\n
\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Roko is an antidiarrhoeal tablet containing loperamide hydrochloride 2 mg<\/strong>, geproduceerd door Cipla Ltd<\/strong> in India. Loperamide is a synthetic opioid-receptor agonist that acts specifically within the gut wall to slow intestinal motility and reduce stool frequency. Unlike older opioids (codeine, diphenoxylate), loperamide has essentially no central nervous system activity at therapeutic doses because it is actively excluded from the brain by the blood-brain barrier’s P-glycoprotein transporter.<\/p>\n This pharmacological targeting makes Roko uniquely suitable for controlling diarrhoea without the sedation, euphoria, respiratory depression or abuse potential associated with other opioids. It has been a mainstay antidiarrhoeal worldwide since its introduction in the 1970s and is on the WHO Model List of Essential Medicines.<\/p>\n Loperamide binds to \u03bc-opioid receptors<\/strong> in the myenteric plexus of the large intestine \u2014 the network of nerve cells that regulates peristalsis. Binding inhibits release of acetylcholine and prostaglandins, which reduces the strength and frequency of intestinal contractions. The result is slower transit time<\/strong>, giving the colon more opportunity to reabsorb water and electrolytes from the stool. Net stool volume decreases and stools become firmer.<\/p>\n Loperamide also reduces anal sphincter tone abnormalities seen in diarrhoea, improving continence. At therapeutic doses, there is no analgesic or central opioid effect because of the P-glycoprotein efflux barrier at the blood-brain barrier. This is why loperamide is not classified as a controlled substance in most countries.<\/p>\n Adult dose for acute diarrhoea<\/strong>: 4 mg (two tablets) initially, followed by 2 mg (one tablet) after each subsequent loose stool. Maximum 16 mg (8 tablets) in 24 hours. Discontinue when stools become formed.<\/p>\n Adult dose for chronic diarrhoea<\/strong>: 4 mg initially, then 2 mg after each loose stool or as needed. Maintenance dose 2\u201312 mg daily, adjusted to clinical response. Maximum 16 mg daily.<\/p>\n Children aged 4\u20138 years<\/strong>: 1 mg up to 3 times daily, maximum 2 days. Children 9\u201312 years<\/strong>: 2 mg twice daily, maximum 5 days. Do not use in children under 4 without medical advice.<\/p>\n Important interactions: ritonavir, quinidine, itraconazole, ketoconazole<\/strong> \u2014 inhibit loperamide metabolism and P-glycoprotein efflux, increasing plasma levels and risk of central opioid effects and cardiac toxicity; cholestyramine<\/strong> \u2014 binds loperamide in gut, reducing absorption; QT-verlengende geneesmiddelen<\/strong> (amiodarone, sotalol, macrolide antibiotics, some antipsychotics) \u2014 additive arrhythmia risk at high loperamide doses; other opioids<\/strong> \u2014 theoretical additive central effects at very high doses.<\/p>\n Store below 25 \u00b0C in the original blister, protected from moisture. Keep out of reach of children. Do not use after the expiry date.<\/p>\n Relief typically begins within 30 minutes to 1 hour of the first 4 mg dose. Peak effect is at 4\u20135 hours. Most episodes of acute diarrhoea resolve within 24 hours of starting Roko, though chronic diarrhoea requires longer ongoing dosing adjusted to individual response.<\/p>\n Yes \u2014 Roko is effective for symptomatic relief of traveller’s diarrhoea and can be combined with appropriate antibiotic therapy in moderate-to-severe cases. If bloody stool, high fever, or severe abdominal pain develop, seek medical care rather than self-treating with loperamide alone.<\/p>\n For chronic conditions such as IBS-D or ileostomy management, loperamide can be used long-term under medical supervision at the lowest effective dose. Monitor for constipation and adjust dose as needed. Long-term use at standard doses is not associated with dependence or tolerance.<\/p>\n Loperamide is not recommended for children under 2 years due to increased risk of paralytic ileus. For children 4\u20138 years, 1 mg doses can be given for short periods. Always consult a paediatrician first, and ensure adequate fluid intake with oral rehydration salts regardless of whether Roko is used.<\/p>\n Loperamide is actively pumped out of the brain by P-glycoprotein at the blood-brain barrier. At therapeutic doses, effectively none reaches the central opioid receptors responsible for euphoria or dependence. At extremely high doses (>60 mg), the transporter saturates and some central effects can occur \u2014 which is why package-size limits have been introduced in several countries.<\/p>\n Do not take Roko if you have: bloody stool, high fever (over 38.5 \u00b0C), severe abdominal pain suggestive of ileus or peritonitis, antibiotic-associated colitis, or an active flare of ulcerative colitis or Crohn’s disease. In these situations, slowing motility can worsen the underlying condition.<\/p>\n A modest overdose (up to 16 mg above the daily limit) usually only causes severe constipation or abdominal cramps. Large overdoses (above 60 mg in a day) can cause cardiac arrhythmia and require urgent medical attention \u2014 ECG monitoring and supportive care. If in doubt, call your poison control centre or seek emergency care.<\/p>\n <\/p>\n Andere producten in Algemene gezondheid<\/strong> die klanten ook bekijken:<\/p>\n Roko contains Loperamide hydrochloride<\/span><\/p>","protected":false},"featured_media":54847,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3812],"product_tag":[3813],"class_list":{"0":"post-54846","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-trapped-wind-relief","9":"product_tag-loperamide-hydrochloride","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/54846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=54846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/54847"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=54846"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=54846"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=54846"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=54846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Waarom bestellen bij MedsBase<\/h3>\n
What Is Roko?<\/h2>\n
Uses of Roko<\/h2>\n
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How Roko Works<\/h2>\n
Dosering en toediening<\/h2>\n
How to Use Roko<\/h2>\n
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Side Effects of Roko<\/h2>\n
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Precautions and Warnings<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
Opslag<\/h2>\n
Veelgestelde vragen<\/h2>\n
How quickly does Roko work?<\/h3>\n
Can I take Roko for traveller’s diarrhoea?<\/h3>\n
Is Roko safe for long-term use?<\/h3>\n
Can I give Roko to my child?<\/h3>\n
Why is loperamide not addictive?<\/h3>\n
When should I NOT take Roko?<\/h3>\n
What should I do if I accidentally took too much?<\/h3>\n
Gerelateerde alternatieven<\/h3>\n
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\u2705 Diarrhea Symptom Relief
\n\u2705 Normalizes Bowel Function
\n\u2705 Alleviates Associated Symptoms
\n\u2705 Quick and Effective
\n\u2705 Enhanced Quality of Life<\/h5>\n