{"id":56206,"date":"2024-02-07T05:56:25","date_gmt":"2024-02-07T05:56:25","guid":{"rendered":"https:\/\/medsname.com\/obsenil\/"},"modified":"2026-04-30T10:24:39","modified_gmt":"2026-04-30T10:24:39","slug":"obsenil","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/obsenil\/","title":{"rendered":"Obsenil"},"content":{"rendered":"

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\u26a1 Snel antwoord<\/h3>\n

Obsenil (Clomipramine 10 \/ 25 \/ 50 \/ 75 mg) is a tricyclic antidepressant. Most effective antidepressant for OCD; reserved for SSRI-refractory disease because of side-effect burden.<\/p>\n<\/div>\n

\nWat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde klantbeoordelingen<\/a>\n<\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Obsenil at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Reshipment Assurance Policy<\/a> \u2014 20 werkdagen levertermijn of wij sturen kosteloos opnieuw \u2014 en komt in aanmerking voor ons klantenloyaliteitsprogramma<\/a>. Wereldwijde verzending is beschikbaar naar de meeste bestemmingen.<\/p>\n

What Obsenil is and how it works<\/h2>\n

Obsenil is a Clomipramine-containing tablet supplied by Sun Pharma. Available strengths: 10 \/ 25 \/ 50 \/ 75 mg<\/strong>.<\/p>\n

Clomipramine is the most serotonergic TCA and the most effective antidepressant of any class for OCD<\/strong>. The CMI-Collaborative Study (1991) and subsequent meta-analyses show clomipramine outperforms SSRIs for OCD by approximately 5\u201310 percentage points on response rate. It is reserved for OCD that has failed at least two adequate SSRI trials (including high-dose) because of its tolerability burden.<\/p>\n

Tricyclic antidepressants block the reuptake of serotonin and noradrenaline at presynaptic transporters, similar to SSRIs and SNRIs. Their tolerability disadvantage comes from off-target receptor blockade<\/strong>: muscarinic (anticholinergic side effects), histaminergic H1 (sedation, weight gain), and \u03b11-adrenergic (orthostatic hypotension). They also block fast sodium channels in cardiac tissue \u2014 the basis for both their analgesic action and their cardiac toxicity in overdose.<\/p>\n

Clomipramine + SSRI combinations are sometimes used for severe refractory OCD but require careful TDM and serotonin-syndrome monitoring.<\/p>\n

Indicaties en dosering<\/h2>\n\n\n\n\n\n\n\n\n
Indicatie<\/th>\nStartdosering<\/th>\nStreefdosering<\/th>\nMaximaal<\/th>\n<\/tr>\n<\/thead>\n
OCD (adult)<\/td>\n25 mg HS \u00d7 1 wk<\/td>\n100\u2013250 mg\/day<\/td>\n250 mg<\/td>\n<\/tr>\n
OCD (paediatric \u226510 y)<\/td>\n25 mg voor het slapen<\/td>\n3 mg\/kg or 100 mg (lower)<\/td>\n200 mg<\/td>\n<\/tr>\n
Major depression \/ panic<\/td>\n25 mg voor het slapen<\/td>\n100\u2013225 mg\/day<\/td>\n250 mg<\/td>\n<\/tr>\n
Premature ejaculation (off-label)<\/td>\n10\u201325 mg PRN or 25 mg\/day<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Belangrijke veiligheidsoverwegingen<\/h2>\n
\nCardiac risk and overdose toxicity<\/strong><\/p>\n

TCAs prolong QRS and QT, and overdose is life-threatening<\/strong> \u2014 historically the most common cause of antidepressant fatalities. Baseline ECG before initiating in patients with known cardiac disease, on QT-prolonging therapy, or in older adults. Do not start in recent MI, conduction abnormality, uncompensated heart failure, or congenital long QT. Limit dispense quantities in patients at suicide risk \u2014 the therapeutic-to-toxic ratio is narrow.<\/p>\n<\/div>\n

\nAnticholinergic burden<\/strong><\/p>\n

Dry mouth, constipation, blurred vision, urinary hesitancy, cognitive slowing \u2014 universal at therapeutic doses. Avoid in narrow-angle glaucoma, BPH with significant retention, and dementia. Pair with chewing gum \/ sugar-free lozenges, fibre + fluid, and stool softeners.<\/p>\n<\/div>\n

\nZwarte waarschuwing voor su\u00efcidaliteit (onder 25)<\/strong><\/p>\n

All antidepressants carry an FDA black-box warning for increased suicidal ideation in patients under 25 \u2014 particularly relevant for clomipramine in adolescent OCD.<\/p>\n<\/div>\n

Veelvoorkomende bijwerkingen<\/h2>\n