{"id":56297,"date":"2024-02-07T06:00:14","date_gmt":"2024-02-07T06:00:14","guid":{"rendered":"https:\/\/medsname.com\/flexabenz-er\/"},"modified":"2026-05-05T05:21:56","modified_gmt":"2026-05-05T05:21:56","slug":"flexabenz-er","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/flexabenz-er\/","title":{"rendered":"Flexabenz ER"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Flexabenz ER?<\/h3>\n<p style=\"margin:0;\"><strong>Flexabenz ER<\/strong> is een <strong>cyclobenzaprine 15&nbsp;mg extended-release capsule<\/strong> used as a short-course adjunct for acute musculoskeletal muscle spasm. It offers <strong>dagelijkse dosering<\/strong> with smoother plasma levels and typically less peak-related drowsiness than immediate-release cyclobenzaprine. Usual adult dose is <strong>one 15&nbsp;mg capsule once daily<\/strong> for 2 to 3 weeks maximum; 30&nbsp;mg once daily may be used in patients who need more effect and tolerate the 15&nbsp;mg dose well.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<p><strong>Flexabenz ER 15&nbsp;mg<\/strong> is the extended-release capsule form of <strong>cyclobenzaprine<\/strong>, designed for once-daily oral administration. The ER formulation releases cyclobenzaprine gradually over 24 hours, giving a smoother and more prolonged plasma level than the 5&nbsp;mg immediate-release tablet dosed three times daily. This has two clinical benefits: simpler adherence (one dose a day) and fewer dose-related peak side effects (lower peak drowsiness, lower peak anticholinergic effect).<\/p>\n<p>Like all cyclobenzaprine formulations, Flexabenz ER is intended as a <em>short-course<\/em> treatment (2&ndash;3 weeks) for acute painful muscle spasm associated with musculoskeletal injury. It is not a chronic pain medication and is not useful for spasticity from upper motor neuron disease.<\/p>\n<h2 class=\"wp-block-heading\">What Is Flexabenz ER Used For?<\/h2>\n<ul>\n<li>Acute low back pain with muscle spasm<\/li>\n<li>Acute neck pain and cervical strain<\/li>\n<li>Muscle strain of the shoulder, trunk, or limb<\/li>\n<li>Post-traumatic muscle spasm (whiplash, soft-tissue injury)<\/li>\n<li>Myofascial pain syndrome (adjunct)<\/li>\n<li>Fibromyalgia-associated muscle pain and sleep disturbance (off-label, short courses)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">How Does Flexabenz ER Work?<\/h2>\n<p>The active molecule, cyclobenzaprine, acts at the brainstem (primarily locus coeruleus) to reduce descending excitatory drive to spinal alpha motor neurons. This lowers the tonic muscle spasm that accompanies painful musculoskeletal injury. The ER capsule technology spreads the delivery of the full dose across 12&ndash;24 hours, flattening the plasma peak and giving steady cover.<\/p>\n<h2 class=\"wp-block-heading\">Flexabenz ER Dosing<\/h2>\n<ul>\n<li><strong>Startdosis:<\/strong> 15&nbsp;mg once daily, with or without food<\/li>\n<li><strong>Increase:<\/strong> to 30&nbsp;mg once daily (two 15&nbsp;mg capsules) if the 15&nbsp;mg dose is tolerated but not fully effective<\/li>\n<li><strong>Duration:<\/strong> up to 2 to 3 weeks<\/li>\n<li><strong>Ouderen:<\/strong> avoid or use the 5&nbsp;mg immediate-release form instead &mdash; ER cyclobenzaprine at 15&nbsp;mg is generally not recommended in patients &gt; 65 years<\/li>\n<li><strong>Mild hepatic impairment:<\/strong> niet aanbevolen<\/li>\n<li><strong>Moderate or severe hepatic impairment:<\/strong> gecontra-indiceerd<\/li>\n<\/ul>\n<p>Swallow Flexabenz ER capsules whole. <strong>Do not open, crush, or chew<\/strong> &mdash; this destroys the extended-release matrix and converts a 24-hour dose into an immediate burst, raising peak drowsiness and anticholinergic load.<\/p>\n<p>Many patients take the capsule in the evening to use the drowsiness for sleep.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:16px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>Driving and CNS safety for Flexabenz ER.<\/strong> Centrally-acting muscle relaxants cause drowsiness, dizziness, and slowed reaction time &mdash; especially in the first few days of treatment. Do not drive, operate machinery, or make safety-critical decisions until you know how you react to this medicine. The effect is stronger with alcohol, opioid pain medication, sleeping tablets, or anti-anxiety medication &mdash; avoid these combinations unless your doctor has cleared them. Muscle relaxants are <em>short-course<\/em> medicines &mdash; typically used for 1&ndash;3 weeks at the start of a musculoskeletal injury while physiotherapy and exercise do the longer-term work.<\/p>\n<\/div>\n<h2 class=\"wp-block-heading\">Who Should Not Take Flexabenz ER?<\/h2>\n<ul>\n<li>Known hypersensitivity to cyclobenzaprine<\/li>\n<li>Concurrent MAOI use or within 14 days of stopping one<\/li>\n<li>Acute post-myocardial infarction period<\/li>\n<li>Heart block or significant arrhythmia<\/li>\n<li>Congestive heart failure<\/li>\n<li>Hyperthyreo\u00efdie<\/li>\n<li>Mild, moderate, or severe hepatic impairment (ER form is contraindicated in all hepatic impairment per label)<\/li>\n<li>Angle-closure glaucoma<\/li>\n<li>Significant urinary retention or prostatic obstruction<\/li>\n<li>Age &gt; 65 years (use immediate-release 5&nbsp;mg instead)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Bijwerkingen<\/h2>\n<ul>\n<li><strong>Zeer vaak voorkomend:<\/strong> drowsiness, dry mouth, dizziness, fatigue<\/li>\n<li><strong>Vaak voorkomend:<\/strong> headache, nausea, constipation, urinary retention, blurred vision, mild palpitations<\/li>\n<li><strong>Minder vaak voorkomend:<\/strong> confusion (especially if taken in the elderly), raised liver enzymes, skin rash<\/li>\n<li><strong>Zeldzaam maar ernstig:<\/strong> serotonin syndrome with serotonergic drugs (SSRIs, SNRIs, tramadol, MAOIs), cardiac arrhythmias, severe hepatotoxicity<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Geneesmiddelinteracties<\/h2>\n<ul>\n<li><strong>MAO-remmers<\/strong> \u2014 absolute contra-indicatie<\/li>\n<li><strong>SSRIs, SNRIs, tramadol, triptans<\/strong> &mdash; serotonin syndrome risk<\/li>\n<li><strong>Alcohol, opioids, benzodiazepines<\/strong> &mdash; additive CNS depression<\/li>\n<li><strong>Anticholinergica<\/strong> &mdash; additive anticholinergic load<\/li>\n<li><strong>CYP1A2\/CYP3A4 inhibitors<\/strong> &mdash; raise cyclobenzaprine exposure<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Bestellen &amp; Levering<\/h2>\n<p>MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. If your preferred pack size is out of stock, contact customer support for an ETA.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:20px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>Medisch disclaimer.<\/strong> The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. Talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, liver disease, or are pregnant.<\/p>\n<\/div>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">What is Flexabenz ER used for?<\/h3>\n<p>Flexabenz ER (cyclobenzaprine 15&nbsp;mg extended release) is used for acute muscle spasm from musculoskeletal injury &mdash; low back pain, neck pain, torticollis, and muscle strain. Once-daily dosing with 24-hour cover.<\/p>\n<h3 class=\"wp-block-heading\">How is Flexabenz ER different from Flexabenz 5 mg?<\/h3>\n<p>Same molecule (cyclobenzaprine). Flexabenz 5&nbsp;mg is immediate release, dosed 3 times a day. Flexabenz ER is 15&nbsp;mg extended release, dosed once daily &mdash; smoother plasma profile, simpler schedule, usually less peak drowsiness.<\/p>\n<h3 class=\"wp-block-heading\">Can I crush or open the Flexabenz ER capsule?<\/h3>\n<p>No. The extended-release mechanism must stay intact. Crushing or opening converts the full 15&nbsp;mg into an immediate dose, which raises peak sedation and anticholinergic side effects.<\/p>\n<h3 class=\"wp-block-heading\">How long does Flexabenz ER take to work?<\/h3>\n<p>Muscle-relaxing effect usually begins within 1&ndash;2 hours of the first dose; full effect builds over 3&ndash;5 days of daily use.<\/p>\n<h3 class=\"wp-block-heading\">Should I take Flexabenz ER in the morning or at bedtime?<\/h3>\n<p>Either is acceptable. Many patients take it in the evening to use the drowsiness for sleep; daytime dosing is fine once you know how you react.<\/p>\n<h3 class=\"wp-block-heading\">How long can I take Flexabenz ER?<\/h3>\n<p>Up to 2 to 3 weeks. It is not intended for long-term use.<\/p>\n<h3 class=\"wp-block-heading\">Is Flexabenz ER safe in older adults?<\/h3>\n<p>The 15&nbsp;mg ER dose is generally not recommended in patients over 65 &mdash; anticholinergic and cardiac effects are stronger and clearance is slower. The 5&nbsp;mg immediate-release form, at low doses, is the preferred option in the elderly.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Flexabenz ER with an SSRI?<\/h3>\n<p>Use with caution. Combined use raises the risk of serotonin syndrome. Discuss with your doctor; watch for agitation, confusion, shivering, diarrhoea, rapid heart rate, or fever.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol while taking Flexabenz ER?<\/h3>\n<p>Avoid alcohol. The combination greatly increases drowsiness and fall risk.<\/p>\n<h3 class=\"wp-block-heading\">Is Flexabenz ER addictive?<\/h3>\n<p>Cyclobenzaprine is not a controlled substance and is not considered to cause meaningful physical dependence. Take as prescribed.<\/p>\n<h3 class=\"wp-block-heading\">Wat als ik een dosis vergeet?<\/h3>\n<p>Take it when you remember unless your next dose is due within 12 hours &mdash; then skip. Never double up.<\/p>\n<p data-mb-link-target=\"synaptol\" data-mb-anchor-variant=\"v2\" style=\"margin-top:1em;font-size:0.95em;color:#444;border-left:3px solid #2c7cb0;padding:0.5em 0.75em;background:#f4f8fb;\"><strong>Zie ook:<\/strong> <a href=\"https:\/\/medsbase.com\/nl\/synaptol\/\"><strong>tolperisone alternative (Synaptol)<\/strong><\/a> \u2014 tolperisone alternative when cyclobenzaprine sedation is unacceptable \u2014 centrally acting without H1 antihistamine drowsiness.<\/p>\n<p class=\"medsbase-link-boost-2026-05-05\" data-marker=\"mb-link-boost-synaptol\">Waar <a href=\"https:\/\/medsbase.com\/nl\/flexabenz-er\/\">Flexabenz ER<\/a> (cyclobenzaprine extended-release) delivers strong relief but pronounced anticholinergic side effects, <a href=\"https:\/\/medsbase.com\/nl\/synaptol\/\">Synaptol (tolperisone 50&nbsp;mg)<\/a> offers a non-sedating substitute for spasticity and musculoskeletal spasm without the dry mouth or daytime grogginess.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde alternatieven<\/h3>\n<p>Andere producten in <strong>Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/psyquit\/\">Psyquit<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/avonza\/\">Avonza<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/montek-plus\/\">Montek Plus<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/prilox-cream\/\">Prilox Cream<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Relieves muscle spasms<br \/>\n\u2705 Reduces muscle stiffness<br \/>\n\u2705 Verbeterd mobiliteit<br \/>\n\u2705 Alleviates musculoskeletal pain<br \/>\n\u2705 Enhances physical therapy effectiveness<\/p>\n<p>Flexabenz ER contains Cyclobenzaprime.<\/p>","protected":false},"featured_media":56298,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3555],"product_tag":[4092,4094],"class_list":{"0":"post-56297","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-pain-relief-medication","9":"product_tag-cyclobenzaprime","10":"product_tag-flexabenz-er","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/56297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=56297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/56298"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=56297"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=56297"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=56297"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=56297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}