{"id":56730,"date":"2024-02-27T17:05:50","date_gmt":"2024-02-27T17:05:50","guid":{"rendered":"https:\/\/medsname.com\/crema-gel\/"},"modified":"2026-04-30T10:24:35","modified_gmt":"2026-04-30T10:24:35","slug":"crema-gel","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/crema-gel\/","title":{"rendered":"Crema Gel"},"content":{"rendered":"

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⚡ Quick Answer — What is Crema Gel?<\/h3>\n

Crema Gel<\/strong> is topical diltiazem 2 percent w\/w<\/strong> (30 g tube) — a calcium channel blocker formulated for chronic anal fissure<\/strong>. Applied two to three times daily into the anal canal, it relaxes the internal anal sphincter, lowers resting anal pressure, and improves blood flow to the fissure base, allowing healing without surgery. Healing rates are 65–75 percent over 6–8 weeks. It is the preferred topical agent over nitroglycerin (GTN)<\/strong> because it causes far fewer headaches. Manufactured under WHO-GMP standards.<\/p>\n<\/div>\n

Waarom bestellen bij MedsBase:<\/strong> \u2714 WHO-GMP gecertificeerde fabrikant<\/strong> \u2714 Discrete verpakking \u2714 Wereldwijde verzending \u2714 Geverifieerde klantbeoordelingen (1.400+ klanten)<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n

💡 First-line topical for chronic anal fissure (per ASCRS 2017).<\/strong> Diltiazem 2 percent and nifedipine 0.3 percent are both effective topical CCBs for anal fissure. Diltiazem is preferred in most modern protocols because of fewer headaches than 0.2 percent GTN ointment. Botulinum toxin injection and lateral internal sphincterotomy are second\/third-line.<\/div>\n

Waarom bestellen bij MedsBase<\/h3>\n

Crema Gel is supplied from a WHO-GMP gecertificeerde fabrikant<\/strong>. Elke bestelling wordt discreet wereldwijd verzonden en valt onder onze Reshipment Assurance Policy<\/a> — if it does not arrive within 20 business days, we reship at no cost. Topical diltiazem is preferred over GTN ointment because of a much lower headache rate (5–15 percent vs 35–50 percent for GTN) while delivering similar healing rates.<\/p>\n

Werkingsmechanisme<\/h2>\n

Diltiazem is a non-dihydropyridine calcium channel blocker. Topically applied in the anal canal, it relaxes the internal anal sphincter (smooth muscle), reducing resting anal pressure (a key driver of fissure pain and ischaemia) and improving capillary perfusion of the posterior midline mucosa. Lower sphincter pressure allows the fissure to heal. Systemic absorption from a 2 percent topical preparation is small (~10 percent), so the systemic CCB effects (low BP, bradycardia, leg oedema) are minimal at standard doses.<\/p>\n

Indicaties<\/h2>\n