{"id":56798,"date":"2024-02-27T17:08:07","date_gmt":"2024-02-27T17:08:07","guid":{"rendered":"https:\/\/medsname.com\/doxin\/"},"modified":"2026-04-30T10:24:34","modified_gmt":"2026-04-30T10:24:34","slug":"doxin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/doxin\/","title":{"rendered":"Doxin"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Snel antwoord<\/h3>\n

Doxin (Doxepin 10 \/ 25 \/ 75 mg) is a tricyclic antidepressant. Most modern use is at low doses for chronic insomnia (3\u20136 mg) or full antidepressant doses (75\u2013300 mg) for sedating\/anxiolytic depression.<\/p>\n<\/div>\n

\nWat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde klantbeoordelingen<\/a>\n<\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Doxin at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Reshipment Assurance Policy<\/a> \u2014 20 werkdagen levertermijn of wij sturen kosteloos opnieuw \u2014 en komt in aanmerking voor ons klantenloyaliteitsprogramma<\/a>. Wereldwijde verzending is beschikbaar naar de meeste bestemmingen.<\/p>\n

What Doxin is and how it works<\/h2>\n

Doxin is a Doxepin-containing tablet supplied by Sun Pharma. Available strengths: 10 \/ 25 \/ 75 mg<\/strong>.<\/p>\n

Doxepin is unusual among TCAs in that its primary modern use is at low doses (3\u20136 mg) for chronic insomnia<\/strong> \u2014 its profound H1 antihistamine action is the strongest of any tricyclic and produces sleep-maintenance benefit without the addictive profile of benzodiazepines or Z-drugs. At full antidepressant doses (75\u2013300 mg), it functions as a classic mixed serotonin-noradrenaline TCA with sedating, anxiolytic, and analgesic properties.<\/p>\n

Tricyclic antidepressants block the reuptake of serotonin and noradrenaline at presynaptic transporters, similar to SSRIs and SNRIs. Their tolerability disadvantage comes from off-target receptor blockade<\/strong>: muscarinic (anticholinergic side effects), histaminergic H1 (sedation, weight gain), and \u03b11-adrenergic (orthostatic hypotension). They also block fast sodium channels in cardiac tissue \u2014 the basis for both their analgesic action and their cardiac toxicity in overdose.<\/p>\n

The 3\u20136 mg insomnia indication is the only TCA dose range that does not require ECG and TCA-class anticholinergic counselling \u2014 at those doses, systemic exposure is negligible.<\/p>\n

Indicaties en dosering<\/h2>\n\n\n\n\n\n\n\n\n
Indicatie<\/th>\nStartdosering<\/th>\nStreefdosering<\/th>\nMaximaal<\/th>\n<\/tr>\n<\/thead>\n
Major depression \/ anxiety<\/td>\n25\u201375 mg HS<\/td>\n75\u2013300 mg\/day<\/td>\n300 mg<\/td>\n<\/tr>\n
Chronic insomnia (low-dose)<\/td>\n3 mg HS<\/td>\n3\u20136 mg HS<\/td>\n6 mg<\/td>\n<\/tr>\n
Chronic urticaria \/ pruritus<\/td>\n10 mg TID<\/td>\n10\u201325 mg TID<\/td>\nby tolerability<\/td>\n<\/tr>\n
Older adults<\/td>\n10 mg HS<\/td>\n30\u201375 mg\/day<\/td>\n150 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Belangrijke veiligheidsoverwegingen<\/h2>\n
\nCardiac risk and overdose toxicity<\/strong><\/p>\n

TCAs prolong QRS and QT, and overdose is life-threatening<\/strong> \u2014 historically the most common cause of antidepressant fatalities. Baseline ECG before initiating in patients with known cardiac disease, on QT-prolonging therapy, or in older adults. Do not start in recent MI, conduction abnormality, uncompensated heart failure, or congenital long QT. Limit dispense quantities in patients at suicide risk \u2014 the therapeutic-to-toxic ratio is narrow.<\/p>\n<\/div>\n

\nAnticholinergic burden<\/strong><\/p>\n

Dry mouth, constipation, blurred vision, urinary hesitancy, cognitive slowing \u2014 universal at therapeutic doses. Avoid in narrow-angle glaucoma, BPH with significant retention, and dementia. Pair with chewing gum \/ sugar-free lozenges, fibre + fluid, and stool softeners.<\/p>\n<\/div>\n

\nZwarte waarschuwing voor su\u00efcidaliteit (onder 25)<\/strong><\/p>\n

All antidepressants carry an FDA black-box warning for increased suicidal ideation in patients under 25 \u2014 particularly relevant for clomipramine in adolescent OCD.<\/p>\n<\/div>\n

Veelvoorkomende bijwerkingen<\/h2>\n