{"id":56848,"date":"2024-02-27T17:10:28","date_gmt":"2024-02-27T17:10:28","guid":{"rendered":"https:\/\/medsname.com\/yaz\/"},"modified":"2026-04-30T10:17:17","modified_gmt":"2026-04-30T10:17:17","slug":"yaz","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/yaz\/","title":{"rendered":"Yaz"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Snel antwoord<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Yaz<\/strong> is a combined oral contraceptive (COC) containing <strong>drospirenone<\/strong> (a 4th-generation progestin with antimineralocorticoid (potassium-sparing) and antiandrogenic activity) with <strong>ethinyl estradiol<\/strong>. Taken once daily, it is ~99% effective with perfect use (~91% with typical use). Pack: drospirenone 3 mg + ethinyl estradiol 0.02 mg (28-tablet 24+4 regimen). Starts working after 7 consecutive days of correct use in a new cycle. Used for contraception and commonly for cycle regulation, heavy periods, acne, and PMS\/PMDD. This is a <strong>low-dose \/ ultra-low-dose<\/strong> formulation \u2014 the estrogen component is at 20 mcg EE or lower, which reduces estrogen-related side effects (nausea, breast tenderness) at a modest cost in cycle control stability.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.95em;\">\n<strong>\ud83d\udd12 Waarom bestellen bij MedsBase:<\/strong> Geverifieerde echte fabrikantlevering \u00b7 Discrete wereldwijde verzending \u00b7 Veilig afrekenen (creditcard, crypto) \u00b7 Beoordeeld met 4.9\u2605 door 1.400+ klanten\n<\/div>\n<h2><strong>What Is Yaz?<\/strong><\/h2>\n<p>Yaz is a branded generic combined oral contraceptive containing <strong>drospirenone<\/strong> en <strong>ethinyl estradiol (EE)<\/strong>. It prevents pregnancy through three mechanisms:<\/p>\n<ul>\n<li><strong>Ovulation suppression<\/strong> (primary) \u2014 steady hormone levels prevent the LH surge.<\/li>\n<li><strong>Cervical mucus thickening<\/strong> \u2014 hindering sperm penetration.<\/li>\n<li><strong>Endometrial thinning<\/strong> \u2014 reducing implantation potential.<\/li>\n<\/ul>\n<p>Strengths: <strong>drospirenone 3 mg + ethinyl estradiol 0.02 mg (28-tablet 24+4 regimen)<\/strong>. Manufactured by Bayer.<\/p>\n<h2><strong>Progestin Profile: Drospirenone<\/strong><\/h2>\n<p><strong>VTE (clotting) risk:<\/strong> <strong>Slightly higher VTE risk than LNG<\/strong> (~9\u201312 cases per 10,000 woman-years). The absolute risk remains low but the relative risk vs LNG is ~1.5\u20132\u00d7. Discuss with a clinician if you have clotting risk factors.<\/p>\n<p><strong>Androgenic \/ other activity:<\/strong> <strong>Antiandrogenic<\/strong> \u2014 specifically helpful for acne, PMS\/PMDD, and hirsutism. Also mild diuretic effect may reduce bloating and breast tenderness.<\/p>\n<p><strong>Best-fit users:<\/strong> Acne, PMS\/PMDD, hormonal bloating, women without VTE risk factors.<\/p>\n<h2><strong>Genitale herpes (eerste episode):<\/strong><\/h2>\n<ul>\n<li><strong>Contraception<\/strong> \u2014 ~99% effective with perfect use, ~91% typical use.<\/li>\n<li><strong>Menstrual cycle regulation<\/strong> \u2014 for irregular periods.<\/li>\n<li><strong>Heavy menstrual bleeding (menorrhagia)<\/strong> \u2014 reduces blood loss 50%+.<\/li>\n<li><strong>Painful periods (dysmenorrhea)<\/strong> \u2014 reduces prostaglandin-mediated cramps.<\/li>\n<li><strong>Acne vulgaris and PMS\/PMDD<\/strong> \u2014 particularly responsive due to drospirenone&#8217;s antiandrogenic profile.<\/li>\n<li><strong>Endometriosis pain<\/strong> (off-label, continuous-use regimens).<\/li>\n<li><strong>Ovarian cyst prevention<\/strong> and reduced ovarian cancer risk with long-term use.<\/li>\n<\/ul>\n<h2><strong>How to Take Yaz<\/strong><\/h2>\n<ol>\n<li><strong>Start on day 1 of your period<\/strong> for immediate contraceptive protection. Starting at other times requires 7 days of backup contraception.<\/li>\n<li>Neem <strong>one tablet daily at the same time each day<\/strong> \u2014 set a phone alarm. Consistency is critical.<\/li>\n<li>Follow the pack order. 21-day packs: take one tablet daily for 21 days, then 7 tablet-free days. 28-day packs: take all 28 tablets consecutively (last 7 are placebo\/iron).<\/li>\n<li>Expect a withdrawal bleed during the tablet-free \/ placebo week \u2014 lighter than a natural period.<\/li>\n<li>After the break, start the next pack on the scheduled day regardless of whether bleeding has stopped.<\/li>\n<\/ol>\n<h2><strong>Missed Pill Rules (CRITICAL \u2014 read carefully)<\/strong><\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Scenario<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Actie<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>1 pill missed (&lt;24 hours late)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Take the missed pill as soon as you remember. Continue the rest of the pack as normal. No backup needed.<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>2+ pills missed (48+ hours late)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Take the most recent missed pill immediately. Use condoms or abstain for <strong>7 dagen<\/strong>. If missed pills occurred in the last 7 days of the active pack, <strong>skip the placebo week<\/strong> and start the next pack directly. Consider emergency contraception if unprotected sex in the prior 5 days.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Vomiting within 2 hours of taking a pill<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Treat as a missed pill. Take another from a spare pack if available, or apply missed-pill rules.<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Severe diarrhoea for &gt;24 hours<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Treat as missed pills; use backup for 7 days after recovery.<\/td>\n<\/tr>\n<\/table>\n<h2><strong>Bijwerkingen<\/strong><\/h2>\n<p><strong>Common, usually transient (improve over 3 cycles):<\/strong> nausea, breast tenderness, headache, mood changes, breakthrough bleeding\/spotting, reduced libido, weight-neutral to slight gain.<\/p>\n<p><strong>Minder vaak:<\/strong> migraine, melasma (skin pigmentation), contact-lens intolerance, chloasma.<\/p>\n<p><strong>Ernstig (zeldzaam maar belangrijk):<\/strong> venous thromboembolism (DVT\/PE), arterial thromboembolism (stroke, MI), hypertension, cholestatic jaundice, hepatic adenoma, breast cancer (small increase during use, returns to baseline within 10 years of stopping).<\/p>\n<p><strong>VTE warning signs \u2014 STOP and seek urgent medical help:<\/strong> severe leg pain or swelling (DVT), sudden shortness of breath or chest pain (PE), sudden severe headache with neurological symptoms (stroke), severe abdominal pain (mesenteric thrombosis).<\/p>\n<h2><strong>Who Should Not Take Yaz<\/strong><\/h2>\n<p>Combined oral contraceptives are <strong>absolutely contraindicated<\/strong> in:<\/p>\n<ul>\n<li><strong>Smoking + age \u226535<\/strong> \u2014 dramatic stroke\/MI risk increase.<\/li>\n<li>History of VTE (DVT or PE), thrombophilia (Factor V Leiden, protein C\/S deficiency, antiphospholipid antibodies).<\/li>\n<li>History of stroke, transient ischaemic attack, or coronary artery disease.<\/li>\n<li><strong>Migraine with aura<\/strong> \u2014 significant stroke risk.<\/li>\n<li>Uncontrolled hypertension (&gt;160\/100 mmHg).<\/li>\n<li>Active or recent (within 10 years) breast cancer.<\/li>\n<li>Active liver disease (hepatitis, cirrhosis, tumour).<\/li>\n<li>Known pregnancy or unexplained vaginal bleeding.<\/li>\n<li>Major surgery with prolonged immobilisation (stop 4 weeks before).<\/li>\n<li>Breastfeeding under 6 weeks postpartum (reduces milk supply; VTE risk high).<\/li>\n<li>Severe diabetes with vascular complications.<\/li>\n<\/ul>\n<h2><strong>Geneesmiddelinteracties<\/strong><\/h2>\n<ul>\n<li><strong>Enzyme inducers (REDUCE contraceptive effect \u2014 backup needed):<\/strong> rifampicin, rifabutin, phenytoin, phenobarbital, carbamazepine, topiramate, primidone, some HIV antiretrovirals (ritonavir, efavirenz), St John&#8217;s Wort.<\/li>\n<li><strong>Antibiotics (most do NOT reduce efficacy)<\/strong> \u2014 the old advice to use backup during antibiotics applies only to rifampicin\/rifabutin. Other antibiotics (amoxicillin, doxycycline, cephalexin) do not reduce COC efficacy for most women.<\/li>\n<li><strong>Lamotrigine<\/strong> \u2014 COCs reduce lamotrigine levels; dose adjustment may be needed.<\/li>\n<li><strong>Drospirenone + potassium-sparing drugs<\/strong> (ACE inhibitors, ARBs, K+-sparing diuretics, NSAIDs long-term): small hyperkalaemia risk. Check potassium in the first cycle if combining.<\/li>\n<li><strong>Grapefruitsap<\/strong> \u2014 may raise estrogen levels modestly; not clinically significant.<\/li>\n<\/ul>\n<h2><strong>Non-Contraceptive Benefits<\/strong><\/h2>\n<ul>\n<li>~50% reduction in ovarian cancer risk with 5+ years of use (persists decades after stopping).<\/li>\n<li>~50% reduction in endometrial cancer risk.<\/li>\n<li>Lighter, shorter, more predictable periods.<\/li>\n<li>Reduced menstrual cramps, mittelschmerz, and PMS symptoms.<\/li>\n<li>Improved acne (especially drospirenone- or cyproterone-containing COCs).<\/li>\n<li>Reduction in benign ovarian cysts and fibrocystic breast changes.<\/li>\n<li>Potential protective effect against pelvic inflammatory disease (thickened cervical mucus).<\/li>\n<\/ul>\n<h2><strong>Opslag<\/strong><\/h2>\n<p>Store at room temperature (15\u201325 \u00b0C \/ 59\u201377 \u00b0F) in the original blister. Keep out of direct sunlight and humidity. Do not use after the printed expiry date. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does Yaz work?<\/h3>\n<p>If started on day 1 of your period, it is effective immediately. Starting any other day requires 7 days of backup contraception (condoms or abstinence).<\/p>\n<h3 class=\"wp-block-heading\">What happens if I want to get pregnant?<\/h3>\n<p>Fertility usually returns within 1\u20133 months of stopping. Some women conceive the first cycle after discontinuation. Taking folic acid for 3 months before trying is recommended.<\/p>\n<h3 class=\"wp-block-heading\">Will Yaz make me gain weight?<\/h3>\n<p>Modern low-dose COCs are generally weight-neutral in placebo-controlled trials. Some women report 1\u20132 kg changes but this is often fluid retention that resolves after 3 months. Drospirenone-containing COCs (mild diuretic effect) may be weight-favourable.<\/p>\n<h3 class=\"wp-block-heading\">Can I use Yaz to skip my period?<\/h3>\n<p>Yes \u2014 &#8220;tricycling&#8221; or continuous use is safe for most women. Skip the tablet-free week and start the next pack directly to delay or skip the withdrawal bleed. Some breakthrough spotting may occur; discuss with a clinician for long-term continuous use.<\/p>\n<h3 class=\"wp-block-heading\">Is Yaz safe if I am overweight?<\/h3>\n<p>Moderate obesity (BMI 30\u201335) does not absolutely contraindicate COCs but increases VTE risk. Progestin-only pills or non-hormonal methods may be preferable if BMI is &gt;35. Discuss with a clinician.<\/p>\n<h3 class=\"wp-block-heading\">What about breastfeeding?<\/h3>\n<p>Combined pills are not recommended for breastfeeding mothers under 6 weeks postpartum (VTE risk + milk supply reduction). Progestin-only pills (mini-pills) are preferred during breastfeeding.<\/p>\n<h3 class=\"wp-block-heading\">Does Yaz protect against STIs?<\/h3>\n<p>No. Hormonal contraceptives provide zero protection against STIs. Use condoms as barrier protection against chlamydia, gonorrhoea, HIV, herpes, syphilis, and HPV.<\/p>\n<h3 class=\"wp-block-heading\">What if I forget a pill?<\/h3>\n<p>See the Missed Pill Rules table above. Briefly: 1 pill missed (&lt;24 h late) = take and continue; 2+ pills missed (48+ h late) = take the most recent + 7 days backup.<\/p>\n<h3 class=\"wp-block-heading\">When should I call a doctor urgently?<\/h3>\n<p>Severe leg pain or swelling (possible DVT), chest pain or shortness of breath (possible PE), severe headache with visual\/neurological changes (possible stroke), severe abdominal pain, yellowing of skin or eyes (liver problem).<\/p>\n<h3 class=\"wp-block-heading\">Can I switch from Yaz to a different pill?<\/h3>\n<p>Yes \u2014 start the new pill the day after finishing the current pack (no tablet-free gap) if switching another COC. If switching to a POP, overlap by 7 days. Always consult a clinician if changing due to side effects or health changes.<\/p>\n<h3 class=\"wp-block-heading\">Related Contraceptive Products<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/yasmin\/\">Yasmin (Drospirenone + EE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/ovral-l\/\">Ovral-L (Levonorgestrel + EE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/ovral-g\/\">Ovral-G (Norgestrel + EE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/loette\/\">Loette (LNG + EE ultra-low)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/duoluton-l\/\">Duoluton-L (LNG + EE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/triquilar\/\">Triquilar (Triphasic LNG + EE)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/femilon\/\">Femilon (Desogestrel + EE low-dose)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f Medische disclaimer:<\/strong> Hormonal contraceptives have contraindications and interactions. Consult a clinician before starting. If you smoke and are over 35, have migraine with aura, a history of VTE, active liver disease, or known cardiovascular disease, combined oral contraceptives may not be safe for you. Emergency contraception is not a substitute for regular birth control.<\/p>\n<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde alternatieven<\/h3>\n<p>Andere producten in <strong>Behandeling van acne<\/strong> die klanten ook bekijken:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/isotroin\/\">Isotroin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/epilite\/\">Epilite<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/melacare-forte-cream\/\">Melacare Forte Cream<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/tretinex-cream\/\">Tretinex Cr\u00e8me<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/isofair\/\">Isofair<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p><span style=\"font-weight: 400;\">\u2705 Prevents Pregnancy<br \/>\n<\/span><span style=\"font-weight: 400;\">\u2705 Regulates Menstrual Cycle<br \/>\n<\/span><span style=\"font-weight: 400;\">\u2705 Vermindert acne-uitbraken<br \/>\n<\/span><span style=\"font-weight: 400;\">\u2705 Decreases Menstrual Cramps<br \/>\n<\/span><span style=\"font-weight: 400;\">\u2705 Prescribed Birth Control<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Yaz contains Drospirenone and Ethinylestradiol.<\/span><\/p>","protected":false},"featured_media":56849,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3215,3530,3141,3223,3502],"product_tag":[4183,4186,4187],"class_list":{"0":"post-56848","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-acne-treatment","7":"product_cat-alternative-contraceptives","8":"product_cat-category-overview","9":"product_cat-chronic-conditions","10":"product_cat-womens-health","11":"product_tag-drospirenone","12":"product_tag-ethinylestradiol","13":"product_tag-yaz","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/56848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=56848"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/56849"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=56848"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=56848"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=56848"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=56848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}