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Allegra<\/strong> is een merk van fexofenadine<\/strong> (120 mg or 180 mg), a second-generation, non-sedating oral antihistamine<\/strong> gebruikt voor hay fever (allergic rhinitis), chronic idiopathic urticaria (hives), itchy skin, and allergic conjunctivitis<\/strong>. It blocks histamine H1 receptors in the peripheral tissues that drive allergy symptoms — sneezing, runny nose, itchy eyes, skin hives — without crossing the blood-brain barrier meaningfully, so it does not make most people drowsy. Onset: 60 minutes; duration: 12–24 hours. Once-daily dosing. The most non-sedating antihistamine available<\/strong> — preferred for drivers, pilots, and anyone who cannot afford any drowsiness. Do not take with fruit juice<\/strong> (grapefruit, orange, apple) — juice reduces absorption by ~30–40% via OATP inhibition. Safe for long-term daily use (months to years) in most adults. Common side effects: mild headache, dry mouth, fatigue. Avoid in known hypersensitivity; dose-reduce in significant renal impairment.<\/p>\n<\/div>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Allegra is an oral antihistamine containing fexofenadine<\/strong> (120 mg or 180 mg), supplied as tablets. Manufactured by Sanofi, in packs of 30, 60, 90 or 180 tablets. Originator brand: Allegra \/ Telfast (Sanofi, 1996).<\/p>\n fexofenadine belongs to the second-generation (non-sedating) H1 antihistamine class<\/strong> — developed to keep the allergy-blocking effect of older drugs like diphenhydramine or pheniramine while removing the sedation, dry mouth, and cognitive impairment caused by their passage into the brain. Second-generation agents are the first-line oral antihistamines for allergic rhinitis and chronic urticaria in every major allergy guideline (ARIA, EAACI, AAAAI).<\/p>\n Het is niet<\/strong> a treatment for anaphylaxis (use adrenaline\/epinephrine auto-injector), asthma (use inhaled corticosteroid + bronchodilator), or allergic food reactions beyond mild skin symptoms.<\/p>\n When you are exposed to an allergen (pollen, dust, animal dander), mast cells and basophils in the skin and mucosa release histamine<\/strong>. Histamine binds H1 receptors and causes the classic allergy cascade: vasodilation, vascular leakage, itch, sneeze, increased mucus secretion, and smooth-muscle contraction.<\/p>\n fexofenadine is a selective inverse agonist at H1 receptors<\/strong>. It stabilises the receptor in its inactive state, reducing signalling even at baseline histamine levels. Key features of the second-generation class:<\/p>\n Standaard dosering:<\/strong> 120 mg once daily for seasonal allergic rhinitis, or 180 mg once daily for chronic urticaria, in adults and children aged 12+. Children 6–11: 30 mg twice daily. Reduce in renal impairment.<\/p>\n Essentially no sedation<\/strong> — fexofenadine has the lowest brain penetration of any 2nd-generation antihistamine and is specifically approved by aviation authorities for use by pilots in many jurisdictions.<\/p>\n Common (< 5% in most trials):<\/strong><\/p>\n Minder vaak voorkomend:<\/strong><\/p>\n Zwangerschap:<\/strong> Limited human data — loratadine and cetirizine have more outcome data and are usually preferred in pregnancy.<\/p>\n Borstvoeding:<\/strong> second-generation antihistamines pass into breast milk in tiny amounts and are considered compatible with breastfeeding. Loratadine and cetirizine have the most data.<\/p>\n Kinderen:<\/strong> Approved from age 6 months (30 mg oral suspension) in many markets; 120 mg \/ 180 mg tablets from age 12.<\/p>\n Store Allegra below 25°C in a dry place, in the original blister. Keep out of reach of children.<\/p>\n Yes — Allegra contains the active ingredient fexofenadine. Bioequivalence to the originator brand (Allegra \/ Telfast (Sanofi, 1996)) is required by regulatory authorities, so clinical effect is the same at the same dose.<\/p>\n Grapefruit, orange, and apple juice contain compounds (flavonoids) that inhibit intestinal OATP (organic anion transporting polypeptide) — the transporter fexofenadine uses to cross into the bloodstream. Taking fexofenadine with fruit juice can reduce plasma levels by 30–40%, weakening its effect. Take with water and separate any fruit juice by at least 4 hours.<\/p>\n Essentially no sedation<\/strong> — fexofenadine has the lowest brain penetration of any 2nd-generation antihistamine and is specifically approved by aviation authorities for use by pilots in many jurisdictions. If you do feel drowsy, take your dose in the evening, or switch to fexofenadine (the least-sedating 2nd-generation antihistamine).<\/p>\n Yes — long-term daily use of 2nd-generation antihistamines is well-studied and safe for most adults. There is no tachyphylaxis<\/strong> (the effect does not fade), no cumulative organ toxicity, and no withdrawal syndrome. Chronic urticaria patients often take an antihistamine daily for years.<\/p>\n Yes, in most cases. Combining an oral antihistamine with an intranasal corticosteroid (e.g. mometasone, fluticasone) is the standard combination for moderate hay fever<\/strong>. Eye drops (olopatadine, ketotifen) can be added for eye symptoms. Avoid combining two oral antihistamines at the same time without medical advice.<\/p>\n Onset is usually 60 minutes, with peak effect at 2–3 hours. For seasonal hay fever, starting 1–2 weeks before your usual trigger season gives the best control.<\/p>\n Single-dose overdoses of 2nd-generation antihistamines rarely cause serious harm at a few multiples of the standard dose, but can cause drowsiness, tachycardia, and (rarely) QT prolongation. Seek medical advice if more than 5× the standard dose has been taken, especially in children.<\/p>\n You can order Allegra (120 mg or 180 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n <\/p>\n Andere producten in Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n \u2705 Relieves Allergy Symptoms Allegra contains Fexofenadine.<\/p>","protected":false},"featured_media":57019,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3975],"product_tag":[4219,4220],"class_list":{"0":"post-57018","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hay-fever-allergies-treatment","9":"product_tag-allegra","10":"product_tag-fexofenadine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/57018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=57018"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/57019"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=57018"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=57018"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=57018"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=57018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Waarom bestellen bij MedsBase<\/h3>\n
What Is Allegra?<\/h2>\n
What Is Allegra Used For?<\/h2>\n
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How Does Allegra Work?<\/h2>\n
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Dosering en toediening<\/h2>\n
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Bijwerkingen<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
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Use in Pregnancy and Children<\/h2>\n
Who Should Not Take Allegra?<\/h2>\n
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Opslag<\/h2>\n
Veelgestelde vragen<\/h2>\n
Is Allegra the same as fexofenadine?<\/h3>\n
Why does fruit juice interact with fexofenadine?<\/h3>\n
Will Allegra make me drowsy?<\/h3>\n
Is it safe to take Allegra every day for months or years?<\/h3>\n
Can I take Allegra with other allergy medications?<\/h3>\n
How quickly does Allegra work?<\/h3>\n
What happens if I take more than the recommended dose?<\/h3>\n
Where can I buy Allegra online?<\/h3>\n
Gerelateerde allergiemedicijnen<\/h2>\n
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Gerelateerde alternatieven<\/h3>\n
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\n\u2705 Controls Hay Fever
\n\u2705 Minimizes Itching
\n\u2705 Non-Drowsy Formula
\n\u2705 Oraal medicatie-optie<\/p>\n