{"id":57266,"date":"2024-02-27T17:33:29","date_gmt":"2024-02-27T17:33:29","guid":{"rendered":"https:\/\/medsname.com\/griso\/"},"modified":"2026-04-30T10:24:29","modified_gmt":"2026-04-30T10:24:29","slug":"griso","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/griso\/","title":{"rendered":"Griso"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 Snel antwoord<\/h3>\n<p style=\"margin-bottom:0;\">Griso is griseofulvin 250 mg \u2014 an older oral antifungal used mainly for <strong>tinea capitis (scalp ringworm) in children<\/strong>, especially when the cause is Microsporum canis (terbinafine works less well on this organism). Active only against dermatophytes (Trichophyton, Epidermophyton, Microsporum); inactive against Candida, Malassezia, moulds. Long course required (6\u20138 weeks for tinea capitis, 6\u201312 months for onychomycosis). Mostly displaced by terbinafine and itraconazole for adult dermatophyte infections, but still relevant in paediatrics.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>gecertificeerde fabrikant<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>Discrete verpakking<\/strong><br \/>ongemarkeerde envelop<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>Wereldwijde verzending<\/strong><br \/>naar de meeste landen<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>1.400+ klanten<\/strong><br \/><a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">lees beoordelingen<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 Why order Griso from MedsBase<\/h2>\n<ul>\n<li><strong>WHO-GMP gecertificeerde fabrikant<\/strong> \u2014 afkomstig uit een gereguleerde faciliteit, complete verpakking met batchnummer en vervaldatum.<\/li>\n<li><strong>Discrete verpakking<\/strong> \u2014 gewone envelop, geen medicatienaam aan de buitenkant.<\/li>\n<li><strong>Wereldwijde verzending<\/strong> naar de meeste landen met <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>Loyaliteitspunten<\/strong> \u2014 1 punt per $1 uitgegeven (peptiden\/verzendkosten uitgezonderd); 100 punten = $5 korting op uw volgende bestelling.<\/li>\n<\/ul>\n<h2 id=\"uses\">Toepassingen &amp; indicaties<\/h2>\n<p>Griso (griseofulvin 250 mg, Pharmajunction) is one of the oldest oral antifungal agents. It binds to fungal microtubules, disrupting mitosis and inhibiting hyphal growth. Modern practice has largely replaced it with terbinafine and itraconazole for adults \u2014 but it remains relevant when:<\/p>\n<ul>\n<li>Treating tinea capitis caused by <strong>Microsporum<\/strong> (terbinafine has lower cure rates against Microsporum than against Trichophyton).<\/li>\n<li>Treating tinea capitis in children \u2014 long-established paediatric experience and safety data.<\/li>\n<li>Newer oral antifungals are unavailable, contraindicated, or unaffordable.<\/li>\n<\/ul>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Indicatie<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Standaard behandelingsschema<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea capitis \u2014 children<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">10\u201320 mg\/kg\/day microsize (or 5\u201310 mg\/kg ultramicrosize) \u00d7 6\u20138 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea capitis \u2014 adults<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500 mg\/day microsize \u00d7 4\u20136 weeks<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea corporis \/ cruris \/ pedis (refractory)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500 mg\/day microsize \u00d7 2\u20136 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomycosis \u2014 fingernail (largely abandoned)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500\u20131000 mg\/day microsize \u00d7 4\u20136 months<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomycosis \u2014 toenail (largely abandoned)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500\u20131000 mg\/day microsize \u00d7 9\u201312 months<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-to-take\">Hoe in te nemen<\/h2>\n<ul>\n<li>Take with a fatty meal \u2014 fat increases griseofulvin absorption ~2-fold.<\/li>\n<li>For children, the tablet can be crushed into food or yogurt if a paediatric oral suspension is unavailable.<\/li>\n<li>Complete the full course \u2014 symptomatic improvement comes within 1\u20132 weeks but stopping early causes relapse.<\/li>\n<\/ul>\n<h2 id=\"mechanism\">Hoe het werkt<\/h2>\n<p>Griseofulvin binds to fungal microtubules (specifically, \u03b2-tubulin) and disrupts mitotic spindle formation. The result is impaired hyphal growth. The drug is incorporated into newly-synthesised keratin in the hair, skin, and nail \u2014 meaning protected new growth replaces fungus-infected old keratin as it sheds. This is why long courses are required, especially for nail (which grows slowly).<\/p>\n<h2 id=\"side-effects\">Bijwerkingen<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Frequentie<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Effecten<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vaak voorkomend<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Headache (often early in therapy, often resolves), nausea, abdominal pain, photosensitivity, urticaria, dizziness<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Minder vaak<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Mild LFT rise, leukopenia, peripheral neuritis, taste disturbance, insomnia<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Zeldzaam maar ernstig<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Severe hepatitis (rare), Stevens-Johnson syndrome, lupus exacerbation, agranulocytosis, photosensitive rash that can resemble erythema multiforme<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"interactions\">Geneesmiddelinteracties<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Geneesmiddel<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Effect<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Actie<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Warfarine<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\"><strong>INR falls<\/strong> (griseofulvin induces metabolism)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor INR; increase warfarin dose<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Combined oral contraceptive pill<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\"><strong>Reduced contraceptive efficacy<\/strong> (CYP induction; ethinylestradiol metabolism)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Use additional barrier contraception during therapy and for 1 month after<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Phenobarbital<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduces griseofulvin levels<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Increase griseofulvin dose 50%<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Ciclosporine<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Levels fall<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor; increase ciclosporin<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Alcohol<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Disulfiram-like flushing reaction (rare)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Limit alcohol<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">Contra-indicaties<\/h2>\n<ul>\n<li>Severe liver disease, porphyria.<\/li>\n<li>Pregnancy (teratogenic in animals).<\/li>\n<li>Hypersensitivity to griseofulvin.<\/li>\n<li>Systemic lupus erythematosus (can precipitate flares).<\/li>\n<\/ul>\n<h2 id=\"pregnancy\">Zwangerschap &amp; borstvoeding<\/h2>\n<p>Griseofulvin is contraindicated in pregnancy. Effective contraception is required during therapy <strong>and for 1 month after the last dose<\/strong> (washout period). Men: limited data suggest sperm quality may be temporarily reduced \u2014 many guidelines recommend avoiding conception for 6 months after a course in men too, though the evidence base is weaker. Excretion in breast milk is unclear \u2014 alternatives are preferred.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>When is griseofulvin still preferred over terbinafine?<\/h3>\n<p>For tinea capitis caused by Microsporum canis (typically picked up from cats \/ dogs). Terbinafine has 60\u201370% cure rates for Microsporum versus &gt; 90% for Trichophyton; griseofulvin has 80\u201390% cure rates for Microsporum. The cause is determined by fungal culture or PCR. Pre-school children with kitten exposure \u2014 Microsporum is a common cause.<\/p>\n<h3>My child has scalp ringworm \u2014 what should I expect?<\/h3>\n<p>6\u20138 weeks of daily oral griseofulvin (or 4 weeks oral terbinafine if Trichophyton). Plus medicated shampoo (selenium sulphide or ketoconazole) twice weekly to reduce shedding to others. Don&#8217;t share hairbrushes \/ hats. School policy: most schools allow attendance once treatment is started.<\/p>\n<h3>Why does griseofulvin reduce the contraceptive pill?<\/h3>\n<p>Griseofulvin induces hepatic CYP enzymes that metabolise oestrogen and progestogen. Ethinylestradiol levels can fall enough to allow ovulation. Use additional barrier contraception during the course and for 1 month after the last dose. This warning applies to combined pills, mini-pills, contraceptive patch, and vaginal ring; the levonorgestrel IUS and copper IUD are unaffected.<\/p>\n<h3>Why a fatty meal?<\/h3>\n<p>Griseofulvin is poorly water-soluble. Taken with a high-fat meal (e.g. eggs, full-fat yogurt, peanut butter on toast), bioavailability roughly doubles compared to fasting. For paediatric dosing, mixing the crushed tablet into yogurt or peanut butter is both an absorption strategy and a palatability strategy.<\/p>\n<h3>Is Griso the same as Fulcin \/ Grisactin?<\/h3>\n<p>Yes \u2014 Fulcin and Grisactin are older brand names of griseofulvin. Griso contains the same active ingredient, manufactured by Pharmajunction under WHO-GMP. Bioequivalent.<\/p>\n<h3>Why am I getting a rash on my arms in the sun?<\/h3>\n<p>Griseofulvin is photosensitising. UV exposure during therapy can produce an itchy rash on sun-exposed skin. Use SPF 30+ broad-spectrum sunscreen, long sleeves outdoors, and avoid sunbeds during the course.<\/p>\n<h3>Can my child play sport with tinea capitis?<\/h3>\n<p>Yes \u2014 once treatment is started. Avoid sharing helmets \/ caps \/ hairbrushes; wash bedding hot. Most school and sports authorities allow return to activity 24\u201348 hours after starting oral antifungal.<\/p>\n<h3>What if my tinea pedis or onychomycosis hasn&#8217;t cleared after 12 weeks of griseofulvin?<\/h3>\n<p>Switch to terbinafine or itraconazole \u2014 both have higher cure rates for adult-onset dermatophyte nail and skin infections. Recheck the fungal diagnosis with a clipping for microscopy \/ culture before changing \u2014 the original diagnosis may have been wrong.<\/p>\n<h3>Is it safe to drink alcohol on griseofulvin?<\/h3>\n<p>A rare disulfiram-like reaction (flushing, tachycardia, nausea) has been reported. Most patients tolerate moderate alcohol without issue. Avoid heavy drinking during the course.<\/p>\n<h3>Why is the course so long for nails?<\/h3>\n<p>Griseofulvin only protects newly-formed keratin \u2014 it does not eradicate fungus from existing infected nail. The nail has to grow out from the cuticle. Toenails grow ~1.5 mm per month, so a fully grown-out toenail takes ~9 months. Modern practice prefers terbinafine or itraconazole for nail because they concentrate in the existing nail and shorten the active treatment phase.<\/p>\n<h2 id=\"storage\">Opslag<\/h2>\n<p>Store tablets at 15\u201325 \u00b0C, away from light and moisture. Keep out of reach of children. Do not use after expiry.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Andere antischimmelmiddelen die u mogelijk interesseren<\/h2>\n<p>If Griso is unavailable, here are alternatives \u2014 same molecule from a different manufacturer, plus first-line modern alternatives where griseofulvin is no longer preferred.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/zimig\/\"><strong>Zimig (terbinafine 250 mg)<\/strong><\/a> \u2014 First-line for adult dermatophyte tinea \/ onychomycosis.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/sporanox-capsule\/\"><strong>Sporanox (itraconazol 100 mg)<\/strong><\/a> \u2014 Onychomycosis pulse therapy alternative.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/clocip\/\"><strong>Clocip (clotrimazol 1% cr\u00e8me)<\/strong><\/a> \u2014 Topical for skin tinea + Candida; pregnancy-safe.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/keto-cream\/\"><strong>Keto Cream (ketoconazol 2%)<\/strong><\/a> \u2014 Topical for tinea + seborrhoeic dermatitis.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/loceryl-nail-liq\/\"><strong>Loceryl (amorolfine 5%)<\/strong><\/a> \u2014 Topical lacquer for mild distal nail infection.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>Medisch disclaimer.<\/strong> Deze pagina bevat productinformatie voor volwassenen die antischimmelmedicijnen voor persoonlijk gebruik bestellen. Het is geen vervanging voor individueel medisch advies. Bespreek het juiste antischimmelmiddel, de dosering en de behandelduur met een gekwalificeerde clinicus \u2014 vooral als u leveraandoeningen heeft, zwanger bent of borstvoeding geeft, warfarine gebruikt, een statine gebruikt, immunosuppressiva gebruikt of een schimmelnagelinfectie heeft die een andere diagnose kan zijn (psoriasis, lichen planus, trauma).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fights Fungal Infections<br \/>\n\u2705 Clears Ringworm<br \/>\n\u2705 Antifungal Properties<br \/>\n\u2705 Targets Dermatophytes<br \/>\n\u2705 Inhibits Fungal Growth<\/p>\n<p>Griso contains Griseofulvin.<\/p>","protected":false},"featured_media":57267,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[4272,4273],"class_list":{"0":"post-57266","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-griseofulvin","11":"product_tag-griso","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/57266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=57266"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/57267"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=57266"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=57266"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=57266"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=57266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}