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Brufen<\/strong> is een Ibuprofen<\/strong> tablet verkrijgbaar in 200, 400, and 600 mg<\/strong> strengths. It is a non-selective non-steroidal anti-inflammatory drug (NSAID)<\/strong> widely used for pain, fever, and inflammation — including headache, dental pain, menstrual cramps, musculoskeletal injury, osteoarthritis, and rheumatoid arthritis. Typical adult dose is 400 mg three to four times daily<\/strong> with food; the safest long-term dose is 1,200 mg\/day or less.<\/p>\n<\/div>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Brufen 400 mg<\/strong> is one of the most widely prescribed ibuprofen brands in the world, marketed by Abbott and originally developed by Boots in the 1960s. Ibuprofen is on the WHO Essential Medicines List and has the best overall safety profile of any oral NSAID at low to moderate doses. It is the first-line option for most community-level pain and inflammation because it works predictably, is cheap, and is comparatively gentle on the stomach at 1,200 mg\/day or less.<\/p>\n Brufen is available in three tablet strengths:<\/p>\n Brufen is indicated for a broad range of acute and chronic pain and inflammatory conditions:<\/p>\n Brufen is niet<\/em> a disease-modifying drug in rheumatoid arthritis — it relieves symptoms but does not slow joint damage. DMARDs such as methotrexate or biologics are needed for that.<\/p>\n Ibuprofen is a non-selective NSAID<\/strong> — it blocks both COX-1<\/strong> (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2<\/strong> (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.<\/p>\n The therapeutic chain of events is the same for every NSAID:<\/p>\n Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.<\/p>\n Adults:<\/strong><\/p>\n Children (> 6 months, weight-based):<\/strong> 5–10 mg\/kg every 6–8 hours, max 40 mg\/kg\/day, under paediatric supervision.<\/p>\n Take Brufen with food or a glass of milk<\/strong>. Swallow tablets whole; do not crush, break, or chew a 600 mg tablet. If you forget a dose, take it when you remember unless your next dose is due within 2 hours — then skip the missed dose. Never double up.<\/p>\n GI safety — read this before the first dose.<\/strong> Every NSAID, including Brufen, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Brufen with food<\/em>, use the lowest effective dose for the shortest reasonable time<\/em>, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.<\/p>\n<\/div>\n All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.<\/p>\n NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors\/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.<\/p>\n Most short-course users tolerate Brufen well. Reported effects include:<\/p>\n Vaak (1\u201310%):<\/strong><\/p>\n Zeldzaam maar belangrijk:<\/strong><\/p>\n Zeldzaam ernstig:<\/strong> aseptic meningitis (especially in SLE), Stevens-Johnson syndrome, severe hepatotoxicity.<\/p>\nWaarom bestellen bij MedsBase<\/h3>\n
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What Is Brufen Used For?<\/h2>\n
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How Does Ibuprofen Work?<\/h2>\n
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Brufen Dosing<\/h2>\n
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Who Should Not Take Brufen?<\/h2>\n
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Cardiovasculair risico<\/h3>\n
Renal (kidney) safety<\/h3>\n
Common Side Effects of Brufen<\/h2>\n
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Brufen vs Other Pain Relievers<\/h2>\n