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Inmecin<\/strong> is een indomethacin capsule<\/strong> verkrijgbaar in 25 mg and 50 mg<\/strong> strengths. Indomethacin is one of the most potent non-selective NSAIDs and is first-line for acute gout, pericarditis, ankylosing spondylitis, and Bartter syndrome<\/strong>. The usual adult dose is 25–50 mg two to three times daily with food<\/strong>. Indomethacin has a stronger CNS side-effect profile (headache, dizziness) than ibuprofen or diclofenac, and should be used at the lowest effective dose for the shortest reasonable time.<\/p>\n<\/div>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Inmecin<\/strong> is an immediate-release oral capsule containing indomethacin<\/strong>, a powerful non-selective NSAID developed in 1963. Indomethacin is on the WHO Essential Medicines List and remains the gold-standard oral NSAID for several specific indications where its unusually strong anti-inflammatory effect outweighs its relatively higher side-effect burden compared to newer NSAIDs.<\/p>\n Two capsule strengths are available:<\/p>\n Indomethacin is a non-selective NSAID<\/strong> — it blocks both COX-1<\/strong> (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2<\/strong> (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.<\/p>\n The therapeutic chain of events is the same for every NSAID:<\/p>\n Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.<\/p>\n Always take with food or an antacid to reduce gastric irritation. Swallow capsules whole with a full glass of water. Do not lie down for at least 15 minutes after a dose (reduces oesophageal irritation).<\/p>\n Because indomethacin has a 4-hour half-life, three-times-daily dosing is standard. For a simpler once-daily or twice-daily schedule, a sustained-release formulation such as Inmecin-R 75 mg<\/strong> is available.<\/p>\n GI safety — read this before the first dose.<\/strong> Every NSAID, including Inmecin, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Inmecin met voedsel<\/em>, use the lowest effective dose for the shortest reasonable time<\/em>, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.<\/p>\n<\/div>\n Indomethacin-specific cautions:<\/strong><\/p>\n All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.<\/p>\n NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors\/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.<\/p>\n Indomethacin has a stronger side-effect profile than ibuprofen or diclofenac, particularly in the central nervous system.<\/p>\n Very common (>10%):<\/strong><\/p>\n Vaak (1\u201310%):<\/strong><\/p>\n Zeldzaam maar ernstig:<\/strong><\/p>\n Indomethacin headache is the single most common reason patients discontinue therapy. If it is intolerable, your doctor may switch to naproxen, diclofenac, or a COX-2 selective agent.<\/p>\nWaarom bestellen bij MedsBase<\/h3>\n
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What Is Inmecin Used For?<\/h2>\n
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How Does Indomethacin Work?<\/h2>\n
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Inmecin Dosing<\/h2>\n
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Who Should Not Take Inmecin?<\/h2>\n
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Cardiovasculair risico<\/h3>\n
Renal (kidney) safety<\/h3>\n
Common Side Effects of Inmecin<\/h2>\n
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Inmecin vs Inmecin-R vs Other Gout NSAIDs<\/h2>\n