{"id":58445,"date":"2024-02-27T18:36:12","date_gmt":"2024-02-27T18:36:12","guid":{"rendered":"https:\/\/medsname.com\/lomoother\/"},"modified":"2026-04-30T10:24:13","modified_gmt":"2026-04-30T10:24:13","slug":"lomoother","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/lomoother\/","title":{"rendered":"Lomoother"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Lomoother?<\/h3>\n<p style=\"margin:0;\"><strong>Lomoother<\/strong> is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong> &mdash; a nitrosourea alkylating agent that crosses the blood-brain barrier. Used for <strong>recurrent or refractory primary brain tumours<\/strong> (high-grade glioma, ependymoma) and as part of older Hodgkin lymphoma combination regimens. Standard adult monotherapy dose: <strong>100&ndash;130 mg\/m&sup2; orally as a single dose every 6 weeks<\/strong> &mdash; the 6-week interval is mandatory because nadir is delayed (4&ndash;6 weeks) and recovery slow. Mandatory: FBC at baseline, weekly between cycles, and on day 42 before next dose. <strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> because of cumulative myelotoxicity and pulmonary fibrosis risk. Pregnancy contraindication; offer fertility preservation.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Specialistisch toezicht vereist.<\/strong> Kankermedicatie moet worden voorgeschreven door een behandelend oncoloog met een bevestigde diagnose, baseline-stadi\u00ebring en een gedefinieerd behandelplan. Start, stop, wijzig de dosis of gebruik kankermedicatie nooit buiten een door oncologie geleid zorgplan. De meeste kankermedicijnen vereisen regelmatige bloedtestmonitoring (FBC, LFT, nierfunctie), zijn absoluut gecontra-indiceerd tijdens zwangerschap en hebben significante geneesmiddelinteracties.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Versleutelde Afrekenprocedure<\/strong> \u00b7 <strong>\ud83d\udcb3 Geverifieerde Betaalprocessor<\/strong> \u00b7 <strong>\ud83d\ude9a Wereldwijde Verzending<\/strong> \u00b7 <strong>\u2b50 4.9\/5 van 1.400+ klanten<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Lomoother?<\/h2>\n<p>Lomoother is an oral capsule from Beacon Pharmaceuticals containing <strong>lomustine (CCNU) 40 mg<\/strong>. Lomustine is a nitrosourea alkylating agent that crosses the blood-brain barrier (CSF concentration ~30&ndash;50% of plasma), making it one of the few oral cytotoxics with meaningful CNS penetration. Used in primary brain tumours, particularly recurrent high-grade glioma after temozolomide failure.<\/p>\n<h2 class=\"wp-block-heading\">Toepassingen en Indicaties<\/h2>\n<ul>\n<li><strong>Recurrent or refractory glioblastoma multiforme<\/strong> after temozolomide<\/li>\n<li><strong>Anaplastic astrocytoma, anaplastic oligodendroglioma<\/strong> (PCV regimen)<\/li>\n<li><strong>Hodgkin lymphoma<\/strong> (older CCNU-containing combinations)<\/li>\n<li><strong>Brain metastases (selected)<\/strong><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage and How to Take<\/h2>\n<ul>\n<li><strong>Standard:<\/strong> 100&ndash;130 mg\/m&sup2; PO as a SINGLE dose every 6 weeks<\/li>\n<li><strong>PCV regimen (oligodendroglioma):<\/strong> 110 mg\/m&sup2; day 1 + procarbazine + vincristine, every 6 weeks<\/li>\n<\/ul>\n<ol>\n<li>Take as a single oral dose at bedtime, on an empty stomach (no food 2 hours before or 2 hours after).<\/li>\n<li>Antiemetic (ondansetron 8 mg) 1 hour before dose.<\/li>\n<li>Swallow capsules whole with water. Do NOT open.<\/li>\n<li><strong>Mandatory 6-week interval between doses<\/strong> &mdash; nadir is delayed (typically week 4&ndash;6), recovery slow. Dosing more frequently than every 6 weeks risks cumulative pancytopenia.<\/li>\n<li><strong>Verplichte monitoring:<\/strong> FBC at baseline, weekly throughout the cycle, and on day 42 before next dose. LFTs and renal function monthly. PFTs (DLCO) baseline and if dyspnoea.<\/li>\n<li><strong>Cumulative dose limit ~1,000 mg\/m&sup2;<\/strong> over the lifetime &mdash; cumulative myelotoxicity and pulmonary fibrosis become rate-limiting.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Bijwerkingen<\/h2>\n<p><strong>Vaak voorkomend:<\/strong> nausea (significant), vomiting, anorexia.<\/p>\n<p><strong>Belangrijk:<\/strong><\/p>\n<ul>\n<li><strong>Delayed cumulative myelosuppression<\/strong> &mdash; thrombocytopenia and leucopenia at week 4&ndash;6, recovery slow<\/li>\n<li><strong>Pulmonary fibrosis<\/strong> at high cumulative dose &mdash; mandatory PFTs if dyspnoea<\/li>\n<li>Hepatotoxiciteit<\/li>\n<li>Niertoxiciteit<\/li>\n<li>Secondary leukaemia (long-term, dose-related)<\/li>\n<li>Permanent infertility (gonadotoxic)<\/li>\n<li>Confusion, lethargy, ataxia (high doses)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Waarschuwingen<\/h2>\n<ul>\n<li><strong>Zwangerschap:<\/strong> teratogenic; strict contraception throughout + 6 months after.<\/li>\n<li><strong>Borstvoeding:<\/strong> avoid.<\/li>\n<li><strong>Pre-existing pulmonary disease:<\/strong> baseline DLCO; avoid in severe.<\/li>\n<li><strong>Severe hepatic \/ renal impairment:<\/strong> reduce dose.<\/li>\n<li><strong>Levende vaccins:<\/strong> contraindicated.<\/li>\n<li><strong>Cumulative dose tracking<\/strong> &mdash; specialist responsibility.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Geneesmiddelinteracties<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Combineren met<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Effect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Wat te doen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other myelosuppressives<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive prolonged pancytopenia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Specialist supervision.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increases lomustine marrow toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use ranitidine or famotidine instead.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Levende vaccins<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Disseminated infection<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Opslag<\/h2>\n<ul>\n<li>Refrigerate at <strong>2&ndash;8&deg;C<\/strong>.<\/li>\n<li>Out of reach of children, women of childbearing potential, pets.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Gerelateerde alternatieven op MedsBase<\/h2>\n<p>Andere oncologische medicijnen die naast dit product wordt aangeboden:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/endoxan\/\"><strong>Endoxan (cyclophosphamide 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/temotero\/\"><strong>Temotero (temozolomide 20 \/ 100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/temozol-20\/\"><strong>Temozol (temozolomide 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/endace\/\"><strong>Endace (megestrol 40 \/ 160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/nl\/anti-cancer-medication\/\">Bekijk alle anti-kankermedicijnen \u2192<\/a><\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">Why must doses be 6 weeks apart?<\/h3>\n<p>Lomustine causes <strong>delayed cumulative myelosuppression<\/strong>. The blood count nadir typically occurs at <strong>week 4&ndash;6<\/strong> after a dose, with slow recovery thereafter. Dosing more frequently than every 6 weeks stacks the marrow toxicity and risks severe pancytopenia. The 6-week interval is rigid &mdash; even if you feel well, do not dose-advance without specialist instruction.<\/p>\n<h3 class=\"wp-block-heading\">Why is there a cumulative dose limit?<\/h3>\n<p>Cumulative pulmonary fibrosis and persistent thrombocytopenia become limiting at total exposure above ~1,000 mg\/m&sup2; (lifetime). Specialists track cumulative dose and stop or extend the interval as the limit is approached. Tell every doctor about every previous chemotherapy course.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Lomoother with food?<\/h3>\n<p>No &mdash; take on an empty stomach (no food for 2 hours before or 2 hours after). Most patients take the dose at bedtime &ge; 2 hours after dinner. Pre-medicate with ondansetron 8 mg about 1 hour before to prevent the significant nausea and vomiting characteristic of nitrosoureas.<\/p>\n<h3 class=\"wp-block-heading\">Welke bloedtesten heb ik nodig?<\/h3>\n<p>FBC at baseline, weekly between cycles, and on day 42 before each next dose. LFTs and renal function monthly. PFTs (with DLCO) at baseline and any time you develop new dyspnoea or persistent dry cough.<\/p>\n<h3 class=\"wp-block-heading\">Will Lomoother work for my brain tumour?<\/h3>\n<p>Lomustine has a long history in primary brain tumours. In recurrent glioblastoma after temozolomide failure, lomustine produces modest disease-control benefit in some patients. In oligodendroglioma, the PCV regimen (procarbazine + lomustine + vincristine) has documented overall survival benefit when combined with radiotherapy in 1p\/19q co-deleted disease. Discuss expected benefit specific to your tumour with the neuro-oncologist.<\/p>\n<h3 class=\"wp-block-heading\">Why must Lomoother be refrigerated?<\/h3>\n<p>Lomustine is heat-sensitive and degrades at room temperature, especially in warmer climates. Refrigeration (2&ndash;8&deg;C) preserves potency. Keep in original blister.<\/p>\n<h3 class=\"wp-block-heading\">Caregivers handling Lomoother?<\/h3>\n<p>Wear gloves when handling capsules and patient body fluids in the first 48 hours after a dose. Wash hands afterwards. Pregnant caregivers should avoid handling.<\/p>\n<h3 class=\"wp-block-heading\">Can I have live vaccines?<\/h3>\n<p>No &mdash; contraindicated during lomustine and for at least 6 months after the last dose. Inactivated vaccines safe and recommended.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Elke batch wordt ingekocht bij een <strong>WHO-GMP gecertificeerde fabrikant<\/strong>. Bestellingen worden verzonden in eenvoudige, ongemarkeerde verpakkingen door onze logistieke partners en vallen onder onze <a href=\"\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>: als een pakket niet binnen 20 werkdagen arriveert, sturen wij kosteloos een nieuwe zending, zonder vragen te stellen.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde Antikankermedicijnen<\/h3>\n<p>Andere oncologische medicijnen die naast dit product wordt aangeboden:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/endoxan\/\">Endoxan (cyclophosphamide 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/celkeran\/\">Celkeran (chlorambucil 2 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/temozol-20\/\">Temozol 20 (temozolomide 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/temotero\/\">Temotero (temozolomide 100\/250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Brain tumor treatment<br \/>\n\u2705 Chemotherapy drug<br \/>\n\u2705 Slows tumor growth<br \/>\n\u2705 Alkylating agent<br \/>\n\u2705 Oral medication<\/p>\n<p>Lomoother contains Lomustine.<\/p>","protected":false},"featured_media":58446,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4493,4494],"class_list":{"0":"post-58445","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-lomoother","10":"product_tag-lomustine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/58445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=58445"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/58446"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=58445"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=58445"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=58445"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=58445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}