{"id":58609,"date":"2024-02-28T05:19:38","date_gmt":"2024-02-28T05:19:38","guid":{"rendered":"https:\/\/medsname.com\/oliza\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"oliza","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/oliza\/","title":{"rendered":"Oliza"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Snel antwoord<\/h3>\n<p style=\"margin-bottom:0;\">Oliza (Olanzapine 2.5 \/ 5 \/ 10 mg) is an atypical antipsychotic for schizophrenia, bipolar mania and maintenance, treatment-resistant depression (with fluoxetine), and acute agitation. The most robust antipsychotic effect of the atypicals \u2014 but the heaviest metabolic burden.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Oliza at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20 werkdagen levertermijn of wij sturen kosteloos opnieuw \u2014 en komt in aanmerking voor ons <a href=\"https:\/\/medsbase.com\/nl\/loyalty-points\/\">klantenloyaliteitsprogramma<\/a>. Wereldwijde verzending is beschikbaar naar de meeste bestemmingen.<\/p>\n<h2>What Oliza is and how it works<\/h2>\n<p>Oliza is an olanzapine tablet supplied by Cipla. Available strengths: <strong>2.5 \/ 5 \/ 10 mg<\/strong>. Olanzapine is a thienobenzodiazepine atypical antipsychotic with strong D2 antagonism, strong 5-HT2A antagonism, and substantial H1 (sedation, weight gain), M1 (anticholinergic), and \u03b11 (orthostasis) blockade. The H1+M1 receptor profile is responsible both for its calming\/sedative effect (useful in acute agitation) and for its metabolic burden.<\/p>\n<h2>Indicaties en dosering<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indicatie<\/th>\n<th>Startdosering<\/th>\n<th>Streefdosering<\/th>\n<th>Maximaal<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Schizofrenie (volwassenen)<\/td>\n<td>5\u201310 mg eenmaal daags<\/td>\n<td>10\u201320 mg OD<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizofrenie (adolescenten \u2265 13 jaar)<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>10 mg eenmaal daags<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolaire manie (volwassenen)<\/td>\n<td>10\u201315 mg eenmaal daags<\/td>\n<td>10\u201320 mg OD<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Acute agitation (IM)<\/td>\n<td>10 mg IM<\/td>\n<td>\u2014<\/td>\n<td>3 doses\/24h<\/td>\n<\/tr>\n<tr>\n<td>Treatment-resistant depression (with fluoxetine)<\/td>\n<td>5 mg + 20 mg fluoxetine<\/td>\n<td>5\u201318 mg<\/td>\n<td>18 mg<\/td>\n<\/tr>\n<tr>\n<td>Older adults<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>5\u201310 mg eenmaal daags<\/td>\n<td>op basis van tolerantie<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Belangrijke veiligheidsoverwegingen<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA black-box \u2014 dementiegerelateerde psychose<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Alle atypische antipsychotica dragen een FDA black-box waarschuwing voor verhoogde sterfte (voornamelijk cardiovasculair en infectieus) bij gebruik voor gedragsstoornissen bij oudere volwassenen met dementie. <strong>Atypische antipsychotica zijn niet goedgekeurd voor dementiegerelateerde psychose of agitatie.<\/strong>.  Gebruik bij deze populatie is off-label, als laatste redmiddel, tijdelijk en vereist een expliciet risico-voordeel gesprek.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Heaviest metabolic burden of the atypicals<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Olanzapine produces the most weight gain (typically 4\u201310 kg in the first 6 months, sometimes far more), the most insulin resistance, and the most lipid disturbance of any commonly-used antipsychotic. Patients can develop type 2 diabetes within months of initiation. <strong>Mandatory monitoring: weight at every visit; fasting glucose \/ HbA1c and fasting lipids at baseline, 12 weeks, then 6-monthly.<\/strong> Counsel about diet and exercise from initiation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Sedation and anticholinergic burden<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Strong sedation in the first 1\u20132 weeks. Anticholinergic effects (dry mouth, constipation, urinary hesitancy) are universal. Both lessen but do not disappear.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Olanzapine + benzodiazepine IM \u2014 caution<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Combining IM olanzapine with parenteral benzodiazepines has produced cases of severe hypotension, respiratory depression, and death. If both are clinically necessary in acute agitation, separate by \u2265 1 hour and monitor closely.<\/p>\n<\/div>\n<h2>Veelvoorkomende bijwerkingen<\/h2>\n<ul>\n<li><strong>Weight gain and metabolic syndrome<\/strong> \u2014 the dominant long-term concern.<\/li>\n<li><strong>Sedatie<\/strong> \u2014 universal at initiation.<\/li>\n<li><strong>Orthostatic hypotension<\/strong> \u2014 common at initiation; titrate slowly in older adults.<\/li>\n<li><strong>Anticholinergic<\/strong> \u2014 dry mouth, constipation, urinary hesitancy.<\/li>\n<li><strong>Akathisia, EPS<\/strong> \u2014 less common than risperidone, more common than aripiprazole.<\/li>\n<li><strong>Prolactine<\/strong> \u2014 modest rise; less than risperidone.<\/li>\n<li><strong>Hepatic<\/strong> \u2014 transient AST\/ALT rises common.<\/li>\n<\/ul>\n<h2>Geneesmiddelinteracties<\/h2>\n<ul>\n<li><strong>CYP1A2-remmers<\/strong> (fluvoxamine, ciprofloxacin) \u2014 raise olanzapine levels markedly.<\/li>\n<li><strong>Roken<\/strong> \u2014 induces CYP1A2; smokers have lower levels and need higher doses; smoking cessation can produce toxicity.<\/li>\n<li><strong>Carbamazepine<\/strong> \u2014 strong CYP1A2 induction; raises olanzapine clearance.<\/li>\n<li><strong>CNS-depressiva<\/strong> \u2014 additive sedation.<\/li>\n<li><strong>Anticholinergica<\/strong> \u2014 additive burden.<\/li>\n<\/ul>\n<h2>Zwangerschap, borstvoeding, pediatrie<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires alternative or close monitoring. Paediatric: licensed from 13 (schizophrenia, bipolar).<\/p>\n<h2>Opslag<\/h2>\n<p>Bewaren bij 15\u201330 \u00b0C in originele verpakking.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>Why does Oliza cause so much weight gain?<\/h3>\n<p>Olanzapine&rsquo;s combined H1 antihistamine, 5-HT2C antagonism, and other receptor effects produce strong appetite stimulation, slowed satiety, and shifted carbohydrate preference. Weight gain is dose-related but real even at low doses. Counselling about diet and exercise from week 1, plus regular weight monitoring, is mandatory.<\/p>\n<h3>How is Oliza different from risperidone or aripiprazole?<\/h3>\n<p>Olanzapine has the strongest acute antipsychotic effect and the fastest calming action \u2014 useful in acute agitation. The trade-off is the heaviest metabolic burden. Risperidone is more efficacious for some positive symptoms but raises prolactin substantially. Aripiprazole is metabolically cleanest but produces more akathisia.<\/p>\n<h3>Should I monitor my blood sugar on Oliza?<\/h3>\n<p>Yes \u2014 fasting glucose or HbA1c at baseline, 12 weeks, and then 6-monthly. Olanzapine can produce diabetes within months of initiation, sometimes presenting with diabetic ketoacidosis. Don&rsquo;t skip the monitoring.<\/p>\n<h3>Can Oliza be used long-term?<\/h3>\n<p>Yes \u2014 particularly for schizophrenia maintenance where olanzapine often outperforms other atypicals on relapse rate. The metabolic burden is the main reason long-term use requires careful weight, glucose, and lipid monitoring, plus active management of cardiometabolic risk.<\/p>\n<h3>How long until Oliza works?<\/h3>\n<p>Calming effect within 1\u20132 hours of the first oral dose. Antipsychotic effect builds over 1\u20132 weeks; full antipsychotic and mood-stabilising effect at 4\u20136 weeks.<\/p>\n<h3>What about driving on Oliza?<\/h3>\n<p>Avoid driving in the first 1\u20132 weeks of titration. Most patients on stable doses drive normally, but the sedation can be persistent at higher doses.<\/p>\n<h3>Is the orodispersible form different?<\/h3>\n<p>Yes \u2014 orodispersible (ODT) versions of olanzapine exist (Zyprexa Zydis, Olimelt) and dissolve on the tongue without water. Bioequivalent to standard tablets but useful in adherence-uncertain or dysphagia patients.<\/p>\n<h3>Can Oliza be combined with fluoxetine?<\/h3>\n<p>Yes \u2014 the olanzapine-fluoxetine combination (OFC, Symbyax) is FDA-approved for treatment-resistant depression and bipolar depression. The fluoxetine partly addresses olanzapine&rsquo;s lack of antidepressant effect; olanzapine adds a strong mood-stabilising component.<\/p>\n<h3>Why does smoking matter?<\/h3>\n<p>Smoking strongly induces CYP1A2, which is olanzapine&rsquo;s main metabolic enzyme. Smokers metabolise olanzapine faster and need higher doses; abrupt cessation of smoking (e.g. hospital admission) can produce olanzapine toxicity if the dose isn&rsquo;t adjusted. Tell the prescriber if smoking status changes.<\/p>\n<h3>Can Oliza be stopped abruptly?<\/h3>\n<p>Generally not \u2014 taper over 2\u20134 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and an antipsychotic relapse. Never stop without prescriber agreement.<\/p>\n<h2>Andere medicijnen voor geestelijke gezondheid<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/aripicon\/\">Aripicon (Aripiprazol \u2014 D2-parti\u00eble agonist)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/olanzap\/\">Olanzap (Olanzapine \u2014 krachtig antipsychoticum)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/risdone\/\">Risdone (Risperidon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/seroquit\/\">Seroquit (Quetiapine \u2014 bipolaire depressie)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/atlura\/\">Atlura (Lurasidone \u2014 metabolisch neutraal)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medisch disclaimer.<\/strong> Deze pagina is educatief en geen vervanging voor persoonlijk medisch advies. Farmacotherapie voor geestelijke gezondheid dient te worden gestart, gecontroleerd en aangepast onder begeleiding van een gekwalificeerde clinicus. Als u of iemand die u kent in een su\u00efcidale crisis verkeert, neem dan onmiddellijk contact op met de plaatselijke hulpdiensten, of bel de su\u00efcidepreventielijn van uw land (VS\/Canada: 988; VK: Samaritans 116 123; internationale lijst: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Oliza (Olanzapine 2.5\/5\/10 mg) \u2014 thienobenzodiazepine atypical for schizophrenia and bipolar mania. strong acute calming effect for severe agitation.<\/p>","protected":false},"featured_media":58610,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4529],"class_list":{"0":"post-58609","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-oliza","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/58609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=58609"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/58610"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=58609"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=58609"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=58609"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=58609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}