{"id":58686,"date":"2024-02-28T05:23:06","date_gmt":"2024-02-28T05:23:06","guid":{"rendered":"https:\/\/medsname.com\/lurakem\/"},"modified":"2026-04-30T10:24:10","modified_gmt":"2026-04-30T10:24:10","slug":"lurakem","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/lurakem\/","title":{"rendered":"Lurakem"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Snel antwoord<\/h3>\n<p style=\"margin-bottom:0;\">Lurakem (Lurasidone 40 \/ 80 mg) is an atypical antipsychotic for schizophrenia and bipolar depression. <strong>Must be taken with food (\u2265 350 kcal)<\/strong> \u2014 fasting halves absorption and produces treatment failure. Metabolically among the cleanest atypicals.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Lurakem at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20 werkdagen levertermijn of wij sturen kosteloos opnieuw \u2014 en komt in aanmerking voor ons <a href=\"https:\/\/medsbase.com\/nl\/loyalty-points\/\">klantenloyaliteitsprogramma<\/a>. Wereldwijde verzending is beschikbaar naar de meeste bestemmingen.<\/p>\n<h2>What Lurakem is and how it works<\/h2>\n<p>Lurakem is a lurasidone tablet supplied by Alkem. Available strengths: <strong>40 \/ 80 mg<\/strong>. Lurasidone is a D2\/5-HT2A antagonist with additional 5-HT7 antagonism (the 5-HT7 component is the basis for its bipolar-depression indication). It is one of the cleanest atypicals on metabolic markers \u2014 minimal weight gain, minimal lipid effect, minimal glucose effect.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>CRITICAL \u2014 must be taken with food (\u2265 350 kcal)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Fasting bioavailability of lurasidone is approximately <strong>half<\/strong> the fed bioavailability. Patients who skip a meal or take the dose at a small snack reach inadequate plasma levels and frequently appear to &#8220;fail&#8221; therapy. <strong>Take with the largest meal of the day, every day, at the same time.<\/strong> A glass of milk or a small biscuit is not enough \u2014 aim for at least 350 kcal of mixed-macronutrient food.<\/p>\n<\/div>\n<h2>Indicaties en dosering<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indicatie<\/th>\n<th>Startdosering<\/th>\n<th>Streefdosering<\/th>\n<th>Maximaal<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Schizophrenia (adult)<\/td>\n<td>40 mg OD with food<\/td>\n<td>40\u201380 mg OD<\/td>\n<td>160 mg<\/td>\n<\/tr>\n<tr>\n<td>Schizophrenia (adolescent \u2265 13 y)<\/td>\n<td>40 mg OD with food<\/td>\n<td>40\u201380 mg OD<\/td>\n<td>80 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar depression (adult, monotherapy or adjunct)<\/td>\n<td>20 mg OD with food<\/td>\n<td>20\u201360 mg OD<\/td>\n<td>120 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar depression (paediatric \u2265 10 y)<\/td>\n<td>20 mg OD with food<\/td>\n<td>20\u201380 mg OD<\/td>\n<td>80 mg<\/td>\n<\/tr>\n<tr>\n<td>Nierfunctiestoornis (CrCl &lt; 50)<\/td>\n<td>20 mg OD with food<\/td>\n<td>up to 80 mg<\/td>\n<td>80 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Belangrijke veiligheidsoverwegingen<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA black-box \u2014 dementia-related psychosis<\/strong><\/p>\n<p style=\"margin-bottom:0;\">All atypical antipsychotics carry an FDA black-box warning for increased mortality (mostly cardiovascular and infectious) when used to treat behavioural disturbance in older adults with dementia. <strong>Atypicals are not approved for dementia-related psychosis or agitation<\/strong>. Use in this population is off-label, last-resort, time-limited, and requires explicit risk-benefit conversation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Akathisia and EPS<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Akathisia is common at higher doses. EPS (rigidity, tremor, dystonia) less common than first-generation antipsychotics but can occur. Manageable with dose reduction or anticholinergic adjunct.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Strong CYP3A4 substrate<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Avoid concurrent strong CYP3A4 inhibitors (azoles, clarithromycin, ritonavir, grapefruit juice) \u2014 they raise lurasidone levels several-fold. Avoid strong inducers (rifampicin, carbamazepine, phenytoin, St John&rsquo;s wort) \u2014 they reduce levels into the ineffective range.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Suicidality (under-25, bipolar depression indication)<\/strong><\/p>\n<p style=\"margin-bottom:0;\">All antidepressant-class indications carry the under-25 suicidality warning.<\/p>\n<\/div>\n<h2>Veelvoorkomende bijwerkingen<\/h2>\n<ul>\n<li><strong>Somnolence and sedation<\/strong> \u2014 common; usually settles.<\/li>\n<li><strong>Akathisia<\/strong> \u2014 dose-dependent.<\/li>\n<li><strong>Misselijkheid<\/strong> \u2014 first 1\u20132 weeks; mitigated by food (which is mandatory anyway).<\/li>\n<li><strong>EPS<\/strong> \u2014 uncommon but possible.<\/li>\n<li><strong>Gewichtstoename<\/strong> \u2014 modest, generally less than olanzapine\/quetiapine.<\/li>\n<li><strong>Prolactin<\/strong> \u2014 small dose-dependent rise.<\/li>\n<li><strong>Kenmerkende afwezigheid:<\/strong> minimal effect on lipids, glucose, QT.<\/li>\n<\/ul>\n<h2>Geneesmiddelinteracties<\/h2>\n<ul>\n<li><strong>Sterke CYP3A4-remmers<\/strong> \u2014 contraindicated.<\/li>\n<li><strong>Sterke CYP3A4-induceerders<\/strong> \u2014 contraindicated.<\/li>\n<li><strong>Moderate CYP3A4 inhibitors<\/strong> (diltiazem, verapamil, fluconazole, erythromycin) \u2014 halve lurasidone dose; max 40 mg.<\/li>\n<li><strong>Other CNS depressants<\/strong> \u2014 additive sedation.<\/li>\n<li><strong>Other antipsychotics<\/strong> \u2014 additive EPS, prolactin, NMS risk.<\/li>\n<\/ul>\n<h2>Zwangerschap, borstvoeding, pediatrie<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness. Breastfeeding: insufficient data; generally avoided. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar depression).<\/p>\n<h2>Opslag<\/h2>\n<p>Bewaren bij 15\u201330 \u00b0C in originele verpakking.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>Why does Lurakem need to be taken with food?<\/h3>\n<p>Fasting absorption is approximately half of fed absorption. The food requirement is not optional \u2014 patients who take Lurakem on an empty stomach often appear to fail therapy when in fact they are simply under-dosed. The minimum threshold for adequate absorption is approximately 350 kcal of mixed food (a normal meal, not a snack).<\/p>\n<h3>Why is Lurakem preferred for bipolar depression?<\/h3>\n<p>Lurasidone has FDA approval for bipolar depression as monotherapy or adjunct (PREVAIL-2 trial) \u2014 one of only three atypicals with this indication (others are quetiapine and olanzapine-fluoxetine). The 5-HT7 antagonism is thought to underlie the antidepressant effect. Lurasidone is a metabolically cleaner choice than quetiapine or olanzapine for bipolar depression.<\/p>\n<h3>Will Lurakem make me gain weight?<\/h3>\n<p>Less than olanzapine, clozapine, quetiapine, or risperidone \u2014 typically 1\u20132 kg over 6 months in monotherapy. One of the better metabolic profiles among atypicals.<\/p>\n<h3>How long until Lurakem works?<\/h3>\n<p>Schizophrenia: positive symptoms typically improve over 2\u20134 weeks; full effect at 4\u20136 weeks. Bipolar depression: 2\u20136 weeks for full effect. Compliance with the food requirement matters \u2014 if response is poor, check that doses are being taken with adequate meals.<\/p>\n<h3>Can Lurakem be combined with mood stabilisers?<\/h3>\n<p>Yes \u2014 lurasidone is FDA-approved as an adjunct to lithium or valproate in bipolar depression. Combination is common and well-tolerated.<\/p>\n<h3>What about driving on Lurakem?<\/h3>\n<p>Sedation is dose-dependent. Most patients on stable doses drive normally; the first 1\u20132 weeks of titration can impair reaction time.<\/p>\n<h3>How is Lurakem different from olanzapine?<\/h3>\n<p>Lurasidone has a substantially better metabolic profile (less weight gain, less glucose disturbance, less lipid disturbance) but a slightly higher rate of akathisia and somnolence. Olanzapine is more sedating and has stronger acute antipsychotic effect; lurasidone is preferred for long-term metabolic safety.<\/p>\n<h3>Can Lurakem be stopped abruptly?<\/h3>\n<p>Generally taper over 1\u20132 weeks, although withdrawal is mild. The relapse risk in schizophrenia and bipolar disease is the main reason for caution \u2014 never stop without prescriber agreement.<\/p>\n<h3>Why is grapefruit juice a problem?<\/h3>\n<p>Grapefruit juice is a strong CYP3A4 inhibitor. Lurasidone is a CYP3A4 substrate; grapefruit raises levels several-fold, increasing sedation, akathisia, and EPS risk. Avoid grapefruit and grapefruit juice during Lurakem therapy.<\/p>\n<h3>Does Lurakem prolong the QT interval?<\/h3>\n<p>Less than ziprasidone, less than thioridazine. Lurasidone has a small QT signal but is generally regarded as one of the cleaner atypicals for QT. Pre-treatment ECG is not routinely required but is reasonable in patients with cardiac risk factors.<\/p>\n<h2>Andere medicijnen voor geestelijke gezondheid<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/aripicon\/\">Aripicon (Aripiprazole \u2014 D2 partial agonist)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/olanzap\/\">Olanzap (Olanzapine \u2014 robust antipsychotic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/risdone\/\">Risdone (Risperidone)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/seroquit\/\">Seroquit (Quetiapine \u2014 bipolar depression)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/atlura\/\">Atlura (Lurasidone \u2014 metabolically clean)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medisch disclaimer.<\/strong> Deze pagina is educatief en geen vervanging voor persoonlijk medisch advies. Farmacotherapie voor geestelijke gezondheid dient te worden gestart, gecontroleerd en aangepast onder begeleiding van een gekwalificeerde clinicus. Als u of iemand die u kent in een su\u00efcidale crisis verkeert, neem dan onmiddellijk contact op met de plaatselijke hulpdiensten, of bel de su\u00efcidepreventielijn van uw land (VS\/Canada: 988; VK: Samaritans 116 123; internationale lijst: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Lurakem (Lurasidone 40\/80 mg) \u2014 5-HT7-active atypical for schizophrenia and bipolar depression. must be taken with the largest meal of the day.<\/p>","protected":false},"featured_media":58687,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4542,4454],"class_list":{"0":"post-58686","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-lurakem","10":"product_tag-lurasidone","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/58686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=58686"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/58687"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=58686"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=58686"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=58686"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=58686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}