{"id":58789,"date":"2024-02-28T05:28:20","date_gmt":"2024-02-28T05:28:20","guid":{"rendered":"https:\/\/medsname.com\/folitrax\/"},"modified":"2026-04-30T10:24:08","modified_gmt":"2026-04-30T10:24:08","slug":"folitrax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/folitrax\/","title":{"rendered":"Folitrax"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Folitrax?<\/h3>\n<p style=\"margin:0;\"><strong>Folitrax<\/strong> is an oral tablet from Ipca Laboratories containing <strong>methotrexate 7.5 mg<\/strong> &mdash; an antimetabolite (dihydrofolate reductase inhibitor) used for <strong>maintenance therapy of acute lymphoblastic leukaemia (ALL)<\/strong>, <strong>some lymphomas<\/strong>, <strong>severe rheumatoid arthritis<\/strong>, <strong>severe psoriasis<\/strong>, and other immune-mediated disease. Oncology maintenance dose: typically <strong>15&ndash;30 mg\/m&sup2; per WEEK<\/strong> (NOT daily) &mdash; weekly dosing is the most critical safety point. <strong>Daily dosing of methotrexate by mistake is one of the most common preventable serious medication errors and can be fatal.<\/strong> Verplicht: <strong>folic acid 5 mg weekly<\/strong> on a different day; baseline + ongoing FBC, LFTs, U&#038;E, CXR. Absolute contraindication in pregnancy and breastfeeding (potent teratogen).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Specialistisch toezicht vereist.<\/strong> Kankermedicatie moet worden voorgeschreven door een behandelend oncoloog met een bevestigde diagnose, baseline-stadi\u00ebring en een gedefinieerd behandelplan. Start, stop, wijzig de dosis of gebruik kankermedicatie nooit buiten een door oncologie geleid zorgplan. De meeste kankermedicijnen vereisen regelmatige bloedtestmonitoring (FBC, LFT, nierfunctie), zijn absoluut gecontra-indiceerd tijdens zwangerschap en hebben significante geneesmiddelinteracties.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Versleutelde Afrekenprocedure<\/strong> \u00b7 <strong>\ud83d\udcb3 Geverifieerde Betaalprocessor<\/strong> \u00b7 <strong>\ud83d\ude9a Wereldwijde Verzending<\/strong> \u00b7 <strong>\u2b50 4.9\/5 van 1.400+ klanten<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Folitrax?<\/h2>\n<p>Folitrax is an oral tablet from Ipca Laboratories containing <strong>methotrexate 7.5 mg<\/strong>. Methotrexate is a folate antagonist (dihydrofolate reductase inhibitor) used at low doses for <strong>maintenance therapy of acute lymphoblastic leukaemia (ALL)<\/strong>, several lymphomas, certain solid tumours, and at similar low doses for severe rheumatoid arthritis, psoriasis, Crohn&#39;s disease and other immune-mediated conditions.<\/p>\n<h2 class=\"wp-block-heading\">Toepassingen en Indicaties<\/h2>\n<ul>\n<li><strong>Maintenance phase of acute lymphoblastic leukaemia<\/strong> (oral methotrexate weekly with mercaptopurine daily)<\/li>\n<li><strong>Trophoblastic disease (gestational choriocarcinoma)<\/strong> &mdash; specialist oncology<\/li>\n<li><strong>Cutaneous T-cell lymphoma, mycosis fungoides<\/strong><\/li>\n<li><strong>Ernstige reumato\u00efde artritis<\/strong> &mdash; first-line DMARD<\/li>\n<li><strong>Severe psoriasis, psoriatic arthritis<\/strong><\/li>\n<li><strong>Severe Crohn&#39;s disease maintenance<\/strong><\/li>\n<li><strong>Several other immune-mediated conditions:<\/strong> ANCA vasculitis, dermatomyositis, juvenile idiopathic arthritis<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage and How to Take &mdash; CRITICAL<\/h2>\n<p>Standaard <strong>oncology maintenance<\/strong> dose: <strong>15&ndash;30 mg\/m&sup2; per WEEK<\/strong> (typically 20&ndash;25 mg\/week for an adult). Standard <strong>rheumatology \/ dermatology<\/strong> dose: 7.5&ndash;25 mg per week.<\/p>\n<ol>\n<li><strong>WEEKLY DOSING ONLY.<\/strong> Methotrexate is dosed once a week, NOT daily. Choose one fixed day of the week (e.g. Monday) and take all tablets together that day. <strong>Daily dosing by mistake is potentially fatal.<\/strong> This is the most common preventable serious medication error involving methotrexate.<\/li>\n<li><strong>Folic acid 5 mg weekly<\/strong> on a different day (e.g. Friday) reduces nausea, mouth ulcers and LFT rise without significantly reducing efficacy.<\/li>\n<li>Innemen met of zonder voedsel.<\/li>\n<li><strong>Verplichte monitoring:<\/strong> baseline FBC, LFTs (AST, ALT), U&#038;E + creatinine, CXR. Repeat FBC + LFTs every 2 weeks for first 3 months, then monthly. Annual cumulative-dose tracking for hepatic fibrosis risk (specialist).<\/li>\n<li>Stop and seek same-day review for: severe mouth ulcers, severe diarrhoea, new dyspnoea or cough, fever, jaundice, easy bruising or bleeding, or unusual rash.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Bijwerkingen<\/h2>\n<p><strong>Vaak voorkomend:<\/strong> nausea, mouth ulcers, fatigue, hair thinning, mild LFT rise, mild cytopenia.<\/p>\n<p><strong>Belangrijk:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuppressie<\/strong> &mdash; neutropenia, thrombocytopenia, anaemia. Severe pancytopenia can occur with daily-dosing errors.<\/li>\n<li><strong>Hepatotoxiciteit<\/strong> &mdash; LFT rises common; cumulative-dose hepatic fibrosis with long-term use<\/li>\n<li><strong>Pneumonitis<\/strong> &mdash; idiosyncratic; new dyspnoea or dry cough warrants stopping and review<\/li>\n<li>Renal impairment &mdash; accumulation toxicity<\/li>\n<li>Mucositis &mdash; often the rate-limiting side effect at higher doses<\/li>\n<li>Fotosensitiviteit<\/li>\n<li>Severe skin reactions (Stevens-Johnson syndrome) &mdash; rare but documented<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Warnings &mdash; CRITICAL<\/h2>\n<ul>\n<li><strong>Pregnancy: ABSOLUTE CONTRAINDICATION (FDA Pregnancy Category X).<\/strong> Methotrexate is a potent teratogen and abortifacient. Reliable contraception throughout treatment AND for at least <strong>3 months after the last dose in women, 6 months in men<\/strong> (some guidelines require 6 months in both).<\/li>\n<li><strong>Breastfeeding: contraindicated<\/strong> &mdash; methotrexate excreted in breast milk.<\/li>\n<li><strong>Nierfunctiestoornis:<\/strong> reduce dose for eGFR &lt; 60 mL\/min; avoid if eGFR &lt; 30. Methotrexate is renally cleared and accumulates rapidly in renal failure with severe toxicity.<\/li>\n<li><strong>Severe hepatic impairment, active alcoholism, hepatitis B\/C:<\/strong> avoid &mdash; high risk of severe hepatotoxicity.<\/li>\n<li><strong>Actieve infectie:<\/strong> hold methotrexate during serious infection.<\/li>\n<li><strong>Levende vaccins<\/strong> (MMR, yellow fever, BCG, oral polio): contraindicated during methotrexate therapy.<\/li>\n<li><strong>Pleural effusion or ascites:<\/strong> methotrexate accumulates in third-space fluid and re-releases, causing prolonged toxicity. Drain effusions before starting.<\/li>\n<li><strong>NSAID interaction risk:<\/strong> see drug interaction table.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Geneesmiddelinteracties<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Combineren met<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Effect<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Wat te doen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">NSAIDs (ibuprofen, naproxen, diclofenac), aspirin (analgesic dose)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce methotrexate clearance &mdash; toxicity risk; severe at high MTX doses, modest at low maintenance doses<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Generally OK at stable low oral MTX doses with monitoring; avoid with high-dose IV MTX. Paracetamol is safer.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Trimethoprim, co-trimoxazole (Septrin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive antifolate effect &mdash; severe pancytopenia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">AVOID. Use alternative antibiotic.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Live vaccines (MMR, yellow fever, BCG, varicella)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Disseminated infection from live vaccine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Gecontra-indiceerd.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">PPIs (omeprazole) at high-dose IV methotrexate<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce MTX clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hold PPIs around high-dose IV MTX (specialist). Generally OK at low oral doses.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alcohol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additieve hepatotoxiciteit<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Limit to occasional small amounts. No more than 1&ndash;2 drinks per week.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Probenecid, penicillins (high dose)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce MTX renal clearance &mdash; toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vermijd combinatie.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Folic acid 5 mg weekly<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduces toxicity (mucositis, GI, LFT rise) without significantly reducing efficacy<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">STANDARD &mdash; take 5 mg weekly on a different day from MTX.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Opslag<\/h2>\n<ul>\n<li>Kamertemperatuur, 15\u201325\u00b0C, originele blister.<\/li>\n<li>Keep out of reach of children, women of childbearing potential, and pets &mdash; methotrexate is a potent teratogen.<\/li>\n<li>Wash hands after handling tablets.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Gerelateerde alternatieven op MedsBase<\/h2>\n<p>Andere oncologische medicijnen die naast dit product wordt aangeboden:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/imutrex\/\"><strong>Imutrex (methotrexate 2.5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/noltrexate\/\"><strong>Noltrexate (methotrexate 2.5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/leetrexate\/\"><strong>Leetrexate (methotrexate 2.5 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/nl\/anti-cancer-medication\/\">Bekijk alle anti-kankermedicijnen \u2192<\/a><\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">Why is methotrexate dosed weekly, not daily?<\/h3>\n<p><strong>Methotrexate is dosed once a week (not daily) at low oncology-maintenance and rheumatology doses.<\/strong> Daily dosing of methotrexate by mistake is potentially fatal &mdash; it has caused multiple inquest-level adverse events worldwide and is one of the most common preventable serious medication errors. Pick one fixed day of the week (e.g. Monday), take all tablets together that day, and never dose more frequently. Tell every doctor and pharmacist about your weekly schedule.<\/p>\n<h3 class=\"wp-block-heading\">Why do I take folic acid?<\/h3>\n<p>Folic acid 5 mg once weekly (on a different day from methotrexate, e.g. Friday) reduces the most common methotrexate side effects &mdash; nausea, mouth ulcers, GI upset, LFT rise &mdash; without significantly reducing efficacy. It is a standard part of every long-term methotrexate regimen.<\/p>\n<h3 class=\"wp-block-heading\">Welke bloedtesten heb ik nodig?<\/h3>\n<p>Baseline: FBC, LFTs (AST, ALT), U&#038;E + creatinine, CXR. Then FBC + LFTs every 2 weeks for the first 3 months, then monthly. Annual cumulative-dose review for hepatic fibrosis risk (specialist). Tell your doctor about any infection, mouth ulcers, easy bruising, or jaundice.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on methotrexate?<\/h3>\n<p>Limit alcohol to 1&ndash;2 standard drinks per week or less &mdash; both alcohol and methotrexate are hepatotoxic. Heavier drinking significantly raises the risk of methotrexate-induced liver damage and hepatic fibrosis on long-term therapy.<\/p>\n<h3 class=\"wp-block-heading\">Can I get pregnant on methotrexate?<\/h3>\n<p><strong>No &mdash; methotrexate is FDA Pregnancy Category X.<\/strong> Methotrexate is teratogenic and abortifacient. Reliable contraception is mandatory throughout treatment and for at least <strong>3 months after the last dose in women<\/strong> and at least <strong>6 months in men<\/strong> (some guidelines extend the female window to 6 months also). Discuss family planning with your specialist before starting; switch to a non-teratogenic alternative (azathioprine, sulfasalazine in some indications) if pregnancy planned.<\/p>\n<h3 class=\"wp-block-heading\">Can I have live vaccines on methotrexate?<\/h3>\n<p>Live vaccines (MMR, yellow fever, BCG, oral polio, varicella) are contraindicated during methotrexate therapy &mdash; risk of disseminated infection from the vaccine virus. Inactivated vaccines (annual flu shot, pneumococcal, COVID-19, hepatitis B) are not only safe but recommended. Plan live vaccines at least 4 weeks before starting methotrexate, or 3 months after stopping.<\/p>\n<h3 class=\"wp-block-heading\">What antibiotics are unsafe with methotrexate?<\/h3>\n<p><strong>Trimethoprim and co-trimoxazole (Septrin\/Bactrim)<\/strong> are the most dangerous &mdash; they have additive antifolate effects with methotrexate and have caused fatal pancytopenia. AVOID. Use alternative antibiotics &mdash; amoxicillin, doxycycline, cefalexin etc are safe. Tell every doctor about your methotrexate before any antibiotic is prescribed.<\/p>\n<h3 class=\"wp-block-heading\">Why must I tell my doctor before any surgery?<\/h3>\n<p>Methotrexate impairs wound healing and increases infection risk. For elective major surgery, methotrexate is sometimes held for 1&ndash;2 weeks pre-op and resumed once the wound has healed. For minor surgery (skin biopsy, dental work) it can usually be continued. Specialist guidance.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Elke batch wordt ingekocht bij een <strong>WHO-GMP gecertificeerde fabrikant<\/strong>. Bestellingen worden verzonden in eenvoudige, ongemarkeerde verpakkingen door onze logistieke partners en vallen onder onze <a href=\"\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>: als een pakket niet binnen 20 werkdagen arriveert, sturen wij kosteloos een nieuwe zending, zonder vragen te stellen.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde Antikankermedicijnen<\/h3>\n<p>Andere oncologische medicijnen die naast dit product wordt aangeboden:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/imutrex\/\">Imutrex (methotrexaat 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/leetrexate\/\">Leetrexate (methotrexate 2.5\/7.5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/noltrexate\/\">Noltrexate (methotrexate 2.5\/7.5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/endoxan\/\">Endoxan (cyclofosfamide 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Behandelt reumato\u00efde artritis<br \/>\n\u2705 Vermindert gewrichtsontsteking<br \/>\n\u2705 Vertraagt de ziekteprogressie<br \/>\n\u2705 Beheerst auto-immuunziekten<br \/>\n\u2705 Improves symptoms<\/p>\n<p>Folitrax contains Methotrexate.<\/p>","protected":false},"featured_media":58790,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4570,4466],"class_list":{"0":"post-58789","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-folitrax","10":"product_tag-methotrexate","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/58789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=58789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/58790"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=58789"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=58789"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=58789"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=58789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}