<\/p>\n
Reglan<\/strong> is metoclopramide 10 mg — a centrally and peripherally acting dopamine D2 receptor antagonist used as an antiemetic and prokinetic. It accelerates gastric emptying, increases LES tone, and blocks the chemoreceptor trigger zone. Indications include nausea\/vomiting (post-operative, chemotherapy adjunct, migraine-associated), gastroparesis, and prevention of aspiration. Standard dose: 10 mg three times daily before meals, for a maximum of 5 days (FDA) or 12 weeks (EMA gastroparesis exception)<\/strong>. WHO-GMP gecertificeerde fabrikant.<\/p>\n<\/div>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Reglan is supplied from a WHO-GMP gecertificeerde fabrikant<\/strong>. Elke bestelling wordt discreet wereldwijd verzonden en valt onder onze Reshipment Assurance Policy<\/a> — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.<\/p>\n Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.<\/p>\n Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea\/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.<\/p>\n Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.<\/p>\n Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.<\/p>\n There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.<\/p>\n Category B in the US. Used in pregnancy for nausea\/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.<\/p>\n Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.<\/p>\n Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.<\/p>\n Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.<\/p>\n Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.<\/p>\n Below 25°C in a dry place. Keep out of reach of children.<\/p>\n Take it before the next meal, then continue. Do not double up.<\/p>\n <\/p>\n Reglan (Metoclopramide 10 mg) \u2014 central + peripheral D2 antagonist prokinetic and antiemetic. Carries FDA black-box for tardive dyskinesia (12-week max). For nausea, vomiting, gastroparesis, migraine-associated nausea. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":59005,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4610,4611],"class_list":{"0":"post-59004","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-metoclopramide","10":"product_tag-reglan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/59004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=59004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/59005"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=59004"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=59004"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=59004"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=59004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Waarom bestellen bij MedsBase<\/h3>\n
Waarom bestellen bij MedsBase<\/h3>\n
Werkingsmechanisme<\/h2>\n
Indicaties<\/h2>\n
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Dosering<\/h2>\n
Bijwerkingen<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
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Veelgestelde vragen<\/h2>\n
How is Reglan different from domperidone?<\/h3>\n
What does the FDA black-box mean for me?<\/h3>\n
Can I take it for travel sickness?<\/h3>\n
Is het veilig tijdens de zwangerschap?<\/h3>\n
Can I drive on this?<\/h3>\n
What if I develop a stiff neck or strange jaw movements?<\/h3>\n
Why do I have leaky breasts on this medication?<\/h3>\n
Can it interact with my Parkinson’s drugs?<\/h3>\n
Opslag<\/h3>\n
Wat als ik een dosis vergeet?<\/h3>\n
Andere Maag-Darm Gezondheidsmedicijnen<\/h3>\n
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