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Inderal<\/strong> is een 20 mg \/ 40 mg propranolol immediate-release tablet<\/strong> from AstraZeneca — a non-selective beta-blocker and the classic first-line preventive medication for episodic migraine<\/strong>, FDA-approved for this indication since 1979. Also used for hypertension, angina, atrial fibrillation rate control, thyrotoxicosis, essential tremor, infantile haemangioma, performance anxiety, and portal-hypertensive varices prophylaxis. Typical migraine-prevention dose: 40-80 mg twice daily (80-160 mg\/day total)<\/strong>. Full effect at 8-12 weeks. Reduces migraine frequency by ~50% in roughly half of treated patients. Safe in pregnancy<\/strong> (Category C but extensive reassuring data) — making propranolol the preferred preventive in women of childbearing potential. Contraindicated in asthma, severe bradycardia, second\/third degree heart block, and acute heart failure.<\/strong> Key side effects: fatigue, cold extremities, bradycardia, postural dizziness, sleep disturbance with vivid dreams, exercise intolerance.<\/p>\n<\/div>\n Inderal is an oral immediate-release tablet of propranolol hydrochloride 20 mg \/ 40 mg<\/strong> from AstraZeneca, supplied in 30-180 tablet packs. Propranolol was the first beta-blocker introduced into clinical practice (Sir James Black, 1964; Nobel Prize 1988) and remains the benchmark non-selective beta-blocker — widely used across multiple indications and arguably the most important cardiovascular drug ever developed.<\/p>\n The immediate-release formulation has a short plasma half-life (3-6 hours) and requires twice- or thrice-daily dosing. For once-daily dosing, consider Inderal LA (long-acting)<\/a>.<\/p>\n The precise mechanism in migraine prophylaxis remains debated (this was actually serendipitously discovered when propranolol-treated angina patients noticed their migraines improved). Current theories include:<\/p>\n Only lipophilic non-selective beta-blockers (propranolol, metoprolol, nadolol, timolol) work for migraine prevention — water-soluble atenolol and selective agents like bisoprolol do not. The CNS-penetrating non-selective profile is the active ingredient.<\/p>\n Monitoring:<\/strong> check pulse (<50 bpm = dose reduction), blood pressure (hypotension caution), and clinical response. Routine blood work is not needed.<\/p>\n Stopzetting:<\/strong> Taper over 1-2 weeks.<\/strong> Abrupt discontinuation of a beta-blocker can precipitate rebound tachycardia, angina, or myocardial infarction in patients with cardiovascular disease — even in migraineurs without heart disease, taper slowly.<\/p>\n Zeer vaak voorkomend:<\/strong><\/p>\n Vaak (1-10%):<\/strong><\/p>\n Important but less common:<\/strong><\/p>\n Zwangerschap:<\/strong> FDA Category C but with extensive reassuring real-world data. Propranolol is the preferred migraine preventive in women planning or during pregnancy<\/strong>. Small risk of mild intrauterine growth restriction, neonatal bradycardia, and hypoglycaemia; these are monitored but rarely clinically significant.<\/p>\n Borstvoeding:<\/strong> compatible. Minimal amounts in breast milk; routine use during breastfeeding is considered safe.<\/p>\n Bewaren onder 25\u00b0C. Buiten bereik van kinderen houden.<\/p>\n Allow 8-12 weeks at target dose. Keep a migraine diary. A clinically meaningful response is a 50% reduction in monthly migraine days. If no response after 12 weeks at 160 mg\/day, switch preventive (topiramate<\/a>, valproate ER<\/a>, amitriptyline, valproaat<\/a>).<\/p>\n No — propranolol is non-selective and blocks beta-2 receptors in bronchial smooth muscle, which can precipitate severe bronchospasm in asthmatics. Absolute contraindication. For asthmatic migraineurs, topiramate<\/a>, amitriptyline, or valproaat<\/a> are safer alternatives.<\/p>\n Ja \u2014 propranolol is the preferred migraine preventive in pregnancy and in women of childbearing potential.<\/strong> Extensive reassuring real-world data; small risk of mild intrauterine growth restriction, neonatal bradycardia, and hypoglycaemia (monitored but rarely problematic). Topiramate and valproate are contraindicated; propranolol is the go-to option.<\/p>\n Yes to some extent — beta blockade blunts the heart-rate response to exercise, so your maximum heart rate is lower and you fatigue faster at high intensities. For recreational exercise most people adapt; for competitive endurance athletes, propranolol can substantially impair performance and is banned in some sports (archery, shooting — where it reduces tremor). Discuss with your doctor if you train competitively.<\/p>\n Moderate alcohol is generally acceptable but alcohol potentiates the hypotensive and CNS-depressant effects. Stand up slowly after drinking. Alcohol is also a common migraine trigger, so reducing intake often improves migraine frequency independently.<\/p>\n Taper over 1-2 weeks. Abrupt discontinuation of a beta-blocker can cause rebound tachycardia and — in patients with any cardiovascular disease — precipitate angina or MI. Migraine itself may also flare on abrupt stop.<\/p>\n Inderal IR needs twice- or thrice-daily dosing and has higher peak plasma levels. For migraine prevention, Inderal LA<\/a> is the preferred formulation (once daily, smoother levels). IR is useful when dose flexibility matters (performance anxiety, tremor, thyrotoxicosis).<\/p>\n Yes. Propranolol is a preventive, triptans are abortive. They work through different mechanisms. Special note: rizatriptan<\/strong> levels rise ~70% when combined with propranolol — use rizatriptan at 5 mg maximum (not 10 mg) when also on propranolol. Sumatriptan<\/a> en zolmitriptan<\/a> do not have this interaction.<\/p>\n You can buy Inderal (propranolol 20 mg \/ 40 mg immediate-release tablet, 30-180 tablet packs) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n <\/p>\n Andere producten in Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n Inderal is propranolol hydrochloride 20 \/ 40 mg immediate-release tablets from AstraZeneca \u2014 the original non-selective beta-blocker and first-line migraine preventive (FDA-approved 1979). Also used for hypertension, angina, essential tremor, thyrotoxicosis, performance anxiety. Safe in pregnancy. Target migraine-prevention dose 80-160 mg\/day. Contraindicated in asthma, severe bradycardia, heart block.<\/p>","protected":false},"featured_media":59023,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223,3342,3260,3356,3554],"product_tag":[4615,3381],"class_list":{"0":"post-59022","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-heart-blood-pressure","11":"product_cat-high-blood-pressure-medication","12":"product_cat-migraine-treatment","13":"product_tag-inderal","14":"product_tag-propranolol","16":"first","17":"instock","18":"shipping-taxable","19":"purchasable","20":"product-type-variable","21":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/59022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=59022"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/59023"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=59022"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=59022"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=59022"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=59022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What Is Inderal?<\/h2>\n
How Propranolol Prevents Migraine<\/h2>\n
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Goedgekeurde Toepassingen<\/h2>\n
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Inderal Dosage for Migraine Prevention<\/h2>\n
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Bijwerkingen<\/h2>\n
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Contra-indicaties<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
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Opslag<\/h2>\n
Veelgestelde vragen<\/h2>\n
How long until Inderal starts preventing migraines?<\/h3>\n
Can I take Inderal if I have asthma?<\/h3>\n
Is Inderal safe in pregnancy?<\/h3>\n
Will Inderal affect my exercise performance?<\/h3>\n
Can I drink alcohol on Inderal?<\/h3>\n
How do I stop Inderal?<\/h3>\n
Is Inderal IR better than Inderal LA?<\/h3>\n
Can I take Inderal with a triptan?<\/h3>\n
Where can I buy Inderal online?<\/h3>\n
Gerelateerde migrainebehandelingen op MedsBase<\/h2>\n
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Waarom bestellen bij MedsBase<\/h3>\n
Gerelateerde alternatieven<\/h3>\n
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