{"id":59232,"date":"2024-02-28T05:47:25","date_gmt":"2024-02-28T05:47:25","guid":{"rendered":"https:\/\/medsname.com\/sertima\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"sertima","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/sertima\/","title":{"rendered":"Sertima"},"content":{"rendered":"

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⚡ Quick Answer — What is Sertima?<\/h3>\n
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Sertima<\/strong> bevat sertraline hydrochloride (50 mg \/ 100 mg)<\/strong> from a WHO-GMP certified manufacturer (made by Intas Pharmaceuticals) — an SSRI<\/strong> with broad evidence across depression and anxiety-spectrum disorders. Standard adult dose: 50 mg eenmaal daags<\/strong> with food (range 50–200 mg\/day; titrate by 50 mg every 1–2 weeks). Onset is gradual: anxiety\/sleep often improve in 1–2 weeks; full mood response at 4–6 weeks. Common early side effects<\/strong> — nausea, loose stools, headache, jitteriness, transient insomnia or somnolence — usually subside within 7–14 days. Persistent<\/strong>: sexual dysfunction (~40%), sweating, and modest weight changes. Sertraline has the cleanest CYP profile of the SSRIs<\/strong> — weaker CYP2D6 inhibition than paroxetine or fluoxetine, making it a sensible choice in patients on multiple medicines.<\/p>\n<\/div>\n

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Waarom bestellen bij MedsBase<\/h3>\n

Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<\/div>\n

Important — this is not a situational-anxiety medication.<\/strong> Sertima is a selectieve serotonineheropnameremmer (SSRI)<\/strong>, prescribed and titrated over weeks for major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD)<\/strong>. It is niet<\/strong> the right drug for acute, performance-related anxiety (flying, public speaking, exams) — for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.<\/div>\n
FDA black-box warning — suicidality.<\/strong> All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.<\/div>\n

What Is Sertima?<\/h2>\n

Sertima is an oral tablet of sertraline hydrochloride (50 mg \/ 100 mg)<\/strong> manufactured by Intas Pharmaceuticals under WHO-GMP certification. Sertraline (brand name Zoloft<\/strong> in the US, Lustral<\/strong> in the UK) is a selectieve serotonineheropnameremmer (SSRI)<\/strong> launched by Pfizer in 1991 and one of the most-prescribed antidepressants worldwide. It selectively blocks the presynaptic serotonin transporter (SERT), increasing synaptic serotonin available to bind to postsynaptic 5-HT receptors over weeks of treatment.<\/p>\n

Sertraline is a first-line treatment recommendation in NICE, APA, and WFSBP guidelines for major depression in adults and the FDA-approved first-line SSRI for paediatric OCD (age ≥ 6).<\/p>\n

Goedgekeurde indicaties<\/h2>\n
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  • Major depressive disorder (MDD)<\/strong> in adults; sertraline-paroxetine and sertraline-mirtazapine combinations are commonly used in treatment-resistant depression.<\/li>\n
  • Obsessieve-compulsieve stoornis (OCD)<\/strong> in adults and children aged 6+; doses typically titrated higher than for MDD (100–200 mg\/day).<\/li>\n
  • Paniekstoornis<\/strong> with or without agoraphobia; start lower (12.5–25 mg) to avoid early panic exacerbation.<\/li>\n
  • Social anxiety disorder (social phobia)<\/strong> — chronic \/ generalised type, not performance-only.<\/li>\n
  • Posttraumatische stressstoornis (PTSS)<\/strong> — one of two FDA-approved SSRIs for this indication (with paroxetine).<\/li>\n
  • Premenstrual dysphoric disorder (PMDD)<\/strong> — can be dosed continuously or only luteal-phase (cycle days 14–28).<\/li>\n<\/ul>\n

    Standard Dosing by Indication<\/h2>\n\n\n\n\n\n\n\n\n\n
    Indicatie<\/th>\nStart<\/th>\nStreefdosering<\/th>\nTitratie<\/th>\n<\/tr>\n<\/thead>\n
    MDD, social anxiety, PTSD, PMDD<\/td>\n50 mg once daily with food<\/td>\n50–200 mg\/day<\/td>\nIncrease by 50 mg every 1–2 weeks if tolerated and partial response<\/td>\n<\/tr>\n
    Paniekstoornis<\/td>\n12.5–25 mg\/day × 1 week<\/td>\n50–200 mg\/day<\/td>\nSlower up-titration to minimise early jitteriness and panic exacerbation<\/td>\n<\/tr>\n
    OCD (volwassenen)<\/td>\n50 mg eenmaal daags<\/td>\n100–200 mg\/day<\/td>\nOften requires the upper end of the dose range; allow 8–12 weeks for response assessment<\/td>\n<\/tr>\n
    OCD (paediatric 6–12 y)<\/td>\n25 mg eenmaal daags<\/td>\n25–200 mg\/day<\/td>\nUp-titrate slowly; weight-based caps in younger children<\/td>\n<\/tr>\n
    Leverfunctiestoornis<\/td>\n25 mg eenmaal daags<\/td>\nUp to 100 mg with care<\/td>\nReduced clearance — use the lowest effective dose<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Bijwerkingen<\/h2>\n

    Common, persistent, and rare side effects<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Frequentie<\/th>\nEffect<\/th>\nNotes \/ management<\/th>\n<\/tr>\n<\/thead>\n
    Common (>10%)<\/td>\nNausea, diarrhoea, loose stools<\/td>\nTake with food; usually subsides within 1–2 weeks<\/td>\n<\/tr>\n
    Vaak voorkomend<\/td>\nSlapeloosheid of slaperigheid<\/td>\nVariable — if activating, dose in the morning; if sedating, dose at bedtime<\/td>\n<\/tr>\n
    Vaak voorkomend<\/td>\nHoofdpijn, duizeligheid<\/td>\nAdequate hydration; usually transient<\/td>\n<\/tr>\n
    Vaak voorkomend<\/td>\nSeksuele disfunctie (vertraagde orgasme, verminderd libido)<\/td>\nPersistent in up to 40%; consider drug holiday, dose reduction, or switch to bupropion \/ mirtazapine if intolerable<\/td>\n<\/tr>\n
    Vaak voorkomend<\/td>\nZweten, droge mond<\/td>\nPersistent low-grade nuisance<\/td>\n<\/tr>\n
    Minder vaak voorkomend<\/td>\nWeight gain (modest, +1–3 kg over months)<\/td>\nLess than paroxetine or mirtazapine<\/td>\n<\/tr>\n
    Minder vaak voorkomend<\/td>\nBruising, GI bleeding<\/td>\nSSRIs reduce platelet serotonin uptake; caution with NSAIDs \/ anticoagulants<\/td>\n<\/tr>\n
    Zeldzaam<\/td>\nHyponatraemia (SIADH)<\/td>\nOlder adults at greatest risk; check Na+ if confusion or seizure<\/td>\n<\/tr>\n
    Zeldzaam<\/td>\nSerotoninesyndroom<\/td>\nSee drug interactions section<\/td>\n<\/tr>\n
    Zeldzaam<\/td>\nQT prolongation at high dose<\/td>\nDocument baseline ECG in patients with cardiac risk<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Geneesmiddelinteracties<\/h2>\n

    Absolute contraindications<\/strong>: monoamine oxidase inhibitors (MAOIs) including selegiline, rasagiline, linezolid (an antibiotic with MAOI activity), methylene blue — allow 14 dagen<\/strong> washout before or after sertraline. Concurrent pimozide is contraindicated due to QT risk.<\/p>\n

    Serotonin syndrome risk — combine with caution and only under prescriber direction<\/strong>: triptans (sumatriptan, rizatriptan), tramadol, pethidine (meperidine), dextromethorphan, St John’s wort, lithium, other serotonergic antidepressants.<\/p>\n

    Bleeding risk — combine with caution<\/strong>: NSAIDs, aspirin, warfarin, DOACs — SSRIs reduce platelet serotonin uptake.<\/p>\n

    Plasma-level shifts<\/strong>: sertraline mildly inhibits CYP2D6 (less than paroxetine \/ fluoxetine) — modest interaction with metoprolol, codeine, tamoxifen, atomoxetine.<\/p>\n

    Discontinuation Syndrome<\/h2>\n

    Sertraline has a moderate-half-life (~26 h)<\/strong> — discontinuation symptoms are milder than paroxetine or venlafaxine but real<\/strong>. Symptoms (FINISH mnemonic): Flu-like aches, Insomnia, Nausea, Imbalance \/ dizziness, Sensory disturbance (the “brain zaps”), Hyperarousal. Typically begin 2–4 days after a missed dose or abrupt stop and resolve in 1–3 weeks. Taper<\/strong>: reduce by 25–50 mg every 2–4 weeks; for long-term users (> 12 months), taper more slowly using hyperbolic step-downs to avoid prolonged withdrawal.<\/p>\n

    Zwangerschap en borstvoeding<\/h2>\n

    Sertraline is one of the preferred SSRIs in pregnancy<\/strong> when antidepressant treatment is indicated — the largest registry data and ACOG guidance support continued use in moderate-to-severe MDD. Late-third-trimester exposure carries a small risk of neonatal adaptation syndrome<\/strong> (jitteriness, feeding difficulties — usually resolves within 1–2 weeks). Sertraline transfers minimally into breast milk and is the preferred SSRI in breastfeeding<\/strong>.<\/p>\n

    Choosing Sertraline vs Other SSRIs<\/h2>\n

    Compared with other commonly-used SSRIs<\/h2>\n\n\n\n\n\n\n\n\n
    Geneesmiddel<\/th>\nNotable strengths<\/th>\nNotable weaknesses<\/th>\n<\/tr>\n<\/thead>\n
    Sertraline<\/td>\nCleanest CYP profile; preferred in pregnancy \/ breastfeeding; broad indications<\/td>\nGI side effects more prominent at start<\/td>\n<\/tr>\n
    Paroxetine (Xepar)<\/td>\nGood for GAD and panic; sedating — helpful with insomnia<\/td>\nWorst discontinuation syndrome; weight gain; pregnancy category D<\/td>\n<\/tr>\n
    Escitalopram<\/td>\nCleanest tolerability; well-studied for GAD<\/td>\nDose-dependent QT prolongation; max 20 mg, 10 mg in elderly<\/td>\n<\/tr>\n
    Fluoxetine<\/td>\nLong half-life cushions discontinuation; activating<\/td>\nCYP2D6 inhibition; takes longer to wash out for switches<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Veelgestelde vragen<\/h2>\n

    How long does Sertima take to work?<\/h3>\n

    Anxiety, sleep, and somatic symptoms often improve within 1–2 weeks. Full mood response in MDD typically appears at 4–6 weeks. OCD often requires 8–12 weeks at the upper dose range. Do not judge effectiveness before 6 weeks at an adequate dose.<\/p>\n

    Can I stop Sertima once I feel better?<\/h3>\n

    For a first episode of MDD, guidelines recommend continuing for at least 6–9 months after remission. For recurrent MDD or chronic anxiety, longer courses (1–2+ years) are common. Always taper rather than stop abruptly.<\/p>\n

    Will Sertima cause weight gain?<\/h3>\n

    Sertraline causes only modest weight gain over months — far less than paroxetine or mirtazapine. Some patients lose weight initially due to GI side effects.<\/p>\n

    Does Sertima cause sexual side effects?<\/h3>\n

    Yes — SSRIs as a class can cause delayed orgasm, reduced libido, and erectile difficulty in around 40% of users. If persistent and bothersome, options include dose reduction, drug holidays (with prescriber input), or switching to bupropion or mirtazapine.<\/p>\n

    Can I drink alcohol on Sertima?<\/h3>\n

    Light, occasional alcohol is generally tolerated, but alcohol worsens depression and anxiety, increases sedation, and is implicated in disinhibited or impulsive behaviour during the first weeks of treatment. Avoid heavy use.<\/p>\n

    Wat gebeurt er als ik een dosis mis?<\/h3>\n

    Take it as soon as you remember unless it is close to the next dose — never double up. Missing a single dose rarely causes problems given sertraline’s 26-hour half-life.<\/p>\n

    Is Sertima safe in pregnancy?<\/h3>\n

    Sertraline is one of the preferred SSRIs when antidepressant treatment is needed in pregnancy. Discuss benefit and risk individually with the prescriber, especially in the first trimester and around delivery.<\/p>\n

    Can Sertima be combined with other antidepressants?<\/h3>\n

    Combinations (e.g. with mirtazapine in “California rocket fuel”) are used in treatment-resistant depression but only under prescriber direction. Combining with MAOIs, linezolid, methylene blue, or excessive serotonergic agents (triptans, tramadol, St John’s wort) risks serotonin syndrome.<\/p>\n

    How is Sertima different from Sertima alternatives like Sertima or Zosert?<\/h3>\n

    All sertraline brands are pharmacologically identical at the molecule level. Brand differences come down to manufacturer, tablet appearance, excipients, and pricing. We supply WHO-GMP certified Indian generics across multiple brand names so customers can pick what is in stock.<\/p>\n

    How should Sertima be stored?<\/h3>\n

    Store at 15–30 °C in the original blister packaging, away from moisture and direct sunlight. Keep out of reach of children — sertraline overdose, while less dangerous than TCAs, is medically significant.<\/p>\n

    Medische disclaimer:<\/strong> Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.<\/div>\n

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