<\/p>\n
Sazo<\/strong> bevat sulfasalazine<\/strong> (500 mg), a prodrug<\/strong> that is split in the colon by gut bacteria into two active components: 5-aminosalicylic acid (5-ASA, mesalamine)<\/strong> which acts locally in the colon, and sulfapyridine<\/strong> which is absorbed systemically. Used for ulcerative colitis, Crohn’s disease with colonic involvement, and rheumatoid arthritis<\/strong>. Not a first-line treatment for IBS — IBS is a functional disorder without inflammation. Sulfasalazine is older than pure mesalamine formulations and has more systemic side effects (driven by the sulfapyridine component), but remains useful in RA and in IBD patients who tolerate it well. Typical starting dose: 500 mg 4 times daily, titrated. Common side effects: nausea, headache, orange discolouration of urine\/tears\/skin (harmless), reduced sperm count (reversible). Check FBC, LFTs, U&Es periodically; screen G6PD deficiency if relevant.<\/p>\n<\/div>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Sazo is an oral tablet containing sulfasalazine<\/strong> (500 mg), manufactured by WHO-GMP certified manufacturer. Supplied in packs of 30, 60, 90 or 180 tablets. Sulfasalazine has been in clinical use since the 1940s and was the first disease-modifying anti-inflammatory drug used in ulcerative colitis. It is on the WHO Essential Medicines List.<\/p>\n Sulfasalazine is a prodrug<\/strong> (azo-bonded sulfapyridine + 5-ASA). The intact molecule is not absorbed in the small intestine; gut bacteria in the colon cleave the azo bond, releasing both components. 5-ASA stays in the colon and acts locally (this is the UC effect); sulfapyridine is absorbed and circulates systemically (responsible for the RA effect and most of the side effects).<\/p>\n Sazo is niet<\/strong> for irritable bowel syndrome (IBS), which is a functional disorder and does not involve intestinal inflammation.<\/p>\n After oral dosing, about 10–20% of sulfasalazine is absorbed in the small intestine; the rest reaches the colon intact. There, bacterial azoreductases cleave the azo bond<\/strong>, liberating:<\/p>\n Because the cleavage happens in the colon, sulfasalazine delivers 5-ASA efficiently to colitis patients without needing an enteric coating — effectively an early “biological” colon-targeting system.<\/p>\n Ulcerative colitis (adults, induction):<\/strong> 500 mg four times daily for 1–2 weeks, then increase to 1 g four times daily (total 4 g\/day). Maintenance: 2 g\/day in divided doses.<\/p>\n Rheumatoid arthritis (adults):<\/strong> 500 mg\/day for the first week, then increase by 500 mg\/day each week to a maintenance of 2 g\/day (maximum 3 g\/day). Gradual titration is the single biggest predictor of tolerability.<\/p>\n Kinderen:<\/strong> weight-based; specialist prescribing only.<\/p>\n Sulfasalazine’s side-effect profile is broader than pure mesalamine because of the sulfapyridine component. Most effects are dose-dependent and improve with slower titration.<\/p>\n Common (up to 30% of users in the first weeks):<\/strong><\/p>\n Zeldzaam maar belangrijk:<\/strong><\/p>\n Store Sazo below 25°C in a dry place, in the original blister. Keep out of reach of children. Protect from light.<\/p>\n Not quite. Sulfasalazine is a prodrug of mesalamine joined by an azo bond to sulfapyridine. In the colon, bacteria split it, releasing free mesalamine (which acts locally in UC) and sulfapyridine (which is absorbed and causes most of the systemic side effects). Pure mesalamine (Asacol, Mesacol) gives you the UC benefit without the sulfa. Sulfasalazine is preferred when you want both the UC effect en<\/em> the anti-rheumatic effect — e.g. in UC patients who also have peripheral arthritis, or in pure rheumatoid arthritis.<\/p>\n Sulfapyridine metabolites are coloured. Orange discolouration of urine, sweat, and sometimes tears is expected, harmless, and not an indication to stop. Do warn soft-contact-lens wearers — the pigment can stain lenses permanently.<\/p>\n It causes reversible oligospermia<\/strong> in about 80% of male users (low sperm count, reduced motility). Sperm counts usually return to normal within 2–3 months of stopping. Men planning conception can switch to pure mesalamine (for UC) or another cDMARD (for RA). No similar effect has been described in women.<\/p>\n No — IBS is a functional disorder without bowel inflammation. Sulfasalazine has no role in IBS. For IBS, see mebeverine (Colospa) for cramps, rifaximin (Rifagut) for IBS-D, dietary intervention (low-FODMAP), or central modulators.<\/p>\n Yes. Baseline FBC, LFTs, U&Es; then every 2 weeks for 3 months, monthly for the next 3 months, quarterly thereafter. This catches the rare but important blood, liver, and kidney adverse effects early.<\/p>\n You can order Sazo (500 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n <\/p>\n Andere producten in Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n \u2705 Rheumatoid arthritis relief Sazo contains Sulfasalazine.<\/p>","protected":false},"featured_media":59358,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3565],"product_tag":[4683,4682],"class_list":{"0":"post-59357","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-irritable-bowel-syndrome-ibs-treatment","9":"product_tag-sazo","10":"product_tag-sulfasalazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/59357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=59357"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/59358"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=59357"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=59357"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=59357"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=59357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Waarom bestellen bij MedsBase<\/h3>\n
What Is Sazo?<\/h2>\n
What Is Sazo Used For?<\/h2>\n
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How Does Sazo Work?<\/h2>\n
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Dosering en toediening<\/h2>\n
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Bijwerkingen<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
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Who Should Not Take Sazo?<\/h2>\n
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Opslag<\/h2>\n
Veelgestelde vragen<\/h2>\n
Is Sazo the same as mesalamine?<\/h3>\n
Why does my urine turn orange on Sazo?<\/h3>\n
Does Sazo affect fertility?<\/h3>\n
Can I take Sazo for IBS?<\/h3>\n
Do I need blood tests on Sazo?<\/h3>\n
Where can I buy Sazo online?<\/h3>\n
Gerelateerde IBS & IBD-medicijnen<\/h2>\n
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Gerelateerde alternatieven<\/h3>\n
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\n\u2705 Inflammatory bowel disease treatment
\n\u2705 Ulcerative colitis management
\n\u2705 Crohn’s disease alleviation
\n\u2705 Joint pain reduction<\/p>\n