{"id":59683,"date":"2024-02-28T06:10:41","date_gmt":"2024-02-28T06:10:41","guid":{"rendered":"https:\/\/medsname.com\/udimax-300\/"},"modified":"2026-04-30T10:23:56","modified_gmt":"2026-04-30T10:23:56","slug":"udimax-300","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/udimax-300\/","title":{"rendered":"Udimax 300"},"content":{"rendered":"

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⚡ Quick Answer — What is Udimax 300?<\/h3>\n

Udimax 300<\/strong> is ursodeoxycholic acid (UDCA) 300 mg<\/strong> — a hydrophilic bile acid that is the standard of care for primary biliary cholangitis (PBC), cholesterol gallstones in patients unfit for surgery, intrahepatic cholestasis of pregnancy (ICP), bile-acid diarrhoea, and pruritus of cholestatic liver disease<\/strong>. UDCA reduces cholesterol saturation in bile, replaces toxic hydrophobic bile acids in the bile-acid pool, exerts cytoprotective and anti-apoptotic effects on hepatocytes and cholangiocytes, and stimulates bicarbonate-rich choleresis. Standard adult doses range from 10–15 mg\/kg\/day for PBC and gallstones to 14–30 mg\/kg\/day for cholestasis of pregnancy<\/strong>. WHO-GMP gecertificeerde fabrikant.<\/p>\n<\/div>\n

Waarom bestellen bij MedsBase:<\/strong> \u2714 WHO-GMP gecertificeerde fabrikant<\/strong> \u2714 Discrete verpakking \u2714 Wereldwijde verzending \u2714 Geverifieerde klantbeoordelingen (1.400+ klanten)<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n

💡 First-line for PBC since 1994.<\/strong> UDCA is the only therapy proven to extend transplant-free survival in primary biliary cholangitis. In 30–40 percent of PBC patients ALP does not normalise on UDCA alone and obeticholic acid or a fibrate is added (specialist hepatology decision).<\/div>\n

Waarom bestellen bij MedsBase<\/h3>\n

Udimax 300 is supplied from a WHO-GMP gecertificeerde fabrikant<\/strong>. Elke bestelling wordt discreet wereldwijd verzonden en valt onder onze Reshipment Assurance Policy<\/a> — if it does not arrive within 20 business days, we reship at no cost. UDCA has been on the WHO Essential Medicines List for decades and is the cornerstone of medical therapy for cholestatic liver disease.<\/p>\n

Werkingsmechanisme<\/h2>\n

UDCA is a naturally occurring hydrophilic 7β-hydroxy bile acid (“the bear bile acid”). When taken orally it enriches the bile-acid pool, replacing toxic hydrophobic acids (chenodeoxycholic, lithocholic) that damage cholangiocytes and hepatocytes in cholestasis. Three actions matter clinically: (1) it reduces biliary cholesterol saturation, dissolving cholesterol gallstones over months; (2) it exerts direct cytoprotective and anti-apoptotic effects on liver cells, reducing immune-mediated damage in PBC; (3) it stimulates a bicarbonate-rich “alkaline tide” choleresis, which protects cholangiocytes from the detergent action of hydrophobic bile acids. Onset of biochemical improvement in PBC is typically 2–6 months.<\/p>\n

Indications & doses<\/h2>\n\n\n\n\n\n\n\n\n\n
Indicatie<\/th>\nDosering<\/th>\nOpmerkingen<\/th>\n<\/tr>\n<\/thead>\n
Primaire biliaire cholangitis (PBC)<\/td>\n13–15 mg\/kg\/day in 1–2 divided doses<\/td>\nLevenslang<\/td>\n<\/tr>\n
Cholesterol gallstones (radiolucent, non-calcified, < 15 mm, functioning gallbladder)<\/td>\n8–10 mg\/kg\/day<\/td>\n6–24 months; recurrence common after stopping<\/td>\n<\/tr>\n
Intrahepatic cholestasis of pregnancy<\/td>\n10–15 mg\/kg\/day, may rise to 25 mg\/kg\/day<\/td>\nReduces pruritus, normalises bile acids; PITCHES trial showed mixed effect on stillbirth<\/td>\n<\/tr>\n
Bile-acid diarrhoea<\/td>\n250–500 mg twice daily (off-label)<\/td>\nCombine with bile-acid binders (cholestyramine)<\/td>\n<\/tr>\n
PSC, cystic fibrosis liver disease, paediatric biliary atresia<\/td>\n20–30 mg\/kg\/day<\/td>\nSpecialist supervision; high-dose in PSC limited to 20 mg\/kg\/day after a 30 mg\/kg trial showed harm<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Bijwerkingen<\/h2>\n