{"id":59689,"date":"2024-02-28T06:10:44","date_gmt":"2024-02-28T06:10:44","guid":{"rendered":"https:\/\/medsname.com\/valcosign\/"},"modified":"2026-05-03T06:09:49","modified_gmt":"2026-05-03T06:09:49","slug":"valcosign","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/valcosign\/","title":{"rendered":"Valcosign"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 8px 0;\"><strong>\ud83d\udca1 Snel antwoord<\/strong><\/p>\n<p style=\"margin:0;\"><strong>Valcosign<\/strong> is <strong>valacyclovir<\/strong>, a prescription antiviral used for genital herpes (HSV-2), cold sores (HSV-1), and shingles (VZV). Daily dosing can reduce outbreak frequency by up to 75% and lowers partner transmission risk. Take with or without food; start within 24 hours of symptom onset for episodic treatment.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f6f7fb;border:1px solid #e3e5ee;border-radius:8px;padding:14px 18px;margin:18px 0;font-size:14px;line-height:1.55;\"><strong>Wat u krijgt bij MedsBase:<\/strong> Bestellen bij MedsBase garandeert inkoop van een WHO-GMP-gecertificeerde fabrikant, discrete verpakking in gewone enveloppen, wereldwijde verzending en een 4,9\u2605 beoordeling van meer dan 1.400 geverifieerde klanten. Betalingen met kaart worden verwerkt via een gereguleerde crypto-onramp \u2014 de beschrijving op uw bankafschrift zal de naam van de verwerker tonen (een gereguleerde kaartbetalingverwerker), nooit 'MedsBase' of een medicijnnaam. Elk pakket wordt gedekt door onze <a href=\"\/nl\/reviews\/\" rel=\"noopener\">1.400+ geverifieerde klantbeoordelingen<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Wat Is Acivir 200 DT? <a href=\"\/nl\/medsbase-re-shipment-assurance-policy\/\" rel=\"noopener\">Reshipment Assurance Policy<\/a>.<\/p>\n<h2><strong>What Is Valcosign?<\/strong><\/h2>\n<p>Valcosign is a branded generic of <strong>valacyclovir<\/strong>, the L-valyl ester prodrug of aciclovir. After oral dosing, valacyclovir is rapidly converted to aciclovir, delivering <strong>3\u20135\u00d7 higher plasma levels than oral aciclovir<\/strong> at the same dose frequency. This lets most adults dose twice daily instead of five times daily, improving adherence without sacrificing efficacy.<\/p>\n<p>Valacyclovir treats three main conditions: genital herpes (HSV-2), oral herpes \/ cold sores (HSV-1), and shingles (varicella-zoster virus). It is available in strengths of <strong>500 mg, 1000 mg<\/strong>.<\/p>\n<h2><strong>Genitale herpes (eerste episode):<\/strong><\/h2>\n<ul>\n<li><strong>Genital herpes (first episode):<\/strong> 1000 mg twice daily for 10 days<\/li>\n<li><strong>Genitale herpes (terugkerende episoden):<\/strong> 500 mg twice daily for 3 days \u2014 start within 24 hours of prodrome<\/li>\n<li><strong>Genitale herpes (onderdrukkend):<\/strong> 500 mg once daily (up to 1000 mg daily for \u226510 outbreaks\/year)<\/li>\n<li><strong>Reducing partner transmission:<\/strong> 500 mg once daily \u2014 shown to reduce transmission by ~48% in heterosexual serodiscordant couples (Corey et al., 2004)<\/li>\n<li><strong>Koortslip (herpes labialis):<\/strong> 2000 mg twice daily for one day (two doses 12 hours apart)<\/li>\n<li><strong>Gordelroos (herpes zoster):<\/strong> 1000 mg three times daily for 7 days \u2014 start within 72 hours of rash onset<\/li>\n<\/ul>\n<h2><strong>Hoe in te nemen<\/strong><\/h2>\n<ol>\n<li>Swallow the tablet whole with a full glass of water. With or without food \u2014 either is fine.<\/li>\n<li>Stay well hydrated. Valacyclovir is cleared renally; dehydration plus high doses can crystallise in tubules (rare but reversible).<\/li>\n<li>For episodic genital or oral herpes, <strong>start dosing at the first sign<\/strong> (tingling, itching, burning) \u2014 every hour of delay reduces benefit.<\/li>\n<li>For daily suppressive therapy, take at the same time each day; missing doses reduces suppression effectiveness.<\/li>\n<li>Maak de volledige kuur af, zelfs als de symptomen verdwijnen.<\/li>\n<\/ol>\n<h2><strong>Renal Dosing Adjustment<\/strong><\/h2>\n<p>Valacyclovir is almost entirely cleared by the kidneys. Standard doses may require reduction in renal impairment:<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:12px 0;\">\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Creatinine clearance (mL\/min)<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Dosering aanpassen<\/th>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u226550<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">No adjustment<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">30\u201349<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce dose or extend interval (e.g. 1000 mg every 12 h \u2192 every 24 h)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">10\u201329<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Significant reduction; consult clinician<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">&lt;10<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Specialist dosing required<\/td>\n<\/tr>\n<\/table>\n<h2><strong>Bijwerkingen<\/strong><\/h2>\n<p><strong>Vaak (\u22651%):<\/strong> headache, nausea, abdominal pain, fatigue. Usually mild and self-limiting.<\/p>\n<p><strong>Minder vaak:<\/strong> dizziness, rash, photosensitivity.<\/p>\n<p><strong>Ernstig (zeldzaam):<\/strong> thrombotic thrombocytopenic purpura \/ hemolytic uremic syndrome (TTP\/HUS) has been reported at very high doses in severely immunocompromised patients. Acute kidney injury in dehydrated patients at high doses. Neurotoxicity (confusion, hallucinations) rare and usually associated with renal impairment + high dose.<\/p>\n<h2><strong>Who Should Not Take Valcosign<\/strong><\/h2>\n<ul>\n<li>Known hypersensitivity to valacyclovir or aciclovir<\/li>\n<li>Severe immunodeficiency without specialist supervision (TTP\/HUS risk)<\/li>\n<li>Caution in renal impairment \u2014 dose adjustment required<\/li>\n<li>Caution in pregnancy \/ breastfeeding \u2014 discuss with clinician (category B in most jurisdictions; widely used but individual risk-benefit assessment required)<\/li>\n<\/ul>\n<h2><strong>Geneesmiddelinteracties<\/strong><\/h2>\n<ul>\n<li><strong>Probenecid + cimetidine:<\/strong> reduce renal clearance of aciclovir \u2014 may raise plasma levels. Clinically significant only at high doses.<\/li>\n<li><strong>Mycofenolaatmofetil:<\/strong> may increase valacyclovir plasma concentration.<\/li>\n<li><strong>Andere nefrotoxische geneesmiddelen<\/strong> (aminoglycosides, high-dose NSAIDs, amphotericin B): combined use requires careful hydration and renal monitoring.<\/li>\n<li><strong>Zidovudine:<\/strong> may increase neurotoxicity risk in combination.<\/li>\n<\/ul>\n<h2><strong>Opslag<\/strong><\/h2>\n<p>Store at room temperature (15\u201330 \u00b0C \/ 59\u201386 \u00b0F) away from direct sunlight and moisture. Keep tablets in the original foil blister. Keep out of reach of children. Do not use after the printed expiry date.<\/p>\n<h2><strong>Valcosign vs Aciclovir<\/strong><\/h2>\n<p>Valacyclovir is a prodrug of aciclovir with much better bioavailability (~55% vs ~15\u201320%). Practical implication: twice-daily valacyclovir produces the same antiviral effect as five-times-daily aciclovir, making it far easier to stick with. Most modern herpes guidelines (CDC, BASHH, WHO) list valacyclovir as first-line for outpatient use. Aciclovir remains standard when cost is the primary constraint or for IV administration.<\/p>\n<p>See our detailed comparison: <a href=\"https:\/\/medsbase.com\/nl\/valacyclovir-vs-acyclovir\/\"><strong>Valacyclovir versus Acyclovir<\/strong><\/a>.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">Does Valcosign cure herpes?<\/h3>\n<p>No. There is no cure for herpes \u2014 the virus remains latent in nerve ganglia for life. Valcosign suppresses viral replication, shortens outbreaks, reduces outbreak frequency, and lowers partner transmission risk, but cannot eliminate the virus from the body.<\/p>\n<h3 class=\"wp-block-heading\">How quickly does Valcosign work?<\/h3>\n<p>For episodic treatment, most patients report symptom improvement within 24\u201348 hours of starting. Lesions heal ~1\u20132 days faster than untreated. For suppressive daily dosing, full effect (reduced outbreak frequency) builds over the first month.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol while taking Valcosign?<\/h3>\n<p>Alcohol does not directly interact with valacyclovir, but dehydration from heavy drinking can stress the kidneys (valacyclovir clears renally). Moderate intake is generally fine; hydrate well.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Valcosign during pregnancy?<\/h3>\n<p>Valacyclovir is Category B in most jurisdictions and is widely used in pregnancy, particularly near term to reduce neonatal herpes risk in women with active genital herpes. Always discuss with your obstetrician.<\/p>\n<h3 class=\"wp-block-heading\">Will Valcosign protect my partner?<\/h3>\n<p>Daily suppressive valacyclovir reduces heterosexual transmission by ~48% (Corey et al., 2004). It is not 100% protective \u2014 consistent condom use and avoiding sex during outbreaks remain important.<\/p>\n<h3 class=\"wp-block-heading\">How long can I stay on suppressive therapy?<\/h3>\n<p>Years, safely. Long-term studies show valacyclovir is well tolerated for suppressive use over 5+ years with no cumulative toxicity at standard doses in people with normal kidney function.<\/p>\n<h3 class=\"wp-block-heading\">Wat als ik een dosis vergeet?<\/h3>\n<p>Take it as soon as you remember, unless it is almost time for the next dose \u2014 in that case skip and continue. Do not double-dose.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Valcosign for shingles?<\/h3>\n<p>Yes \u2014 1000 mg three times daily for 7 days, started within 72 hours of rash onset. Earlier treatment reduces pain, speeds healing, and lowers post-herpetic neuralgia risk.<\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde producten &amp; gidsen<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/valacyclovir-vs-acyclovir\/\">Valacyclovir vs Acyclovir Gids<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/herpes-antivirals-daily-vs-episodic-treatment\/\">Dagelijkse versus episodische behandeling van herpes<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/valclovir\/\">Valclovir (Valacyclovir)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/valovera\/\">Valovera (Valacyclovir)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/acivir-200-dt\/\">Acivir 200 DT (Aciclovir)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/zovirax-suspension\/\">Zovirax Suspension (Aciclovir)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:16px 0;border-radius:4px;font-size:0.9em;\">\n<p style=\"margin:0;\"><strong>\u2695\ufe0f Medische disclaimer:<\/strong> De informatie op deze pagina is alleen voor educatieve doeleinden en vervangt geen medisch advies. Raadpleeg altijd een gekwalificeerde arts voordat u begint, stopt of een medicatie wijzigt. Voorschriftproducten mogen alleen onder medisch toezicht worden gebruikt.<\/p>\n<\/div>\n<p class=\"medsbase-link-boost-2026-05-03\" data-marker=\"mb-link-boost-centrex\">Patients ordering <a href=\"https:\/\/medsbase.com\/nl\/valcosign\/\">Valcosign (valacyclovir 500 mg)<\/a> for HSV suppression sometimes need the higher 1 g strength for shingles or a single-day cold-sore course \u2014 <a href=\"https:\/\/medsbase.com\/nl\/centrex\/\">Centrex (valacyclovir 500 \/ 1000 mg)<\/a> carries both strengths and the same WHO-GMP valacyclovir hydrochloride.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde alternatieven<\/h3>\n<p>Andere producten in <strong>Seksuele gezondheid<\/strong> die klanten ook bekijken:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/penvir\/\">Penvir<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/valclovir\/\">Valclovir<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/neckcin-100-dt\/\">Neckcin 100 DT<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/neckcin-250-dt\/\">Neckcin 250 DT<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/asitomycin-250\/\">Asitomycin 250<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Treats herpes infections<br \/>\n\u2705 Reduces severity of outbreaks<br \/>\n\u2705 Verkort de genezingstijd<br \/>\n\u2705 Relieves pain and itching<br \/>\n\u2705 Prevents viral spread<\/p>\n<p>Valcosign contains Valacyclovir.<\/p>","protected":false},"featured_media":59690,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3832,3337],"product_tag":[3313,4729],"class_list":{"0":"post-59689","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-genital-herpes-treatment","9":"product_cat-sexual-health","10":"product_tag-valacyclovir","11":"product_tag-valcosign","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/59689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=59689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/59690"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=59689"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=59689"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=59689"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=59689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}