{"id":59937,"date":"2024-02-28T06:24:31","date_gmt":"2024-02-28T06:24:31","guid":{"rendered":"https:\/\/medsname.com\/antiflu\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"antiflu","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/antiflu\/","title":{"rendered":"Antiflu"},"content":{"rendered":"

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Snelle antwoord<\/h3>\n

Antiflu (oseltamivir 75 mg, Cipla<\/strong>) is an oral neuraminidase inhibitor for influenza A and B. For maximum benefit start within 48 hours of symptom onset<\/strong>; standard treatment is 75 mg twice daily for 5 days. Post-exposure prophylaxis is 75 mg once daily for 7–10 days. Take with food to reduce nausea. Renal-dose adjustment is required when CrCl < 60 mL\/min. Available in 10\/20\/30\/60-capsule packs.<\/p>\n<\/div>\n

\n\u2705 WHO-GMP gecertificeerd<\/strong> manufacturer (Cipla)<\/span>
\n\ud83d\udce6 Discrete verpakking<\/span>
\n\ud83c\udf0d Wereldwijde verzending<\/span>
\n\ud83d\udc65 Vertrouwd door 1.400+ klanten \u2014 lees beoordelingen<\/a><\/span>\n<\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

MedsBase sources Antiflu directly from Cipla, a WHO-GMP-certified manufacturer that has supplied oseltamivir into pandemic-preparedness stockpiles since 2009. Each strip is in its original blister, untouched between dispatch and your door. Crypto, SEPA, and credit-card checkout are all available, and the Reshipment Assurance Policy above means a parcel that fails to arrive in 20 business days is reshipped at no extra cost.<\/p>\n

How Antiflu works<\/h3>\n

Oseltamivir is an oral prodrug. After absorption it is hydrolysed by hepatic carboxylesterase to oseltamivir carboxylate<\/strong>, a competitive inhibitor of viral neuraminidase<\/strong> — the surface enzyme influenza A and B viruses use to cleave sialic acid residues from infected host cells. Without that cleavage, newly assembled virion progeny stay anchored to the cell membrane and cannot spread to neighbouring respiratory epithelium. The viral burst is contained within roughly the first 48 hours of clinical illness, which is why early initiation matters far more than total duration<\/strong>.<\/p>\n

Indications and dose<\/h3>\n

Adult dose tables below cover treatment, post-exposure prophylaxis, and outbreak prophylaxis. Paediatric weight-band dosing follows.<\/p>\n\n\n\n\n\n\n\n\n
Indicatie<\/th>\nDosering<\/th>\nDuur<\/th>\nOpmerkingen<\/th>\n<\/tr>\n<\/thead>\n
Influenza treatment (adult, >13 y, normal renal)<\/td>\n75 mg twice daily<\/td>\n5 dagen<\/td>\nStart within 48 h of symptom onset<\/td>\n<\/tr>\n
Severe \/ hospitalised flu<\/td>\n75 mg twice daily<\/td>\n10 days (prolonged courses considered)<\/td>\nSpecialist setting; resistance testing if no clinical response<\/td>\n<\/tr>\n
Post-exposure prophylaxis (close contact)<\/td>\n75 mg once daily<\/td>\n7–10 days from last exposure<\/td>\nStart within 48 h of contact<\/td>\n<\/tr>\n
Outbreak \/ community prophylaxis<\/td>\n75 mg once daily<\/td>\nUp to 6 weeks (pandemic up to 12 weeks)<\/td>\nUse when vaccination is contraindicated, ineffective, or unavailable<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Paediatric weight-band dosing (treatment, twice daily × 5 days; halve frequency to once daily for prophylaxis):<\/strong><\/p>\n\n\n\n\n\n\n\n\n
Lichaamsgewicht<\/th>\nTreatment dose<\/th>\nCapsule equivalent<\/th>\n<\/tr>\n<\/thead>\n
≤ 15 kg<\/td>\n30 mg BID<\/td>\nSuspension preferred (commercial 6 mg\/mL)<\/td>\n<\/tr>\n
15.1–23 kg<\/td>\n45 mg BID<\/td>\nSuspension preferred<\/td>\n<\/tr>\n
23.1–40 kg<\/td>\n60 mg BID<\/td>\nSuspension preferred<\/td>\n<\/tr>\n
> 40 kg<\/td>\n75 mg BID<\/td>\nOne Antiflu capsule BID<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Renal-dose adjustment (CrCl by Cockcroft-Gault):<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
CrCl mL\/min<\/th>\nTreatment dose<\/th>\nProphylaxis dose<\/th>\n<\/tr>\n<\/thead>\n
> 60<\/td>\n75 mg BID<\/td>\n75 mg OD<\/td>\n<\/tr>\n
30–60<\/td>\n30 mg BID<\/td>\n30 mg OD<\/td>\n<\/tr>\n
10–30<\/td>\n30 mg OD<\/td>\n30 mg every 48 h<\/td>\n<\/tr>\n
Hemodialyse<\/td>\n30 mg after each session, max 5 doses<\/td>\n30 mg after every other session<\/td>\n<\/tr>\n
CAPD \/ CrCl < 10 (no dialysis)<\/td>\nNiet aanbevolen<\/td>\nNiet aanbevolen<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u2014 verbetert de verdraagzaamheid van metformine.<\/h3>\n

Capsules are bioavailable empty-stomach, but taking with food roughly halves the rate of nausea\/vomiting (the most common reason for early discontinuation). If a dose is missed, take it as soon as remembered unless within 2 hours of the next scheduled dose — do not double up. The full 5-day course must be completed even if symptoms resolve sooner.<\/p>\n

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Neuropsychiatric events — especially in children and adolescents.<\/strong> Post-marketing reports (concentrated in Japan but globally documented) describe delirium, agitation, abnormal behaviour, hallucinations, and rare self-injury during influenza illness in patients on oseltamivir. The contribution of oseltamivir versus the underlying febrile illness is uncertain. The FDA package insert advises that paediatric and adolescent patients should be closely monitored for behavioural changes<\/strong> during the 5-day course, and the medication stopped if delirium-like symptoms emerge. Adults are not exempt — report any unusual behavioural change to the prescriber.<\/p>\n<\/div>\n

Bijwerkingen<\/h3>\n

Common (≥ 1 %):<\/strong> nausea, vomiting, headache, abdominal discomfort, fatigue, insomnia. GI symptoms are dose-related and largely mitigated by taking capsules with food.<\/p>\n

Minder vaak:<\/strong> rash, diarrhoea, dyspepsia, conjunctivitis, dizziness, mild liver-enzyme elevation.<\/p>\n

Zeldzaam maar belangrijk:<\/strong> severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis — stop immediately and seek emergency care), neuropsychiatric events as above, anaphylaxis, hepatic injury.<\/p>\n

Geneesmiddelinteracties<\/h3>\n\n\n\n\n\n\n\n\n
Interacting agent<\/th>\nEffect<\/th>\nActie<\/th>\n<\/tr>\n<\/thead>\n
Live attenuated influenza vaccine (LAIV, nasal)<\/td>\nOseltamivir inhibits replication of the vaccine virus<\/td>\nAvoid LAIV from 48 h before to 14 days after oseltamivir; inactivated injectable flu vaccine is unaffected<\/td>\n<\/tr>\n
Probenecide<\/td>\nDoubles oseltamivir carboxylate exposure (renal tubular secretion blocked)<\/td>\nNo dose change required at standard doses; consider in renal impairment<\/td>\n<\/tr>\n
Methotrexaat (hooggedoseerd)<\/td>\nTheoretical reduction of methotrexate clearance<\/td>\nMonitor methotrexate levels in oncology \/ rheumatology cases<\/td>\n<\/tr>\n
Warfarine<\/td>\nInfluenza illness itself raises INR; oseltamivir contribution minor<\/td>\nIncrease INR monitoring during the febrile illness, not because of oseltamivir per se<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Resistance and when oseltamivir doesn’t help<\/h3>\n

The principal resistance mutation is H275Y<\/strong> in the N1 subtype, seen as a transient global signal in 2007–2008 seasonal H1N1 before the 2009 pandemic strain replaced it. Current circulating influenza A(H1N1)pdm09, A(H3N2), and B viruses are predominantly oseltamivir-sensitive, but local resistance surveillance evolves — if a patient with confirmed influenza fails to defervesce after 48 h on therapy, resistance testing is reasonable.<\/p>\n

Oseltamivir does niet<\/strong> shorten illness caused by rhinovirus, RSV, parainfluenza, adenovirus, SARS-CoV-2, or any other non-influenza respiratory virus. A negative influenza test or a clinical picture lasting beyond the typical flu window should prompt rediagnosis rather than dose escalation.<\/p>\n

Pregnancy, breastfeeding, and high-risk groups<\/h3>\n

Influenza in pregnancy carries elevated maternal and foetal mortality. The CDC, ACOG, WHO, and UKHSA all recommend oseltamivir as first-line for pregnant women with suspected or confirmed influenza, in any trimester, irrespective of the 48-hour window<\/strong>. Breastfeeding is compatible — less than 0.5 % of the maternal weight-adjusted dose appears in breast milk.<\/p>\n

Other high-risk groups for whom early oseltamivir matters: age < 5 (especially < 2), age ≥ 65, chronic pulmonary disease (asthma, COPD, cystic fibrosis), cardiovascular disease, diabetes, chronic kidney or liver disease, haematological or neurological disease, immunosuppression (HIV, transplant, chemotherapy), and BMI ≥ 40.<\/p>\n

Opslag<\/h3>\n

Store capsules at room temperature (15–30 °C), protected from moisture. Keep blister strips in their carton and out of reach of children. Reconstituted oral suspension (commercial form) is refrigerated and stable 17 days — capsules are not affected by this.<\/p>\n

Veelgestelde vragen<\/h2>\n

How quickly does Antiflu work?<\/h3>\n

When started within 48 h of symptom onset, oseltamivir typically shortens the course of uncomplicated flu by about 17–25 hours, reduces symptom severity, and lowers the risk of lower-respiratory complications and antibiotic prescriptions. Subjective improvement is usually felt within 24–36 hours of the first dose.<\/p>\n

Should I take Antiflu if it’s already day 3 of my flu?<\/h3>\n

The benefit shrinks with delay, and routine outpatient guidance is to start within 48 hours. However, in patients hospitalised with severe influenza, who are pregnant, who are immunocompromised, or who have progressing lower-respiratory disease, treatment is recommended regardless of how many days have elapsed<\/strong> — oseltamivir still reduces mortality in these settings.<\/p>\n

Is Antiflu the same as Tamiflu?<\/h3>\n

Yes — both contain the same active molecule, oseltamivir phosphate 75 mg. Antiflu is Cipla’s brand of oseltamivir, manufactured under WHO-GMP standards; Tamiflu is the original Roche\/Genentech brand. Generic oseltamivir is bioequivalent and accepted by WHO, FDA, EMA, and national stockpiling programmes.<\/p>\n

Can I use Antiflu to prevent COVID-19?<\/h3>\n

No. Oseltamivir is specific to influenza A and B neuraminidase. SARS-CoV-2 has no neuraminidase. Antiflu has no role in COVID-19 prevention or treatment, and using it during a non-influenza viral illness simply exposes you to side effects without benefit.<\/p>\n

Why do I need to take it for 5 full days if I feel better on day 2?<\/h3>\n

Influenza viral shedding continues for several days beyond the point of symptomatic recovery. A short course allows residual virus to rebound and may select for resistant strains, particularly in household clusters. Always finish the full 5 days.<\/p>\n

Can my child take Antiflu capsules?<\/h3>\n

Children > 40 kg can take the 75 mg capsule. For lower weight bands, the commercial 6 mg\/mL oral suspension is preferred because the dose is fractional (30 mg, 45 mg, 60 mg). Capsule contents must not be opened and divided unless under pharmacist supervision.<\/p>\n

Will Antiflu protect me if my partner has flu?<\/h3>\n

Yes — post-exposure prophylaxis with oseltamivir 75 mg once daily for 7–10 days, started within 48 hours of contact, reduces the risk of clinical influenza in the contact by roughly 70 %. It is niet<\/em> a substitute for influenza vaccination in the longer term.<\/p>\n

Wat moet ik doen als ik een dosis heb gemist?<\/h3>\n

Take the missed dose as soon as you remember, unless it’s within 2 hours of the next scheduled dose — in that case, skip the missed dose and resume the normal schedule. Never double up.<\/p>\n

Can I drink alcohol while taking Antiflu?<\/h3>\n

There is no specific oseltamivir-alcohol interaction. However, alcohol worsens dehydration during a febrile illness and can amplify nausea. Light intake is acceptable; heavy drinking is best avoided until the flu has resolved.<\/p>\n

Does Antiflu interact with my regular medications?<\/h3>\n

Oseltamivir has a clean drug-interaction profile — it is not a meaningful inhibitor or inducer of cytochrome P450 enzymes, and it does not displace common protein-bound drugs. Probenecid raises levels but is rarely clinically relevant. The main flag is the live attenuated nasal<\/em> flu vaccine (LAIV), which should be separated by 48 h before \/ 2 weeks after the course. Inactivated injectable flu vaccine is unaffected.<\/p>\n

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Other medications customers viewing Antiflu also consider<\/h3>\n

For symptomatic relief alongside the antiviral course:<\/p>\n