{"id":59996,"date":"2024-02-28T06:28:05","date_gmt":"2024-02-28T06:28:05","guid":{"rendered":"https:\/\/medsname.com\/metopar\/"},"modified":"2026-04-30T10:23:52","modified_gmt":"2026-04-30T10:23:52","slug":"metopar","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/metopar\/","title":{"rendered":"Metopar"},"content":{"rendered":"

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⚡ Quick Answer — What is Metopar?<\/h3>\n

Metopar<\/strong> is een vaste combinatie van paracetamol 500 mg + metoclopramide 5 mg<\/strong> designed for acute migraine attacks with nausea<\/strong>. Paracetamol provides simple analgesia; metoclopramide accelerates gastric emptying (which is paralysed during migraine, otherwise blunting absorption of any oral analgesic) and acts centrally as a D2 antagonist antiemetic. Manufactured by Macleods under WHO-GMP standards. Onset 30–60 minutes; usual dose 1–2 tablets every 4–6 hours, max 4 tablets\/day.<\/p>\n<\/div>\n

Waarom bestellen bij MedsBase:<\/strong> \u2714 WHO-GMP gecertificeerde fabrikant<\/strong> \u2714 Discrete verpakking \u2714 Wereldwijde verzending \u2714 Geverifieerde klantbeoordelingen (1.400+ klanten)<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n

⚠️ Metoclopramide course-length and EPS warnings.<\/strong> Metoclopramide is restricted to 5 days FDA \/ 12 weeks EMA<\/strong> due to risk of tardive dyskinesia — a permanent involuntary movement disorder. FDA black-box warning<\/strong> applies for tardive dyskinesia with prolonged or high-dose use. Avoid in Parkinson’s disease (D2 antagonism worsens motor symptoms). Acute dystonic reactions (oculogyric crisis, torticollis) are most common in young women receiving IV\/IM and can occur after even one oral dose — treat with IV procyclidine or diphenhydramine. Avoid in epilepsy, GI obstruction, perforation, or bleeding. Paracetamol overdose risk:<\/strong> do not exceed 4 g\/day total paracetamol from all sources (combined with this product, other paracetamol, and combination cold\/flu products).<\/div>\n

Why combine paracetamol with metoclopramide for migraine?<\/h2>\n

During an acute migraine attack, gastric motility slows or stops (gastric stasis). This means oral analgesics are absorbed slowly and incompletely — explaining why some patients say “paracetamol does nothing for my migraine”. Adding metoclopramide does three things:<\/p>\n

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  1. Restores gastric motility<\/strong> — the paracetamol is now absorbed at normal rate and reaches therapeutic plasma levels.<\/li>\n
  2. Treats the nausea\/vomiting<\/strong> directly via D2 antagonism at the chemoreceptor trigger zone.<\/li>\n
  3. Direct anti-migraine action<\/strong> — metoclopramide alone has been shown to reduce migraine pain in IV trials (mechanism not fully understood, possibly D2 antagonism in the trigeminocervical complex).<\/li>\n<\/ol>\n

    The combination is well established in UK and European migraine guidelines as a first-step treatment before triptans for moderate attacks.<\/p>\n

    Waarom bestellen bij MedsBase<\/h3>\n

    Metopar is supplied from a WHO-GMP gecertificeerde fabrikant<\/strong>. Elke bestelling wordt discreet wereldwijd verzonden en valt onder onze Reshipment Assurance Policy<\/a> — if it does not arrive within 20 business days, we reship at no cost. Metopar pairs the most-used analgesic with the most-used prokinetic antiemetic in a single tablet calibrated to overcome migraine-induced gastric stasis — a clinical pharmacology problem that simple paracetamol alone cannot solve.<\/p>\n

    Werkingsmechanisme<\/h2>\n

    Paracetamol (acetaminophen)<\/strong> works mainly through central inhibition of prostaglandin synthesis (likely via COX-3 in the CNS or peroxide-dependent COX-1\/COX-2 inhibition) and activation of the descending serotonergic pain-modulating pathway. It is a weaker analgesic than NSAIDs but lacks the gastric\/renal\/cardiovascular toxicity of NSAIDs and is safe in pregnancy.<\/p>\n

    Metoclopramide<\/strong> is a D2 dopamine receptor antagonist that crosses the blood-brain barrier (unlike domperidone). It acts centrally at the chemoreceptor trigger zone (antiemetic) and the nigrostriatal system (giving its EPS risk), and peripherally on D2 receptors in the gut wall to accelerate gastric emptying and tighten the lower-oesophageal sphincter. The 5 mg per tablet in this combination is well below the 10 mg standard antiemetic dose — a single combination tablet contains a low-dose metoclopramide, allowing 1–2 tablets per dose without exceeding daily limits.<\/p>\n

    Indicaties<\/h2>\n