{"id":60249,"date":"2024-02-28T06:40:15","date_gmt":"2024-02-28T06:40:15","guid":{"rendered":"https:\/\/medsname.com\/stemetil-md\/"},"modified":"2026-04-30T10:23:49","modified_gmt":"2026-04-30T10:23:49","slug":"stemetil-md","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/stemetil-md\/","title":{"rendered":"Stemetil MD"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Stemetil MD?<\/h3>\n<p style=\"margin:0;\"><strong>Stemetil MD<\/strong> is een <strong>orally disintegrating tablet<\/strong> van <strong>prochlorperazine maleate 5 mg<\/strong>, a phenothiazine D2 dopamine antagonist with strong antiemetic and vestibular-suppressant action. The MD\/ODT formulation dissolves on the tongue without water, useful when active vomiting prevents reliable swallowing. Indicated for <strong>vertigo, vestibular nausea, Meniere&rsquo;s disease, severe nausea, and migraine-associated nausea<\/strong>. Manufactured by Sun Pharma under WHO-GMP standards. Onset 30&ndash;60 minutes; usual dose 5 mg three times daily.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Waarom bestellen bij MedsBase:<\/strong> \u2714 <strong>WHO-GMP gecertificeerde fabrikant<\/strong> \u2714 Discrete verpakking \u2714 Wereldwijde verzending \u2714 <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">Geverifieerde klantbeoordelingen (1.400+ klanten)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Acute dystonia and FGA dementia mortality.<\/strong> Prochlorperazine is a first-generation antipsychotic by class; even at antiemetic doses it can cause <strong>acute dystonic reactions<\/strong> (oculogyric crisis, torticollis, jaw spasm), particularly in young adults and patients receiving the IM\/IV form. Treat with IV procyclidine or diphenhydramine. <strong>FDA black-box warning<\/strong> applies: increased mortality in elderly patients with dementia-related psychosis when antipsychotics are used long-term &mdash; do not use prochlorperazine for chronic sedation in dementia. Avoid in Parkinson&rsquo;s disease (D2 antagonism worsens motor symptoms). Rare but serious: neuroleptic malignant syndrome (fever, rigidity, autonomic instability, delirium).<\/div>\n<h2 class=\"wp-block-heading\">When prochlorperazine is the right antiemetic<\/h2>\n<p>Prochlorperazine is the <strong>first-line antiemetic for vestibular vertigo and Meniere&rsquo;s symptom flare<\/strong>. It is also useful for <strong>migraine-associated nausea<\/strong> (often combined with a triptan) and for non-chemotherapy moderate nausea where 5-HT3 antagonists are not warranted. It is <strong>geen eerstelijnsbehandeling voor chemotherapie-ge\u00efnduceerde misselijkheid<\/strong> (5-HT3 antagonists like ondansetron\/granisetron are preferred) and <strong>niet eerste keus bij misselijkheid en braken tijdens zwangerschap<\/strong> (doxylamine+B6). The MD\/ODT formulation is particularly useful for acute vertigo when the patient cannot reliably swallow water.<\/p>\n<h3 class=\"wp-block-heading\">Waarom bestellen bij MedsBase<\/h3>\n<p>Stemetil MD is supplied from a <strong>WHO-GMP gecertificeerde fabrikant<\/strong>. Elke bestelling wordt discreet wereldwijd verzonden en valt onder onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Stemetil MD is the standard ODT formulation of prochlorperazine, the established first-line drug for vestibular vertigo and Meniere&rsquo;s acute attacks. The orodispersible form bypasses the swallowing problem common in active vomiting episodes.<\/p>\n<h2 class=\"wp-block-heading\">Werkingsmechanisme<\/h2>\n<p>Prochlorperazine is a piperazine phenothiazine. Its dominant action is <strong>D2 dopamine receptor antagonism at the chemoreceptor trigger zone<\/strong> in the area postrema, which interrupts the central emetic signal. It also has weaker H1, alpha-1, and muscarinic blockade, contributing to its anti-vertigo effect (vestibular suppression) and to side effects (sedation, hypotension, dry mouth). The phenothiazine ring structure shared with chlorpromazine explains the small risk of extrapyramidal reactions and the FDA dementia black-box warning shared with all D2 antagonist antipsychotics.<\/p>\n<h2 class=\"wp-block-heading\">Indicaties<\/h2>\n<ul>\n<li><strong>Vertigo and vestibular nausea:<\/strong> labyrinthitis, vestibular neuritis, BPPV, Meniere&rsquo;s acute attacks.<\/li>\n<li><strong>Migraine-gerelateerde misselijkheid:<\/strong> often with sumatriptan or other triptans; some evidence for direct migraine-pain relief.<\/li>\n<li><strong>Severe non-chemotherapy nausea and vomiting:<\/strong> gastroenteritis (when ondansetron unavailable), drug-induced nausea, post-radiation.<\/li>\n<li><strong>Adjunct in psychiatric agitation:<\/strong> historic use; rarely first-line today.<\/li>\n<li><strong>Hyperemesis gravidarum<\/strong> (third-line, jurisdiction-dependent).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosering<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;\">Indicatie<\/th>\n<th style=\"padding:8px;text-align:left;\">Dosering<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Acute vertigo \/ vestibular nausea<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">5 mg three times daily; up to 5 mg every 4&ndash;6 h in severe attacks (max 30 mg\/day)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Maintenance after acute attack<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">5&ndash;10 mg twice or three times daily; taper as soon as symptoms allow (long-term use slows vestibular compensation)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Migraine nausea<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">5&ndash;10 mg as needed; ODT is convenient when migraine-associated vomiting is active<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Oudere volwassenen<\/td>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Start at half-dose (2.5 mg); risk of falls, postural hypotension, EPS<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border-bottom:1px solid #ddd;\">Children &lt; 10 kg or &lt; 2 y<\/td>\n<td style=\"padding:8px;\">CONTRAINDICATED<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Place the ODT on a dry tongue and let it dissolve in 10&ndash;30 seconds. Do not push through the foil &mdash; peel back. No water needed.<\/p>\n<h2 class=\"wp-block-heading\">Bijwerkingen<\/h2>\n<ul>\n<li><strong>Vaak voorkomend:<\/strong> drowsiness, dry mouth, blurred vision, dizziness, postural hypotension, mild constipation<\/li>\n<li><strong>Minder vaak:<\/strong> akathisia (restlessness), tremor, cogwheel rigidity, mild EPS, hyperprolactinaemia<\/li>\n<li><strong>Significant:<\/strong> acute dystonic reactions (oculogyric crisis, torticollis &mdash; particularly in young men, IM\/IV more than oral); QT prolongation<\/li>\n<li><strong>Zeldzaam maar ernstig:<\/strong> neuroleptic malignant syndrome, tardive dyskinesia (long-term), agranulocytosis, cholestatic jaundice, seizures in overdose<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Geneesmiddelinteracties<\/h2>\n<ul>\n<li><strong>Levodopa, dopamineagonisten:<\/strong> antagonised by prochlorperazine &mdash; avoid in Parkinson&rsquo;s disease.<\/li>\n<li><strong>QT-verlengende geneesmiddelen<\/strong> (azithromycin, citalopram, methadone, ondansetron, hydroxychloroquine, antipsychotics): additive QT effect &mdash; monitor ECG or avoid.<\/li>\n<li><strong>CNS-depressiva<\/strong> (alcohol, opioids, benzodiazepines, gabapentinoids): additive sedation.<\/li>\n<li><strong>Anticholinergica<\/strong> (TCAs, oxybutynin, atropine): additive anticholinergic burden in older adults.<\/li>\n<li><strong>Antihypertensiva:<\/strong> may potentiate hypotension &mdash; monitor BP.<\/li>\n<\/ul>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">How fast does Stemetil MD work?<\/h3>\n<p>Onset is typically 30&ndash;60 minutes after the ODT dissolves. The orodispersible formulation is particularly useful when active vomiting prevents reliable swallowing of a standard tablet.<\/p>\n<h3 class=\"wp-block-heading\">Will Stemetil MD make me drowsy?<\/h3>\n<p>Yes &mdash; sedation is a common side effect, especially with the first few doses. Avoid driving, operating machinery, or making important decisions until you know how it affects you.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Stemetil MD for chemotherapy nausea?<\/h3>\n<p>Prochlorperazine is not first-line for CINV &mdash; modern oncology uses 5-HT3 antagonists (ondansetron, granisetron) &plusmn; dexamethasone &plusmn; aprepitant. Prochlorperazine is reserved for breakthrough nausea or where 5-HT3 antagonists have failed.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Stemetil MD in pregnancy?<\/h3>\n<p>Prochlorperazine is third-line for hyperemesis gravidarum after doxylamine+B6 (Doxinate, Pregnidoxin NU) and metoclopramide. Discuss with a clinician before use in pregnancy.<\/p>\n<h3 class=\"wp-block-heading\">What is an acute dystonic reaction?<\/h3>\n<p>A sudden involuntary muscle contraction &mdash; commonly oculogyric crisis (eyes roll up), torticollis (neck twists), or jaw\/tongue spasm. It is dramatic and frightening but reversible with IV procyclidine or diphenhydramine. Risk is highest in young men receiving the IM\/IV form; oral ODT risk is much lower but not zero. Stop the drug and get medical help.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Stemetil MD long-term for vertigo?<\/h3>\n<p>No. Long-term phenothiazine use slows vestibular compensation and exposes you to tardive dyskinesia (involuntary movements), hyperprolactinaemia, and the FDA dementia mortality signal. Use during the acute attack only and taper as symptoms allow; for chronic vertigo betahistine (Vertin\/Betavert) is more appropriate.<\/p>\n<h3 class=\"wp-block-heading\">Why is the ODT version useful for vertigo?<\/h3>\n<p>Severe vestibular attacks often cause active vomiting that prevents you from keeping a swallowed tablet down. The ODT dissolves on a dry tongue with saliva alone &mdash; no water, no risk of immediate vomiting before absorption.<\/p>\n<h3 class=\"wp-block-heading\">How does Stemetil MD compare to Avomine (promethazine)?<\/h3>\n<p>Both treat vestibular nausea. <strong>Prochlorperazine<\/strong> is mainly a D2 antagonist with strong antiemetic action and a small risk of EPS. <strong>Promethazine<\/strong> is mainly an H1 antihistamine + anticholinergic with stronger sedation but no D2\/EPS risk. Promethazine is preferred for motion sickness; prochlorperazine for severe vestibular vertigo and Meniere&rsquo;s.<\/p>\n<h3 class=\"wp-block-heading\">What does the FDA dementia warning mean?<\/h3>\n<p>All first-generation D2 antagonist antipsychotics share an FDA black-box warning that <strong>long-term use in elderly dementia patients<\/strong> increases mortality (cardiovascular, infection). Short-course antiemetic use in non-dementia patients is not affected by this warning, but prochlorperazine should not be used as a chronic sedative in dementia care.<\/p>\n<h3 class=\"wp-block-heading\">How is Stemetil MD stored?<\/h3>\n<p>Store ODT blisters at room temperature (below 25&deg;C), protect from light and moisture. Do not refrigerate. Keep blisters sealed until use; do not push through the foil &mdash; peel the back away first.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Andere behandelingen tegen misselijkheid<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/avomine\/\">Avomine (promethazine &mdash; H1 antihistamine, motion sickness)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/vertin\/\">Vertin (betahistine &mdash; chronic Meniere&rsquo;s)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/dompewal-tablet\/\">Dompewal (domperidone &mdash; gastroparesis nausea)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/ondem\/\">Ondem (ondansetron \u2014 serotonine-gerelateerde misselijkheid)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/metopar\/\">Metopar (paracetamol + metoclopramide &mdash; migraine)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/nausea-treatment\/\"><strong>Bekijk alle behandelingen tegen misselijkheid<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 Medisch disclaimer.<\/strong> Deze pagina is alleen voor informatieve doeleinden en vervangt geen medisch advies van een gekwalificeerde zorgverlener. Aanhoudend braken, bloed in braaksel, ernstige buikpijn, tekenen van uitdroging, vermoedelijke zwangerschapscomplicaties of chemotherapie-gerelateerde symptomen vereisen evaluatie door een arts.<\/div>","protected":false},"excerpt":{"rendered":"<p>Stemetil MD (Prochlorperazine maleate 5 mg orally disintegrating) \u2014 first-line phenothiazine antiemetic for vestibular vertigo, Meniere&#8217;s, and migraine nausea.<\/p>","protected":false},"featured_media":60250,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3543],"product_tag":[4832,4833],"class_list":{"0":"post-60249","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-nausea-treatment","9":"product_tag-prochlorperazine","10":"product_tag-stemetil-md","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/60249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=60249"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/60250"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=60249"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=60249"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=60249"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=60249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}