{"id":60293,"date":"2024-02-28T06:41:59","date_gmt":"2024-02-28T06:41:59","guid":{"rendered":"https:\/\/medsname.com\/phenergan\/"},"modified":"2026-05-20T05:24:59","modified_gmt":"2026-05-20T05:24:59","slug":"phenergan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/phenergan\/","title":{"rendered":"Phenergan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Snelle antwoord<\/h3>\n<p><strong>Phenergan<\/strong> is een merk van <strong>promethazine 10 mg<\/strong> \u2014 a first-generation H1 antihistamine with strong anticholinergic, antiemetic, and sedative action. Take one tablet 30\u201360 minutes before travel for motion sickness, or 10\u201320 mg every 4\u20136 hours for nausea \/ allergic symptoms (usual maximum 100 mg\/day in adults). The 10 mg tablet is the milder, finer-titration option compared with the 25 mg <a href=\"https:\/\/medsbase.com\/nl\/avimax\/\">Avimax<\/a> tablet.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3 class=\"wp-block-heading\">Waarom bestellen bij MedsBase<\/h3>\n<p>Phenergan is sourced from <strong>WHO-GMP gecertificeerde fabrikanten<\/strong>, discreet verpakt en wereldwijd verzonden. Elke bestelling wordt gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> en ondersteund door meer dan 1.400 <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>.<\/p>\n<h2 class=\"wp-block-heading\">How Phenergan works<\/h2>\n<p>Promethazine combines four mechanisms in one molecule: H1 antihistamine blockade reduces allergic symptoms; central anticholinergic action suppresses the vestibular nuclei that drive motion sickness; D2 dopamine antagonism in the chemoreceptor trigger zone provides direct antiemetic effect; and CNS H1\/M1 occupancy produces dose-dependent sedation. Onset is around 20 minutes after an oral dose, peak effect at 1\u20132 hours, and duration of effect is 4\u20136 hours (sedation may persist longer in older adults).<\/p>\n<h2 class=\"wp-block-heading\">Indications and dose<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indicatie<\/th>\n<th>Adult dose (10 mg tablets)<\/th>\n<th>Opmerkingen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Motion sickness \u2014 prevention<\/strong><\/td>\n<td>20 mg (2 tablets) 30\u201360 min before travel; repeat 10\u201320 mg every 6\u20138 hours if needed<\/td>\n<td>Take ahead of travel \u2014 once nausea has started, oral absorption is blunted<\/td>\n<\/tr>\n<tr>\n<td><strong>Nausea \/ vomiting<\/strong><\/td>\n<td>10\u201320 mg every 4\u20136 hours as needed<\/td>\n<td>Maximum 100 mg\/day; assess underlying cause<\/td>\n<\/tr>\n<tr>\n<td><strong>Allergic rhinitis \/ urticaria<\/strong><\/td>\n<td>10\u201320 mg up to three times daily<\/td>\n<td>Often a single 20 mg evening dose<\/td>\n<\/tr>\n<tr>\n<td><strong>Short-term sedation<\/strong><\/td>\n<td>20\u201350 mg at bedtime<\/td>\n<td>Not for long-term insomnia \u2014 tolerance and anticholinergic burden build<\/td>\n<\/tr>\n<tr>\n<td><strong>Children 5\u201310 years<\/strong><\/td>\n<td>10\u201320 mg at night for allergy \/ motion sickness<\/td>\n<td>Specialist advice in younger children<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Important \u2014 children under 2 years<\/h3>\n<p>Promethazine is <strong>contraindicated in children under 2 years of age<\/strong>. Fatal cases of respiratory depression have been reported. Use with caution in children aged 2\u20136 years and only at the lowest effective dose.<\/p>\n<\/div>\n<h2 class=\"wp-block-heading\">Bijwerkingen<\/h2>\n<p><strong>Vaak (dosisgerelateerd):<\/strong> drowsiness, dry mouth, blurred vision, urinary hesitancy, mild constipation, dizziness on standing.<\/p>\n<p><strong>Minder vaak:<\/strong> photosensitivity, paradoxical excitation in children, tinnitus, mild tachycardia.<\/p>\n<p><strong>Serious \u2014 seek urgent care:<\/strong> respiratory depression (especially in young children or with opioids\/benzodiazepines), neuroleptic malignant syndrome (rigidity + fever + altered consciousness), acute dystonic reaction (oculogyric crisis, neck spasm \u2014 IV procyclidine reverses), severe orthostatic hypotension, seizures at high doses.<\/p>\n<h2 class=\"wp-block-heading\">Contra-indicaties en waarschuwingen<\/h2>\n<ul>\n<li>Children under 2 years (absolute)<\/li>\n<li>Narrow-angle (closure) glaucoma<\/li>\n<li>Severe benign prostatic hyperplasia or symptomatic urinary retention<\/li>\n<li>Severe respiratory disease \u2014 especially when sedation may worsen ventilation<\/li>\n<li>Gelijktijdig gebruik van MAO-remmers<\/li>\n<li>Older adults (Beers Criteria caution \u2014 anticholinergic burden, falls, delirium)<\/li>\n<li>Driving or operating machinery \u2014 strong sedation persists 6\u201312 hours<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Geneesmiddelinteracties<\/h2>\n<table>\n<thead>\n<tr>\n<th>Interagerend geneesmiddel<\/th>\n<th>Effect<\/th>\n<th>Actie<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Opioids, benzodiazepines, barbiturates, alcohol<\/td>\n<td>Additive CNS + respiratory depression<\/td>\n<td>Avoid combination or reduce both doses<\/td>\n<\/tr>\n<tr>\n<td>Other anticholinergics (TCAs, FGA antipsychotics, antiparkinson agents)<\/td>\n<td>Additive dry mouth, retention, confusion<\/td>\n<td>Avoid stacking; lower elderly dose<\/td>\n<\/tr>\n<tr>\n<td>MAO-remmers<\/td>\n<td>Prolonged anticholinergic + sedative effect<\/td>\n<td>Avoid; 14-day wash-out either side<\/td>\n<\/tr>\n<tr>\n<td>Adrenaline (for hypotension)<\/td>\n<td>Reverse vasopressor effect via alpha block<\/td>\n<td>Use noradrenaline \/ phenylephrine instead<\/td>\n<\/tr>\n<tr>\n<td>Levodopa<\/td>\n<td>D2 antagonism reduces antiparkinson efficacy<\/td>\n<td>Avoid in Parkinson disease \u2014 use ondansetron \/ domperidone<\/td>\n<\/tr>\n<tr>\n<td>QT-prolonging drugs (azithromycin, quinine, amiodarone)<\/td>\n<td>Additive QT signal at high doses<\/td>\n<td>Caution; avoid at higher promethazine doses<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and storage<\/h2>\n<p>Promethazine has a long real-world record of use in pregnancy (NVP and severe nausea) \u2014 historically classified low-risk but, like any medication, the lowest effective dose for the shortest course is preferred and a clinician should make the call. Small amounts pass into breast milk and may sedate the infant; short occasional use is generally acceptable, regular use less so. Store below 30 \u00b0C, protected from light.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">How long before travel should I take Phenergan?<\/h3>\n<p>Take 20 mg (two 10 mg tablets) about 30\u201360 minutes before departure. Once motion sickness has started, gastric stasis blunts oral absorption \u2014 better to take a second dose 6\u20138 hours later than to double-up if symptoms are already severe.<\/p>\n<h3 class=\"wp-block-heading\">Phenergan 10 mg vs Avimax 25 mg \u2014 which should I pick?<\/h3>\n<p>Both are promethazine, just different strengths. The 10 mg tablet (Phenergan) is the better choice for evening allergy management, mild motion sickness, paediatric dosing (over age 2), and any situation where you need finer titration or less sedation. The 25 mg tablet (<a href=\"https:\/\/medsbase.com\/nl\/avimax\/\">Avimax<\/a>) is appropriate for short-haul travel where you do not need to drive at the destination, post-operative nausea, and adult doses where 10 mg has been insufficient.<\/p>\n<h3 class=\"wp-block-heading\">Can I drive after taking Phenergan?<\/h3>\n<p>No. Even at 10 mg promethazine causes meaningful drowsiness and impairs reaction time for at least 6\u201312 hours. Combine that with alcohol or any sedating co-medication and the impairment is much worse. Plan around the dose.<\/p>\n<h3 class=\"wp-block-heading\">Is Phenergan safe in children?<\/h3>\n<p>It is contraindicated below 2 years of age because of fatal respiratory depression in case reports. Use cautiously between 2 and 6 years and only at the lowest effective dose. Children over 5 commonly receive 10\u201320 mg for motion sickness or allergic urticaria.<\/p>\n<h3 class=\"wp-block-heading\">Phenergan vs cetirizine or loratadine \u2014 what is the difference?<\/h3>\n<p>Cetirizine and loratadine are second-generation antihistamines designed to skip the brain \u2014 they relieve allergy without much sedation, but they have no antiemetic or vestibular effect. Promethazine is a first-generation drug that crosses freely into the brain \u2014 it sedates, it suppresses motion sickness, and it stops vomiting. Pick the second-generation drug for ordinary allergy and Phenergan when the sedation or antiemetic action is wanted.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Phenergan with my sleeping tablet or anxiolytic?<\/h3>\n<p>Phenergan adds significantly to the depression of breathing and consciousness produced by zolpidem, benzodiazepines, opioids, gabapentin or alcohol. The combination is not safe at standard doses. Discuss with the prescribing clinician before stacking it on top.<\/p>\n<h3 class=\"wp-block-heading\">Will Phenergan help with vertigo?<\/h3>\n<p>It has some benefit in acute peripheral vertigo because of its anticholinergic vestibular suppression. For chronic Meniere&#8217;s disease or recurrent peripheral vertigo, betahistine (<a href=\"https:\/\/medsbase.com\/nl\/vertin\/\">Vertin<\/a>, <a href=\"https:\/\/medsbase.com\/nl\/betavert\/\">Betavert<\/a>, <a href=\"https:\/\/medsbase.com\/nl\/betavert-tab\/\">Betavert Tab<\/a>) is the more appropriate agent. Promethazine is short-course only \u2014 long-term use slows the brain&#8217;s vestibular compensation.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Phenergan with food or alcohol?<\/h3>\n<p>Food is fine and may reduce stomach upset. Alcohol is not \u2014 it dramatically increases sedation, lowers blood pressure further, and impairs cognition far beyond either drug alone.<\/p>\n<h3 class=\"wp-block-heading\">Is Phenergan safe in pregnancy?<\/h3>\n<p>It has been used in pregnancy for severe nausea and vomiting for many decades and is generally regarded as low risk, but no antiemetic should be taken without medical advice during pregnancy. First-line for nausea and vomiting of pregnancy is <a href=\"https:\/\/medsbase.com\/nl\/doxinate\/\">Doxinate<\/a> (doxylamine + B6).<\/p>\n<h3 class=\"wp-block-heading\">Why does Phenergan dry my mouth?<\/h3>\n<p>Promethazine&#8217;s anticholinergic action reduces saliva, tears and respiratory secretions. Useful for nausea but unpleasant for the mouth. Sip water, chew sugar-free gum, and avoid stacking with other anticholinergic drugs (TCAs, oxybutynin, hyoscine patches).<\/p>\n<h3 class=\"wp-block-heading\">How do I store Phenergan?<\/h3>\n<p>Below 30 \u00b0C in its original pack, protected from light and moisture. Keep out of reach of children \u2014 even a small overdose in a young child can produce serious respiratory depression.<\/p>\n<p class=\"medsbase-link-boost-2026-05-20\" data-marker=\"mb-link-boost-avimax\" style=\"margin:16px 0;padding:12px 16px;background:#f4f8fb;border-left:3px solid #2c7cb0;font-size:14px;line-height:1.6;\">Travellers who find the 10 mg strength of <a href=\"https:\/\/medsbase.com\/nl\/phenergan\/\">Phenergan (promethazine)<\/a> leaves residual nausea on long-haul flights or coach trips usually step up to the higher-dose sibling <a href=\"https:\/\/medsbase.com\/nl\/avimax\/\">Avimax (promethazine 25 mg)<\/a>, taken 30 to 60 minutes before departure for stronger antihistamine antiemetic cover at double the per-tablet potency.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Other Travel Sickness Treatments<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/avimax\/\">Avimax (Promethazine 25 mg) \u2014 same molecule, higher strength<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/diligan\/\">Diligan (Meclizine 25 mg) \u2014 less sedating antihistamine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/draminate\/\">Draminate (Dimenhydrinate 50 mg) \u2014 original Dramamine equivalent<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/vertin\/\">Vertin (Betahistine 8 mg) \u2014 for vestibular vertigo \/ Meniere&#8217;s<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/betavert-tab\/\">Betavert Tab (Betahistine 24 mg) \u2014 full dose Meniere&#8217;s<\/a><\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Medische Disclaimer<\/h2>\n<p><em>This page is for educational purposes and does not replace personalised medical advice. Severe vertigo with hearing loss, neurological deficit, or fluctuating consciousness is not motion sickness \u2014 seek same-day medical assessment. Antihistamines and anticholinergics interact dangerously with alcohol and CNS depressants. Discuss any new medication with a qualified clinician, particularly during pregnancy, breastfeeding, or when taking other drugs.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Nausea relief<br \/>\n\u2705 Vomiting prevention<br \/>\n\u2705 Verlichting van allergiesymptomen<br \/>\n\u2705 Motion sickness treatment<br \/>\n\u2705 Sedation induction<\/p>\n<p>Phenergan contains Promethazine.<\/p>","protected":false},"featured_media":60294,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3448,3449],"product_tag":[4839,4613],"class_list":{"0":"post-60293","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-travel-health-category-overview","8":"product_cat-travel-sickness-tablets","9":"product_tag-phenergan","10":"product_tag-promethazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/60293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=60293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/60294"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=60293"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=60293"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=60293"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=60293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}