<\/p>\n
Saaz<\/strong> is sulfasalazine 500 mg gastro-resistant tablet<\/strong> — a sulfa-linked prodrug of mesalazine (5-aminosalicylic acid) used for mild-to-moderate ulcerative colitis<\/strong> (induction and maintenance), Crohn’s colitis<\/strong>, and as a conventional synthetic DMARD for rheumatoid and juvenile idiopathic arthritis<\/strong>. Colonic bacteria cleave the azo bond, releasing 5-ASA (the active GI moiety) and sulfapyridine (the carrier responsible for most side effects). Standard adult dose: UC 2–4 g\/day in divided doses; RA 2–3 g\/day after slow titration over 4 weeks<\/strong>. WHO-GMP gecertificeerde fabrikant.<\/p>\n<\/div>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n Saaz is supplied from a WHO-GMP gecertificeerde fabrikant<\/strong>. Elke bestelling wordt discreet wereldwijd verzonden en valt onder onze Reshipment Assurance Policy<\/a> — if it does not arrive within 20 business days, we reship at no cost. Sulfasalazine is on the WHO Essential Medicines List for both inflammatory bowel disease and rheumatoid arthritis — it is the most extensively studied conventional DMARD with multi-decade follow-up.<\/p>\n Sulfasalazine is a prodrug: 5-ASA linked to sulfapyridine through an azo (-N=N-) bond. Less than 30 percent is absorbed in the small intestine; the remainder reaches the colon where bacterial azoreductases cleave the bond. 5-ASA<\/strong> acts locally on colonic mucosa via PPAR-γ agonism, COX\/LOX inhibition, NF-κB suppression, and reactive-oxygen scavenging — this is the IBD-relevant action. Sulfapyridine<\/strong> is absorbed systemically and accounts for most side effects (rash, photosensitivity, oligospermia, haematological); in rheumatoid arthritis the systemic sulfapyridine is thought to be the active moiety, modulating cytokine production and folate metabolism.<\/p>\n UC induction:<\/strong> 1–2 g four times daily (max 4 g\/day), reduce to 2 g\/day for maintenance. RA \/ JIA:<\/strong> start 500 mg\/day, increase by 500 mg weekly to 1 g twice daily (max 3 g\/day). Folic acid 5 mg weekly recommended on RA dose. Take with food to reduce GI upset. Hepatic or renal impairment: caution, halve the dose.<\/p>\n Yes — sulfasalazine and its metabolite sulfapyridine are coloured. Urine, sweat, tears, and contact lenses can take an orange-yellow tint. It is harmless and reverses on stopping the drug.<\/p>\n For UC: stool blood and tenesmus often improve within 2–4 weeks; full effect by 8–12 weeks. For RA: it takes 8–12 weeks to feel benefit; do not stop early.<\/p>\n Sulfasalazine inhibits folate absorption and metabolism. Folate deficiency causes megaloblastic anaemia and worsens cytopenia. 5 mg weekly is standard with the RA dose.<\/p>\n Yes — among the safest DMARDs in pregnancy. Continue through pregnancy if needed for IBD or RA. Folic acid supplementation 5 mg\/day is essential. Sulfasalazine causes reversible oligospermia in men and should be stopped 3 months before conception attempts in male partners.<\/p>\n Baseline FBC, LFTs, U&E, and G6PD if of African, Asian, or Mediterranean ancestry. Then FBC and LFTs at 2 weeks, 4 weeks, then 3-monthly for the first year, then 6-monthly thereafter.<\/p>\n Light to moderate alcohol is acceptable; heavy alcohol increases hepatotoxicity. Discuss with the prescriber.<\/p>\n Mesalamine is just the 5-ASA portion without the sulfa carrier. Mesalamine has fewer side effects (no sulfa allergy risk, no oligospermia) but is more expensive. Sulfasalazine is preferred when DMARD effect is needed for joint disease in addition to gut disease.<\/p>\n No. Switch to mesalamine (Asacol, Mesacol, or Pentasa) for IBD; switch to a different DMARD (methotrexate, leflunomide) for arthritis.<\/p>\n Below 30°C in a dry place. Keep tablets in the original blister.<\/p>\n Take it as soon as you remember unless it is close to the next dose. Do not double up.<\/p>\n <\/p>\n Saaz (Sulfasalazine 500 mg gastro-resistant tablet) \u2014 5-ASA prodrug for mild-to-moderate ulcerative colitis, Crohn’s colitis, and conventional synthetic DMARD for rheumatoid and juvenile idiopathic arthritis. WHO Essential Medicine. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":60670,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4902,4682],"class_list":{"0":"post-60669","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-saaz","10":"product_tag-sulfasalazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/60669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=60669"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/60670"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=60669"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=60669"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=60669"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=60669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Waarom bestellen bij MedsBase<\/h3>\n
Waarom bestellen bij MedsBase<\/h3>\n
Werkingsmechanisme<\/h2>\n
Indicaties<\/h2>\n
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Dosering<\/h2>\n
Bijwerkingen<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
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Veelgestelde vragen<\/h2>\n
Will my urine really turn orange?<\/h3>\n
Hoelang duurt het voordat ik verbetering merk?<\/h3>\n
Why do I need folic acid with it?<\/h3>\n
Is het veilig tijdens de zwangerschap?<\/h3>\n
Welke bloedtesten heb ik nodig?<\/h3>\n
Mag ik alcohol drinken tijdens de behandeling?<\/h3>\n
How is it different from mesalamine (Asacol\/Mesacol)?<\/h3>\n
I have a sulfa allergy. Can I take it?<\/h3>\n
Opslag<\/h3>\n
Wat als ik een dosis vergeet?<\/h3>\n
Andere Maag-Darm Gezondheidsmedicijnen<\/h3>\n
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