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Encorate<\/strong> is een 200 mg sodium valproate \/ valproic acid immediate-release tablet<\/strong> from Sun Pharma — an antiepileptic \/ mood-stabiliser \/ migraine preventive. In migraine prevention it is used at 250 mg twice daily, titrated up to 500-1,500 mg\/day in divided doses<\/strong> as a third- or fourth-line preventive after propranolol, topiramate, and amitriptyline. Absolute contraindication in pregnancy and in women of childbearing potential without pregnancy-prevention programme<\/strong> — valproate causes a 10% risk of major congenital malformations (neural tube defects, craniofacial, cardiac, limb, urogenital) and a 30-40% risk of neurodevelopmental impairment (reduced IQ 7-10 points, autism spectrum). The EMA and MHRA have issued progressively stricter prescribing restrictions since 2014. Other important side effects: hepatotoxicity (idiosyncratic; serious rarely fatal), pancreatitis, thrombocytopenia, hyperammonaemia, weight gain, hair loss, tremor, and polycystic ovarian syndrome in women.<\/p>\n<\/div>\n Encorate is an oral immediate-release tablet of sodium valproate \/ valproic acid 200 mg<\/strong> from Sun Pharma, supplied in 30-180 tablet packs. Valproate is a branched short-chain fatty acid originally used as a solvent in pharmaceutical chemistry, later serendipitously discovered to have antiepileptic activity. It has been a first-line anticonvulsant for generalised and partial epilepsy since the 1970s and became the third drug with US FDA approval for migraine prophylaxis in 1996 (after propranolol and timolol).<\/p>\n The immediate-release formulation requires twice- or thrice-daily dosing. For patients who prefer once-daily dosing, consider Encorate Chrono (extended-release)<\/a>.<\/p>\n Valproate works through multiple mechanisms relevant to migraine:<\/p>\n In migraine-prevention trials (Jensen 1994, Mathew 1995, Klapper 1997), valproate 500-1,500 mg\/day reduced monthly migraine frequency by ~50% in about half of treated patients.<\/p>\n Valproate is titrated upward<\/strong> over 2-4 weeks to minimise nausea:<\/p>\n Monitoring:<\/strong><\/p>\n Stopzetting:<\/strong> taper over 2-4 weeks if stopping. In patients with co-existing epilepsy, never stop valproate without neurology input (seizure risk).<\/p>\n Very common (>10%):<\/strong> nausea, dyspepsia, drowsiness, tremor, weight gain, hair thinning \/ hair loss, alopecia (usually transient; hair regrows after dose reduction or stopping).<\/p>\n Vaak (1-10%):<\/strong> ataxia, dizziness, headache, transient elevation of LFTs, thrombocytopenia (usually mild and dose-related), amenorrhoea or irregular menses, polycystic ovarian syndrome (in younger women), decreased libido, peripheral oedema.<\/p>\n Zeldzaam maar ernstig:<\/strong><\/p>\n Borstvoeding:<\/strong> valproate passes into milk in low amounts (milk\/plasma ratio ~0.02). Generally considered acceptable during breastfeeding if the drug is needed; monitor the infant for unusual lethargy or poor feeding.<\/p>\n Store below 25°C in original blister. Protect from moisture. Keep out of reach of children.<\/p>\n Allow 8-12 weeks at target dose for full effect. Keep a migraine diary recording days per month at baseline and at week 12. A clinically meaningful response is a 50% reduction in monthly migraine days.<\/p>\n Nee.<\/strong> Valproate is one of the most teratogenic drugs in clinical use (~10% malformation risk, 30-40% neurodevelopmental impairment risk). Women of childbearing potential should be switched to a safer preventive (propranolol<\/a> is preferred in pregnancy) before conception. A 3-month washout is usually recommended before trying to conceive. Valproate should not be used in women planning or able to become pregnant without a formal pregnancy-prevention programme.<\/p>\n Same molecule (sodium valproate \/ valproic acid), different release profile. Encorate IR is immediate-release, requires twice- or thrice-daily dosing, and has slightly higher peak plasma levels (more nausea, tremor at peak). Encorate Chrono (extended-release)<\/a> allows once-daily dosing with better tolerability.<\/p>\n Yes — weight gain is one of the most common side effects (average 3-5 kg over 6-12 months, more in some). Mechanism includes increased appetite, possibly altered glucose metabolism. If weight gain is problematic, consider switching to topiramate<\/a> (which causes weight loss) or propranolol<\/a> (weight-neutral).<\/p>\n Valproate can cause hepatotoxicity, pancreatitis, thrombocytopenia, and hyperammonaemia. Baseline + periodic LFTs, full blood count, and clinical monitoring catch problems early. Therapeutic drug monitoring (levels 50-100 μg\/mL) is not routinely needed for migraine prevention — dose by clinical response.<\/p>\n Avoid regular or heavy alcohol use. Alcohol is additive with valproate’s sedation and adds to hepatic stress. Occasional small amounts are not absolutely contraindicated but regular drinking raises the risk of hepatotoxicity. Alcohol is also a common migraine trigger; reducing intake often improves migraine independent of valproate.<\/p>\n No — taper over 2-4 weeks. Abrupt discontinuation can trigger rebound migraine and, in patients with any seizure tendency, seizure.<\/p>\n You can buy Encorate (sodium valproate 200 mg immediate-release tablet, 30-180 tablet packs) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n \ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n <\/p>\n Andere producten in Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n Encorate is sodium valproate 200 mg immediate-release tablets from Sun Pharma \u2014 an antiepileptic \/ mood-stabiliser \/ migraine preventive. For migraine prevention: 250 mg twice daily titrated to 500-1,500 mg\/day divided doses. WARNING: Pregnancy Category D \u2014 valproate causes ~10% major congenital malformation risk and 30-40% neurodevelopmental impairment risk. Women of childbearing potential require formal pregnancy-prevention programme.<\/p>","protected":false},"featured_media":61046,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223],"product_tag":[4968,4677],"class_list":{"0":"post-61045","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-encorate","10":"product_tag-sodium-valproate","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/61045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=61045"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/61046"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=61045"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=61045"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=61045"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=61045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What Is Encorate?<\/h2>\n
How Valproate Prevents Migraine<\/h2>\n
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Goedgekeurde Toepassingen<\/h2>\n
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Encorate Dosage for Migraine Prevention<\/h2>\n
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Bijwerkingen<\/h2>\n
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Contra-indicaties<\/h2>\n
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Geneesmiddelinteracties<\/h2>\n
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Opslag<\/h2>\n
Veelgestelde vragen<\/h2>\n
How long until Encorate starts preventing migraines?<\/h3>\n
Is Encorate safe if I am planning pregnancy?<\/h3>\n
Why is the immediate-release form different from Encorate Chrono?<\/h3>\n
Will Encorate make me gain weight?<\/h3>\n
Why do I need blood tests on Encorate?<\/h3>\n
Can I drink alcohol on Encorate?<\/h3>\n
Can I stop Encorate abruptly?<\/h3>\n
Where can I buy Encorate online?<\/h3>\n
Gerelateerde migrainebehandelingen op MedsBase<\/h2>\n
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Waarom bestellen bij MedsBase<\/h3>\n
Gerelateerde alternatieven<\/h3>\n
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