{"id":61084,"date":"2024-02-28T07:23:46","date_gmt":"2024-02-28T07:23:46","guid":{"rendered":"https:\/\/medsname.com\/thioril\/"},"modified":"2026-04-30T10:23:39","modified_gmt":"2026-04-30T10:23:39","slug":"thioril","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/thioril\/","title":{"rendered":"Thioril"},"content":{"rendered":"

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\u26a1 Snel antwoord<\/h3>\n

Thioril (Thioridazine 10 \/ 25 \/ 100 mg) is a first-generation phenothiazine antipsychotic. Reserved as last-resort second-line because of the FDA black-box QT warning.<\/p>\n<\/div>\n

\nWat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde klantbeoordelingen<\/a>\n<\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n

Waarom bestellen bij MedsBase<\/h3>\n

Thioril at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Reshipment Assurance Policy<\/a> \u2014 20 werkdagen levertermijn of wij sturen kosteloos opnieuw \u2014 en komt in aanmerking voor ons klantenloyaliteitsprogramma<\/a>. Wereldwijde verzending is beschikbaar naar de meeste bestemmingen.<\/p>\n

What Thioril is and how it works<\/h2>\n

Thioril is a Thioridazine tablet supplied by Sun Pharma. Available strengths: 10 \/ 25 \/ 100 mg<\/strong>.<\/p>\n

Thioridazine is a piperidine phenothiazine. It carries an FDA black-box warning for fatal QT prolongation and torsades de pointes<\/strong> and is now reserved as a last-resort second-line antipsychotic \u2014 it was withdrawn or restricted in many jurisdictions in 2000\u20132005. Atypical antipsychotics are preferred for nearly all current indications.<\/p>\n

Indicaties en dosering<\/h2>\n

Reserved for treatment-refractory schizophrenia where atypicals and other typicals have failed. Adult: 50\u2013100 mg TID, max 800 mg\/day. Pre-treatment ECG and electrolyte correction required. Some jurisdictions now require continuous QT monitoring during the first weeks.<\/p>\n

Belangrijke veiligheidsoverwegingen<\/h2>\n
\nFDA black-box \u2014 fatal QT and torsades<\/strong><\/p>\n

Thioridazine carries an FDA black-box warning for dose-dependent QT prolongation and torsades de pointes.<\/strong> Reports of sudden cardiac death at therapeutic doses. Pre-treatment ECG mandatory.<\/strong> Contraindicated in known long QT, conduction abnormality, hypokalaemia, hypomagnesaemia, on other QT-prolonging therapy, in CYP2D6 poor metabolisers, and in concurrent strong CYP2D6 inhibitors (paroxetine, fluoxetine, bupropion, quinidine \u2014 all dramatically raise thioridazine levels). Many regulatory agencies have withdrawn thioridazine from the market or restricted to last-resort use; switch to a safer atypical wherever clinically possible<\/strong>.<\/p>\n<\/div>\n

\nAnticholinergische belasting, sedatie, orthostatische hypotensie<\/strong><\/p>\n

Alle fenothiazines hebben aanzienlijke anticholinergische, antihistaminische en \u03b11-blokkerende activiteit. Vooral problematisch bij ouderen - vallen, delirium, urineretentie en obstipatie komen vaak voor. Vermijd bij dementie, BPH, nauwe kamerhoekglaucoom, ernstige leverziekte.<\/p>\n<\/div>\n

\nFotogevoeligheid en huidpigmentatie<\/strong><\/p>\n

Fenothiazines veroorzaken fotosensitiviteit (ernstige zonnebrand) en, bij langdurig gebruik, blauw-grijze huidpigmentatie, en zelden lens-\/hoornvliespigmentatie (vooral chloorpromazine). Zonnebescherming is verplicht.<\/p>\n<\/div>\n

Veelvoorkomende bijwerkingen<\/h2>\n