{"id":61224,"date":"2024-02-28T07:30:24","date_gmt":"2024-02-28T07:30:24","guid":{"rendered":"https:\/\/medsname.com\/tridon\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"tridon","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/tridon\/","title":{"rendered":"Tridon"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Tridon?<\/h3>\n<div style=\"margin:0;\">\n<p style=\"margin:0;\"><strong>Tridon<\/strong> bevat <strong>trazodone hydrochloride (100 mg)<\/strong> from a WHO-GMP certified manufacturer (Intas Pharmaceuticals) &mdash; a <strong>SARI<\/strong> antidepressant whose primary modern use is <strong>insomnia at low dose (25&ndash;100 mg at bedtime)<\/strong> rather than depression. Mechanism: 5-HT<sub>2A<\/sub> antagonism plus weak SRI plus alpha-1 antagonism plus H<sub>1<\/sub> antagonism &mdash; the 5-HT<sub>2A<\/sub>\/H<sub>1<\/sub>\/alpha-1 combination drives sedation. <strong>Antidepressant doses (150&ndash;400 mg\/day)<\/strong> are uncommon today &mdash; SSRIs and SNRIs largely replaced trazodone for MDD. Off-label insomnia is its dominant use. Important warnings: <strong>priapism<\/strong> (rare, 1 in 1,000&ndash;10,000 &mdash; emergency if &gt; 4 h), orthostatic hypotension (alpha-1), QT prolongation at high doses. Very <strong>safe in overdose<\/strong> compared to TCAs.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Wat u krijgt bij MedsBase:<\/strong> WHO-GMP gecertificeerde fabrikant \u00b7 Discrete verpakking \u00b7 Wereldwijde verzending \u00b7 1.400+ geverifieerde <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen \u2014 geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor \u2014 nooit \u201cMedsBase\u201d of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>Important &mdash; this is not a situational-anxiety medication.<\/strong> Tridon is a <strong>serotonin antagonist and reuptake inhibitor (SARI)<\/strong>, prescribed and titrated over weeks for <strong>major depressive disorder (MDD); off-label widely used at low dose for chronic insomnia<\/strong>. It is <strong>niet<\/strong> the right drug for acute, performance-related anxiety (flying, public speaking, exams) &mdash; for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>FDA black-box warning &mdash; suicidality.<\/strong> All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.<\/div>\n<h2 class=\"wp-block-heading\">What Is Tridon?<\/h2>\n<p>Tridon is an oral tablet of <strong>trazodone hydrochloride (100 mg)<\/strong> manufactured by Intas Pharmaceuticals. Trazodone (US brand <strong>Desyrel<\/strong>) is a <strong>serotonin antagonist and reuptake inhibitor (SARI)<\/strong> introduced in 1981. It blocks 5-HT<sub>2A<\/sub> receptors potently, weakly inhibits the serotonin transporter, and antagonises alpha-1 adrenergic and H<sub>1<\/sub> histamine receptors. The combination is heavily sedating &mdash; which is why trazodone has become predominantly an off-label hypnotic rather than an antidepressant in modern practice.<\/p>\n<h2 class=\"wp-block-heading\">Indicaties<\/h2>\n<ul>\n<li><strong>Major depressieve stoornis<\/strong> &mdash; on-label, but uncommon today (SSRIs \/ SNRIs are first-line)<\/li>\n<li><strong>Insomnia (off-label, low-dose)<\/strong> &mdash; the most common modern use; 25&ndash;100 mg at bedtime<\/li>\n<li>Off-label adjuncts: SSRI-induced insomnia, anxiety with insomnia, agitation in dementia (used with caution)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosering<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Indicatie<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Start<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Typical<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Maximum<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Opmerkingen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Insomnia (off-label)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50&ndash;100 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">150 mg voor het slapengaan<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Most commonly used dose range; effective hypnotic without significant antidepressant action<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">MDD (on-label)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50&ndash;75 mg\/day in divided doses<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">150&ndash;400 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">600 mg\/day inpatient<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Daytime divided doses for antidepressant effect; sedation often prohibitive<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Elderly insomnia<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">100 mg<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Caution &mdash; orthostasis and falls<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Leverfunctiestoornis<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Reduce by 25&ndash;50%<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Langzamere titratie<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Bijwerkingen<\/h2>\n<h2 class=\"wp-block-heading\">Side-effect profile<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Frequentie<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Effect<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Opmerkingen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vaak voorkomend<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Sedation, drowsiness<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">The point of off-label hypnotic use; problematic for daytime dosing<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vaak voorkomend<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Orthostatische hypotensie, duizeligheid<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Alpha-1 blockade &mdash; falls risk in elderly<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vaak voorkomend<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Dry mouth, blurred vision<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Mild anticholinergic<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vaak voorkomend<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Misselijkheid, braken<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014 verbetert de verdraagzaamheid van metformine.<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Minder vaak voorkomend<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Headache, nasal congestion<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Alpha-1 blockade<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Minder vaak voorkomend<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Weight gain (modest)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Less than mirtazapine or paroxetine<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Zeldzaam<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Priapism (1 in 1,000&ndash;10,000)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Persistent erection &gt; 4 h is a urological emergency &mdash; mechanism is alpha-1 blockade interfering with detumescence; men should be counselled and report immediately<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Zeldzaam<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">QT-verlenging<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Dose-related; caution with other QT-prolonging drugs<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Zeldzaam<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Serotoninesyndroom<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">See interactions<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Geneesmiddelinteracties<\/h2>\n<p><strong>Absolute contraindications<\/strong>: MAOIs (14-day washout).<\/p>\n<p><strong>Additive sedation<\/strong>: alcohol, benzodiazepines, opioids, antihistamines, sedating antipsychotics &mdash; main interaction concern in older adults.<\/p>\n<p><strong>QT-verlenging<\/strong>: caution with citalopram (high dose), ondansetron, methadone, fluoroquinolones.<\/p>\n<p><strong>CYP3A4 substrate<\/strong>: levels rise with strong inhibitors (ketoconazole, ritonavir, clarithromycin) &mdash; reduce dose or avoid.<\/p>\n<p><strong>Antihypertensiva<\/strong>: additive orthostasis with alpha-blockers, doxazosin, prazosin, terazosin.<\/p>\n<h2 class=\"wp-block-heading\">Why Trazodone for Insomnia?<\/h2>\n<p>Trazodone has become the most-prescribed off-label sleep medication in many countries despite very thin formal sleep-disorder evidence. The reasons are pragmatic:<\/p>\n<ul>\n<li>Heavy sedation at low dose (25&ndash;100 mg)<\/li>\n<li>No physiological dependence or rebound insomnia (unlike benzodiazepines \/ Z-drugs)<\/li>\n<li>No DEA scheduling<\/li>\n<li>Low overdose toxicity<\/li>\n<li>Generic and inexpensive<\/li>\n<li>Useful when SSRI-induced insomnia complicates depression treatment<\/li>\n<\/ul>\n<p>Limitations: orthostatic falls (especially in older adults), priapism risk in men, and limited objective data on sleep-architecture preservation. Daytime grogginess can persist with low-dose 100 mg use.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3 class=\"wp-block-heading\">How long does Tridon take to work for sleep?<\/h3>\n<p>Sedation begins within 1&ndash;2 hours of taking the dose. Take 30 minutes before intended bedtime.<\/p>\n<h3 class=\"wp-block-heading\">Will Tridon help with depression at low dose?<\/h3>\n<p>No &mdash; antidepressant effect requires 150&ndash;400 mg\/day in divided doses. Bedtime 25&ndash;100 mg is purely a hypnotic dose.<\/p>\n<h3 class=\"wp-block-heading\">Is Tridon safer than zolpidem (Ambien) or benzodiazepines for sleep?<\/h3>\n<p>Different risk profile. Trazodone has no dependence potential and far lower overdose risk, but more orthostasis, falls, priapism (rare), and daytime grogginess. The right choice depends on patient age, fall risk, sex (priapism in men), and history of substance use.<\/p>\n<h3 class=\"wp-block-heading\">What is priapism and how worried should I be?<\/h3>\n<p>Priapism is a persistent erection unrelieved by ejaculation, usually painful, lasting more than 4 hours. It is a urological emergency &mdash; without prompt treatment, permanent erectile dysfunction can result. Trazodone-related priapism is rare (1 in 1,000&ndash;10,000) but real. Men starting trazodone should be told to seek emergency care for any erection lasting more than 4 hours.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Tridon?<\/h3>\n<p>Avoid &mdash; additive sedation and orthostasis. Combining trazodone with alcohol significantly increases sedation and fall risk.<\/p>\n<h3 class=\"wp-block-heading\">Does Tridon cause sexual dysfunction?<\/h3>\n<p>Less than SSRIs. Mechanism is different &mdash; the 5-HT<sub>2A<\/sub> blockade does not cause SSRI-style sexual side effects. Priapism in men is the rare specific concern.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Tridon abruptly?<\/h3>\n<p>Better to taper, but discontinuation syndrome is much milder than SSRIs \/ SNRIs. Tapering over 1&ndash;2 weeks is usually sufficient.<\/p>\n<h3 class=\"wp-block-heading\">Is Tridon safe in pregnancy?<\/h3>\n<p>Limited data &mdash; not first-line. Discuss individually with the prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Can Tridon cause weight gain?<\/h3>\n<p>Modest weight gain over months &mdash; less than mirtazapine, paroxetine, or olanzapine. Not a major concern at hypnotic doses.<\/p>\n<h3 class=\"wp-block-heading\">How should Tridon be stored?<\/h3>\n<p>Store at 15&ndash;30 &deg;C in the original blister packaging away from moisture and sunlight. Keep out of reach of children &mdash; trazodone is much safer in overdose than TCAs but still medically significant.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;font-size:13.5px;line-height:1.55;\"><strong>Medische disclaimer:<\/strong> Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Gerelateerde alternatieven<\/h3>\n<p>Andere producten in <strong>Chronische aandoeningen<\/strong> die klanten ook bekijken:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/methycobal-injection\/\">Methycobal Injectie<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/cosart\/\">Cosart<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/tavin-em\/\">Tavin EM<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/ventab-xl\/\">Ventab XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/bacloheal\/\">Bacloheal<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Treats depression<br \/>\n\u2705 Manages anxiety<br \/>\n\u2705 Improves sleep quality<br \/>\n\u2705 Relieves insomnia<br \/>\n\u2705 Enhances mood<\/p>\n<p>Tridon contains Trazodone Hydrochloride.<\/p>","protected":false},"featured_media":61225,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,4647],"product_tag":[4719,4999,5000],"class_list":{"0":"post-61224","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-situational-anxiety-treatment","9":"product_tag-trazodone","10":"product_tag-trazodone-hydrochloride","11":"product_tag-tridon","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/61224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=61224"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/61225"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=61224"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=61224"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=61224"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=61224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}