{"id":65535,"date":"2025-01-18T10:49:18","date_gmt":"2025-01-18T10:49:18","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=65535"},"modified":"2026-04-30T10:23:28","modified_gmt":"2026-04-30T10:23:28","slug":"restfine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/restfine\/","title":{"rendered":"Restfine"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1; border-left:4px solid #f5a623; padding:14px 18px; margin:0 0 18px 0;\">\n<h3 style=\"margin-top:0;\"><strong>Snelle antwoord<\/strong><\/h3>\n<p><strong>Restfine<\/strong> bevat <strong>melatonin 10 mg<\/strong> \u2014 a high-dose formulation of the body&#8217;s natural sleep-onset hormone. The 10 mg strength is best suited to <strong>delayed sleep-phase disorder, severe shift work, age over 55<\/strong>, or patients who haven&#8217;t responded to lower doses. For typical adult insomnia, clinical evidence supports starting at 1\u20133 mg taken 30\u201360 minutes before bedtime \u2014 higher doses do not consistently improve outcomes and may cause more morning grogginess and vivid dreams.<\/p>\n<p><strong>Begin:<\/strong> 30\u201360 minutes. <strong>Indicatie:<\/strong> short-term insomnia, jet lag, delayed sleep-phase disorder, shift work, blind non-24-hour sleep-wake disorder. <strong>Not for:<\/strong> chronic insomnia (CBT-I is first-line), pregnancy or breastfeeding without specialist input, autoimmune disease without specialist supervision.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8; border-radius:6px; padding:14px 18px; margin:18px 0; display:flex; flex-wrap:wrap; gap:18px; font-size:14px;\">\n<span>\u2705 <strong>WHO-GMP gecertificeerd<\/strong> manufacturer<\/span><br \/>\n<span>\ud83d\udce6 Discrete verpakking<\/span><br \/>\n<span>\ud83c\udf0d Wereldwijde verzending<\/span><br \/>\n<span>\u2b50 <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">1.400+ klantbeoordelingen<\/a><\/span>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<ul>\n<li><strong>WHO-GMP gecertificeerde fabrikant<\/strong> \u2014 quality-controlled finished tablets, batch-traceable.<\/li>\n<li><strong>Discrete verpakking<\/strong> \u2014 plain envelope, no medication or pharmacy text on the outside.<\/li>\n<li><strong>Reshipment Assurance<\/strong> \u2014 every order covered (see policy for terms).<\/li>\n<li><strong>Wereldwijde verzending<\/strong> with multiple courier options.<\/li>\n<li><strong>1.400+ klantbeoordelingen<\/strong> across 8 years of trading.<\/li>\n<\/ul>\n<div style=\"background:#fff8e1; border-left:4px solid #f5a623; padding:14px 18px; margin:18px 0;\">\n<h3 style=\"margin-top:0;\">Important \u2014 high-dose formulation<\/h3>\n<p>Restfine is <strong>10 mg melatonin<\/strong>. Endogenous melatonin peaks at roughly 60\u201370 picograms per millilitre overnight; a single 10 mg dose produces serum levels several hundred times physiological. <strong>For typical adult insomnia, 0.5\u20133 mg is as effective as 5\u201310 mg in head-to-head trials<\/strong> (Brzezinski 2005 meta-analysis; Buscemi 2005 systematic review for AHRQ) and is associated with less next-morning grogginess and fewer vivid dreams.<\/p>\n<p>Reasonable indications for staying at 10 mg:<\/p>\n<ul>\n<li><strong>Delayed sleep-phase disorder<\/strong> (DSPD) where lower doses gave inadequate phase-shift in a clinical trial.<\/li>\n<li><strong>Age over 55<\/strong> with measured low endogenous melatonin and inadequate response to 2 mg prolonged-release formulations.<\/li>\n<li><strong>Severe shift work<\/strong> requiring deep daytime sleep.<\/li>\n<li><strong>Tumour-related sleep disturbance<\/strong> where higher doses are sometimes used under specialist supervision.<\/li>\n<\/ul>\n<p>If you are using melatonin for typical insomnia and are new to it, <strong>quarter or half the tablet<\/strong> to start at 2.5\u20135 mg and only go higher if needed. Meloset (3 mg, Sun Pharma) is our lower-dose option.<\/p>\n<\/div>\n<h3>How melatonin works<\/h3>\n<p>Melatonin is a hormone secreted by the pineal gland in response to darkness. It binds to MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN) \u2014 the master circadian pacemaker in the hypothalamus. MT1 activation reduces wake drive (sleep onset), MT2 activation phase-shifts the circadian clock. Unlike GABA-A agonists (Z-drugs, benzodiazepines), melatonin does not produce general CNS depression, does not impair memory consolidation, does not cause physical dependence, and does not impair next-day cognitive performance at standard doses.<\/p>\n<p>The phase-shifting role is why timing matters. Melatonin taken at bedtime advances onset (helps with falling asleep). Melatonin taken in the late afternoon advances the entire circadian phase (helps with delayed sleep-phase disorder and eastward jet lag). Taken in the early morning, it delays the phase (helps with westward jet lag and advanced sleep-phase disorder).<\/p>\n<h3>Dosering per indicatie<\/h3>\n<table style=\"width:100%; border-collapse:collapse; margin:12px 0; font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0; color:#fff;\">\n<th style=\"padding:8px; text-align:left;\">Indicatie<\/th>\n<th style=\"padding:8px;\">Dosering<\/th>\n<th style=\"padding:8px;\">Timing<\/th>\n<th style=\"padding:8px;\">Duur<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;\">Short-term insomnia (adults &lt; 55)<\/td>\n<td style=\"padding:8px; text-align:center;\">1\u20133 mg (start with quarter or half tablet)<\/td>\n<td style=\"padding:8px;\">30\u201360 min before bed<\/td>\n<td style=\"padding:8px;\">1\u20132 weken<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Insomnia age 55+<\/td>\n<td style=\"padding:8px; text-align:center;\">2 mg PR or 5\u201310 mg IR<\/td>\n<td style=\"padding:8px;\">1\u20132 hours before bed<\/td>\n<td style=\"padding:8px;\">up to 13 weeks (NICE)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Delayed sleep-phase disorder<\/td>\n<td style=\"padding:8px; text-align:center;\">0.5\u20135 mg (titrate)<\/td>\n<td style=\"padding:8px;\">4\u20136 hours before desired sleep onset<\/td>\n<td style=\"padding:8px;\">onder begeleiding van een specialist<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Eastward jet lag (\u2265 5 time zones)<\/td>\n<td style=\"padding:8px; text-align:center;\">2\u20135 mg<\/td>\n<td style=\"padding:8px;\">local bedtime at destination, 2\u20134 nights<\/td>\n<td style=\"padding:8px;\">until adapted<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Shift-work sleep disorder<\/td>\n<td style=\"padding:8px; text-align:center;\">1\u201310 mg<\/td>\n<td style=\"padding:8px;\">before daytime sleep period<\/td>\n<td style=\"padding:8px;\">while on rotation<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Non-24-hour sleep-wake (blind patients)<\/td>\n<td style=\"padding:8px; text-align:center;\">0.5\u201310 mg<\/td>\n<td style=\"padding:8px;\">fixed clock time daily<\/td>\n<td style=\"padding:8px;\">indefinite, specialist-led<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>PR = prolonged-release. IR = immediate-release. Restfine is an immediate-release tablet.<\/em><\/p>\n<h3>Bijwerkingen<\/h3>\n<p><strong>Common (typically mild and self-limiting):<\/strong> drowsiness or grogginess on waking, headache, mild dizziness, nausea, vivid dreams. Vivid dreams are dose-related \u2014 stepping down from 10 mg to 3 mg usually resolves them. Daytime sleepiness suggests the dose is too high or taken too late.<\/p>\n<p><strong>Minder vaak:<\/strong> low mood transient (especially in patients with seasonal affective tendencies), reduced libido, mild blood-pressure changes (both directions reported), gastrointestinal upset, irritability, joint discomfort.<\/p>\n<p><strong>Zeldzaam maar belangrijk:<\/strong> seizures (lower threshold reported in patients with epilepsy \u2014 caution and specialist input), allergic skin reactions, autoimmune flare in patients with rheumatoid arthritis or lupus.<\/p>\n<h3>Geneesmiddelinteracties<\/h3>\n<table style=\"width:100%; border-collapse:collapse; margin:12px 0; font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0; color:#fff;\">\n<th style=\"padding:8px; text-align:left;\">Geneesmiddelklasse<\/th>\n<th style=\"padding:8px;\">Interactie<\/th>\n<th style=\"padding:8px;\">Actie<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;\">Fluvoxamine (SSRI)<\/td>\n<td style=\"padding:8px;\">CYP1A2 inhibition raises melatonin levels 17-fold<\/td>\n<td style=\"padding:8px;\">avoid combination \u2014 substitute another SSRI<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Warfarine<\/td>\n<td style=\"padding:8px;\">case reports of raised INR<\/td>\n<td style=\"padding:8px;\">monitor INR after starting or stopping<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Diabetes medication (insulin, sulfonylureas)<\/td>\n<td style=\"padding:8px;\">melatonin reduces insulin secretion overnight<\/td>\n<td style=\"padding:8px;\">monitor fasting glucose; specialist input in T1DM<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Antihypertensiva<\/td>\n<td style=\"padding:8px;\">may potentiate effect of nifedipine; may raise BP with some agents<\/td>\n<td style=\"padding:8px;\">monitor BP at start of treatment<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Immunosuppressants (ciclosporin, methotrexate)<\/td>\n<td style=\"padding:8px;\">melatonin has immunostimulant effects<\/td>\n<td style=\"padding:8px;\">avoid in solid-organ transplant or active autoimmune disease<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Gecombineerd oraal anticonceptivum<\/td>\n<td style=\"padding:8px;\">CYP1A2 inhibition raises melatonin levels<\/td>\n<td style=\"padding:8px;\">consider lower melatonin dose<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Cafe\u00efne<\/td>\n<td style=\"padding:8px;\">caffeine inhibits melatonin metabolism mildly; both also CYP1A2 substrates<\/td>\n<td style=\"padding:8px;\">avoid caffeine within 6 hours of bedtime regardless<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;\">Benzodiazepines, Z-drugs, alcohol, opioids<\/td>\n<td style=\"padding:8px;\">additive sedation<\/td>\n<td style=\"padding:8px;\">avoid combining; do not drink alcohol with melatonin<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;\">Anticonvulsants<\/td>\n<td style=\"padding:8px;\">may lower seizure threshold (case reports)<\/td>\n<td style=\"padding:8px;\">specialist input in epilepsy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Contra-indicaties en waarschuwingen<\/h3>\n<ul>\n<li><strong>Zwangerschap en borstvoeding<\/strong> \u2014 safety not established; avoid unless specialist-supervised.<\/li>\n<li><strong>Active autoimmune disease<\/strong> (RA, lupus, MS, IBD) \u2014 melatonin has immunostimulant effects; specialist input required.<\/li>\n<li><strong>Solid-organ transplant on immunosuppression<\/strong> \u2014 avoid.<\/li>\n<li><strong>Ernstige leverfunctiestoornis<\/strong> \u2014 accumulation; reduce dose or avoid.<\/li>\n<li><strong>Epilepsy<\/strong> \u2014 case reports of lowered seizure threshold; specialist input.<\/li>\n<li><strong>Children and adolescents under 18<\/strong> \u2014 only under specialist paediatric supervision (used in autism spectrum sleep disturbance; not for typical childhood insomnia).<\/li>\n<li><strong>Driving or operating machinery<\/strong> \u2014 do not drive within 8 hours of dose, particularly in the first few nights.<\/li>\n<li><strong>Alcohol<\/strong> \u2014 avoid; potentiates sedation and blunts melatonin&#8217;s circadian effect.<\/li>\n<\/ul>\n<h3>Opslag<\/h3>\n<p>Store at 15\u201330\u00b0C (room temperature) in the original blister, away from direct sunlight, heat, and humidity. Do not refrigerate. Keep out of reach of children. Do not use after the expiry date printed on the strip.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>Is 10 mg melatonin too high for typical insomnia?<\/h3>\n<p>For most adults under 55 with typical short-term insomnia, yes \u2014 0.5\u20133 mg has the same sleep-onset effect with less morning grogginess and fewer vivid dreams. Use 10 mg if lower doses haven&#8217;t worked, for delayed sleep-phase disorder under specialist input, for severe shift work, or for age 55+ with confirmed low endogenous melatonin.<\/p>\n<h3>Can I split a Restfine tablet in half?<\/h3>\n<p>Yes. Restfine is an immediate-release uncoated tablet \u2014 splitting in half gives ~5 mg, in quarters gives ~2.5 mg. Use a tablet splitter for accuracy. Do not crush or chew if you find the taste unpleasant \u2014 it is bitter.<\/p>\n<h3>How long does melatonin take to work?<\/h3>\n<p>30\u201360 minutes for sleep onset. Peak plasma concentration is roughly 60 minutes after an oral immediate-release dose; half-life is 30\u201350 minutes. The phase-shifting effect on circadian rhythm builds over several nights.<\/p>\n<h3>Is melatonin habit-forming?<\/h3>\n<p>No. Melatonin does not cause physical dependence, tolerance, or rebound insomnia in standard short-term use. This is its main advantage over benzodiazepines and Z-drugs (zolpidem, zopiclone). Long-term use (more than 3 months) has less evidence and should be reviewed with your doctor periodically.<\/p>\n<h3>Can I take melatonin with alcohol?<\/h3>\n<p>No. Alcohol fragments sleep architecture, suppresses REM, and disrupts the circadian rhythm \u2014 the opposite of what melatonin is trying to do. The combination produces additive next-day grogginess without improving sleep quality.<\/p>\n<h3>Will melatonin help with chronic insomnia (more than 3 months)?<\/h3>\n<p>Modestly at best. The most effective long-term treatment for chronic insomnia is cognitive-behavioural therapy for insomnia (CBT-I), not pharmacotherapy. Online programmes are widely available. If insomnia persists despite CBT-I and good sleep hygiene, sleep-medicine review can identify contributors (sleep apnoea, restless legs, depression, perimenopause).<\/p>\n<h3>Does melatonin work for jet lag?<\/h3>\n<p>Yes \u2014 particularly for eastward travel across 5+ time zones. Take 2\u20135 mg at local bedtime at the destination for 2\u20134 nights. Westward travel responds less to melatonin (the body adapts more easily to delaying the clock than advancing it). Combine with bright daylight exposure at the destination.<\/p>\n<h3>Can I take melatonin for shift work?<\/h3>\n<p>Yes \u2014 melatonin before the daytime sleep period helps shift workers consolidate sleep. The challenge is finding the right time: it is roughly the start of your &ldquo;biological night&rdquo;, which depends on your shift pattern. Avoid taking before driving home from a night shift \u2014 wait until you are at home and ready for bed.<\/p>\n<h3>Does melatonin interact with my contraceptive pill?<\/h3>\n<p>Combined oral contraceptives raise endogenous melatonin levels by about 20% via CYP1A2 inhibition. This usually does not require a melatonin dose change, but if you are sensitive to morning grogginess on melatonin, consider stepping down from 10 mg to 3 mg.<\/p>\n<h3>Can melatonin trigger an autoimmune flare?<\/h3>\n<p>It can. Melatonin has immunostimulant effects \u2014 useful in some research settings but a problem in active rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease. Get specialist input before using melatonin if you have any active autoimmune condition.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3>Other sleep aids and hypnotic medications<\/h3>\n<p>Medications below treat the same indication via different mechanisms. Choice depends on age, comorbid depression or anxiety, and how short-term or long-term the use will be.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/nl\/meloset\/\"><strong>Meloset (Melatonin 3 mg)<\/strong><\/a> \u2014 standard-dose melatonin (Sun Pharma).<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/trazalon\/\"><strong>Trazalon (Trazodone 50 mg)<\/strong><\/a> \u2014 off-label low-dose hypnotic \u2014 most-prescribed off-label sleep aid globally.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/mirzacan\/\"><strong>Mirzacan (Mirtazapine 30 mg)<\/strong><\/a> \u2014 sedating tetracyclic antidepressant \u2014 useful when depression and insomnia coexist.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/spectra\/\"><strong>Spectra (Doxepin)<\/strong><\/a> \u2014 low-dose doxepin (3\u20136 mg) for sleep-maintenance insomnia in older adults.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/nl\/atarax\/\"><strong>Atarax (Hydroxyzine 25 mg)<\/strong><\/a> \u2014 sedating antihistamine for short-term anxiety-related insomnia.<\/li>\n<\/ul>\n<h3>Medische disclaimer<\/h3>\n<p>This page is for educational purposes and does not replace personalised medical advice. Persistent insomnia (more than 3 months) warrants evaluation for underlying causes \u2014 depression, anxiety, sleep apnoea, restless legs, chronic pain, perimenopause, hyperthyroidism. Cognitive-behavioural therapy for insomnia (CBT-I) is the most effective long-term intervention. Speak with your healthcare provider before starting, stopping, or combining sleep aids \u2014 particularly if you take warfarin, diabetes medication, immunosuppressants, fluvoxamine, or oral contraceptives, or if you have an autoimmune condition. If insomnia is paired with persistent low mood, hopelessness, or thoughts of self-harm, contact a crisis line (US 988, UK Samaritans 116 123, or <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).<\/p>","protected":false},"excerpt":{"rendered":"<p>Restfine (melatonin 10 mg) \u2014 high-dose pineal-hormone tablet for delayed sleep-phase disorder, severe shift work, and age 55+ insomnia. Non-addictive, no rebound; lower-dose Meloset 3 mg available for typical adult insomnia.<\/p>","protected":false},"featured_media":65536,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3887],"product_tag":[3888,5346],"class_list":{"0":"post-65535","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-sleeping-tablets","7":"product_tag-melatonin","8":"product_tag-restfine","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/65535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=65535"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/65536"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=65535"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=65535"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=65535"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=65535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}