{"id":66875,"date":"2025-05-07T20:12:54","date_gmt":"2025-05-07T20:12:54","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=66875"},"modified":"2026-04-30T10:23:27","modified_gmt":"2026-04-30T10:23:27","slug":"l-glutathione-250mg","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/l-glutathione-250mg\/","title":{"rendered":"L-Glutathione 250mg"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:0 0 18px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">Snelle antwoord<\/h3>\n<p><strong>L-Glutathione 250mg<\/strong> is reduced glutathione (GSH) in free form \u2014 the body&#8217;s master intracellular antioxidant. Each capsule supplies 250 mg. Typical adult use is 250\u2013500 mg once or twice daily for antioxidant support, hepatic detox adjunct, and skin pigmentation interest. Taken with food. Not a substitute for prescription liver therapy in diagnosed hepatic disease.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e1e4e8;border-radius:4px;padding:14px 18px;margin:18px 0;display:flex;flex-wrap:wrap;gap:14px;font-size:0.95em;\"><span>\u2705 <strong>WHO-GMP gecertificeerd<\/strong> fabrikant<\/span><span>\ud83d\udce6 <strong>Discrete verpakking<\/strong><\/span><span>\ud83c\udf0d <strong>Wereldwijde verzending<\/strong><\/span><span>\ud83d\udcac <a href=\"\/nl\/reviews\/\">1.400+ klantbeoordelingen<\/a><\/span><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<h2>What L-Glutathione is<\/h2>\n<p>Glutathione is a tripeptide of glutamate, cysteine and glycine, synthesised by every cell in the body. It is the dominant intracellular antioxidant \u2014 the GSH\/GSSG redox pair maintains cellular reducing capacity, regenerates vitamin C and vitamin E from their oxidised forms, and serves as a co-substrate for glutathione peroxidases (which detoxify peroxides) and glutathione S-transferases (which conjugate xenobiotics for biliary excretion).<\/p>\n<p>The 250 mg capsule supplies <strong>reduced (GSH) free-form L-glutathione<\/strong>, not oxidised glutathione (GSSG) and not glutathione precursors (NAC, glycine). This matters because oral GSH bioavailability has historically been controversial: gastric peptidases hydrolyse a fraction of the dose, but human pharmacokinetic studies (Allen 2011; Richie 2015) show that sustained 250\u20131,000 mg\/day oral GSH measurably raises whole-blood GSH levels at 1\u20136 months.<\/p>\n<h2>Indications and supportive evidence<\/h2>\n<ul>\n<li><strong>Antioxidant support<\/strong> \u2014 general nutritional adjunct in oxidative stress states (intense training, smoking cessation, ageing).<\/li>\n<li><strong>Hepatic detoxification adjunct<\/strong> \u2014 supports phase-II conjugation in mild-to-moderate steatosis, alcohol-related hepatic strain, paracetamol-induced subclinical liver irritation. <strong>Niet<\/strong> a substitute for medical care in diagnosed liver disease.<\/li>\n<li><strong>Skin pigmentation interest<\/strong> \u2014 oral glutathione is widely used in cosmetic dermatology for tyrosinase modulation and dyschromia. The clinical evidence is mixed (Sonthalia 2018 review): some studies show modest melanin-index reduction at 250\u2013500 mg\/day over 4\u201312 weeks; others show no consistent effect. Effect size is smaller and slower than topical hydroquinone or tretinoin.<\/li>\n<li><strong>Adjunct in PCOS, insulin resistance and metabolic syndrome<\/strong> \u2014 small studies suggest improved insulin sensitivity markers; not a primary therapy.<\/li>\n<\/ul>\n<h2>Typical dosing<\/h2>\n<table>\n<thead>\n<tr>\n<th>Gebruik<\/th>\n<th>Dosering<\/th>\n<th>Duur<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>General antioxidant<\/td>\n<td>250 mg once or twice daily<\/td>\n<td>Voortdurend<\/td>\n<\/tr>\n<tr>\n<td>Hepatic adjunct<\/td>\n<td>500 mg once or twice daily<\/td>\n<td>3\u20136 months, then reassess<\/td>\n<\/tr>\n<tr>\n<td>Skin \/ pigmentation interest<\/td>\n<td>500 mg\/day with vitamin C 500\u20131,000 mg<\/td>\n<td>Min 4\u201312 weeks for any visible change<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Take with a meal containing fat for absorption. Vitamin C 500\u20131,000 mg\/day commonly co-prescribed because ascorbate regenerates GSH from GSSG and is consumed in parallel.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">What this is NOT<\/h3>\n<p>This product is <strong>oral glutathione<\/strong>. Black-market <strong>intravenous glutathione<\/strong> for skin lightening has caused fatal Stevens-Johnson syndrome, toxic epidermal necrolysis, kidney injury and lead-contamination outbreaks (Philippines 2011, Korea 2014). The Philippine FDA and US FDA have repeatedly warned against IV glutathione for non-medical use. We do not supply or recommend it.<\/p>\n<\/div>\n<h2>Bijwerkingen<\/h2>\n<p>Oral glutathione is well tolerated. Reported effects: mild bloating, abdominal cramping, occasional loose stool. Rare allergic reactions. Long-term oral use up to 1 g\/day for 6 months has not produced safety signals.<\/p>\n<h2>Interactions and special populations<\/h2>\n<ul>\n<li>Pregnancy \/ breastfeeding \u2014 not enough data; avoid unless advised by a clinician.<\/li>\n<li>Asthma \u2014 case reports of nebulised (not oral) glutathione triggering bronchospasm in sulphite-sensitive asthmatics. Oral capsules do not contain free sulphite.<\/li>\n<li>Chemotherapy \u2014 the GSH\/GSSG axis interacts with many cytotoxic agents (cisplatin, doxorubicin). Discuss with oncology before adding any antioxidant.<\/li>\n<\/ul>\n<h2>Opslag<\/h2>\n<p>Store below 30 \u00b0C in a dry place, original blister\/bottle. Glutathione oxidises with humidity exposure \u2014 keep desiccant intact.<\/p>\n<h3>Waarom bestellen bij MedsBase<\/h3>\n<p>L-Glutathione 250mg is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our <a href=\"\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>. Your statement descriptor when paying by card shows the regulated payment processor (a regulated card-payment processor), never &quot;MedsBase&quot; or any medication name.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>Does oral L-glutathione actually raise blood glutathione levels?<\/h3>\n<p>Yes, in sustained dosing. Whole-blood GSH rises measurably after 1\u20136 months at 250\u20131,000 mg\/day in human studies (Richie 2015 EJCN). Single doses produce only transient peaks. Daily dosing is what works.<\/p>\n<h3>How long until I see skin-tone changes if I am using it for pigmentation?<\/h3>\n<p>Plan for at least 4\u201312 weeks. Effect size is modest and gradual. Combine with daily SPF 50, vitamin C 500\u20131,000 mg, and treat any underlying cause (UV exposure, hormonal melasma, post-inflammatory hyperpigmentation). Topical agents (hydroquinone, azelaic, tretinoin) act faster and more strongly.<\/p>\n<h3>Is intravenous glutathione for skin lightening safe?<\/h3>\n<p>No. IV glutathione for cosmetic skin lightening is not approved by the FDA, EMA, or Philippine FDA. Reported harms include Stevens-Johnson syndrome, toxic epidermal necrolysis, acute kidney injury, thyroid dysfunction and lead contamination from unregulated compounding. We strongly advise against it.<\/p>\n<h3>How does L-glutathione differ from N-acetylcysteine (NAC)?<\/h3>\n<p>NAC is a precursor \u2014 the body converts it to cysteine and then to glutathione. NAC is cheaper, has stronger evidence for paracetamol overdose (intravenous), and is better studied. Direct GSH supplementation bypasses the conversion step but has historically had lower oral bioavailability. Both are used; in practice, daily oral GSH 250\u2013500 mg or NAC 600 mg is the common range.<\/p>\n<h3>Can I take it with vitamin C?<\/h3>\n<p>Yes \u2014 they are commonly combined. Vitamin C regenerates oxidised glutathione (GSSG) back to active GSH and is depleted in parallel. 500\u20131,000 mg\/day vitamin C is typical alongside.<\/p>\n<h3>Will glutathione cause any laboratory abnormalities?<\/h3>\n<p>No clinically significant abnormalities at oral 250\u2013500 mg\/day. Some labs note a small drop in plasma cysteine and slight rise in whole-blood GSH on long-term use.<\/p>\n<h3>Kan ik het gebruiken tijdens de zwangerschap?<\/h3>\n<p>Insufficient safety data. Avoid in pregnancy and breastfeeding unless your clinician has specifically advised it.<\/p>\n<h3>Do I need to take it on an empty stomach?<\/h3>\n<p>Take with a meal containing some fat. Stomach acid degrades a fraction of any oral peptide, but absorption is more reliable with food.<\/p>\n<h3>How does this product compare to liposomal glutathione?<\/h3>\n<p>Liposomal GSH is encapsulated in phospholipid spheres for improved gastrointestinal absorption, with some PK studies showing higher whole-blood GSH at lower doses. The 250 mg standard capsule format works at higher daily totals (500\u20131,000 mg) and at a fraction of the price; the choice is mostly cost vs convenience.<\/p>\n<h3>Can I open the capsule and mix into food?<\/h3>\n<p>Yes \u2014 the contents are an off-white powder. Mix into yogurt, smoothies or juice. Take immediately after mixing because dissolved GSH oxidises within minutes.<\/p>\n<h2>Other Antioxidant &#038; Skin Care Products<\/h2>\n<ul>\n<li><a href=\"\/nl\/vitamins-and-minerals\/\">Andere Vitamines &amp; Mineralen<\/a><\/li>\n<li><a href=\"\/nl\/melanorm-cream\/\">Melanorm Cream (hydroquinone 2%) \u2014 direct topical depigmentation<\/a><\/li>\n<li><a href=\"\/nl\/skinlite-cream\/\">Skinlite Cream (Kligman triple, HQ 2%) \u2014 multi-modal<\/a><\/li>\n<li><a href=\"\/nl\/skinshine-cream\/\">Skinshine Cream (Kligman triple, HQ 4%) \u2014 stronger triple<\/a><\/li>\n<li><a href=\"\/nl\/eflora-cream\/\">Eflora Cream (eflornithine) \u2014 facial-hair adjunct<\/a><\/li>\n<li><a href=\"\/nl\/celin\/\">Celin (vitamin C 500 mg) \u2014 antioxidant pair for GSH regeneration<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 8px 0;font-size:1.05em;\">Medische Disclaimer<\/h3>\n<p style=\"margin:0;\">This information is provided for educational purposes only and is not a substitute for medical advice. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Supports detoxification process<br \/>\n\u2705 Promotes healthier skin<br \/>\n\u2705 Enhances immune function<br \/>\n\u2705 Reduces oxidative stress<br \/>\n\u2705 Improves cellular repair<\/p>\n<p>Contains\u00a0<strong>L-Glutathione 250mg<\/strong> (reduced) (Free form).<\/p>","protected":false},"featured_media":66876,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[3667,4442],"class_list":{"0":"post-66875","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-glutathione","10":"product_tag-l-glutathione","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/66875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=66875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/66876"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=66875"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=66875"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=66875"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=66875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}