{"id":69013,"date":"2026-03-13T11:58:53","date_gmt":"2026-03-13T11:58:53","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=69013"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"kpv-lysine-proline-valine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/kpv-lysine-proline-valine\/","title":{"rendered":"KPV (Lysine-Proline-Valine)"},"content":{"rendered":"

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Quick Answer \u2014 What is KPV?<\/h3>\n

KPV<\/strong> is the Lys-Pro-Val tripeptide \u2014 the C-terminal anti-inflammatory fragment of alpha-melanocyte stimulating hormone (\u03b1-MSH). Unlike broader melanocortin analogs, KPV has no pigmentation activity<\/strong>; its research signal is purely anti-inflammatory via NFkB inhibition and mast-cell stabilization. Studied for IBD, allergic inflammation, and skin-inflammation research. Supplied in 5\u00a0mg and 10\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n

Wat u krijgt bij MedsBase:<\/strong> Onderzoekskwaliteit lyofiliseerde peptiden \u00b7 HPLC \u226599% zuiverheid (COA op aanvraag) \u00b7 Discrete temperatuurstabiele verpakking \u00b7 Wereldwijde peptidekoerier \u00b7 1.400+ geverifieerd klantbeoordelingen<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specificatie<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS-nummer<\/strong><\/td>\n67727-97-3<\/td>\n<\/tr>\n
Molecuulformule<\/strong><\/td>\nC16<\/sub>H30<\/sub>N4<\/sub>O4<\/sub><\/td>\n<\/tr>\n
Moleculair gewicht<\/strong><\/td>\n342.43 Da<\/td>\n<\/tr>\n
Sequentie<\/strong><\/td>\nLys-Pro-Val (\u03b1-MSH 11\u201313)<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLyofiliseerd poeder (of zoals geleverd)<\/td>\n<\/tr>\n
Zuiverheid<\/strong><\/td>\n\u226599% (HPLC geverifieerd, COA op aanvraag)<\/td>\n<\/tr>\n
Opslag<\/strong><\/td>\nLyofiliseerd: 2\u20138 \u00b0C (koelkast) voor werkvoorraad; \u221220 \u00b0C voor langdurige opslag van ongeopende flesjes. Gereconstitueerd: 2\u20138 \u00b0C, gebruik binnen ~30 dagen. Bescherm tegen licht. Vries de gereconstitueerde oplossing niet in en ontdooi deze niet.<\/td>\n<\/tr>\n
Oplosbaarheid<\/strong><\/td>\nBacteriostatisch water (aanbevolen) of steriel water voor kortere gebruiksperioden<\/td>\n<\/tr>\n
Onderzoeksgebruik<\/strong><\/td>\nAlleen voor laboratoriumonderzoek. Niet voor humaan of veterinair diagnostisch of therapeutisch gebruik.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is KPV?<\/h2>\n

KPV<\/strong> is the three-letter one-letter-code shorthand for the Lys-Pro-Val tripeptide<\/strong> \u2014 the C-terminal three amino acids (positions 11\u201313) of alpha-melanocyte stimulating hormone (\u03b1-MSH). In the 1980s\u20131990s, multiple research groups noticed that the full \u03b1-MSH molecule produced two functionally separable effects: the well-known N-terminal MC-receptor pigmentation\/arousal activity, and a C-terminal anti-inflammatory<\/strong> activity. When the C-terminal KPV tripeptide was synthesised and tested in isolation, it reproduced the anti-inflammatory effects without the pigmentation side-effects.<\/p>\n

Molecular weight approximately 342.4\u00a0Da. KPV is one of the smallest peptides in the melanocortin family and one of the most-studied anti-inflammatory research tripeptides. It is supplied as a high-purity lyophilized powder. KPV is uitsluitend voor laboratoriumonderzoek<\/strong> and is not intended for human or veterinary diagnosis or therapy. For mechanism, IBD research history, and stacking context, see our KPV research guide<\/a>.<\/p>\n

Mechanism of Action \u2014 Three Anti-Inflammatory Pathways<\/h2>\n

KPV’s anti-inflammatory activity operates through at least three complementary pathways, all of which converge on reducing inflammatory signaling without affecting other melanocortin functions:<\/p>\n