{"id":70705,"date":"2026-05-12T09:29:41","date_gmt":"2026-05-12T09:29:41","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=70705"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"oxytocin-acetate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/oxytocin-acetate\/","title":{"rendered":"Oxytocine Acetaat"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Quick Answer \u2014 What is Oxytocin Acetate?<\/h3>\n<p style=\"margin: 0;\"><strong>Oxytocine Acetaat<\/strong> is the acetate-salt form of oxytocin, a 9-amino-acid cyclic neuropeptide with a single disulfide bridge between Cys1 and Cys6. It is one of the oldest and most extensively studied neuropeptides in published research, acting as both a hypothalamic hormone (uterine contraction, milk ejection) and a central neuromodulator of social bonding, trust, and affiliative behaviour. Supplied in 5\u00a0mg and 10\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Wat u krijgt bij MedsBase:<\/strong> Onderzoekskwaliteit lyofiliseerde peptiden \u00b7 HPLC \u226599% zuiverheid (COA op aanvraag) \u00b7 Discrete temperatuurstabiele verpakking \u00b7 Wereldwijde peptidekoerier \u00b7 1.400+ geverifieerd <a href=\"https:\/\/medsbase.com\/nl\/reviews\/\">klantbeoordelingen<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Elke bestelling is gedekt door onze <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">Specificatie<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS-nummer<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">50-56-6 (oxytocin free base); supplied as the acetate salt form<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Molecuulformule<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>43<\/sub>H<sub>66<\/sub>N<sub>12<\/sub>O<sub>12<\/sub>S<sub>2<\/sub> (free base; acetate salt adds CH<sub>3<\/sub>COOH counterion)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Moleculair gewicht<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">1007.19 Da (free base)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Sequentie<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH<sub>2<\/sub> (CYIQNCPLG-NH<sub>2<\/sub>, 9 amino acids; intramolecular disulfide bridge Cys<sup>1<\/sup>\u2013Cys<sup>6<\/sup> forming a 6-residue macrocyclic ring with a 3-residue C-terminal tail; C-terminus amidated)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Form<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyophilized acetate salt (white to off-white powder)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Zuiverheid<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC geverifieerd, COA op aanvraag)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Opslag<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofiliseerd: 2\u20138 \u00b0C (koelkast) voor werkvoorraad; \u221220 \u00b0C voor langdurige opslag van ongeopende flesjes. Gereconstitueerd: 2\u20138 \u00b0C, gebruik binnen ~30 dagen. Bescherm tegen licht. Vries de gereconstitueerde oplossing niet in en ontdooi deze niet.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Oplosbaarheid<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Bacteriostatic water (recommended) or sterile water for shorter use windows. Compatible with intranasal vehicle research formulations.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Onderzoeksgebruik<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Alleen voor laboratoriumonderzoek. Niet voor humaan of veterinair diagnostisch of therapeutisch gebruik.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>What Is Oxytocin Acetate?<\/h2>\n<p><strong>Oxytocine Acetaat<\/strong> is the acetate-salt form of oxytocin, a 9-amino-acid cyclic neuropeptide first isolated by Sir Henry Dale in 1906 and chemically synthesised by Vincent du Vigneaud in 1953 \u2014 the first peptide hormone ever produced by total synthesis, work that earned du Vigneaud the 1955 Nobel Prize in Chemistry. The acetate counterion is used in research-grade lyophilization because it improves long-term peptide stability and water solubility relative to free-base oxytocin without altering pharmacology \u2014 the acetate dissociates rapidly in physiological solution.<\/p>\n<p>The well-characterised sequence is CYIQNCPLG-NH<sub>2<\/sub> with an intramolecular disulfide bridge between Cys1 and Cys6 that creates a 6-residue macrocyclic ring and a 3-residue C-terminal tail. Molecular weight is 1007.19\u00a0Da (free base); empirical formula C<sub>43<\/sub>H<sub>66<\/sub>N<sub>12<\/sub>O<sub>12<\/sub>S<sub>2<\/sub>. Oxytocin is supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. Pharmaceutical oxytocin is FDA-approved as an injectable obstetric medication (Pitocin, Syntocinon) for labour induction and postpartum haemorrhage control; the research-grade oxytocin acetate sold here is supplied <strong>uitsluitend voor laboratoriumonderzoek<\/strong> and is not FDA-approved for human or veterinary administration. For related small-peptide CNS research, see our <a href=\"https:\/\/medsbase.com\/nl\/selank\/\">Selank<\/a> en <a href=\"https:\/\/medsbase.com\/nl\/pt-141\/\">PT-141<\/a> productpagina's.<\/p>\n<h2>Mechanism of Action \u2014 Peripheral Endocrine and Central Neuromodulator Roles<\/h2>\n<p>What makes oxytocin unusual among research peptides is its <strong>dual identity<\/strong> as both a peripheral endocrine hormone and a central neuromodulator. The same molecule, released from different anatomical compartments, produces fundamentally different physiological effects:<\/p>\n<ul>\n<li><strong>Peripheral endocrine release \u2014 uterine and mammary effects<\/strong> \u2014 Oxytocin is synthesised in magnocellular neurons of the supraoptic and paraventricular hypothalamic nuclei and released into systemic circulation from the posterior pituitary. Peripheral oxytocin binds OXTR receptors on uterine smooth muscle (stimulating contractions during labour) and on myoepithelial cells of the mammary alveoli (driving the milk-ejection reflex). The peripheral half-life is short (~3\u20135 minutes IV) due to rapid metabolism by oxytocinase and other peptidases.<\/li>\n<li><strong>Central release \u2014 social, affiliative, and stress-buffering behaviour<\/strong> \u2014 A separate population of parvocellular oxytocin neurons projects axonally into brain regions including the amygdala, nucleus accumbens, ventral tegmental area, and prefrontal cortex. Central oxytocin release does not enter systemic circulation and is not measured by plasma assays. In published research it modulates pair-bonding, in-group affiliation, trust, fear extinction, and stress reactivity. The prairie-vole pair-bonding literature is the canonical mechanistic dataset for central oxytocin signalling.<\/li>\n<li><strong>Receptor pharmacology and signal transduction<\/strong> \u2014 Oxytocin acts on a single G-protein-coupled receptor (OXTR), which couples primarily to G\u03b1<sub>q\/11<\/sub> to activate phospholipase C, IP<sub>3<\/sub>, and intracellular calcium release in smooth muscle. In the CNS, OXTR signalling is more complex and includes G\u03b1<sub>i\/o<\/sub> coupling, modulation of GABAergic interneurons, and crosstalk with the closely-related vasopressin V1a receptor. Selective OXTR agonists and antagonists are heavily used in current research to dissect oxytocin vs vasopressin contributions to behaviour.<\/li>\n<\/ul>\n<p>The intranasal administration route is one of the most-cited research delivery methods because it produces measurable CNS effects on social behaviour without raising peripheral plasma oxytocin to physiologically meaningful levels. The exact mechanism by which intranasal oxytocin reaches CNS compartments \u2014 whether through olfactory and trigeminal nerve transport, cribriform plate diffusion, or a peripheral feedback signal \u2014 remains an active research question. The behavioural effects are reproducible enough that intranasal administration has become the standard route in human and rodent oxytocin behavioural research.<\/p>\n<h2>Gepubliceerde onderzoeksapplicaties<\/h2>\n<p>Oxytocin Acetate is used in laboratory research contexts that investigate:<\/p>\n<ul>\n<li><strong>Social behaviour and pair-bonding<\/strong> \u2014 prairie vole partner-preference tests, partner-preference formation in monogamous vs polygamous voles, social-recognition paradigms in rodents (Insel &amp; Hulihan, Behav Neurosci 1995; Young &amp; Wang, Nat Neurosci 2004)<\/li>\n<li><strong>Autism spectrum and social-cognition research<\/strong> \u2014 preclinical models of social-deficit phenotypes, OXTR variant cohort studies, intranasal oxytocin behavioural endpoints; one of the most active areas of contemporary oxytocin clinical research<\/li>\n<li><strong>Trust and cooperation behavioural research<\/strong> \u2014 trust-game economic paradigms, cooperative decision-making under uncertainty; in-group vs out-group bias modulation<\/li>\n<li><strong>Stress, anxiety, and fear extinction<\/strong> \u2014 amygdala-dependent fear conditioning, stress-induced HPA-axis activation, cortisol response modulation in published research<\/li>\n<li><strong>Maternal behaviour and parental care<\/strong> \u2014 postpartum maternal-behaviour induction in rodents, paternal-care research in monogamous vole species, alloparental behaviour<\/li>\n<li><strong>Reproductive physiology research<\/strong> \u2014 uterine contractility assays, mammary myoepithelial-cell research, labour and parturition mechanism studies<\/li>\n<li><strong>Wound healing and tissue regeneration<\/strong> \u2014 OXTR expression on dermal fibroblasts and keratinocytes; emerging research on local oxytocin signalling in cutaneous wound repair<\/li>\n<li><strong>Comparative neuropeptide research<\/strong> \u2014 benchmarking against vasopressin (closely related 9-aa cyclic neuropeptide with one amino-acid difference) and against other small CNS-active peptides such as <a href=\"https:\/\/medsbase.com\/nl\/selank\/\">Selank<\/a>.<\/li>\n<\/ul>\n<p>For broader context on where oxytocin fits within the small-peptide neuromodulator landscape, see <a href=\"https:\/\/medsbase.com\/nl\/selank\/\">Selank<\/a> (anxiolytic heptapeptide), <a href=\"https:\/\/medsbase.com\/nl\/pt-141\/\">PT-141<\/a> (CNS-active melanocortin agonist), and <a href=\"https:\/\/medsbase.com\/nl\/semax\/\">Semax<\/a> (nootropic heptapeptide). Browse the full <a href=\"https:\/\/medsbase.com\/nl\/peptides\/\">onderzoekspeptiden catalogus<\/a> voor gerelateerde verbindingen.<\/p>\n<h2>Beschikbare sterktes en concentraties<\/h2>\n<p>MedsBase stocks Oxytocin Acetate in two lyophilized vial sizes calibrated to typical research protocol lengths. Each strength is available in 10-vial or 20-vial pack formats with full reconstitution guidance:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Vulsterkte<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Typisch Onderzoeksgebruik<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Verpakkingsgroottes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standard research strength, intranasal-vehicle formulation, behavioural-test protocols<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 of 20 flesjes<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Extended-cycle research, lowest per-mg cost, multi-cohort behavioural studies<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 of 20 flesjes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Both strengths are the same chemical form (lyophilized acetate-salt powder, 99%+ HPLC purity). Because oxytocin&#8217;s research dose range is in the low-microgram-per-administration regime, a single 5\u00a0mg vial supports many weeks of behavioural research at typical intranasal doses (24\u00a0IU \u2248 40\u00a0mcg per administration in human research, with rodent doses scaled lower).<\/p>\n<h2>How It Compares \u2014 Oxytocin Acetate vs Selank<\/h2>\n<p>Oxytocin and <a href=\"https:\/\/medsbase.com\/nl\/selank\/\">Selank<\/a> are both small CNS-active peptides used in behavioural and mood-axis research, but they target different receptors and behavioural domains. They are sometimes compared in research because both are intranasally bioavailable and both produce measurable behavioural effects in published rodent and human studies despite being structurally and pharmacologically unrelated.<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Criterium<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Oxytocine Acetaat<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Selank<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Lengte<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">9 amino acids (cyclic nonapeptide)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">7 amino acids (linear heptapeptide)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Structure<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Disulfide-bridged macrocycle<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Linear with amidated C-terminus<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Primary receptor<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">OXTR (G-protein-coupled)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Non-classical (GABA modulation, BDNF)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Behavioural signal<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Social bonding, trust, affiliative behaviour<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Anxiolytic, stress resilience<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typical research dose (intranasal)<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">24\u201340\u00a0IU (~40\u201365\u00a0mcg)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">300\u2013900\u00a0mcg<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Plasma half-life<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~3\u20135 min (IV)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~15\u201330 min (intranasal)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Approved clinical use<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Labour induction, postpartum haemorrhage<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Anxiolytic (Russia only)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>For behavioural-research stacking, the two peptides have non-overlapping mechanisms (oxytocin acts on its own GPCR; Selank acts via GABA\/BDNF modulation), so co-administration is not pharmacologically redundant. Research protocols studying stress and social behaviour as joint endpoints sometimes use both arms.<\/p>\n<h2>Opslag en Reconstituering<\/h2>\n<p><strong>Voor reconstituering:<\/strong> store lyophilized vials refrigerated at 2\u20138\u00a0\u00b0C in original packaging for short-term working stock. For unopened long-term storage, freeze at \u221220\u00a0\u00b0C. Lyophilized oxytocin acetate is stable under refrigeration for up to 24 months and at \u221220\u00a0\u00b0C for up to 36 months. Avoid freeze-thaw cycles on the lyophilized powder. The acetate-salt form is more hygroscopically stable than the free base, but vials should still be protected from atmospheric humidity.<\/p>\n<p><strong>Reconstitueringsprocedure:<\/strong> inject bacteriostatic water down the side wall of the peptide vial (not directly onto the lyophilized cake). For a 5\u00a0mg vial, 5.0\u00a0mL of bacteriostatic water yields a 1\u00a0mg\/mL working concentration; 0.04\u00a0mL delivers a 40\u00a0mcg research dose (~24\u00a0IU). Swirl gently \u2014 do <strong>niet<\/strong> shake \u2014 and allow 2\u20135 minutes for full dissolution. A correctly reconstituted solution should be clear and colourless. For intranasal-vehicle research formulations, the reconstituted solution can be transferred to a calibrated nasal-spray bottle delivering ~100\u00a0\u03bcL per pump.<\/p>\n<p><strong>Na reconstitutie:<\/strong> store refrigerated at 2\u20138\u00a0\u00b0C and use within 30 days for optimal stability. Do not freeze the reconstituted solution \u2014 freeze-thaw cycles degrade peptide integrity and disrupt the Cys1\u2013Cys6 disulfide bond. Discard any vial showing cloudiness, precipitate, or discolouration.<\/p>\n<h2 id=\"faqs\">Veelgestelde vragen<\/h2>\n<h3>What is Oxytocin Acetate used for in research?<\/h3>\n<p>Oxytocin Acetate is used in laboratory research investigating social behaviour and pair-bonding, autism spectrum and social cognition, trust and cooperation paradigms, stress and fear extinction, maternal and parental care, reproductive physiology, and wound healing. It is one of the most extensively studied neuropeptides in the published literature and serves as the canonical OXTR-axis research compound. The research-grade oxytocin acetate sold here is <strong>niet<\/strong> FDA-approved for non-clinical human use and is supplied strictly for laboratory research.<\/p>\n<h3>What is the difference between oxytocin acetate and free-base oxytocin?<\/h3>\n<p>The acetate counterion does not alter pharmacology \u2014 it dissociates rapidly in physiological solution. The acetate salt is used in research-grade peptide lyophilization because it improves long-term peptide stability, reduces hygroscopicity, and improves aqueous solubility relative to free-base oxytocin. All published behavioural and endocrine effects of oxytocin apply to the acetate salt at equivalent oxytocin content.<\/p>\n<h3>How is Oxytocin different from Selank?<\/h3>\n<p>Both are small CNS-active peptides used in behavioural research, but they target different receptors and behavioural domains. Oxytocin is a 9-amino-acid disulfide-bridged macrocyclic peptide that binds the OXTR G-protein-coupled receptor, with primary research signal in social bonding and trust paradigms. Selank is a 7-amino-acid linear heptapeptide that acts via GABA modulation and BDNF expression, with primary research signal in anxiolysis and stress resilience. The two are pharmacologically unrelated.<\/p>\n<h3>What is the typical Oxytocin research dose?<\/h3>\n<p>Published human intranasal research protocols typically use 24\u201340\u00a0IU per administration (1\u00a0IU \u2248 1.7\u00a0mcg, so 24\u00a0IU \u2248 40\u00a0mcg). Rodent doses are scaled lower in absolute mass but higher in mg\/kg. A 5\u00a0mg vial reconstituted with 5.0\u00a0mL bacteriostatic water yields 1\u00a0mg\/mL \u2014 40\u00a0mcg per 0.04\u00a0mL.<\/p>\n<h3>Is Oxytocin Acetate FDA approved?<\/h3>\n<p>Pharmaceutical injectable oxytocin (Pitocin, Syntocinon) is FDA-approved for specific obstetric indications \u2014 labour induction, postpartum haemorrhage control, and milk-letdown facilitation \u2014 manufactured to GMP standards by approved pharmaceutical manufacturers. The research-grade oxytocin acetate sold here is a separate product supplied for laboratory research only and is <strong>niet<\/strong> FDA-approved for human or veterinary use outside those obstetric indications.<\/p>\n<h3>How should Oxytocin Acetate be stored?<\/h3>\n<p>Lyophilized vials: refrigerated at 2\u20138\u00a0\u00b0C for short-term working stock, or \u221220\u00a0\u00b0C for long-term storage of unopened vials. Reconstituted solution: refrigerated at 2\u20138\u00a0\u00b0C, use within 30 days. Do not freeze reconstituted solution \u2014 freeze-thaw cycles degrade the peptide and can disrupt the disulfide bridge. Protect from direct light at all times.<\/p>\n<h3>How do I reconstitute Oxytocin Acetate?<\/h3>\n<p>Volg de hierboven beschreven reconstitutieprocedure. Voeg bacteriostatisch water toe langs de zijkant van het flesje (niet rechtstreeks op het gevriesdroogde poeder), draai voorzichtig en laat 2\u20135 minuten staan voor volledige oplossing. Schud <strong>niet<\/strong> shake the vial \u2014 vigorous agitation can disrupt the disulfide bond. A correctly reconstituted solution is clear and colourless. For a 5\u00a0mg vial + 5.0\u00a0mL diluent, the working concentration is 1\u00a0mg\/mL.<\/p>\n<h3>Welke sterktes heeft MedsBase op voorraad?<\/h3>\n<p>MedsBase carries Oxytocin Acetate in 5\u00a0mg and 10\u00a0mg lyophilized vials. Each strength is available in 10-vial or 20-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis available on request.<\/p>\n<h3>Can Oxytocin be administered intranasally in research?<\/h3>\n<p>Yes \u2014 intranasal administration is one of the most-cited research delivery routes for oxytocin behavioural studies. Intranasal oxytocin produces measurable CNS effects on social behaviour, trust, and stress reactivity without raising peripheral plasma oxytocin to physiologically meaningful levels. The exact mechanism of CNS access remains an active research question (olfactory and trigeminal nerve transport, cribriform plate diffusion, or peripheral feedback). Subcutaneous and intracerebroventricular routes are also documented in rodent research.<\/p>\n<h3>What is the half-life of Oxytocin?<\/h3>\n<p>In published research, oxytocin has a plasma half-life of approximately 3\u20135 minutes following intravenous administration. The short peripheral half-life is due to rapid metabolism by oxytocinase (also called cystinyl aminopeptidase) and other peptidases. Behavioural effects following intranasal administration outlast plasma clearance because central oxytocin compartments are distinct from peripheral circulation.<\/p>\n<h3>Why is the disulfide bridge important?<\/h3>\n<p>The Cys1\u2013Cys6 disulfide bond locks oxytocin into the cyclic conformation required for receptor binding. Reduction of the disulfide bond converts oxytocin into an inactive linear form \u2014 this is why reconstitution procedures specifically avoid vigorous shaking and freeze-thaw cycles, which can disrupt the bridge and degrade peptide activity. The closely-related neuropeptide vasopressin has the same disulfide-bridge architecture with only one amino-acid difference at position 3 (Phe in vasopressin vs Ile in oxytocin).<\/p>\n<h3>Does Oxytocin cause side effects in research?<\/h3>\n<p>The most consistent finding in oxytocin research is dose-dependence of behavioural effects \u2014 the response is not monotonic at high doses, and very large doses can produce paradoxical effects. Acute peripheral effects can include uterine contraction (relevant in pregnancy research models) and modest vasoactive effects at supraphysiological doses. Long-term behavioural research has reported context-dependent effects \u2014 e.g., increased in-group affiliation can be accompanied by increased out-group bias in some social-cognition paradigms.<\/p>\n<h3>How long does Oxytocin take to show effects in preclinical research?<\/h3>\n<p>Acute behavioural effects on social-recognition, partner-preference, and trust-game paradigms are detectable within 30\u201360 minutes of intranasal administration in human and rodent research. Peripheral effects (uterine contraction, milk-ejection) occur within seconds of intravenous administration due to direct OXTR coupling to PLC\/IP<sub>3<\/sub>\/Ca<sup>2+<\/sup> signalling.<\/p>\n<h3>Can I order Oxytocin Acetate for international shipping?<\/h3>\n<p>Yes. MedsBase ships Oxytocin Acetate worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. All orders ship in temperature-controlled packaging with full tracking and are covered by our <a href=\"https:\/\/medsbase.com\/nl\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Peptides for CNS, Behavioural, and Affective Research<\/h2>\n<ul>\n<li><a href=\"\/nl\/selank\/\"><strong>Selank<\/strong><\/a> \u2014 Anxiolytisch heptapeptide tuftsin analoog \u2014 GABA\/BDNF stressbestendigheidsonderzoek<\/li>\n<li><a href=\"\/nl\/semax\/\"><strong>Semax<\/strong><\/a> \u2014 Russisch ontwikkeld nootropisch heptapeptide \u2014 melanocortine en dopaminerge modulatie<\/li>\n<li><a href=\"\/nl\/pt-141\/\"><strong>PT-141 (Bremelanotide)<\/strong><\/a> \u2014 Melanocortin receptor agonist \u2014 CNS-active small peptide for sexual-behaviour research<\/li>\n<li><a href=\"\/nl\/epitalon\/\"><strong>Epitalon<\/strong><\/a> \u2014 AEDG pineal tetrapeptide \u2014 longevity and circadian research<\/li>\n<li><a href=\"\/nl\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Body Protection Compound \u2014 tissue-recovery research<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>Verder lezen<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Explore CNS-active research peptides<\/strong><\/p>\n<p style=\"margin: 0;\">Bekijk het volledige <a href=\"https:\/\/medsbase.com\/nl\/peptides\/\"><strong>onderzoekspeptiden catalogus<\/strong><\/a>, met verwante verbindingen inclusief <a href=\"https:\/\/medsbase.com\/nl\/selank\/\">Selank<\/a> for anxiolytic GABA-axis research, <a href=\"https:\/\/medsbase.com\/nl\/semax\/\">Semax<\/a> for nootropic melanocortin-axis research, and <a href=\"https:\/\/medsbase.com\/nl\/pt-141\/\">PT-141<\/a> for melanocortin sexual-behaviour research.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 9-amino-acid cyclic neuropeptide<br \/>\n\u2705 OXTR receptor agonist<br \/>\n\u2705 Social-bonding &amp; affiliative behavioural research<br \/>\n\u2705 Intranasally bioavailable peptide<br \/>\n\u2705 Acetate salt form \u2014 improved stability<\/p>\n<p><strong>Oxytocine Acetaat<\/strong> bevat synthetisch peptideverbinding.<\/p>","protected":false},"featured_media":70970,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6274,5441],"class_list":{"0":"post-70705","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-oxytocin","8":"product_tag-peptide","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product\/70705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/comments?post=70705"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media\/70970"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/media?parent=70705"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_brand?post=70705"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat?post=70705"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_tag?post=70705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}