{"id":70723,"date":"2026-05-12T09:57:27","date_gmt":"2026-05-12T09:57:27","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70723"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"kisspeptin-10","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/kisspeptin-10\/","title":{"rendered":"Kisspeptine-10"},"content":{"rendered":"

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Quick Answer \u2014 What is Kisspeptin-10?<\/h3>\n

Kisspeptine-10<\/strong> (KP-10) is a 10-amino-acid C-terminally amidated peptide and the most-studied active fragment of the KISS1 gene product. It is the apical endogenous regulator of GnRH neuronal activity \u2014 published research established it as the upstream switch that initiates puberty and drives pulsatile gonadotropin release. Acts via the GPR54 (KISS1R) G-protein-coupled receptor. Supplied in 5\u00a0mg and 10\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n

Wat u krijgt bij MedsBase:<\/strong> Onderzoekskwaliteit lyofiliseerde peptiden \u00b7 HPLC \u226599% zuiverheid (COA op aanvraag) \u00b7 Discrete temperatuurstabiele verpakking \u00b7 Wereldwijde peptidekoerier \u00b7 1.400+ geverifieerd klantbeoordelingen<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specificatie<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS-nummer<\/strong><\/td>\n374675-21-5 (kisspeptin-10, human)<\/td>\n<\/tr>\n
Molecuulformule<\/strong><\/td>\nC63<\/sub>H83<\/sub>N17<\/sub>O14<\/sub><\/td>\n<\/tr>\n
Moleculair gewicht<\/strong><\/td>\n1302.45 Da<\/td>\n<\/tr>\n
Sequentie<\/strong><\/td>\nTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2<\/sub> (YNWNSFGLRF-NH2<\/sub>, 10 amino acids; C-terminally amidated active fragment of the 54-aa mature kisspeptin)<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLyofiliseerd poeder (wit tot off-white)<\/td>\n<\/tr>\n
Zuiverheid<\/strong><\/td>\n\u226599% (HPLC geverifieerd, COA op aanvraag)<\/td>\n<\/tr>\n
Opslag<\/strong><\/td>\nLyofiliseerd: 2\u20138 \u00b0C (koelkast) voor werkvoorraad; \u221220 \u00b0C voor langdurige opslag van ongeopende flesjes. Gereconstitueerd: 2\u20138 \u00b0C, gebruik binnen ~30 dagen. Bescherm tegen licht. Vries de gereconstitueerde oplossing niet in en ontdooi deze niet.<\/td>\n<\/tr>\n
Oplosbaarheid<\/strong><\/td>\nBacteriostatisch water (aanbevolen) of steriel water voor kortere gebruiksperioden<\/td>\n<\/tr>\n
Onderzoeksgebruik<\/strong><\/td>\nAlleen voor laboratoriumonderzoek. Niet voor humaan of veterinair diagnostisch of therapeutisch gebruik.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is Kisspeptin-10?<\/h2>\n

Kisspeptine-10<\/strong> (KP-10) is a 10-amino-acid peptide and the most extensively studied active fragment of the KISS1 gene product, a 145-amino-acid preprokisspeptin that is processed into the 54-amino-acid mature kisspeptin and several shorter C-terminal active fragments (kisspeptin-14, kisspeptin-13, kisspeptin-10). All of the shorter fragments share the C-terminal 10-residue active core and have comparable potency at the kisspeptin receptor \u2014 kisspeptin-10 is the shortest fully active form and is by far the most common research peptide in the kisspeptin literature.<\/p>\n

The well-characterised sequence is YNWNSFGLRF-NH2<\/sub>, molecular weight 1302.45\u00a0Da, empirical formula C63<\/sub>H83<\/sub>N17<\/sub>O14<\/sub>. The C-terminal amidation is essential for full receptor activity. KISS1 was originally identified as a metastasis-suppressor gene by Lee et al. (Cancer Res 1996) and was renamed kisspeptin in honour of Hershey, Pennsylvania (home of Hershey’s Kisses chocolates) where the gene was first cloned. The reproductive role \u2014 KISS1\/GPR54 as the apical regulator of GnRH neurons and the molecular gatekeeper of puberty \u2014 was established by two independent papers in 2003 (Seminara et al., NEJM; de Roux et al., PNAS) demonstrating that loss-of-function GPR54 mutations cause idiopathic hypogonadotropic hypogonadism in humans. Kisspeptin-10 is supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. It is niet goedgekeurd<\/strong> by the FDA, EMA, MHRA, or any other major regulator for human therapeutic use, although ongoing IVF and infertility research is investigating clinical applications. The research-grade kisspeptin-10 sold here is supplied uitsluitend voor laboratoriumonderzoek<\/strong> and is not intended for human or veterinary administration.<\/p>\n

Mechanism of Action \u2014 GPR54 \/ KISS1R Signalling and the HPG Axis<\/h2>\n

What makes kisspeptin-10 mechanistically distinctive among reproductive-research peptides is its position as the apical upstream regulator<\/strong> of the entire hypothalamic-pituitary-gonadal (HPG) axis. The peptide acts at a single receptor \u2014 GPR54 (also called KISS1R) \u2014 but the downstream cascade controls the full reproductive endocrine system in published research:<\/p>\n