{"id":70729,"date":"2026-05-12T10:06:21","date_gmt":"2026-05-12T10:06:21","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70729"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"gdf-8","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/gdf-8\/","title":{"rendered":"GDF-8 (Myostatine)"},"content":{"rendered":"

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Quick Answer \u2014 What is GDF-8 (Myostatin)?<\/h3>\n

GDF-8<\/strong> (Growth\/Differentiation Factor 8), also called myostatin<\/strong>, is a recombinant TGF-\u03b2 superfamily protein and the principal endogenous negative regulator of skeletal muscle mass. Loss-of-function mutations cause the well-known “double-muscling” phenotype in mice, cattle, dogs, and one documented human case. In published research, recombinant GDF-8 is used as a pathway-stimulus tool: inducing atrophy phenotypes, validating myostatin antagonists such as follistatin 344<\/a>, and characterising Smad2\/Smad3 downstream signalling. Supplied in 1\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n

Wat u krijgt bij MedsBase:<\/strong> Research-grade lyophilized recombinant protein \u00b7 HPLC \u226595% purity (COA on request) \u00b7 Discreet temperature-stable packaging \u00b7 Worldwide peptide courier \u00b7 1,400+ verified klantbeoordelingen<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specificatie<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS-nummer<\/strong><\/td>\nNot formally registered for the mature dimer (recombinant protein). Encoded by the MSTN gene; UniProt O14793<\/td>\n<\/tr>\n
Type<\/strong><\/td>\nRecombinant protein (TGF-\u03b2 superfamily ligand; mature 109-amino-acid C-terminal disulfide-linked homodimer cleaved from a 375-aa preproprotein precursor)<\/td>\n<\/tr>\n
Moleculair gewicht<\/strong><\/td>\n~25.8\u00a0kDa (mature homodimer; ~12.9\u00a0kDa per monomer chain)<\/td>\n<\/tr>\n
Structure<\/strong><\/td>\nMature 109-aa monomer with the canonical TGF-\u03b2 superfamily cystine-knot fold; two monomers covalently linked by an intermolecular disulfide bond to form the biologically active homodimer; receptor-binding surfaces engage ActRIIB<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLyophilized recombinant protein (white to off-white)<\/td>\n<\/tr>\n
Zuiverheid<\/strong><\/td>\n\u226595% (HPLC verified, COA on request)<\/td>\n<\/tr>\n
Opslag<\/strong><\/td>\nLyophilized: 2\u20138\u00a0\u00b0C (refrigerator) for working stock; \u221220\u00a0\u00b0C for long-term storage of unopened vials. Reconstituted: 2\u20138\u00a0\u00b0C, use within ~30 days. Protect from light. Do not freeze\u2013thaw the reconstituted solution \u2014 recombinant proteins are particularly sensitive to freeze-thaw denaturation.<\/td>\n<\/tr>\n
Oplosbaarheid<\/strong><\/td>\nBacteriostatic water (recommended) or sterile water for shorter use windows. Carrier protein (BSA, 0.1%) optional for working dilutions to minimise adsorption losses.<\/td>\n<\/tr>\n
Onderzoeksgebruik<\/strong><\/td>\nAlleen voor laboratoriumonderzoek. Niet voor humaan of veterinair diagnostisch of therapeutisch gebruik.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is GDF-8 (Myostatin)?<\/h2>\n

GDF-8<\/strong> (Growth\/Differentiation Factor 8), commonly known as myostatin<\/strong>, is a member of the transforming growth factor beta (TGF-\u03b2) superfamily and the principal physiological negative regulator of skeletal muscle mass. It was first characterised by McPherron, Lawler, and Lee (Nature 1997) as a secreted protein whose targeted disruption in mice produced animals with two- to three-fold greater skeletal muscle mass than wild-type controls. The same gene was rapidly identified as the cause of the “double-muscling” phenotype in Belgian Blue and Piedmontese cattle, the Bully Whippet phenotype in racing greyhounds, and one documented human case of striking infant hypermuscularity (Schuelke et al., NEJM 2004) \u2014 all carrying loss-of-function MSTN mutations.<\/p>\n

Mature myostatin is generated by post-translational processing of a 375-amino-acid preproprotein: the signal peptide is removed during secretion, then the prodomain (~243 aa) is cleaved off by furin proteases, releasing the active 109-amino-acid C-terminal mature myostatin. The active form is a homodimer of two mature monomer chains covalently linked by an intermolecular disulfide bond, with apparent mass approximately 25.8\u00a0kDa on non-reducing SDS-PAGE. The protein adopts the canonical TGF-\u03b2 cystine-knot fold and binds the activin type IIB receptor (ActRIIB) with high affinity to initiate Smad-mediated signalling. Recombinant GDF-8 is supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. Myostatin is niet goedgekeurd<\/strong> by the FDA, EMA, MHRA, or any other major regulator for human therapeutic use. The research-grade GDF-8 sold here is supplied uitsluitend voor laboratoriumonderzoek<\/strong> and is not intended for human or veterinary administration.<\/p>\n

Mechanism of Action \u2014 ActRIIB Signalling and the Smad2\/Smad3 Axis<\/h2>\n

What makes GDF-8 mechanistically distinctive among TGF-\u03b2 superfamily ligands is its dominant role as a tonic brake on muscle growth<\/strong> through a well-characterised three-step signalling cascade documented in published research:<\/p>\n