{"id":71400,"date":"2026-05-20T09:01:36","date_gmt":"2026-05-20T09:01:36","guid":{"rendered":"https:\/\/medsbase.com\/pinealon\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"pinealon","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/pinealon\/","title":{"rendered":"Pinealon"},"content":{"rendered":"

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Quick Answer \u2014 What is Pinealon?<\/h3>\n

Pinealon<\/strong> is a synthetic tripeptide (sequence Glu-Asp-Arg, EDR) belonging to the Khavinson short-peptide bioregulator family developed at the St. Petersburg Institute of Bioregulation and Gerontology. Originally derived from cattle pineal-gland-extract research, Pinealon is studied for neuroprotective, anti-oxidant, and cognitive-aging effects in laboratory models \u2014 with a proposed mechanism involving direct nuclear access and chromatin-level gene-expression regulation. Sibling peptide to Epitalon<\/a> within the Khavinson series. Supplied in 5 mg, 10 mg, and 20 mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n

Wat u krijgt bij MedsBase:<\/strong> Onderzoekskwaliteit lyofiliseerde peptiden \u00b7 HPLC \u226599% zuiverheid (COA op aanvraag) \u00b7 Discrete temperatuurstabiele verpakking \u00b7 Wereldwijde peptidekoerier \u00b7 1.400+ geverifieerd klantbeoordelingen<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specificatie<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS-nummer<\/strong><\/td>\n308067-43-8 (commonly cited; not all peptide-vendor sources publish a registry number)<\/td>\n<\/tr>\n
Type<\/strong><\/td>\nSynthetic tripeptide bioregulator (Khavinson short-peptide family) \u2014 developed at the St. Petersburg Institute of Bioregulation and Gerontology by Vladimir Khavinson; originally based on cattle pineal-gland extract research. Pinealon is the cognitive \/ neuroprotective member of the Khavinson series, paired with Epitalon<\/a> (longevity \/ telomerase) as the two most-studied compounds.<\/td>\n<\/tr>\n
Molecuulformule<\/strong><\/td>\nC15<\/sub>H26<\/sub>N6<\/sub>O8<\/sub><\/td>\n<\/tr>\n
Moleculair gewicht<\/strong><\/td>\n~418.4 Da<\/td>\n<\/tr>\n
Sequentie<\/strong><\/td>\nH-Glu-Asp-Arg-OH (EDR) \u2014 linear 3-residue sequence. Free N- and C-termini; no disulfide bridge, no acylation, no PEGylation. Net charge +1 at neutral pH (one cationic Arg balanced against the carboxylate groups of Glu\/Asp).<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLyofiliseerd poeder (wit tot off-white)<\/td>\n<\/tr>\n
Zuiverheid<\/strong><\/td>\n\u226599% (HPLC geverifieerd, COA op aanvraag)<\/td>\n<\/tr>\n
Opslag<\/strong><\/td>\nLyophilized: 2\u20138 \u00b0C (refrigerator) for working stock; \u221220 \u00b0C for long-term storage of unopened vials. Reconstituted: 2\u20138 \u00b0C, use within ~14\u201328 days. Protect from light. Avoid repeated freeze\u2013thaw cycles of the reconstituted solution.<\/td>\n<\/tr>\n
Oplosbaarheid<\/strong><\/td>\nHighly soluble in bacteriostatic water or sterile water \u2014 short charged tripeptides dissolve rapidly with gentle swirling. No specialised solvents required.<\/td>\n<\/tr>\n
Onderzoeksgebruik<\/strong><\/td>\nAlleen voor laboratoriumonderzoek. Niet voor humaan of veterinair diagnostisch of therapeutisch gebruik.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is Pinealon?<\/h2>\n

Pinealon<\/strong> is a synthetic tripeptide consisting of L-glutamic acid, L-aspartic acid, and L-arginine (sequence Glu-Asp-Arg, single-letter code EDR). It is a member of the Khavinson short-peptide bioregulator family \u2014 a group of 2- to 4-amino-acid peptides developed at the St. Petersburg Institute of Bioregulation and Gerontology under Vladimir Khavinson, originally based on the fractionation and characterisation of bioactive material extracted from cattle pineal gland and other tissues. Within the Khavinson series, Pinealon is the compound most associated with cognitive function and neuroprotection in published research, while its sibling tetrapeptide Epitalon<\/a> (Ala-Glu-Asp-Gly, AEDG) is the most-studied compound in the longevity \/ telomerase context.<\/p>\n

Khavinson short peptides differ structurally from most other research peptides in two important ways: they are extremely short<\/strong> (Pinealon is just three residues, MW ~418 Da, smaller than a typical small-molecule drug) and their proposed mechanism centres on direct nuclear access<\/strong> rather than receptor binding at the plasma membrane. The published Khavinson model holds that short charged peptides can cross both the cell membrane and the nuclear envelope, reach chromatin, and modulate gene expression through sequence-specific interactions with DNA \u2014 a mechanism distinct from the canonical receptor-binding pharmacology of larger peptides. This model is supported by published research from the Khavinson group spanning several decades and is the subject of continued mechanistic investigation by independent researchers.<\/p>\n

Pinealon has been investigated in laboratory research contexts focused on cognitive aging, oxidative-stress protection of neuronal cultures, cerebral ischemia models, and circadian \/ pineal-axis research. It is not approved<\/strong> by the FDA, EMA, MHRA, or any other major regulator for human therapeutic use. The research-grade Pinealon sold here is supplied uitsluitend voor laboratoriumonderzoek<\/strong> and is not intended for human or veterinary administration.<\/p>\n

Mechanism of Action \u2014 Khavinson Short-Peptide Bioregulation<\/h2>\n

The published mechanistic model for Khavinson short peptides \u2014 supported by research from the Khavinson group and tested in independent laboratories \u2014 proposes three principal modes of action:<\/p>\n