{"id":71421,"date":"2026-05-20T10:30:00","date_gmt":"2026-05-20T10:30:00","guid":{"rendered":"https:\/\/medsbase.com\/5-amino-1mq\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"5-amino-1mq","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/5-amino-1mq\/","title":{"rendered":"5-Amino-1MQ (5-Amino-1-Methylquinolinium Iodide)"},"content":{"rendered":"

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Quick Answer \u2014 What is 5-Amino-1MQ?<\/h3>\n

5-Amino-1MQ<\/strong> (5-amino-1-methylquinolinium iodide, CAS 42464-96-0) is a small-molecule, substrate-site selective NNMT (nicotinamide N-methyltransferase) inhibitor<\/strong> with a published IC50<\/sub> of 1.2\u00a0\u00b5M. By blocking NNMT \u2014 the cytosolic enzyme that consumes both nicotinamide (the precursor of NAD+<\/sup>) and S-adenosyl-L-methionine (SAM, the universal methyl donor) \u2014 5-Amino-1MQ has been reported in peer-reviewed studies to raise intracellular NAD+<\/sup> and SAM pools, reduce 3T3-L1 adipocyte lipogenesis, and demonstrate in-vivo efficacy in murine models of diet-induced obesity (20\u00a0mg\/kg\/d), muscle-stem-cell-mediated repair, and ovarian-cancer metastasis with no adverse effects up to 60\u00a0mg\/kg\/d. It is a small molecule (not a peptide<\/em>) supplied as a lyophilized powder for laboratory research use only.<\/p>\n<\/div>\n

Wat u krijgt bij MedsBase:<\/strong> Lyophilized \u226599% HPLC-verified powder \u00b7 COA available on request \u00b7 Discreet temperature-stable packaging \u00b7 Worldwide research-supply courier \u00b7 1,400+ verified klantbeoordelingen<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specificatie<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
Compound Class<\/strong><\/td>\nSmall-molecule quaternary-ammonium quinolinium salt; selective NNMT inhibitor; not a peptide<\/em><\/td>\n<\/tr>\n
Chemical Name<\/strong><\/td>\n5-Amino-1-methylquinolinium iodide<\/td>\n<\/tr>\n
CAS-nummer<\/strong><\/td>\n42464-96-0<\/td>\n<\/tr>\n
Molecuulformule<\/strong><\/td>\nC10<\/sub>H11<\/sub>IN2<\/sub> (iodide salt)<\/td>\n<\/tr>\n
Moleculair gewicht<\/strong><\/td>\n286.11 g\/mol<\/td>\n<\/tr>\n
Werkingsmechanisme<\/strong><\/td>\nSubstrate-site selective nicotinamide N-methyltransferase (NNMT) inhibitor; IC50<\/sub> = 1.2\u00a0\u00b5M (assay: 50\u00a0\u00b5M SAM, 100\u00a0\u00b5M nicotinamide). Does not inhibit related methyltransferases (GNMT, PNMT, COMT) or NAD+<\/sup>-salvage enzymes (NAMPT, NMNAT).<\/td>\n<\/tr>\n
Sequentie<\/strong><\/td>\nn\/a (small-molecule quinolinium salt \u2014 not a peptide)<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLyophilized crystalline \/ powder (off-white to pale yellow); supplied in single-use research vials<\/td>\n<\/tr>\n
Zuiverheid<\/strong><\/td>\n\u226599% (HPLC verified, COA on request) \u2014 matches the Sigma-Aldrich SML2832 reference grade<\/td>\n<\/tr>\n
Oplosbaarheid<\/strong><\/td>\nHighly water-soluble (quaternary ammonium salt is hydrophilic). Reconstitutes readily in bacteriostatic water, sterile water, or PBS at concentrations up to ~50 mg\/mL without precipitation. Also soluble in DMSO for in-vitro cell-culture stock preparation.<\/td>\n<\/tr>\n
Opslag<\/strong><\/td>\nLyophilized: 2\u20138 \u00b0C for short-term working stock; \u221220 \u00b0C for long-term storage of unopened vials (stable \u226536 months at \u221220 \u00b0C). Reconstituted: 2\u20138 \u00b0C, use within ~30 days. Protect from prolonged light exposure. Avoid repeated freeze\u2013thaw of working solutions.<\/td>\n<\/tr>\n
Onderzoeksgebruik<\/strong><\/td>\nAlleen voor laboratoriumonderzoek. Niet voor humaan of veterinair diagnostisch of therapeutisch gebruik.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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What Is 5-Amino-1MQ?<\/h2>\n

5-Amino-1MQ<\/strong> (5-amino-1-methylquinolinium iodide, CAS 42464-96-0) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT)<\/strong>, a cytosolic methyltransferase enzyme whose biology has emerged over the past decade as a node connecting NAD+<\/sup>-axis metabolism, adipocyte lipogenesis, muscle-stem-cell biology, and stromal cancer metabolism. It is not a peptide<\/em> \u2014 it is a synthetic quinolinium quaternary-ammonium salt with the molecular formula C10<\/sub>H11<\/sub>IN2<\/sub> and a molecular weight of 286.11 g\/mol (as the iodide salt). MedsBase stocks it in the same lyophilized-vial format as our research peptide catalogue for convenience of reconstitution and dosing in mixed-protocol research.<\/p>\n

NNMT catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM)<\/strong> \u2014 the universal cellular methyl donor \u2014 onto nicotinamide<\/strong>, generating 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). The reaction terminally consumes both substrates: nicotinamide (which would otherwise be re-salvaged into NAD+<\/sup> by NAMPT), and SAM (which would otherwise be available for the hundreds of cellular methylation reactions performed by other methyltransferases). NNMT therefore sits at the intersection of two of the most-studied cellular biochemistry axes \u2014 the NAD+<\/sup> salvage pathway and one-carbon \/ methylation metabolism \u2014 and its expression is markedly elevated in obesity-associated adipose tissue, cancer stroma, and aged skeletal muscle.<\/p>\n

5-Amino-1MQ is the most-published small-molecule, substrate-site-targeting<\/strong> NNMT inhibitor in the field. It was characterised by Neelakantan et\u00a0al. (2017\u20132018) as a selective inhibitor with a 1.2\u00a0\u00b5M IC50<\/sub> against recombinant NNMT, no off-target activity against related methyltransferases (GNMT, PNMT, COMT) or NAD+<\/sup>-salvage enzymes (NAMPT, NMNAT), and oral bioavailability sufficient to support in-vivo rodent dosing protocols. Subsequent in-vivo research has documented activity in three independent disease-relevant model systems: diet-induced obesity, skeletal-muscle injury repair, and intraperitoneal ovarian-cancer metastasis \u2014 all without adverse effects up to 60\u00a0mg\/kg\/d.<\/p>\n

Mechanism of Action \u2014 NNMT Inhibition and the NAD+<\/sup>\/SAM Axis<\/h2>\n

5-Amino-1MQ’s mechanism is the most-characterised of any small-molecule NNMT inhibitor in the published literature:<\/p>\n