{"id":71489,"date":"2026-05-20T10:10:00","date_gmt":"2026-05-20T10:10:00","guid":{"rendered":"https:\/\/medsbase.com\/slu-pp-332\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"slu-pp-332","status":"publish","type":"product","link":"https:\/\/medsbase.com\/nl\/slu-pp-332\/","title":{"rendered":"SLU-PP-332 (Pan-ERR Agonist Exercise Mimetic)"},"content":{"rendered":"

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Quick Answer \u2014 What is SLU-PP-332?<\/h3>\n

SLU-PP-332<\/strong> (CAS 303760-60-3, MF C18<\/sub>H14<\/sub>N2<\/sub>O2<\/sub>, MW 290.3 g\/mol) is a synthetic small-molecule pan-agonist of estrogen-related receptors<\/strong> (ERR\u03b1 \/ ERR\u03b2 \/ ERR\u03b3) developed in the Burris laboratory at Saint Louis University. ERRs are orphan nuclear-receptor transcription factors that drive mitochondrial biogenesis, fatty-acid oxidation, oxidative-fibre development, and the muscle-adaptation programme normally engaged by exercise \u2014 making SLU-PP-332 a leading “exercise mimetic”<\/strong> research tool. Published in Billon et al. (2023, ACS Chemical Biology<\/em>) \u2014 acute single-dose drives an aerobic-exercise-response gene signature in skeletal muscle; chronic dosing increases Type IIa oxidative-fibre proportion and improves endurance capacity in mice. Small molecule \u2014 not a peptide.<\/em> Note: some supplier batches are labelled SLU-PP-322 \/ SLU-PP-332 interchangeably \u2014 both refer to the same Burris-lab ERR pan-agonist; consult COA for batch-specific identification. For laboratory research use only.<\/p>\n<\/div>\n

Wat u krijgt bij MedsBase:<\/strong> Lyophilized \u226599% HPLC-verified SLU-PP-332 \u00b7 COA available on request \u00b7 Discreet temperature-stable packaging \u00b7 Worldwide research-supply courier \u00b7 1,400+ verified klantbeoordelingen<\/a><\/div>\n

\ud83d\udce6 Elke bestelling is gedekt door onze Reshipment Assurance Policy<\/strong><\/a> \u2014 als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specificatie<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
Compound Class<\/strong><\/td>\nSynthetic small-molecule pan-agonist of estrogen-related receptors (ERR\u03b1 \/ ERR\u03b2 \/ ERR\u03b3); orphan nuclear-receptor agonist; exercise-mimetic research tool; not a peptide<\/em><\/td>\n<\/tr>\n
Chemical Name<\/strong><\/td>\nSLU-PP-332 (synonyms: SLU-PP-322 in some supplier batches; pan-ERR agonist; Burris-lab Compound 332)<\/td>\n<\/tr>\n
CAS-nummer<\/strong><\/td>\n303760-60-3 (canonical, per MedKoo \/ MedChemExpress \/ scientific literature)<\/td>\n<\/tr>\n
Molecuulformule<\/strong><\/td>\nC18<\/sub>H14<\/sub>N2<\/sub>O2<\/sub><\/td>\n<\/tr>\n
Moleculair gewicht<\/strong><\/td>\n290.32 g\/mol<\/td>\n<\/tr>\n
Werkingsmechanisme<\/strong><\/td>\nPan-agonist of ERR\u03b1, ERR\u03b2, ERR\u03b3<\/strong> nuclear receptors with ~4-fold ERR\u03b1 selectivity over ERR\u03b3. EC50<\/sub> ERR\u03b1 ~98 nM (Billon et al. 2023). ERR receptor activation drives transcription of PGC-1\u03b1 target genes \u2014 mitochondrial biogenesis (TFAM, NRF1, NRF2), fatty-acid \u03b2-oxidation (CPT1B, MCAD, LCAD), oxidative-phosphorylation complex subunits, and oxidative-fibre-type myosin heavy chains. Net effect mimics the transcriptional programme of exercise adaptation.<\/td>\n<\/tr>\n
Sequentie<\/strong><\/td>\nn\/a (small-molecule synthetic compound \u2014 not a peptide)<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nLyophilized white-to-off-white powder; single-use research vials<\/td>\n<\/tr>\n
Zuiverheid<\/strong><\/td>\n\u226599% (HPLC geverifieerd, COA op aanvraag)<\/td>\n<\/tr>\n
Oplosbaarheid<\/strong><\/td>\nDMSO \u226550 mg\/mL; aqueous solubility moderate (sub-mg\/mL). For in-vitro work, prepare DMSO stocks and dilute into culture medium just before use. For in-vivo work, formulations typically use DMSO\/PEG\/saline or similar co-solvent systems.<\/td>\n<\/tr>\n
Opslag<\/strong><\/td>\nLyophilized: 2\u20138 \u00b0C short-term, \u221220 \u00b0C long-term (\u226536 months). Reconstituted DMSO: \u221220 \u00b0C, single-thaw use. Protect from light. Avoid repeated freeze-thaw.<\/td>\n<\/tr>\n
Onderzoeksgebruik<\/strong><\/td>\nFor laboratory research use only. Not for human or veterinary diagnostic or therapeutic use. Not currently on the WADA Prohibited List under its specific name, but researchers should be aware that the broader S4 (Hormone and Metabolic Modulators) class includes exercise-mimetic compounds and SLU-PP-332’s regulatory status may evolve.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Mechanism of Action \u2014 Pan-ERR Agonism Drives Exercise-Adaptation Transcription<\/h2>\n

SLU-PP-332 is the most-cited synthetic small-molecule ERR pan-agonist in the published literature. ERRs (estrogen-related receptors \u03b1, \u03b2, \u03b3) are orphan nuclear receptors that share the DNA-binding domain of estrogen receptors but do not bind estrogen \u2014 they are constitutively active in the absence of any natural endogenous ligand and instead are regulated by coactivator-binding (most importantly PGC-1\u03b1). ERRs are the principal transcriptional drivers of:<\/p>\n