{"id":3231,"count":52,"description":"Type 2 diabetes affects more than 530 million adults worldwide and is now the leading cause of preventable blindness, end-stage renal failure, and non-traumatic limb amputation. Tight glycaemic control reduces microvascular complications by 25–40%; modern agents (SGLT-2 inhibitors, GLP-1 receptor agonists, dual PPAR agonists) also cut cardiovascular and renal events independently of HbA1c. MedsBase carries 51 oral and injectable diabetes medications across every major drug class, supplied by WHO-GMP certified manufacturers, with discreet worldwide shipping.\n\nBiguanides — metformin (first-line).<\/strong> Metformin lowers HbA1c by ~1.0–1.5 points, is weight-neutral or weight-losing, has a low hypoglycaemia risk, and is on the WHO Essential Medicines List. We stock metformin sustained-release as Biciphage 1000 SR<\/a>, Glycomet SR<\/a>, Diabetrol SR<\/a>, en Metford<\/a> — all once-daily SR formulations chosen for better GI tolerability than IR tablets.\n\nSulfonylureas — second-line oral secretagogues.<\/strong> SUs work by closing pancreatic K-ATP channels and forcing insulin release; they cut HbA1c by 1.0–1.5 points but carry hypoglycaemia and weight-gain risk. We carry the second-generation glimepiride (Amaryl<\/a>, Glimda<\/a>, Glimith<\/a>, Glypride<\/a>, Healmaryl<\/a>), gliclazide MR (Glide<\/a>, Glizid<\/a>) — the lowest-hypoglycaemia SU and preferred in older patients — the older glibenclamide\/glyburide (Daonil<\/a>, Glybovin<\/a>), and glipizide (Glynase<\/a>, Glynase XL<\/a>).\n\nSU + metformin fixed-dose combinations.<\/strong> Once metformin alone fails to maintain HbA1c <7%, an SU is the cheapest and most studied add-on. Single-tablet combinations improve adherence: glimepiride+metformin (Amaryl M<\/a>, Glycomet-GP<\/a>, Glibaheal M<\/a>), gliclazide+metformin (Glinil M<\/a>), glibenclamide+metformin (Glucored<\/a>), glipizide+metformin (Glynase-MF<\/a>), and pioglitazone+metformin+glimepiride triple (Glisen PM<\/a>).\n\nThiazolidinediones (TZDs) — pioglitazone.<\/strong> Insulin sensitisers acting on PPAR-γ that are particularly useful in NAFLD\/NASH and patients with severe insulin resistance. Carries weight-gain, fluid retention, and bone-fracture risk; not for use in heart failure. We stock pioglitazone monotherapy (Pioz 15<\/a>, P-Glitz<\/a>) and pioglitazone-based combinations (Cyblex MV<\/a>, Glycoheal<\/a>, Pioglit Mf Forte<\/a>).\n\nDPP-4 inhibitors (gliptins) — weight-neutral, low hypoglycaemia.<\/strong> Block degradation of incretin hormones GLP-1 and GIP, prolonging post-meal insulin release. HbA1c reduction is modest (~0.5–0.8 points) but tolerability is excellent. We carry sitagliptin (Januvia<\/a>) and its metformin combination (Janumet<\/a>), vildagliptin (Galvus<\/a>), saxagliptin (Onglyza<\/a>), linagliptin (Trajenta<\/a>) and its combination (Trajenta Duo<\/a>), and teneligliptin (Ziten<\/a>).\n\nSGLT-2 inhibitors — cardio- and reno-protective beyond glycaemia.<\/strong> Block renal glucose reabsorption, causing urinary glucose loss. Reduce major adverse cardiovascular events, heart-failure hospitalisations, and progression of chronic kidney disease independently of HbA1c effect; recommended add-on for any patient with established CV disease, heart failure, or CKD. Class risks include genital mycotic infections and (rare) euglycaemic ketoacidosis. We stock dapagliflozin (Forxiga<\/a>), empagliflozin (Jardiance<\/a>), canagliflozin (Invokana<\/a>), and the empagliflozin+linagliptin fixed-dose Glyxambi<\/a>.\n\nMeglitinides — rapid post-prandial secretagogues.<\/strong> Like sulfonylureas they trigger insulin release, but with a faster onset and shorter duration — useful for patients with prominent post-meal glucose excursions or irregular meal patterns. NovoNorm<\/a> (repaglinide) and Glinate<\/a> (nateglinide) are taken with each meal.\n\nAlpha-glucosidase inhibitors — post-prandial spike control.<\/strong> Acarbose (Glucobay<\/a>), miglitol (Mignar<\/a>), and voglibose (PPG<\/a>, Voglibite<\/a>) work locally in the small intestine to slow carbohydrate digestion. HbA1c reduction is modest (0.5–0.8 points) but post-meal glucose drops sharply. Particularly effective in carbohydrate-rich diets.\n\nSpecialistische middelen.<\/strong> Lipaglyn<\/a> (saroglitazar 4 mg) is a unique dual PPAR-α\/γ agonist for diabetic dyslipidaemia and NAFLD\/NASH — cuts triglycerides 40–50%, raises HDL, and reduces liver fat. Biodib 30<\/a> is a vildagliptin+metformin combination capsule.\n\nRapid-acting insulin pens.<\/strong> Pre-filled disposable analogue insulin pens for mealtime cover. Apidra SoloStar<\/a> contains insulin glulisine; NovoRapid FlexPen<\/a> contains insulin aspart. Both have a 5–15 minute onset, peak in 1–3 hours, and last 3–5 hours — closely matching post-meal glucose curves.\n\nAdjunctive nutritional support.<\/strong> Methycobal Injectie<\/a> (methylcobalamin) is used to treat metformin-induced and diabetic peripheral neuropathy — long-term metformin depletes vitamin B12, and replenishment improves neuropathic symptoms.\n\nNote on Minirin.<\/strong> Minirin tablets<\/a> en Minirin Neusspray<\/a> contain desmopressin and treat diabetes insipidus<\/em>, primary nocturnal enuresis, and nocturia — not type 2 diabetes mellitus. Despite the shared name, the two diseases are unrelated.\n\nAll medications on this page are FDA-approved generics manufactured under WHO-GMP standards. 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