{"id":3334,"count":25,"description":"MedsBase\u2019s Hepatitis Medication-categorie omvat orale antivirale middelen voor de twee verschillende chronische virale leverinfecties die daadwerkelijk met tabletten te behandelen zijn \u2014 chronische hepatitis B (HBV)<\/strong> en chronische hepatitis C (HCV)<\/strong> — along with the tenofovir-based combinations used for both HBV suppression and HIV pre-exposure prophylaxis. Each treatment class has its own goal, mechanism and duration. Choosing the right medication starts with knowing which virus you are treating, your kidney function, and whether you are co-infected with HIV.\n\nHepatitis C: 12-week direct-acting antiviral (DAA) cure\nHCV is the only chronic viral hepatitis that current oral therapy can genezen<\/em>. Direct-acting antivirals (DAAs) richten zich gelijktijdig op het HCV NS5B-polymerase en het NS5A-replicatiecomplex. Het resultaat is een aanhoudende virologische respons (SVR12) \u2014 HCV RNA niet detecteerbaar 12 weken na de laatste tablet \u2014 bij 95% of meer van behandelingsna\u00efeve pati\u00ebnten zonder cirrose. De behandeling duurt 12 weken; eenmaal genezen is geen voortgezette antivirale therapie nodig.\n\nHepcinat LP<\/strong><\/a> — sofosbuvir 400 mg + ledipasvir 90 mg, generic Harvoni. First-line for HCV genotypes 1, 4, 5 and 6.\n\n\nHepatitis B: long-term suppression with tenofovir\nUnlike HCV, chronic hepatitis B is currently a manageable infection rather than a curable one. The cccDNA template inside infected hepatocytes is not eliminated by any oral drug, which is why HBV treatment is usually long-term. The goal is undetectable HBV DNA, normal ALT, and prevention of cirrhosis and hepatocellular carcinoma. Two tenofovir formulations dominate guidelines (EASL, AASLD, APASL, WHO):\n\nTenvir<\/strong><\/a> \u2014 tenofovir disoproxil fumarate (TDF) 300 mg door Cipla. 20+ jaar veiligheidsdata; voorkeursbehandeling tijdens zwangerschap.\nTeravir<\/strong><\/a> \u2014 tenofovir disoproxil fumarate 300 mg door Cipla, alternatief TDF-merk.\nTenvir AF<\/strong><\/a> — tenofovir alafenamide (TAF) 25 mg by Cipla, generic Vemlidy. Same active metabolite as TDF, but ~90% lower plasma exposure: substantially less renal and bone toxicity. Preferred in chronic kidney disease, osteoporosis, age > 60, or pre-existing TDF toxicity.\n\n\nHIV pre-exposure prophylaxis (PrEP) and treatment-combination tablets\nThe same tenofovir backbone, when combined with emtricitabine (FTC), is the standard for HIV pre-exposure prophylaxis — reducing HIV acquisition risk by > 99% when taken daily as directed. These products are listed in this category because TDF alone is also active against HBV; in HBV\/HIV co-infection a single combination tablet covers both. Three branded generics of Truvada are stocked here:\n\nTenvir-EM<\/strong><\/a> \u2014 TDF 300 + FTC 200 door Cipla.\nRicovir EM<\/strong><\/a> \u2014 TDF 300 + FTC 200 door Mylan.\nTenof EM<\/strong><\/a> — TDF 300 + FTC 200 by Hetero.\n\nDaily PrEP, the 2-1-1 event-based regimen (cisgender MSM only), or HIV combination treatment all start with the same molecule. Choice between the three brands is largely about manufacturer preference and stock; pharmacology is identical.\n\nChoosing between options\n\n\n\nNeed\nRecommended starting point\n\n\n\nHepatitis C cure (genotype 1\/4\/5\/6)Hepcinat LP, 12-week course.\nChronic HBV, normal kidneys, age < 60Tenvir or Teravir (TDF 300).\nChronic HBV with CKD, osteoporosis, or age > 60Tenvir AF (TAF 25).\nHIV PrEP — daily or 2-1-1Tenvir-EM, Ricovir EM or Tenof EM (TDF\/FTC).\nHBV + HIV co-infectionA TDF\/FTC combination — covers both.\n\n\n\nAll hepatitis B and HIV regimens require baseline workup (HBV DNA or HIV RNA, HBeAg\/HBsAg, eGFR, ALT, hepatitis screening, lipid panel) and ongoing specialist monitoring. Hepatitis C treatment also benefits from hepatologist supervision, especially if there is any cirrhosis or co-medication that interacts with DAAs. MedsBase supplies the medication; clinical monitoring should be set up locally.","link":"https:\/\/medsbase.com\/nl\/hepatitis-medication\/","name":"Hepatitis-medicatie","slug":"hepatitis-medication","taxonomy":"product_cat","parent":3223,"meta":[],"menu_order":0,"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat\/3334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/taxonomies\/product_cat"}],"up":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat\/3223"}],"wp:post_type":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product?product_cat=3334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}