{"id":5088,"count":2,"description":"Prescription wakefulness-promoting agents (<strong>eugeroics<\/strong>) for the treatment of <strong>excessive daytime sleepiness in narcolepsy, shift-work sleep disorder (SWSD) and residual sleepiness in treated obstructive sleep apnea (OSA)<\/strong>. MedsBase stocks both major molecules in the class so that prescribers and informed patients can choose the profile that fits the clinical situation.\n\n<strong>Modafinil<\/strong> &mdash; the parent drug of the class, FDA-approved in 1998. Racemic (R+S) formulation with <strong>30-60 minute onset<\/strong> en <strong>10-12 hour duration<\/strong>. A sharper early peak and slightly shorter tail than armodafinil. Stocked as <a href=\"https:\/\/medsbase.com\/nl\/modvigil\/\"><strong>Modvigil 200 mg<\/strong><\/a> (HAB Pharma) &mdash; the workhorse generic used by the narcolepsy and cognitive-health communities. Internationally equivalent to Modalert, Modaheal and the originator brand Provigil.\n\n<strong>Armodafinil<\/strong> &mdash; the pure <em>R<\/em>-enantiomer of modafinil, FDA-approved in 2007. <strong>1-2 hour onset<\/strong> en <strong>12-15 hour duration<\/strong> with a smoother, more sustained alertness profile and lower early-peak anxiety risk. Stocked as <a href=\"https:\/\/medsbase.com\/nl\/artvigil\/\"><strong>Artvigil 150 mg<\/strong><\/a> (HAB Pharma) &mdash; internationally equivalent to Waklert, Armodapro and the originator brand Nuvigil. 150 mg armodafinil is approximately equivalent to 200 mg modafinil in wakefulness magnitude.\n\n<strong>Typical clinical choice:<\/strong> modafinil first for faster onset and familiarity; armodafinil if the patient reports an early-afternoon crash, prefers smoother feel, or needs longer-duration alertness for long shifts and long flights. Both are used for the same FDA-approved indications and both are reasonable first-line options within the wakefulness-agent class.\n\n<em>Modafinil and armodafinil are prescription-only Schedule IV controlled substances in the US and most other jurisdictions. Both reduce the effectiveness of hormonal contraceptives via CYP3A4 induction &mdash; non-hormonal backup contraception is required during treatment and for 1 month after the last dose. Rare but serious Stevens-Johnson syndrome, TEN and DRESS reactions have been reported &mdash; stop immediately and seek urgent medical advice if any rash develops. Always use under the supervision of a qualified prescriber. MedsBase does not provide diagnosis or prescription services.<\/em>","link":"https:\/\/medsbase.com\/nl\/narcolepsy-treatment\/","name":"Behandeling van narcolepsie","slug":"narcolepsy-treatment","taxonomy":"product_cat","parent":3223,"meta":[],"menu_order":0,"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat\/5088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat"}],"about":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/taxonomies\/product_cat"}],"up":[{"embeddable":true,"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product_cat\/3223"}],"wp:post_type":[{"href":"https:\/\/medsbase.com\/nl\/wp-json\/wp\/v2\/product?product_cat=5088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}