{"id":50985,"date":"2023-09-20T09:15:48","date_gmt":"2023-09-20T09:15:48","guid":{"rendered":"https:\/\/medsname.com\/abamune\/"},"modified":"2026-04-30T16:19:00","modified_gmt":"2026-04-30T16:19:00","slug":"abamune","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/abamune\/","title":{"rendered":"Abamune"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Abamune<\/strong> \u2014 Abacavir 300 mg (Cipla Inc). NRTI monocomponent abacavir. Test obligatoriu HLA-B*5701 \u00eenainte de ini\u021biere. Combinat cu lamivudin\u0103 + INSTI\/NNRTI pentru un regim complet.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Abamune este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj neutru, facturat printr-un procesor de plat\u0103 reglementat (descrierea extrasului de cont indic\u0103 un procesor de plat\u0103 cu card reglementat \u2014 niciodat\u0103 MedsBase sau numele medicamentului). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Retrimitere \u00een 20 de zile lucr\u0103toare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Black-box: reactivare HBV la \u00eentrerupere<\/strong><br \/>Dac\u0103 ave\u021bi coinfec\u021bie cu VHB (sau statut necunoscut pentru VHB), \u00eentreruperea administr\u0103rii lamivudinei, tenofovirului sau emtricitabinei poate declan\u0219a o exacerbare sever\u0103 a VHB cu posibil\u0103 decompensare. Testa\u021bi HBsAg\/ADN VHB \u00eenainte de ini\u021bierea tratamentului \u0219i nu \u00eentrerupe\u021bi niciodat\u0103 f\u0103r\u0103 supraveghere hepatologic\u0103.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Rezisten\u021b\u0103 \u2014 conformitatea este esen\u021bial\u0103<\/strong><br \/>O conformitate &gt;95% este necesar\u0103 pentru a preveni dezvoltarea rezisten\u021bei la HIV. Dozele ratate sau terapia cu un singur medicament \u00eentr-un regim triplu sunt cauze frecvente ale e\u0219ecului tratamentului. NRTI-urile ca monoterapie sau terapie dual\u0103 NU sunt tratamente acceptabile pentru HIV \u2014 combina\u021bi \u00eentotdeauna cu cel pu\u021bin un medicament dintr-o alt\u0103 clas\u0103.<\/div>\n<h2>Cum func\u021bioneaz\u0103 NRTI-urile<\/h2>\n<p>Inhibitorii nucleozidici\/nucleotidici de transcriptaz\u0103 invers\u0103 (NRTI) sunt analogi de nucleozide care sunt fosforila\u021bi \u00een interiorul celulei gazd\u0103 \u00een forme trifosfat active. Ace\u0219tia concureaz\u0103 cu nucleotidele naturale pentru \u00eencorporarea \u00een lan\u021bul de ADN viral \u00een cre\u0219tere de c\u0103tre transcriptaza invers\u0103 a HIV. Odat\u0103 \u00eencorpora\u021bi, ei \u00eentrerup lan\u021bul \u2014 replicarea viral\u0103 se opre\u0219te.<\/p>\n<p>NRTI-urile reprezint\u0103 baza fiec\u0103rui regim modern de tratament a HIV, fiind combinate cu un inhibitor de transfer al catenei de integraz\u0103 (INSTI), inhibitor non-nucleozidic de transcriptaz\u0103 invers\u0103 (NNRTI) sau inhibitor de proteaz\u0103 (PI) pentru o terapie de cel pu\u021bin trei medicamente.<\/p>\n<h2>Efecte adverse specifice clasei<\/h2>\n<ul>\n<li><strong>Toxicitate mitocondrial\u0103 (NRTI-uri vechi \u2014 stavudina, didanozina, zidovudina):<\/strong> lipoatrofie, neuropatie periferic\u0103, acidoz\u0103 lactic\u0103, steatoz\u0103 hepatic\u0103. NRTI-urile moderne (TDF, TAF, FTC, 3TC, abacavir) au mult mai pu\u021bin\u0103 toxicitate mitocondrial\u0103.<\/li>\n<li><strong>Tenofovir disoproxil (TDF):<\/strong> tubulopatie renal\u0103, sindrom Fanconi, pierdere a densit\u0103\u021bii osoase. Trecerea la tenofovir alafenamid (TAF) dac\u0103 exist\u0103 probleme renale\/osuoase.<\/li>\n<li><strong>Abacavir:<\/strong> reac\u021bie de hipersensibilitate la purt\u0103torii HLA-B*5701 (~5-8% din popula\u021bia caucazian\u0103, mai rar \u00een popula\u021biile africane \u0219i asiatice). Testare \u00eenainte de ini\u021bierea tratamentului; contraindica\u021bie absolut\u0103 dac\u0103 testul este pozitiv.<\/li>\n<li><strong>Lamivudin\u0103 + emtricitabin\u0103:<\/strong> \u00een general bine tolerat\u0103; se aplic\u0103 avertizarea privind coinfec\u021bia cu HBV.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>Acest tratament vindec\u0103 HIV?<\/h3>\n<p>Nu. TARV suprima replicarea viral\u0103, permite recuperarea imun\u0103 \u0219i reduce riscul de transmitere aproape la zero (Nedetectabil = Netransmisibil). Nu eradic\u0103 rezervoarele de HIV. Tratamentul este pe via\u021b\u0103 cu tehnologia actual\u0103.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi doza c\u00e2nd v\u0103 aminti\u021bi dac\u0103 \u00eent\u00e2rzia\u021bi mai pu\u021bin de 6 ore. Dac\u0103 \u00eent\u00e2rzia\u021bi peste 6 ore, omite\u021bi doza \u0219i relua\u021bi programul normal \u2014 nu lua\u021bi o doz\u0103 dubl\u0103. Doze ratate repetate cresc riscul de rezisten\u021b\u0103; discuta\u021bi \u00eentotdeauna provoc\u0103rile de adheren\u021b\u0103 cu echipa de HIV.<\/p>\n<h3>Cum st\u0103m cu testele de rezisten\u021b\u0103?<\/h3>\n<p>Testarea genotipic\u0103 pentru rezisten\u021b\u0103 este recomandat\u0103 la diagnosticul de HIV, \u00eenainte de a \u00eencepe orice regim \u0219i la e\u0219ecul virologic. Rezisten\u021ba poate exista dinainte (rezisten\u021b\u0103 transmis\u0103) sau poate ap\u0103rea din cauza adheren\u021bei slabe.<\/p>\n<h3>Coinfec\u021bie cu HBV?<\/h3>\n<p>Critic \u2014 testa\u021bi HBsAg \u0219i ADN-ul HBV \u00eenainte de a \u00eencepe orice regim care con\u021bine lamivudin\u0103, tenofovir sau emtricitabin\u0103. Aceste medicamente sunt active \u0219i \u00eempotriva HBV; \u00eentreruperea lor poate provoca reactivare sever\u0103 a HBV. Coinfec\u021bia HBV\/HIV necesit\u0103 \u00eentotdeauna management combinat de speciali\u0219ti HIV\/hepatologie.<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Multe NRTI-uri sunt sigure \u00een sarcin\u0103 (tenofovir, lamivudin\u0103, emtricitabin\u0103, abacavir). Stavudina \u0219i didanozina ar trebui evitate. Regimurile ARV \u00een timpul sarcinii reduc transmiterea vertical\u0103 la sub 1% cu management adecvat.<\/p>\n<h3>N=NT?<\/h3>\n<p>Da \u2014 Nedetectabil = Netransmisibil. Persoanele care tr\u0103iesc cu HIV \u0219i men\u021bin o \u00eenc\u0103rc\u0103tur\u0103 viral\u0103 nedetectabil\u0103 (&lt;200 copii\/mL) sub tratament consistent nu transmit HIV prin contact sexual (studiile PARTNER, PARTNER2, Opposites Attract).<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Majoritatea NRTI-urilor au pu\u021bine interac\u021biuni (eliminate renal, f\u0103r\u0103 interac\u021biuni majore cu CYP). Tenofovir + ledipasvir: niveluri crescute de tenofovir, monitoriza\u021bi func\u021bia renal\u0103. Didanozin\u0103 + ribavirin\u0103: evita\u021bi (acidoz\u0103 lactic\u0103). Dezv\u0103lui\u021bi \u00eentotdeauna toate medicamentele, inclusiv cele pe baz\u0103 de plante.<\/p>\n<h3>Monitorizarea func\u021biei renale?<\/h3>\n<p>Tenofovir disoproxil (TDF) necesit\u0103 monitorizare renal\u0103 la fiecare 3-6 luni. \u00centrerupe\u021bi sau trece\u021bi la tenofovir alafenamid\u0103 (TAF) dac\u0103 eGFR &lt;50 mL\/min sau apare proteinurie semnificativ\u0103.<\/p>\n<h3>Densitatea osoas\u0103?<\/h3>\n<p>TDF reduce modest densitatea osoas\u0103; lua\u021bi \u00een considerare DEXA la utilizatorii pe termen lung cu alte riscuri de osteoporoz\u0103. TAF are un efect minim asupra oaselor.<\/p>\n<h3>Pot consuma alcool?<\/h3>\n<p>Consumul moderat de alcool este acceptabil. Consumul excesiv de alcool \u00eenr\u0103ut\u0103\u021be\u0219te adheren\u021ba \u0219i accelereaz\u0103 afec\u021biunile hepatice \u00een coinfec\u021bia cu HBV\/HCV. Evita\u021bi alcoolul dac\u0103 enzimele hepatice sunt anormale.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente HIV \u0219i antivirale<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/trioday\/\">Trioday<\/a> \u2014 TDF + 3TC + EFV \u2014 regim cu o singur\u0103 tablet\u0103 de la Cipla<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/triomune\/\">Triomune<\/a> \u2014 d4T + 3TC + NVP \u2014 regim mai vechi 3-\u00een-1 (pe baz\u0103 de stavudin\u0103)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zepdon\/\">Zepdon<\/a> \u2014 raltegravir 400 mg \u2014 inhibitor de integraz\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/abamune-l\/\">Abamune L<\/a> \u2014 abacavir + lamivudin\u0103 \u2014 alternativ\u0103 pentru scheletul NRTI<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-l\/\">Tenvir L<\/a> \u2014 tenofovir + lamivudine \u2014 alternativ\u0103 de baz\u0103 NRTI<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Tratamentul HIV este o terapie complex\u0103 \u0219i pe termen lung. Alegerea medicamentului depinde de genotip, teste de rezisten\u021b\u0103, comorbidit\u0103\u021bi \u0219i istoricul tratamentelor anterioare. Discuta\u021bi orice modificare a regimenului cu un specialist \u00een HIV. Este necesar\u0103 o conformitate &gt;95% pentru a preveni rezisten\u021ba. Testa\u021bi pentru HBV \u00eenainte de a \u00eencepe orice regimen care con\u021bine tenofovir, lamivudin\u0103 sau emtricitabin\u0103 \u2014 \u00eentreruperea poate provoca o exacerbare sever\u0103 a HBV la pacien\u021bii cu infec\u021bie mixt\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Abamune (Abacavir 300 mg) \u2014 NRTI de la Cipla pentru HIV. Combinat cu lamivudin\u0103 + INSTI sau NNRTI pentru un regim complet. Avertizare pentru reac\u021bie de hipersensibilitate HLA-B*5701.<\/p>","protected":false},"featured_media":50986,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[3305,3306],"class_list":{"0":"post-50985","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","9":"product_tag-abacavir-sulphate","10":"product_tag-abamune","12":"first","13":"outofstock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/50985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=50985"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/50986"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=50985"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=50985"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=50985"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=50985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}