{"id":51017,"date":"2023-09-20T09:16:16","date_gmt":"2023-09-20T09:16:16","guid":{"rendered":"https:\/\/medsname.com\/dinex-ec\/"},"modified":"2026-04-30T16:19:02","modified_gmt":"2026-04-30T16:19:02","slug":"dinex-ec","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/dinex-ec\/","title":{"rendered":"Dinex Ec"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Dinex EC<\/strong> \u2014 capsule enterice cu didanosine 250\/400 mg (Cipla). NRTI pentru HIV \u2014 agent mai vechi, acum rezervat pentru terapie de salvare sau situa\u021bii \u00een care NRTI moderne nu sunt disponibile. Toxicitatea mitocondrial\u0103 (neuropatie periferic\u0103, pancreatit\u0103, acidoz\u0103 lactic\u0103) limiteaz\u0103 utilizarea.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>Dinex EC este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj neutru, facturat prin intermediul unui procesor de pl\u0103\u021bi reglementat (descrierea tranzac\u021biei indic\u0103 un procesor de pl\u0103\u021bi cu card reglementat \u2014 niciodat\u0103 MedsBase sau nume de medicament). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Retrimitere \u00een 20 de zile lucr\u0103toare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Avertisment FDA \u00een cadru negru: pancreatit\u0103 + acidoz\u0103 lactic\u0103<\/strong><br \/>Didanosine are multiple avertismente \u00een cadru negru: acidoz\u0103 lactic\u0103 fatal\u0103 cu stetoz\u0103 hepatic\u0103 (\u00een special cu stavudin\u0103 sau \u00een sarcin\u0103), pancreatit\u0103 sever\u0103 (inciden\u021b\u0103 5-7% \u2014 cazuri fatale raportate), neuropatie periferic\u0103 (12-34%), modific\u0103ri retiniene\/neurit\u0103 optic\u0103. \u00cengrijirea modern\u0103 pentru HIV a \u00eenlocuit \u00een mare m\u0103sur\u0103 didanosine.<\/div>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>De ce se mai folose\u0219te didanosine?<\/h3>\n<p>\u00cen medii cu resurse limitate, regimuri de salvare dup\u0103 HIV multirezistent, sau situa\u021bii istorice specifice. Ghidurile moderne folosesc TDF sau TAF (sau abacavir) + lamivudin\u0103\/emtricitabin\u0103 \u00een schimb \u2014 profil de siguran\u021b\u0103 mult mai bun.<\/p>\n<h3>Avertisment pentru pancreatit\u0103?<\/h3>\n<p>5-7% dezvolt\u0103 pancreatit\u0103. \u00centrerupe\u021bi imediat dac\u0103 apar dureri abdominale + amilaz\u0103\/lipaz\u0103 crescut\u0103. Evita\u021bi combinarea cu alte medicamente cu risc de pancreatit\u0103 (alcool, valproat, hipertrigliceridemie).<\/p>\n<h3>Neuropatie periferic\u0103?<\/h3>\n<p>Frecvent\u0103 (12-34%) \u0219i dependent\u0103 de doz\u0103. De obicei reversibil\u0103 dac\u0103 medicamentul este \u00eentrerupt la timp. Combina\u021bia cu stavudin\u0103 amplific\u0103 riscul \u2014 nu combina\u021bi niciodat\u0103 d4T + ddI.<\/p>\n<h3>Acidoz\u0103 lactic\u0103?<\/h3>\n<p>Caracteristic\u0103 toxicit\u0103\u021bii mitocondriale. Mai frecvent\u0103 cu combina\u021bia d4T+ddI, la femei, \u00een sarcin\u0103, \u00een obezitate. Simptome: stare general\u0103 proast\u0103, oboseal\u0103, dureri abdominale, dificult\u0103\u021bi respiratorii, grea\u021b\u0103. \u00centrerupe\u021bi medicamentul imediat.<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Tenofovir + didanosin\u0103 cre\u0219te nivelurile de ddI \u2014 evita\u021bi combina\u021bia sau reduce\u021bi doza de ddI. Alopurinolul cre\u0219te nivelurile de ddI (evita\u021bi). Metadona reduce nivelurile de ddI (impact clinic minor).<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Evita\u021bi \u00een timpul sarcinii din cauza riscului de acidoz\u0103 lactic\u0103 (\u00een special cu d4T).<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi c\u00e2nd v\u0103 aminti\u021bi dac\u0103 este \u00een aceea\u0219i zi; altfel omite\u021bi. Nu dubla\u021bi doza. Respectarea tratamentului este critic\u0103 \u2014 iar acest medicament este greu de luat constant din cauza restric\u021biilor alimentare \u0219i a efectelor secundare.<\/p>\n<h3>Stomacul gol?<\/h3>\n<p>Formul\u0103rile mai vechi necesitau stomacul gol; formularea EC se ia pe stomacul gol (1 or\u0103 \u00eenainte sau 2 ore dup\u0103 o mas\u0103) \u2014 alimentele reduc absorb\u021bia cu ~50%.<\/p>\n<h3>C\u00e2nd ar trebui oprit?<\/h3>\n<p>Pancreatit\u0103 sever\u0103 (orice), progresia neuropatiei periferice, acidoz\u0103 lactic\u0103, modific\u0103ri retiniene sau e\u0219ec virologic impun oprirea sau \u00eenlocuirea. Majoritatea pacien\u021bilor care iau ddI \u00een \u00eengrijirea modern\u0103 ar trebui discuta\u021bi cu un specialist HIV pentru trecerea la alternative mai sigure.<\/p>\n<h3>Perspectiva pe termen lung?<\/h3>\n<p>Aproape to\u021bi pacien\u021bii cu HIV \u00een \u00eengrijirea modern\u0103 ar trebui s\u0103 fie pe un regim bazat pe TDF, TAF sau abacavir cu un al treilea agent INSTI. Continuarea utiliz\u0103rii ddI ar trebui revizuit\u0103 la fiecare vizit\u0103 la clinic\u0103, cu un plan clar de trecere la alternative mai sigure atunci c\u00e2nd acestea devin disponibile.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente HIV \u0219i antivirale<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/trioday\/\">Trioday<\/a> \u2014 TDF + 3TC + EFV \u2014 regim cu o singur\u0103 tablet\u0103 de la Cipla<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/triomune\/\">Triomune<\/a> \u2014 d4T + 3TC + NVP \u2014 regim mai vechi 3-\u00een-1 (pe baz\u0103 de stavudin\u0103)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zepdon\/\">Zepdon<\/a> \u2014 raltegravir 400 mg \u2014 inhibitor de integraz\u0103<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/abamune-l\/\">Abamune L<\/a> \u2014 abacavir + lamivudin\u0103 \u2014 alternativ\u0103 pentru scheletul NRTI<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-l\/\">Tenvir L<\/a> \u2014 tenofovir + lamivudine \u2014 alternativ\u0103 de baz\u0103 NRTI<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Tratamentul HIV este o terapie complex\u0103 \u0219i pe termen lung. Alegerea medicamentului depinde de genotip, teste de rezisten\u021b\u0103, comorbidit\u0103\u021bi \u0219i istoricul tratamentelor anterioare. Discuta\u021bi orice modificare a regimenului cu un specialist \u00een HIV. Este necesar\u0103 o conformitate &gt;95% pentru a preveni rezisten\u021ba. Testa\u021bi pentru HBV \u00eenainte de a \u00eencepe orice regimen care con\u021bine tenofovir, lamivudin\u0103 sau emtricitabin\u0103 \u2014 \u00eentreruperea poate provoca o exacerbare sever\u0103 a HBV la pacien\u021bii cu infec\u021bie mixt\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>Dinex EC (Didanosine 250\/400 mg) \u2014 NRTI mai vechi de la Cipla pentru HIV. Rezervat pentru terapie de salvare. Avertismente FDA \u00een cadru negru pentru pancreatit\u0103, acidoz\u0103 lactic\u0103 \u0219i neuropatie periferic\u0103.<\/p>","protected":false},"featured_media":51018,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[3318],"class_list":{"0":"post-51017","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","9":"product_tag-didanosine","11":"first","12":"outofstock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/51017","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=51017"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/51018"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=51017"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=51017"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=51017"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=51017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}