{"id":51121,"date":"2023-09-20T09:17:47","date_gmt":"2023-09-20T09:17:47","guid":{"rendered":"https:\/\/medsname.com\/x-vir\/"},"modified":"2026-04-30T16:19:01","modified_gmt":"2026-04-30T16:19:01","slug":"x-vir","status":"publish","type":"product","link":"https:\/\/medsbase.com\/ro\/product\/x-vir\/","title":{"rendered":"X-Vir"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">R\u0103spuns rapid<\/h3>\n<p style=\"margin-bottom:0;\"><strong>X-Vir<\/strong> \u2014 Entecavir 0,5\/1 mg (Natco Pharma). NRTI puternic pentru hepatita B cronic\u0103. Terapie oral\u0103 de prim\u0103 linie pentru HBV al\u0103turi de tenofovir. Doza de 0,5 mg pentru pacien\u021bi naive la nucleozide; 1 mg pentru cei cu experien\u021b\u0103 \u00een lamivudin\u0103. NU utiliza\u021bi NICIODAT\u0102 ca monoterapie HIV \u00een caz de coinfec\u021bie netratat\u0103 \u2014 selecteaz\u0103 rezisten\u021b\u0103 la HIV.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>Ce beneficii ofer\u0103 MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>produc\u0103tor certificat WHO-GMP<\/li>\n<li>Ambalaj discret \u00een plic simplu<\/li>\n<li>Livrare \u00een toat\u0103 lumea<\/li>\n<li>Evaluat de peste 1.400 de clien\u021bi (<a href=\"https:\/\/medsbase.com\/ro\/reviews\/\">cite\u0219te recenziile<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>Garan\u021bia de retransmitere:<\/strong> dac\u0103 comanda dvs. nu a ajuns \u00een 20 de zile lucr\u0103toare de la expediere, o retransmitem f\u0103r\u0103 costuri suplimentare. <a href=\"https:\/\/medsbase.com\/ro\/medsbase-re-shipment-assurance-policy\/\">Cite\u0219te politica<\/a>.<\/p>\n<h3>De ce s\u0103 comanzi de la MedsBase<\/h3>\n<p>X-Vir este expediat de la un produc\u0103tor certificat WHO-GMP \u00een ambalaj neutru, facturat printr-un procesator de pl\u0103\u021bi reglementat (descrierea extrasului de cont men\u021bioneaz\u0103 un procesator de pl\u0103\u021bi reglementat \u2014 niciodat\u0103 MedsBase sau nume de medicamente). Fiecare comand\u0103 beneficiaz\u0103 de Garan\u021bia noastr\u0103 de Reexpediere \u00een 20 de zile lucr\u0103toare.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Testarea HIV esen\u021bial\u0103<\/strong><br \/>Lamivudina \u0219i entecavirul utilizate ca monoterapie \u00een infec\u021bia mixt\u0103 HIV\/VHB netratat\u0103 selecteaz\u0103 rapid rezisten\u021b\u0103 la HIV (M184V pentru lamivudin\u0103; muta\u021bii ale integrazei pentru entecavir). Efectua\u021bi test HIV \u00eenainte de a \u00eencepe orice monoterapie pentru VHB. Dac\u0103 sunte\u021bi HIV-pozitiv, utiliza\u021bi un regim complet de TAR care acoper\u0103 ambele virusuri (de obicei TDF sau TAF + emtricitabin\u0103\/lamivudin\u0103 + un al treilea agent).<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Risc de \u00eentrerupere<\/strong><br \/>\u00centreruperea brusc\u0103 a oric\u0103rui nucleozid\/nucleotid anti-VHB poate provoca o exacerbare acut\u0103 sever\u0103 a VHB cu posibil\u0103 decompensare. Nu \u00eentrerupe\u021bi niciodat\u0103 f\u0103r\u0103 supraveghere hepatologic\u0103 \u0219i monitorizare post-\u00eentrerupere.<\/div>\n<h2 id=\"faqs\">\u00centreb\u0103ri frecvente<\/h2>\n<h3>C\u00e2nd este adecvat\u0103 monoterapia?<\/h3>\n<p>Monoterapia cu Lamivudin\u0103 pentru HBV este \u00een mare parte dep\u0103\u0219it\u0103 din cauza apari\u021biei rezisten\u021bei. Entecavirul \u0219i tenofovirul sunt tratamente de prim\u0103 linie. Lamivudina r\u0103m\u00e2ne o op\u021biune \u00een regiunile cu resurse limitate, \u00een timpul sarcinii (date extinse de siguran\u021b\u0103) sau ca parte a terapiei combinate.<\/p>\n<h3>Exist\u0103 vindecare pentru HBV?<\/h3>\n<p>Vindecarea adev\u0103rat\u0103 (pierderea HBsAg, uneori numit\u0103 vindecare func\u021bional\u0103) este rar\u0103 cu terapia oral\u0103 actual\u0103 \u2014 de obicei &lt;5% pe an. Majoritatea pacien\u021bilor au nevoie de suprimare pe termen lung\/pe via\u021b\u0103. Activitatea bolii, fibroza \u0219i riscul de HCC scad dramatic cu terapia consecvent\u0103 chiar \u0219i f\u0103r\u0103 eliminarea HBsAg.<\/p>\n<h3>C\u00e2nd pot \u00eentrerupe tratamentul?<\/h3>\n<p>\u00centreruperea este luat\u0103 \u00een considerare dup\u0103 seroconversia sus\u021binut\u0103 a HBeAg + ADN HBV nedetectabil timp de \u226512 luni \u00een boala HBeAg-pozitiv\u0103 sau pierderea HBsAg. \u00centreruperea trebuie \u00eentotdeauna supravegheat\u0103 de un specialist cu monitorizare atent\u0103 pentru reactivare HBV.<\/p>\n<h3>Monitorizare HCC?<\/h3>\n<p>To\u021bi pacien\u021bii cu HBV cronic au nevoie de supraveghere HCC la 6 luni cu ecografie abdominal\u0103 \u00b1 AFP, mai ales dac\u0103 sunt cirotici, au antecedente familiale de HCC sau anumite caracteristici demografice (b\u0103rbat asiatic &gt;40, african &gt;20, inflama\u021bie persistent\u0103).<\/p>\n<h3>Sarcin\u0103?<\/h3>\n<p>Tenofovirul este preferat \u00een sarcin\u0103 (TDF sau TAF). Lamivudina este o alternativ\u0103 cu date extinse despre sarcin\u0103. Entecavirul este \u00een general evitat din cauza datelor limitate despre sarcin\u0103.<\/p>\n<h3>Interac\u021biuni medicamentoase?<\/h3>\n<p>Pu\u021bine interac\u021biuni majore pentru aceste medicamente eliminate renal. Evita\u021bi combina\u021bia cu medicamente nefrototoxice (AINS cronice, aminoglicozide). Tenofovir + regimuri de tratament pentru hepatita C care con\u021bin ledipasvir \u2014 monitoriza\u021bi func\u021bia renal\u0103.<\/p>\n<h3>Ce fac dac\u0103 uit o doz\u0103?<\/h3>\n<p>Lua\u021bi c\u00e2nd v\u0103 aminti\u021bi, dac\u0103 este \u00een aceea\u0219i zi; dac\u0103 este a doua zi, omite\u021bi doza ratat\u0103. Nu lua\u021bi o dobl\u0103. Discuta\u021bi dificult\u0103\u021bile de adheren\u021b\u0103 cu hepatologul dumneavoastr\u0103 \u2014 pot fi disponibile regimuri alternative sau scheme posibil simplificate.<\/p>\n<h3>Efecte secundare?<\/h3>\n<p>\u00cen general, bine tolerat. Tenofovir disoproxil: tubulopatie renal\u0103, pierdere a densit\u0103\u021bii osoase pe termen lung. Tenofovir alafenamid: impact renal\/osos minim. Entecavir: acidoz\u0103 lactic\u0103 rar\u0103. Lamivudin\u0103: foarte bine tolerat\u0103.<\/p>\n<h3>Ce se \u00eent\u00e2mpl\u0103 cu HCC dup\u0103 tratament?<\/h3>\n<p>Riscul de HCC asociat HBV persist\u0103 chiar \u0219i dup\u0103 suprimarea viral\u0103 \u2014 nu \u00eenceta\u021bi niciodat\u0103 supravegherea doar pentru c\u0103 ADN-ul HBV este nedetectabil. Pacien\u021bii cu ciroz\u0103 au nevoie \u00een special de ecografii abdominale la fiecare 6 luni pe via\u021b\u0103.<\/p>\n<h3>Vaccinare?<\/h3>\n<p>To\u021bi contactele din gospod\u0103rie \u0219i partenerii sexuali ar trebui testa\u021bi pentru HBsAg \u0219i vaccina\u021bi \u00eempotriva HBV dac\u0103 sunt susceptibili. Pacientul ar trebui s\u0103 primeasc\u0103 \u0219i vaccinare \u00eempotriva HAV, pneumococ, grip\u0103 anual\u0103 \u0219i (dup\u0103 recuperarea CD4 dac\u0103 are coinfec\u021bie HIV) alte vaccinuri indicate.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Alte medicamente antivirale<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/ro\/tenvir-l\/\">Tenvir L<\/a> \u2014 tenofovir + lamivudin\u0103 \u2014 schelet NRTI combinat pentru HIV\/HBV<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/x-vir\/\">X-Vir<\/a> \u2014 entecavir 0,5\/1 mg \u2014 monoterapie de prim\u0103 linie pentru HBV<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/lamivir-hbv\/\">Lamivir HBV<\/a> \u2014 lamivudin\u0103 100 mg \u2014 monoterapie mai veche pentru HBV<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/myhep\/\">MyHep<\/a> \u2014 sofosbuvir 400 mg \u2014 pentru HCV<\/li>\n<li><a href=\"https:\/\/medsbase.com\/ro\/zimivir\/\">Zimivir<\/a> \u2014 valaciclovir 500\/1000 mg \u2014 pentru HSV<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>Disclaimer medical:<\/strong> Tratamentul HIV este o terapie complex\u0103 \u0219i pe termen lung. Alegerea medicamentului depinde de genotip, teste de rezisten\u021b\u0103, comorbidit\u0103\u021bi \u0219i istoricul tratamentelor anterioare. Discuta\u021bi orice modificare a regimenului cu un specialist \u00een HIV. Este necesar\u0103 o conformitate &gt;95% pentru a preveni rezisten\u021ba. Testa\u021bi pentru HBV \u00eenainte de a \u00eencepe orice regimen care con\u021bine tenofovir, lamivudin\u0103 sau emtricitabin\u0103 \u2014 \u00eentreruperea poate provoca o exacerbare sever\u0103 a HBV la pacien\u021bii cu infec\u021bie mixt\u0103.<\/div>","protected":false},"excerpt":{"rendered":"<p>X-Vir (Entecavir 0,5\/1 mg) \u2014 NRTI puternic de la Natco pentru suprimarea cronic\u0103 a virusului hepatitei B. Terapie oral\u0103 de prim\u0103 linie pentru HBV. Este necesar\u0103 separarea strict\u0103 de tratamentul HIV \u00een caz de coinfec\u021bie.<\/p>","protected":false},"featured_media":51122,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3304],"product_tag":[],"class_list":{"0":"post-51121","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hiv-medication","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product\/51121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/comments?post=51121"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media\/51122"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/media?parent=51121"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_brand?post=51121"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_cat?post=51121"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/ro\/wp-json\/wp\/v2\/product_tag?post=51121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}